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Aliases for PTENP1 Gene

Subcategory (RNA class) for PTENP1 Gene

lncRNA

Aliases for PTENP1 Gene

  • Phosphatase And Tensin Homolog Pseudogene 1 2 3 5
  • Phosphatase And Tensin Homolog Pseudogene 1 (Functional) 2 3
  • Phosphatase And Tensin Homolog (Mutated In Multiple Advanced Cancers 1), Pseudogene 1 3
  • PTEN/MMAC1 Pseudogene 3
  • PTEN-Rs 3
  • PTENpg1 3
  • PsiPTEN 3
  • PTEN2 3
  • PTH2 3

External Ids for PTENP1 Gene

ORGUL Members for PTENP1 Gene

Previous GeneCards Identifiers for PTENP1 Gene

  • GC09M033987
  • GC09M033844

Summaries for PTENP1 Gene

Entrez Gene Summary for PTENP1 Gene

  • The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Apr 2013]

GeneCards Summary for PTENP1 Gene

PTENP1 (Phosphatase And Tensin Homolog Pseudogene 1) is a Pseudogene, and is affiliated with the lncRNA class.

Gene Wiki entry for PTENP1 Gene

fRNAdb sequence ontologies for PTENP1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for PTENP1

Additional gene information for PTENP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for PTENP1 Gene

Genomics for PTENP1 Gene

GeneHancer (GH) Regulatory Elements for PTENP1 Gene

Promoters and enhancers for PTENP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I033675 Promoter/Enhancer 1.3 Ensembl ENCODE 550.8 +0.7 683 1.9 RB1 SIN3A ZNF335 GLIS2 ATF7 ZNF280D YY2 CEBPB ZNF398 REST PTENP1 PTENP1-AS ENSG00000260947 LINC01251 NUDT2 TRBV25OR9-2
GH09I033442 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.7 +232.1 232107 6.2 FOXA2 PKNOX1 MLX ARID4B SIN3A YY1 ZNF766 FOS DEK NFYC AQP3 AQP7 NOL6 PTENP1 NFX1 BAG1 SMU1 PIR43065
GH09I033452 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.3 +223.8 223800 2.6 HDGF ELF3 MLX ZFP64 ARID4B ZBTB7B ZNF48 RAD21 RARA ZNF335 GC09P033453 AQP3 NOL6 ANKRD18B CYP4F26P PTENP1 MIR6851
GH09I033455 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.3 +219.6 219590 4.1 BATF IRF4 ELK1 RCOR1 ETV6 FOS RUNX3 ELK4 USF2 JUNB AQP7 NOL6 AQP3 LOC105376020 BAG1 CHMP5 SUGT1P1 PTENP1 GC09P033453 MIR6851
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTENP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTENP1 gene promoter:

Genomic Locations for PTENP1 Gene

Genomic Locations for PTENP1 Gene
chr9:33,673,504-33,677,499
(GRCh38/hg38)
Size:
3,996 bases
Orientation:
Minus strand
chr9:33,673,502-33,677,497
(GRCh37/hg19)

Genomic View for PTENP1 Gene

Genes around PTENP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTENP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTENP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTENP1 Gene

ORGUL Member Location for PTENP1 Gene

ORGUL Member Location for PTENP1 gene

Proteins for PTENP1 Gene

Post-translational modifications for PTENP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PTENP1 Gene

Domains & Families for PTENP1 Gene

Gene Families for PTENP1 Gene

Suggested Antigen Peptide Sequences for PTENP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTENP1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for PTENP1 Gene

Function for PTENP1 Gene

Molecular function for PTENP1 Gene

GENATLAS Biochemistry:
phosphatase and tensin homolog 2,pseudogene 1,playing a role in small cell lung cancer tumorigenesis (see TSG9A)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTENP1 Gene

Localization for PTENP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PTENP1 Gene

Pathways & Interactions for PTENP1 Gene

SuperPathways for PTENP1 Gene

No Data Available

Interacting Proteins for PTENP1 Gene

Gene Ontology (GO) - Biological Process for PTENP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PTENP1 Gene

Drugs & Compounds for PTENP1 Gene

No Compound Related Data Available

Transcripts for PTENP1 Gene

fRNAdb Secondary structures for PTENP1 Gene

  • FR279969
  • FR272101

mRNA/cDNA for PTENP1 Gene

Unigene Clusters for PTENP1 Gene

Phosphatase and tensin homolog pseudogene 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTENP1 Gene

No ASD Table

Relevant External Links for PTENP1 Gene

GeneLoc Exon Structure for
PTENP1
ECgene alternative splicing isoforms for
PTENP1

Expression for PTENP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTENP1 Gene

mRNA differential expression in normal tissues according to GTEx for PTENP1 Gene

This gene is overexpressed in Whole Blood (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of PTENP1 Gene:

PTENP1

SOURCE GeneReport for Unigene cluster for PTENP1 Gene:

Hs.493716
genes like me logo Genes that share expression patterns with PTENP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTENP1 Gene

Orthologs for PTENP1 Gene

Evolution for PTENP1 Gene

ENSEMBL:
Gene Tree for PTENP1 (if available)
TreeFam:
Gene Tree for PTENP1 (if available)

No data available for Orthologs for PTENP1 Gene

Paralogs for PTENP1 Gene

(4) SIMAP similar genes for PTENP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTENP1: view

No data available for Paralogs for PTENP1 Gene

Variants for PTENP1 Gene

Sequence variations from dbSNP and Humsavar for PTENP1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000341772 -- 33,673,715(-) A/C non_coding_transcript_variant
rs1000491893 -- 33,673,373(-) T/C downstream_transcript_variant
rs1002108603 -- 33,675,186(-) T/C non_coding_transcript_variant
rs1002564227 -- 33,674,876(-) C/T non_coding_transcript_variant
rs1002776203 -- 33,677,417(-) A/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PTENP1 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv471653 CNV gain 15918152
nsv518977 CNV gain 19592680
nsv614150 CNV gain 21841781
nsv968605 CNV duplication 23825009

Additional Variant Information for PTENP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTENP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PTENP1 Gene

Disorders for PTENP1 Gene

Additional Disease Information for PTENP1

No disorders were found for PTENP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTENP1 Gene

Publications for PTENP1 Gene

  1. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. (PMID: 9620558) Dahia PL … Eng C (Oncogene 1998) 2 3 22 58
  2. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. (PMID: 20577206) Poliseno L … Pandolfi PP (Nature 2010) 2 3 58
  3. Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. (PMID: 10208437) Fujii GH … Bolen JB (Oncogene 1999) 3 22 58
  4. Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. (PMID: 9467947) Kim SK … Mao L (Oncogene 1998) 3 22 58
  5. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. (PMID: 9393738) Teng DH … Steck PA (Cancer research 1997) 2 3 58

Products for PTENP1 Gene

Sources for PTENP1 Gene

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