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Aliases for MAP4K5 Gene

Aliases for MAP4K5 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 2 3
  • Kinase Homologous To SPS1/STE20 3 4
  • MAPK/ERK Kinase Kinase Kinase 5 3 4
  • Germinal Center Kinase-Related 2 3
  • MEK Kinase Kinase 5 3 4
  • EC 2.7.11.1 4 63
  • MEKKK 5 3 4
  • KHS 3 4
  • EC 2.7.11 63
  • MAPKKKK5 3
  • GCKR 3
  • KHS1 3

External Ids for MAP4K5 Gene

Previous GeneCards Identifiers for MAP4K5 Gene

  • GC14M048208
  • GC14M044682
  • GC14M048875
  • GC14M049954
  • GC14M050885
  • GC14M031011

Summaries for MAP4K5 Gene

Entrez Gene Summary for MAP4K5 Gene

  • This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP4K5 Gene

MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP4K5 include dysgraphia and writing disorder. Among its related pathways are Infectious disease and TGF-Beta Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MAP4K5 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Gene Wiki entry for MAP4K5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K5 Gene

Genomics for MAP4K5 Gene

Regulatory Elements for MAP4K5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP4K5 Gene

Chromosome:
14
Start:
50,418,480 bp from pter
End:
50,561,126 bp from pter
Size:
142,647 bases
Orientation:
Minus strand

Genomic View for MAP4K5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP4K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K5 Gene

Proteins for MAP4K5 Gene

  • Protein details for MAP4K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4K4-M4K5_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 5
    Protein Accession:
    Q9Y4K4
    Secondary Accessions:
    • Q8IYF6

    Protein attributes for MAP4K5 Gene

    Size:
    846 amino acids
    Molecular mass:
    95040 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with both SH3 domains of the adapter proteins CRK and CRKL.

neXtProt entry for MAP4K5 Gene

Proteomics data for MAP4K5 Gene at MOPED

Post-translational modifications for MAP4K5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP4K5 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for MAP4K5

Domains & Families for MAP4K5 Gene

Suggested Antigen Peptide Sequences for MAP4K5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4K4

UniProtKB/Swiss-Prot:

M4K5_HUMAN :
  • Contains 1 CNH domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K5: view

Function for MAP4K5 Gene

Molecular function for MAP4K5 Gene

GENATLAS Biochemistry:
mitogen-activated kinase kinase kinase kinase 5,widely expressed,S cerevisiae STE20 family homolog,activating in N terminal kinase,potentially involved in the stress response of fibroblast
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Enzyme Numbers (IUBMB) for MAP4K5 Gene

Gene Ontology (GO) - Molecular Function for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9038372
GO:0004674 protein serine/threonine kinase activity IDA 9038372
GO:0005515 protein binding IPI 9788432
GO:0005524 ATP binding IDA 9038372
GO:0008349 MAP kinase kinase kinase kinase activity --
genes like me logo Genes that share ontologies with MAP4K5: view
genes like me logo Genes that share phenotypes with MAP4K5: view

Animal Models for MAP4K5 Gene

MGI Knock Outs for MAP4K5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4K5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MAP4K5 Gene

Localization for MAP4K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4K5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP4K5 Gene COMPARTMENTS Subcellular localization image for MAP4K5 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 9038372
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MAP4K5: view

Pathways & Interactions for MAP4K5 Gene

genes like me logo Genes that share pathways with MAP4K5: view

Pathways by source for MAP4K5 Gene

3 Qiagen pathways for MAP4K5 Gene
1 Cell Signaling Technology pathway for MAP4K5 Gene
2 BioSystems pathways for MAP4K5 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4K5 Gene

SIGNOR curated interactions for MAP4K5 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade --
GO:0000185 activation of MAPKKK activity --
GO:0006468 protein phosphorylation IDA 9038372
GO:0007257 activation of JUN kinase activity TAS 9038372
GO:0007346 regulation of mitotic cell cycle --
genes like me logo Genes that share ontologies with MAP4K5: view

Drugs & Compounds for MAP4K5 Gene

(4) Drugs for MAP4K5 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0
serine Nutra 420
threonine Nutra 16

(1) Additional Compounds for MAP4K5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP4K5: view

Transcripts for MAP4K5 Gene

Unigene Clusters for MAP4K5 Gene

Mitogen-activated protein kinase kinase kinase kinase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4K5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b · 34c · 34d
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for MAP4K5 Gene

GeneLoc Exon Structure for
MAP4K5
ECgene alternative splicing isoforms for
MAP4K5

Expression for MAP4K5 Gene

mRNA expression in normal human tissues for MAP4K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP4K5 Gene

This gene is overexpressed in Breast (36.4) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP4K5 Gene



SOURCE GeneReport for Unigene cluster for MAP4K5 Gene Hs.130491

mRNA Expression by UniProt/SwissProt for MAP4K5 Gene

Q9Y4K4-M4K5_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.
genes like me logo Genes that share expression patterns with MAP4K5: view

Protein tissue co-expression partners for MAP4K5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP4K5 Gene

Orthologs for MAP4K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP4K5 35
  • 94.17 (n)
  • 97.52 (a)
MAP4K5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4K5 35
  • 95.11 (n)
  • 98.23 (a)
MAP4K5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map4k5 35
  • 89.36 (n)
  • 96.22 (a)
Map4k5 16
Map4k5 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP4K5 35
  • 99.65 (n)
  • 99.76 (a)
MAP4K5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map4k5 35
  • 88.57 (n)
  • 96.69 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP4K5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP4K5 36
  • 22 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP4K5 35
  • 80.22 (n)
  • 90.96 (a)
MAP4K5 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP4K5 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k5 35
  • 74.48 (n)
  • 82.14 (a)
Str.195 35
zebrafish
(Danio rerio)
Actinopterygii map4k5 35
  • 70.08 (n)
  • 78.72 (a)
zgc55719 35
map4k5 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7097 37
  • 73 (a)
hppy 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC404.9 37
  • 40 (a)
gck-2 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for MAP4K5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K5 Gene

ENSEMBL:
Gene Tree for MAP4K5 (if available)
TreeFam:
Gene Tree for MAP4K5 (if available)

Paralogs for MAP4K5 Gene

Paralogs for MAP4K5 Gene

genes like me logo Genes that share paralogs with MAP4K5: view

Variants for MAP4K5 Gene

Sequence variations from dbSNP and Humsavar for MAP4K5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3267 -- 50,479,565(+) tgact(C/T)gggcc intron-variant
rs974318 -- 50,530,867(-) CCTCC(C/T)AATTA intron-variant
rs974319 -- 50,530,771(-) TTATT(C/G)CTTAA intron-variant
rs1065395 -- 50,464,087(-) AAAAC(A/C)CAAAA missense, reference
rs1344056 -- 50,459,942(+) tgatt(C/T)agccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K5 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv832793 CNV Loss 17160897
esv2674140 CNV Deletion 23128226

Variation tolerance for MAP4K5 Gene

Gene Damage Index Score: 5.97; 74.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP4K5 Gene

HapMap Linkage Disequilibrium report
MAP4K5
Human Gene Mutation Database (HGMD)
MAP4K5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K5 Gene

Disorders for MAP4K5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP4K5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dysgraphia
  • agraphia
writing disorder
- elite association

Relevant External Links for MAP4K5

Genetic Association Database (GAD)
MAP4K5
Human Genome Epidemiology (HuGE) Navigator
MAP4K5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP4K5
genes like me logo Genes that share disorders with MAP4K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4K5 Gene

Publications for MAP4K5 Gene

  1. A novel human SPS1/STE20 homologue, KHS, activates jun N-terminal kinase. (PMID: 9038372) Tung R.M. … Blenis J. (Oncogene 1997) 2 23 67
  2. The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. (PMID: 16914735) Shi C.S. … Kehrl J.H. (Mol. Cell. Biol. 2006) 23 67
  3. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). (PMID: 12591926) Shi C.S. … Kehrl J.H. (J. Biol. Chem. 2003) 23 67
  4. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. (PMID: 10648385) Shi C.S. … Kehrl J.H. (Blood 2000) 23 67
  5. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. (PMID: 10477597) Shi C.S. … Kehrl J.H. (J. Immunol. 1999) 23 67

Products for MAP4K5 Gene

Sources for MAP4K5 Gene

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