Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLK8 Gene

Aliases for KLK8 Gene

  • Kallikrein-Related Peptidase 8 2 3
  • PRSS19 3 4 6
  • TADG14 3 4 6
  • Tumor-Associated Differentially Expressed Gene 14 Protein 3 4
  • Serine Protease TADG-14 3 4
  • Serine Protease 19 3 4
  • Ovasin 3 4
  • NRPN 3 4
  • NP 3 4
  • Kallikrein 8 (Neuropsin/Ovasin) 2
  • EC 3.4.21.118 4
  • Kallikrein-8 3
  • Neuropsin 4
  • EC 3.4.21 63
  • HNP 3
  • HK8 4

External Ids for KLK8 Gene

Previous HGNC Symbols for KLK8 Gene

  • PRSS19

Previous GeneCards Identifiers for KLK8 Gene

  • GC19M052129
  • GC19M051860
  • GC19M056175
  • GC19M056191
  • GC19M051499
  • GC19M047832

Summaries for KLK8 Gene

Entrez Gene Summary for KLK8 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for KLK8 Gene

KLK8 (Kallikrein-Related Peptidase 8) is a Protein Coding gene. Diseases associated with KLK8 include spinal cord injury and radiculopathy. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK8 Gene

  • Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Gene Wiki entry for KLK8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK8 Gene

Genomics for KLK8 Gene

Regulatory Elements for KLK8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLK8 Gene

Start:
50,996,007 bp from pter
End:
51,002,711 bp from pter
Size:
6,705 bases
Orientation:
Minus strand

Genomic View for KLK8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK8 Gene

Proteins for KLK8 Gene

  • Protein details for KLK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60259-KLK8_HUMAN
    Recommended name:
    Kallikrein-8
    Protein Accession:
    O60259
    Secondary Accessions:
    • Q5V9X1
    • Q5V9X2
    • Q8IW69
    • Q9HCB3
    • Q9NR68
    • Q9NR69
    • Q9UIL9
    • Q9UQ47

    Protein attributes for KLK8 Gene

    Size:
    260 amino acids
    Molecular mass:
    28048 Da
    Quaternary structure:
    • Interacts with SPINK9.
    Miscellaneous:
    • Expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer

    Alternative splice isoforms for KLK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK8 Gene

Proteomics data for KLK8 Gene at MOPED

Selected DME Specific Peptides for KLK8 Gene

Post-translational modifications for KLK8 Gene

  • Glycosylation at Asn110
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK8 (Kallikrein 8/Neuropsin)

Protein Products

Domains for KLK8 Gene

Gene Families for KLK8 Gene

HGNC:
  • KLK :Kallikreins
  • PRSS :Serine peptidases / Serine peptidases

Graphical View of Domain Structure for InterPro Entry

O60259

UniProtKB/Swiss-Prot:

KLK8_HUMAN :
  • O60259
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK8: view

Function for KLK8 Gene

Molecular function for KLK8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.07 mM for Pro-Phe-Arg-MCA {ECO:0000269 PubMed:16337200}; KM=0.07 mM for Z-Val-Val-Arg-MCA {ECO:0000269 PubMed:16337200}; KM=0.07 mM for Boc-Val-Pro-Arg-MCA {ECO:0000269 PubMed:16337200}; KM=0.10 mM for Boc-Leu-Lys-Arg-MCA {ECO:0000269 PubMed:16337200}; KM=0.10 mM for Boc-Val-Leu-Lys-MCA {ECO:0000269 PubMed:16337200}; KM=0.07 mM for Boc-Phe-Ser-Arg-MCA {ECO:0000269 PubMed:16337200}; Vmax=7.1 umol/min/mg enzyme toward Pro-Phe-Arg-MCA {ECO:0000269 PubMed:16337200}; Vmax=5.4 umol/min/mg enzyme toward Z-Val-Val-Arg-MCA {ECO:0000269 PubMed:16337200}; Vmax=3.9 umol/min/mg enzyme toward Boc-Val-Pro-Arg-MCA {ECO:0000269 PubMed:16337200}; Vmax=2.6 umol/min/mg enzyme toward Boc-Leu-Lys-Arg-MCA {ECO:0000269 PubMed:16337200}; Vmax=1.9 umol/min/mg enzyme toward Boc-Val-Leu-Lys-MCA {ECO:0000269 PubMed:16337200}; Vmax=1.6 umol/min/mg enzyme toward Boc-Phe-Ser-Arg-MCA {ECO:0000269 PubMed:16337200}; pH dependence: Optimum pH is 8.5. Active from pH 7-10. {ECO:0000269 PubMed:16337200};
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor.
UniProtKB/Swiss-Prot Function: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Enzyme Numbers (IUBMB) for KLK8 Gene

Gene Ontology (GO) - Molecular Function for KLK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IDA 16337200
GO:0005515 protein binding IPI 17761692
genes like me logo Genes that share ontologies with KLK8: view

Phenotypes for KLK8 Gene

genes like me logo Genes that share phenotypes with KLK8: view

Animal Models for KLK8 Gene

MGI Knock Outs for KLK8:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK8

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for KLK8 Gene

Localization for KLK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK8 Gene

Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK8 Gene COMPARTMENTS Subcellular localization image for KLK8 gene
Compartment Confidence
extracellular 5
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KLK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm IDA 17761692
genes like me logo Genes that share ontologies with KLK8: view

Pathways for KLK8 Gene

genes like me logo Genes that share pathways with KLK8: view

Pathways by source for KLK8 Gene

1 BioSystems pathway for KLK8 Gene

Gene Ontology (GO) - Biological Process for KLK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007613 memory ISS --
GO:0008219 cell death ISS --
GO:0009611 response to wounding ISS --
GO:0031642 negative regulation of myelination ISS --
genes like me logo Genes that share ontologies with KLK8: view

Compounds for KLK8 Gene

(2) Novoseek inferred chemical compound relationships for KLK8 Gene

Compound -log(P) Hits PubMed IDs
serine 62.6 7
steroid 10.3 1
genes like me logo Genes that share compounds with KLK8: view

Transcripts for KLK8 Gene

Unigene Clusters for KLK8 Gene

Kallikrein-related peptidase 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLK8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6:
SP7: - - - - - -
SP8: - -

Relevant External Links for KLK8 Gene

GeneLoc Exon Structure for
KLK8
ECgene alternative splicing isoforms for
KLK8

Expression for KLK8 Gene

mRNA expression in normal human tissues for KLK8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK8 Gene

This gene is overexpressed in Esophagus - Mucosa (16.5), Skin - Sun Exposed (Lower leg) (12.4), Skin - Not Sun Exposed (Suprapubic) (11.1), and Vagina (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLK8 Gene

SOURCE GeneReport for Unigene cluster for KLK8 Gene Hs.104570

mRNA Expression by UniProt/SwissProt for KLK8 Gene

O60259-KLK8_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
genes like me logo Genes that share expressions with KLK8: view

In Situ Assay Products

Orthologs for KLK8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK8 35
  • 99.23 (n)
  • 99.67 (a)
KLK8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLK8 35
  • 80.31 (n)
  • 73.84 (a)
KLK8 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK8 35
  • 83.27 (n)
  • 77.99 (a)
mouse
(Mus musculus)
Mammalia Klk8 35
  • 76.58 (n)
  • 72.2 (a)
Klk8 16
Klk8 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk8 35
  • 76.96 (n)
  • 72.2 (a)
Species with no ortholog for KLK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK8 Gene

ENSEMBL:
Gene Tree for KLK8 (if available)
TreeFam:
Gene Tree for KLK8 (if available)

Paralogs for KLK8 Gene

genes like me logo Genes that share paralogs with KLK8: view

Variants for KLK8 Gene

Sequence variations from dbSNP and Humsavar for KLK8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1612902 -- 50,995,939(-) GGCAG(A/G)CTAGG downstream-variant-500B
rs1627239 -- 50,996,569(-) TTTTA(G/T)TAGAG intron-variant
rs1654539 -- 50,997,645(-) GACTT(A/G)GCACC intron-variant
rs1654542 -- 50,995,860(-) TTTTC(C/T)GGAAG downstream-variant-500B
rs1654543 -- 50,995,733(-) AAAGC(A/G)TTTAC downstream-variant-500B

Relevant External Links for KLK8 Gene

HapMap Linkage Disequilibrium report
KLK8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLK8 Gene

Disorders for KLK8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KLK8 Gene including...

Search for KLK8 Gene in MalaCards »

(2) University of Copenhagen DISEASES for KLK8 Gene

(7) Novoseek inferred disease relationships for KLK8 Gene

Disease -log(P) Hits PubMed IDs
hyperkeratosis 57.1 1
residual disease 57 2
ovarian cancer 54.9 8
ovarian carcinoma 49.8 3
psoriasis 31.9 1

Relevant External Links for KLK8

Genetic Association Database (GAD)
KLK8
Human Genome Epidemiology (HuGE) Navigator
KLK8
genes like me logo Genes that share disorders with KLK8: view

No data available for UniProtKB/Swiss-Prot for KLK8 Gene

Publications for KLK8 Gene

  1. A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain. (PMID: 10102990) Mitsui S. … Yamaguchi N. (Eur. J. Biochem. 1999) 2 3 4 23
  2. A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory. (PMID: 17487847) Lu Z.-X. … Su B. (Hum. Mutat. 2007) 3 4 23
  3. Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. (PMID: 18354391) Izumi A. … Kunugi H. (Neuropsychopharmacology 2008) 3 23 48
  4. The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. (PMID: 11309326) Magklara A. … Diamandis E.P. (Clin. Cancer Res. 2001) 3 4 23
  5. Sequence analysis and expression of human neuropsin cDNA and gene. (PMID: 9714609) Yoshida S. … Shiosaka S. (Gene 1998) 2 3 4

Products for KLK8 Gene

Sources for KLK8 Gene

Back to Top

Content