Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTENP1 Gene

Subcategory (RNA class) for PTENP1 Gene

lncRNA

Aliases for PTENP1 Gene

  • Phosphatase And Tensin Homolog Pseudogene 1 (Functional) 2 3
  • Phosphatase And Tensin Homolog (Mutated In Multiple Advanced Cancers 1), Pseudogene 1 3
  • Phosphatase And Tensin Homolog Pseudogene 1 2
  • PTEN/MMAC1 Pseudogene 3
  • PTEN-Rs 3
  • PTENpg1 3
  • PsiPTEN 3
  • PTEN2 3
  • PTH2 3

External Ids for PTENP1 Gene

ORGUL Members for PTENP1 Gene

Previous GeneCards Identifiers for PTENP1 Gene

  • GC09M033987
  • GC09M033844

Summaries for PTENP1 Gene

Entrez Gene Summary for PTENP1 Gene

  • The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Apr 2013]

GeneCards Summary for PTENP1 Gene

PTENP1 (Phosphatase And Tensin Homolog Pseudogene 1 (Functional)) is a Pseudogene, and is affiliated with the lncRNA class. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.

Gene Wiki entry for PTENP1 Gene

fRNAdb sequence ontologies for PTENP1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for PTENP1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for PTENP1 Gene

Genomics for PTENP1 Gene

Regulatory Elements for PTENP1 Gene

Genomic Location for PTENP1 Gene

Chromosome:
9
Start:
33,673,504 bp from pter
End:
33,677,499 bp from pter
Size:
3,996 bases
Orientation:
Minus strand

Genomic View for PTENP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTENP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTENP1 Gene

ORGUL Member Location for PTENP1 Gene

ORGUL Member Location for PTENP1 gene

Proteins for PTENP1 Gene

Post-translational modifications for PTENP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PTENP1 Gene

Domains & Families for PTENP1 Gene

Gene Families for PTENP1 Gene

Suggested Antigen Peptide Sequences for PTENP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTENP1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for PTENP1 Gene

Function for PTENP1 Gene

Molecular function for PTENP1 Gene

GENATLAS Biochemistry:
phosphatase and tensin homolog 2,pseudogene 1,playing a role in small cell lung cancer tumorigenesis (see TSG9A)

Animal Model Products

miRNA for PTENP1 Gene

miRTarBase miRNAs that target PTENP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTENP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PTENP1 Gene

Localization for PTENP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PTENP1 Gene

Pathways & Interactions for PTENP1 Gene

genes like me logo Genes that share pathways with PTENP1: view

Pathways by source for PTENP1 Gene

Interacting Proteins for PTENP1 Gene

Gene Ontology (GO) - Biological Process for PTENP1 Gene

None

No data available for SIGNOR curated interactions for PTENP1 Gene

Drugs & Compounds for PTENP1 Gene

No Compound Related Data Available

Transcripts for PTENP1 Gene

fRNAdb Secondary structures for PTENP1 Gene

  • FR279969
  • FR272101

mRNA/cDNA for PTENP1 Gene

Unigene Clusters for PTENP1 Gene

Phosphatase and tensin homolog pseudogene 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTENP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTENP1 Gene

No ASD Table

Relevant External Links for PTENP1 Gene

GeneLoc Exon Structure for
PTENP1
ECgene alternative splicing isoforms for
PTENP1

Expression for PTENP1 Gene

mRNA expression in normal human tissues for PTENP1 Gene

mRNA differential expression in normal tissues according to GTEx for PTENP1 Gene

This gene is overexpressed in Whole Blood (x7.0).

SOURCE GeneReport for Unigene cluster for PTENP1 Gene Hs.493716

genes like me logo Genes that share expression patterns with PTENP1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PTENP1 Gene

Orthologs for PTENP1 Gene

Evolution for PTENP1 Gene

ENSEMBL:
Gene Tree for PTENP1 (if available)
TreeFam:
Gene Tree for PTENP1 (if available)

No data available for Orthologs for PTENP1 Gene

Paralogs for PTENP1 Gene

(4) SIMAP similar genes for PTENP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTENP1: view

No data available for Paralogs for PTENP1 Gene

Variants for PTENP1 Gene

Sequence variations from dbSNP and Humsavar for PTENP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs855464 -- 33,673,027(+) gcaca(C/T)gtatg downstream-variant-500B
rs7043496 -- 33,673,321(+) ggggc(C/T)tgtca downstream-variant-500B
rs7043915 -- 33,673,794(+) attga(A/G)catct nc-transcript-variant
rs7044016 -- 33,673,798(+) aacat(A/C)ttttg nc-transcript-variant
rs7044249 -- 33,673,937(+) aattt(C/T)tccct nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PTENP1 Gene

Variant ID Type Subtype PubMed ID
nsv471653 CNV Gain 15918152
nsv893026 CNV Gain 21882294
nsv893027 CNV Gain 21882294
nsv518977 CNV Gain 19592680

Relevant External Links for PTENP1 Gene

HapMap Linkage Disequilibrium report
PTENP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PTENP1 Gene

Disorders for PTENP1 Gene

Relevant External Links for PTENP1

Human Genome Epidemiology (HuGE) Navigator
PTENP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTENP1
genes like me logo Genes that share disorders with PTENP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTENP1 Gene

Publications for PTENP1 Gene

  1. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. (PMID: 9620558) Dahia P.L. … Eng C. (Oncogene 1998) 2 23 67
  2. PTEN promoter methylation in sporadic thyroid carcinomas. (PMID: 16487009) Alvarez-NuA+ez F. … Matias-Guiu X. (Thyroid 2006) 23 67
  3. PTEN methylation and expression in glioblastomas. (PMID: 12904991) Baeza N. … Ohgaki H. (Acta Neuropathol. 2003) 23 67
  4. Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. (PMID: 12569555) Byun D.S. … Chi S.G. (Int. J. Cancer 2003) 23 67
  5. Considerations when analyzing the methylation status of PTEN tumor suppressor gene. (PMID: 11891178) Zysman M.A. … Bapat B. (Am. J. Pathol. 2002) 23 67

Products for PTENP1 Gene

Sources for PTENP1 Gene

Back to Top

Content