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Aliases for CHKA Gene

Aliases for CHKA Gene

  • Choline Kinase Alpha 2 3 5
  • Ethanolamine Kinase 3 4
  • CHETK-Alpha 3 4
  • CHK 3 4
  • CKI 3 4
  • CK 3 4
  • EK 3 4
  • Choline Kinase 2
  • EC 2.7.1.32 4
  • EC 2.7.1.82 4

External Ids for CHKA Gene

Previous HGNC Symbols for CHKA Gene

  • CHK

Previous GeneCards Identifiers for CHKA Gene

  • GC11M067596
  • GC11M067576
  • GC11M067820
  • GC11M064155

Summaries for CHKA Gene

Entrez Gene Summary for CHKA Gene

  • The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHKA Gene

CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include Lipid Storage Myopathy Due To Flavin Adenine Dinucleotide Synthetase Deficiency and Small Cell Carcinoma Of The Bladder. Among its related pathways are phosphatidylcholine biosynthesis and Synthesis of PC. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is CHKB.

UniProtKB/Swiss-Prot for CHKA Gene

  • Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Wiki entry for CHKA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHKA Gene

Genomics for CHKA Gene

Regulatory Elements for CHKA Gene

Enhancers for CHKA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G068296 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -176.9 -176866 3.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 C11orf24 CHKA LRP5 LOC105369363
GH11G068059 0.9 FANTOM5 4.2 +61.7 61693 0.4 HDAC1 ATF1 ARNT ZBTB40 ZSCAN5C SMARCA5 ZNF280D CEBPB ZEB2 MEF2D CHKA KMT5B ACY3 PPP6R3 GC11M068058 ENSG00000255031
GH11G068125 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -6.5 -6530 4.0 FOXA2 MLX CREB3L1 ARID4B DMAP1 ETS1 SP3 MCM3 SP5 MXD4 ENSG00000255031 LOC105369362 NDUFS8 CHKA PIR36360 PIR60035
GH11G068141 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -20.9 -20898 1.5 MAX ZBTB7A ATF2 IKZF1 EED ETV6 IKZF2 ZFX MYC ENSG00000255031 NDUFS8 CHKA PIR54954 GC11M068148
GH11G068471 1.3 FANTOM5 Ensembl ENCODE 2.3 -350.7 -350676 1.9 HDGF PKNOX1 ZNF146 WRNIP1 MAX POLR2A EGR1 RELB IKZF2 EGR2 PPP6R3 TCIRG1 CHKA KMT5B IGHMBP2 GC11P068486
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHKA on UCSC Golden Path with GeneCards custom track

Promoters for CHKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041187 544 2201 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF766 ZNF143 ZNF207 FOS KLF13

Genomic Location for CHKA Gene

Chromosome:
11
Start:
68,052,859 bp from pter
End:
68,121,444 bp from pter
Size:
68,586 bases
Orientation:
Minus strand

Genomic View for CHKA Gene

Genes around CHKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHKA Gene

Proteins for CHKA Gene

  • Protein details for CHKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35790-CHKA_HUMAN
    Recommended name:
    Choline kinase alpha
    Protein Accession:
    P35790
    Secondary Accessions:
    • Q8NE29

    Protein attributes for CHKA Gene

    Size:
    457 amino acids
    Molecular mass:
    52249 Da
    Quaternary structure:
    • Heterodimer with CHKB (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for CHKA Gene

    Alternative splice isoforms for CHKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHKA Gene

Post-translational modifications for CHKA Gene

  • Ubiquitination at posLast=195195
  • Modification sites at PhosphoSitePlus

Other Protein References for CHKA Gene

No data available for DME Specific Peptides for CHKA Gene

Domains & Families for CHKA Gene

Protein Domains for CHKA Gene

Suggested Antigen Peptide Sequences for CHKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35790

UniProtKB/Swiss-Prot:

CHKA_HUMAN :
  • Belongs to the choline/ethanolamine kinase family.
Family:
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with CHKA: view

No data available for Gene Families for CHKA Gene

Function for CHKA Gene

Molecular function for CHKA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for choline {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=0.4 mM for ATP {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=12 mM for ethanolamine {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + choline = ADP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Enzyme Numbers (IUBMB) for CHKA Gene

Gene Ontology (GO) - Molecular Function for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004103 choline kinase activity TAS --
GO:0004104 cholinesterase activity IEA --
GO:0004305 ethanolamine kinase activity TAS --
GO:0004871 signal transducer activity TAS 10363580
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHKA: view
genes like me logo Genes that share phenotypes with CHKA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHKA

miRNA for CHKA Gene

miRTarBase miRNAs that target CHKA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CHKA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHKA Gene

Localization for CHKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHKA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHKA gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHKA: view

Pathways & Interactions for CHKA Gene

genes like me logo Genes that share pathways with CHKA: view

Pathways by source for CHKA Gene

UniProtKB/Swiss-Prot P35790-CHKA_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006580 ethanolamine metabolic process IEA --
GO:0006629 lipid metabolic process TAS 10363580
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway IEA --
genes like me logo Genes that share ontologies with CHKA: view

No data available for SIGNOR curated interactions for CHKA Gene

Drugs & Compounds for CHKA Gene

(49) Drugs for CHKA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Enzyme, substrate 154
Adenosine triphosphate Approved Nutra 0
Ethanolamine Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(37) Additional Compounds for CHKA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphorylcholine
  • Choline phosphate
  • N-Trimethyl-2-aminoethylphosphonate
  • O-Phosphocholine
  • Phosphocholine
  • Phosphoryl-choline
3616-04-4
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-vaccenoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(18:1/18:4)
  • GPCho(18:1n7/18:4n3)
  • GPCho(18:1w7/18:4w3)
  • GPCho(36:5)
88542-95-4
genes like me logo Genes that share compounds with CHKA: view

Transcripts for CHKA Gene

Unigene Clusters for CHKA Gene

Choline kinase alpha:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CHKA

Alternative Splicing Database (ASD) splice patterns (SP) for CHKA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
SP1: - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for CHKA Gene

GeneLoc Exon Structure for
CHKA
ECgene alternative splicing isoforms for
CHKA

Expression for CHKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHKA Gene

Protein differential expression in normal tissues from HIPED for CHKA Gene

This gene is overexpressed in Lung (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHKA Gene



Protein tissue co-expression partners for CHKA Gene

NURSA nuclear receptor signaling pathways regulating expression of CHKA Gene:

CHKA

SOURCE GeneReport for Unigene cluster for CHKA Gene:

Hs.77221

Evidence on tissue expression from TISSUES for CHKA Gene

  • Nervous system(2.7)
  • Kidney(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with CHKA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHKA Gene

Orthologs for CHKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHKA 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia CHKA 34 35
  • 88.6 (n)
cow
(Bos Taurus)
Mammalia CHKA 34 35
  • 88.07 (n)
rat
(Rattus norvegicus)
Mammalia Chka 34
  • 86.44 (n)
mouse
(Mus musculus)
Mammalia Chka 34 16 35
  • 86.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHKA 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHKA 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHKA 34 35
  • 75.88 (n)
lizard
(Anolis carolinensis)
Reptilia CHKA 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chka 34
  • 68.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12834 34
zebrafish
(Danio rerio)
Actinopterygii chka 34 35
  • 70.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2201 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cka-2 34 35
  • 51.96 (n)
cka-1 35
  • 30 (a)
ManyToMany
ckb-1 35
  • 27 (a)
ManyToMany
ckb-4 35
  • 25 (a)
ManyToMany
ckb-2 35
  • 24 (a)
ManyToMany
ckb-3 35
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKI1 35
  • 17 (a)
ManyToMany
EKI1 35 37
  • 17 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CK1 34
  • 46.39 (n)
rice
(Oryza sativa)
Liliopsida Os01g0183000 34
  • 48.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for CHKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHKA Gene

ENSEMBL:
Gene Tree for CHKA (if available)
TreeFam:
Gene Tree for CHKA (if available)

Paralogs for CHKA Gene

Paralogs for CHKA Gene

(2) SIMAP similar genes for CHKA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHKA: view

Variants for CHKA Gene

Sequence variations from dbSNP and Humsavar for CHKA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000010515 -- 68,117,333(+) TGTTA(A/G)TTGCT intron-variant
rs1000048065 -- 68,068,778(+) TGTAC(C/G)TAATA intron-variant
rs1000072308 -- 68,063,444(+) GCCAT(A/G)ATCGC intron-variant
rs1000100528 -- 68,114,236(+) CAAAT(A/G)AATTG intron-variant
rs1000114152 -- 68,103,068(+) GAGTT(C/G/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHKA Gene

Variant ID Type Subtype PubMed ID
dgv1221n100 CNV gain 25217958
dgv1983n54 CNV loss 21841781
esv2677355 CNV deletion 23128226
esv2759835 CNV gain+loss 17122850
esv3626732 CNV loss 21293372
nsv1070047 CNV deletion 25765185
nsv1143691 CNV deletion 24896259
nsv371 CNV deletion 18451855
nsv469856 CNV gain 16826518
nsv469964 CNV loss 18288195
nsv825963 CNV gain 20364138
nsv825965 CNV gain 20364138
nsv951026 CNV deletion 24416366

Variation tolerance for CHKA Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHKA Gene

Disorders for CHKA Gene

MalaCards: The human disease database

(6) MalaCards diseases for CHKA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency
  • lipid storage myopathy due to flad1 deficiency
small cell carcinoma of the bladder
  • poorly differentiated neuroendocrine carcinoma of the bladder
microinvasive gastric cancer
  • early gastric cancer
muscle disorders
  • myopathy
leukomalacia
- elite association - COSMIC cancer census association via MalaCards
Search CHKA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHKA

Genetic Association Database (GAD)
CHKA
Human Genome Epidemiology (HuGE) Navigator
CHKA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHKA
genes like me logo Genes that share disorders with CHKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHKA Gene

Publications for CHKA Gene

  1. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PMID: 19915674) Gallego-Ortega D. … Lacal J.C. (PLoS ONE 2009) 3 4 22 64
  2. Structure and function of choline kinase isoforms in mammalian cells. (PMID: 15003397) Aoyama C. … Ishidate K. (Prog. Lipid Res. 2004) 2 3 22 64
  3. Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. (PMID: 1618328) Hosaka K. … Yamashita S. (FEBS Lett. 1992) 2 3 4 64
  4. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. (PMID: 20299452) Hong B.S. … Park H.W. (J. Biol. Chem. 2010) 3 4 64
  5. Associations of folate and choline metabolism gene polymorphisms with orofacial clefts. (PMID: 19737740) Mostowska A. … Jagodzinski P.P. (J. Med. Genet. 2010) 3 46 64

Products for CHKA Gene