Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHKA Gene

Aliases for CHKA Gene

  • Choline Kinase Alpha 2 3 5
  • Ethanolamine Kinase 3 4
  • CHETK-Alpha 3 4
  • CHK 3 4
  • CKI 3 4
  • CK 3 4
  • EK 3 4
  • Choline Kinase 2
  • EC 4
  • EC 4

External Ids for CHKA Gene

Previous HGNC Symbols for CHKA Gene

  • CHK

Previous GeneCards Identifiers for CHKA Gene

  • GC11M067596
  • GC11M067576
  • GC11M067820
  • GC11M064155

Summaries for CHKA Gene

Entrez Gene Summary for CHKA Gene

  • The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHKA Gene

CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include Myositis and Chanarin-Dorfman Syndrome. Among its related pathways are Glycerophospholipid biosynthesis and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is CHKB.

UniProtKB/Swiss-Prot for CHKA Gene

  • Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Wiki entry for CHKA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHKA Gene

Genomics for CHKA Gene

Regulatory Elements for CHKA Gene

Enhancers for CHKA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHKA on UCSC Golden Path with GeneCards custom track

Promoters for CHKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHKA on UCSC Golden Path with GeneCards custom track

Genomic Location for CHKA Gene

68,052,859 bp from pter
68,121,444 bp from pter
68,586 bases
Minus strand

Genomic View for CHKA Gene

Genes around CHKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHKA Gene

Proteins for CHKA Gene

  • Protein details for CHKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline kinase alpha
    Protein Accession:
    Secondary Accessions:
    • Q8NE29

    Protein attributes for CHKA Gene

    457 amino acids
    Molecular mass:
    52249 Da
    Quaternary structure:
    • Heterodimer with CHKB (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for CHKA Gene

    Alternative splice isoforms for CHKA Gene


neXtProt entry for CHKA Gene

Proteomics data for CHKA Gene at MOPED

Post-translational modifications for CHKA Gene

  • Ubiquitination at Lys 195
  • Modification sites at PhosphoSitePlus

Other Protein References for CHKA Gene

No data available for DME Specific Peptides for CHKA Gene

Domains & Families for CHKA Gene

Protein Domains for CHKA Gene


Suggested Antigen Peptide Sequences for CHKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the choline/ethanolamine kinase family.
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with CHKA: view

No data available for Gene Families for CHKA Gene

Function for CHKA Gene

Molecular function for CHKA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for choline {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=0.4 mM for ATP {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=12 mM for ethanolamine {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + choline = ADP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Enzyme Numbers (IUBMB) for CHKA Gene

Gene Ontology (GO) - Molecular Function for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004103 choline kinase activity TAS --
GO:0004104 cholinesterase activity IEA --
GO:0033265 choline binding IEA --
genes like me logo Genes that share ontologies with CHKA: view
genes like me logo Genes that share phenotypes with CHKA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHKA

miRNA for CHKA Gene

miRTarBase miRNAs that target CHKA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHKA Gene

Localization for CHKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHKA Gene


Subcellular locations from

Jensen Localization Image for CHKA Gene COMPARTMENTS Subcellular localization image for CHKA gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CHKA Gene

Pathways & Interactions for CHKA Gene

genes like me logo Genes that share pathways with CHKA: view

Pathways by source for CHKA Gene

UniProtKB/Swiss-Prot P35790-CHKA_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006580 ethanolamine metabolic process IEA --
GO:0006629 lipid metabolic process TAS 10363580
GO:0006644 phospholipid metabolic process TAS --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHKA: view

No data available for SIGNOR curated interactions for CHKA Gene

Drugs & Compounds for CHKA Gene

(49) Drugs for CHKA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Enzyme, substrate 139
Adenosine triphosphate Approved Nutra 0
Phosphocholine Experimental Pharma 0
Ethanolamine Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(37) Additional Compounds for CHKA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
genes like me logo Genes that share compounds with CHKA: view

Transcripts for CHKA Gene

Unigene Clusters for CHKA Gene

Choline kinase alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHKA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
SP1: - - - - -
SP2: - - - - - -
SP5: -

Relevant External Links for CHKA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHKA Gene

mRNA expression in normal human tissues for CHKA Gene

Protein differential expression in normal tissues from HIPED for CHKA Gene

This gene is overexpressed in Lung (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHKA Gene

SOURCE GeneReport for Unigene cluster for CHKA Gene Hs.77221

genes like me logo Genes that share expression patterns with CHKA: view

Protein tissue co-expression partners for CHKA Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHKA Gene

Orthologs for CHKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHKA 35
  • 88.07 (n)
  • 91.5 (a)
  • 91 (a)
(Canis familiaris)
Mammalia CHKA 35
  • 88.6 (n)
  • 91.3 (a)
  • 92 (a)
(Mus musculus)
Mammalia Chka 35
  • 86.39 (n)
  • 88.08 (a)
Chka 16
Chka 36
  • 88 (a)
(Pan troglodytes)
Mammalia CHKA 35
  • 99.74 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chka 35
  • 86.44 (n)
  • 89.43 (a)
(Monodelphis domestica)
Mammalia CHKA 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CHKA 36
  • 76 (a)
(Gallus gallus)
Aves CHKA 35
  • 75.88 (n)
  • 76 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia CHKA 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chka 35
  • 68.64 (n)
  • 72.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12834 35
(Danio rerio)
Actinopterygii chka 35
  • 70.11 (n)
  • 70.67 (a)
chka 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2201 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cka-2 35
  • 51.96 (n)
  • 43.55 (a)
cka-1 36
  • 30 (a)
cka-2 36
  • 35 (a)
ckb-1 36
  • 27 (a)
ckb-2 36
  • 24 (a)
ckb-3 36
  • 24 (a)
ckb-4 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKI1 36
  • 17 (a)
EKI1 36
  • 17 (a)
EKI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CK1 35
  • 46.39 (n)
  • 36.25 (a)
(Oryza sativa)
Liliopsida Os01g0183000 35
  • 48.49 (n)
  • 38.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for CHKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHKA Gene

Gene Tree for CHKA (if available)
Gene Tree for CHKA (if available)

Paralogs for CHKA Gene

Paralogs for CHKA Gene

(2) SIMAP similar genes for CHKA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHKA: view

Variants for CHKA Gene

Sequence variations from dbSNP and Humsavar for CHKA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17853641 - 68,070,830(+) CAAAC(C/T)TAATT nc-transcript-variant, reference, missense
rs17853642 - 68,062,002(+) ACCAC(A/T)GTCCC nc-transcript-variant, reference, missense
rs1703431 -- 68,055,847(-) ggctg(A/G)tctcg intron-variant
rs1703432 -- 68,055,842(-) gtctc(A/G)aactc intron-variant
rs1703439 -- 68,080,361(+) ttttt(C/T)gcatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHKA Gene

Variant ID Type Subtype PubMed ID
dgv394e1 CNV Complex 17122850
nsv469856 CNV Gain 16826518
dgv1203n71 CNV Loss 21882294
dgv1204n71 CNV Loss 21882294
nsv825963 CNV Gain 20364138
nsv469964 CNV Loss 18288195
dgv1207n71 CNV Loss 21882294
nsv897852 CNV Gain 21882294
dgv1208n71 CNV Loss 21882294
nsv897855 CNV Loss 21882294
nsv825965 CNV Gain 20364138
esv2677355 CNV Deletion 23128226
nsv371 CNV Loss 18451855

Variation tolerance for CHKA Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CHKA Gene

Disorders for CHKA Gene

MalaCards: The human disease database

(5) MalaCards diseases for CHKA Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
  • inflammatory disorder of muscle
chanarin-dorfman syndrome
  • cds
muscle disorders
  • myopathy
microinvasive gastric cancer
  • early gastric cancer
- elite association - COSMIC cancer census association via MalaCards
Search CHKA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHKA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CHKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHKA Gene

Publications for CHKA Gene

  1. Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. (PMID: 1618328) Hosaka K. … Yamashita S. (FEBS Lett. 1992) 2 3 4 67
  2. Structure and function of choline kinase isoforms in mammalian cells. (PMID: 15003397) Aoyama C. … Ishidate K. (Prog. Lipid Res. 2004) 2 3 23
  3. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PMID: 19915674) Gallego-Ortega D. … Lacal J.C. (PLoS ONE 2009) 3 23
  4. Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. (PMID: 18172309) Glunde K. … Bhujwalla Z.M. (Cancer Res. 2008) 3 23
  5. Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy. (PMID: 18296102) RamA-rez de Molina A. … Lacal J.C. (Int. J. Biochem. Cell Biol. 2008) 3 23

Products for CHKA Gene

Sources for CHKA Gene