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Aliases for AKAP13 Gene

Aliases for AKAP13 Gene

  • A-Kinase Anchoring Protein 13 2 3 5
  • Lymphoid Blast Crisis Oncogene 2 3 4
  • Breast Cancer Nuclear Receptor-Binding Auxiliary Protein 3 4
  • Non-Oncogenic Rho GTPase-Specific GTP Exchange Factor 3 4
  • Guanine Nucleotide Exchange Factor Lbc 3 4
  • Protein Kinase A-Anchoring Protein 13 3 4
  • Human Thyroid-Anchoring Protein 31 3 4
  • A Kinase (PRKA) Anchor Protein 13 2 3
  • LBC Oncogene 3 4
  • AKAP-Lbc 3 4
  • AKAP-13 3 4
  • PRKA13 3 4
  • Ht31 3 4
  • LBC 3 4
  • BRX 3 4
  • P47 3 4
  • A-Kinase Anchor Protein 13 3
  • PROTO-LBC 3
  • ARHGEF13 3
  • PROTO-LB 3
  • C-Lbc 3
  • HA-3 3

External Ids for AKAP13 Gene

Previous HGNC Symbols for AKAP13 Gene

  • LBC

Previous GeneCards Identifiers for AKAP13 Gene

  • GC15M082290
  • GC15P079144
  • GC15P083511
  • GC15P083653
  • GC15P083724
  • GC15P083578
  • GC15P085925
  • GC15P061986
  • GC15P085777

Summaries for AKAP13 Gene

Entrez Gene Summary for AKAP13 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

GeneCards Summary for AKAP13 Gene

AKAP13 (A-Kinase Anchoring Protein 13) is a Protein Coding gene. Diseases associated with AKAP13 include Tick-Borne Relapsing Fever and Relapsing Fever. Among its related pathways are p75 NTR receptor-mediated signalling and Aquaporin-mediated transport. GO annotations related to this gene include signal transducer activity and protein complex scaffold. An important paralog of this gene is ARHGEF28.

UniProtKB/Swiss-Prot for AKAP13 Gene

  • Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).

Gene Wiki entry for AKAP13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP13 Gene

Genomics for AKAP13 Gene

Regulatory Elements for AKAP13 Gene


Enhancers around AKAP13 on UCSC Golden Path with GeneCards custom track

Promoters for AKAP13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080542 329 2601 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF48 YY1 GLIS2 ZNF143

Genomic Location for AKAP13 Gene

Chromosome:
15
Start:
85,380,571 bp from pter
End:
85,749,358 bp from pter
Size:
368,788 bases
Orientation:
Plus strand

Genomic View for AKAP13 Gene

Genes around AKAP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP13 Gene

Proteins for AKAP13 Gene

  • Protein details for AKAP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12802-AKP13_HUMAN
    Recommended name:
    A-kinase anchor protein 13
    Protein Accession:
    Q12802
    Secondary Accessions:
    • Q14572
    • Q59FP6
    • Q86W90
    • Q8WXQ6
    • Q96JP6
    • Q96P79
    • Q9Y5T0
    • Q9Y5T6

    Protein attributes for AKAP13 Gene

    Size:
    2813 amino acids
    Molecular mass:
    307550 Da
    Quaternary structure:
    • Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:11546812, PubMed:1618839, PubMed:15229649, PubMed:21102438, PubMed:11285229). Interacts with RHOA (PubMed:11546812, PubMed:17537920, PubMed:25186459, PubMed:24993829). Interacts also with RHOB and RHOC (PubMed:11546812). Identified in a ternary complex with RHOA and PRKAR2A (PubMed:11546812). Identified in a complex with NR3C1 and RHOA (PubMed:16469733). Interacts with BRAF and KSR1 (PubMed:21102438). Identified in a complex with BRAF and KSR1 (PubMed:21102438). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Interacts (phosphorylated form) with YWHAB and YWHAZ (PubMed:15229649, PubMed:21224381). Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases (PubMed:15229649, PubMed:21224381). Interacts with GNA12 (PubMed:11546812). Interacts with IKBKB (PubMed:23090968). Interacts with ESR1, THRA, PPARA and NME2 (PubMed:9627117, PubMed:15249197). Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB. Interacts (via the C-terminal domain after the PH domain) with PRKD1 (By similarity).
    SequenceCaution:
    • Sequence=AAC50065.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC50065.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Evidence={ECO:0000305}; Sequence=AAD40799.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD40799.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAL40923.1; Type=Frameshift; Positions=2614, 2647; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKAP13 Gene

    Alternative splice isoforms for AKAP13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP13 Gene

Post-translational modifications for AKAP13 Gene

  • Ubiquitination at Lys186
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for AKAP13

No data available for DME Specific Peptides for AKAP13 Gene

Domains & Families for AKAP13 Gene

Suggested Antigen Peptide Sequences for AKAP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12802

UniProtKB/Swiss-Prot:

AKP13_HUMAN :
  • The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA (PubMed:24993829). Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes (PubMed:9891067).
Domain:
  • The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA (PubMed:24993829). Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes (PubMed:9891067).
  • The PH domain does not play a role in lipid-binding. Instead, it inhibits the guanine nucleotide exchange (GEF) activity of the isolated DH domain (in vitro).
  • The C-terminal domain after the PH domain is involved in protein-protein interactions that are required for normal, compensatory cardiac hypertrophy in response to pressure overload.
genes like me logo Genes that share domains with AKAP13: view

Function for AKAP13 Gene

Molecular function for AKAP13 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RII) anchor protein 13
UniProtKB/Swiss-Prot Function:
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for AKAP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004691 cAMP-dependent protein kinase activity IEA --
GO:0004871 signal transducer activity TAS 8290273
GO:0005078 MAP-kinase scaffold activity IDA 21224381
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
genes like me logo Genes that share ontologies with AKAP13: view
genes like me logo Genes that share phenotypes with AKAP13: view

Animal Models for AKAP13 Gene

MGI Knock Outs for AKAP13:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKAP13 Gene

Localization for AKAP13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP13 Gene

Cytoplasm, cytosol. Cytoplasm. Cytoplasm, cell cortex. Nucleus. Membrane; Peripheral membrane protein. Note=Colocalizes with the actin cytoskeleton at the cell cortex. {ECO:0000269 PubMed:11546812}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP13 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AKAP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with AKAP13: view

Pathways & Interactions for AKAP13 Gene

genes like me logo Genes that share pathways with AKAP13: view

SIGNOR curated interactions for AKAP13 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for AKAP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 11546812
GO:0007507 heart development ISS,IEA --
GO:0010611 regulation of cardiac muscle hypertrophy IEA --
GO:0035023 regulation of Rho protein signal transduction IEA --
genes like me logo Genes that share ontologies with AKAP13: view

Drugs & Compounds for AKAP13 Gene

(18) Drugs for AKAP13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
calcium Nutra 0

(10) Additional Compounds for AKAP13 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with AKAP13: view

Transcripts for AKAP13 Gene

Unigene Clusters for AKAP13 Gene

A kinase (PRKA) anchor protein 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:

ExUns: 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for AKAP13 Gene

GeneLoc Exon Structure for
AKAP13
ECgene alternative splicing isoforms for
AKAP13

Expression for AKAP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKAP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AKAP13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6) and Adrenal (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AKAP13 Gene



Protein tissue co-expression partners for AKAP13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AKAP13 Gene:

AKAP13

SOURCE GeneReport for Unigene cluster for AKAP13 Gene:

Hs.459211

mRNA Expression by UniProt/SwissProt for AKAP13 Gene:

Q12802-AKP13_HUMAN
Tissue specificity: Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle.

Evidence on tissue expression from TISSUES for AKAP13 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Muscle(4.5)
  • Thyroid gland(4.4)
  • Liver(4.3)
  • Kidney(3.5)
  • Heart(2.6)
  • Spleen(2.2)
  • Bone marrow(2)
  • Eye(2)
  • Lymph node(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with AKAP13: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP13 Gene

Orthologs for AKAP13 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKAP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP13 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia AKAP13 34 35
  • 83.89 (n)
mouse
(Mus musculus)
Mammalia Akap13 34 16 35
  • 79.71 (n)
rat
(Rattus norvegicus)
Mammalia Akap13 34
  • 79.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP13 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKAP13 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP13 34 35
  • 70.26 (n)
lizard
(Anolis carolinensis)
Reptilia AKAP13 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akap13 34
  • 63.66 (n)