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Aliases for SLC2A6 Gene

Aliases for SLC2A6 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 6 2 3
  • Glucose Transporter Type 9 3 4
  • Glucose Transporter Type 6 3 4
  • GLUT-9 3 4
  • GLUT-6 3 4
  • GLUT9 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 6 3
  • HSA011372 3
  • GLUT6 3

External Ids for SLC2A6 Gene

Previous GeneCards Identifiers for SLC2A6 Gene

  • GC09M127425
  • GC09M127893
  • GC09M129689
  • GC09M131612
  • GC09M133366
  • GC09M135326
  • GC09M136336
  • GC09M105837

Summaries for SLC2A6 Gene

Entrez Gene Summary for SLC2A6 Gene

  • Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

GeneCards Summary for SLC2A6 Gene

SLC2A6 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 6) is a Protein Coding gene. Diseases associated with SLC2A6 include testis seminoma. Among its related pathways are PAK Pathway and HIF1Alpha Pathway. GO annotations related to this gene include glucose transmembrane transporter activity. An important paralog of this gene is SLC2A8.

UniProtKB/Swiss-Prot for SLC2A6 Gene

  • Facilitative glucose transporter; binds cytochalasin B with low affinity

Gene Wiki entry for SLC2A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A6 Gene

Genomics for SLC2A6 Gene

Regulatory Elements for SLC2A6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC2A6 Gene

Start:
133,471,094 bp from pter
End:
133,479,154 bp from pter
Size:
8,061 bases
Orientation:
Minus strand

Genomic View for SLC2A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A6 Gene

Proteins for SLC2A6 Gene

  • Protein details for SLC2A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGQ3-GTR6_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 6
    Protein Accession:
    Q9UGQ3
    Secondary Accessions:
    • A6NNU6
    • Q5SXD7
    • Q8NCC2

    Protein attributes for SLC2A6 Gene

    Size:
    507 amino acids
    Molecular mass:
    54539 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A6 Gene

Proteomics data for SLC2A6 Gene at MOPED

Post-translational modifications for SLC2A6 Gene

  • Glycosylation at Asn370
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A6 Gene

Domains for SLC2A6 Gene

Gene Families for SLC2A6 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC2A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGQ3

UniProtKB/Swiss-Prot:

GTR6_HUMAN :
  • Q9UGQ3
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A6: view

Function for SLC2A6 Gene

Molecular function for SLC2A6 Gene

UniProtKB/Swiss-Prot Function: Facilitative glucose transporter; binds cytochalasin B with low affinity

Gene Ontology (GO) - Molecular Function for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity NAS 10970791
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A6: view

Phenotypes for SLC2A6 Gene

GenomeRNAi human phenotypes for SLC2A6:
genes like me logo Genes that share phenotypes with SLC2A6: view

Animal Model Products

CRISPR Products

miRNA for SLC2A6 Gene

miRTarBase miRNAs that target SLC2A6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC2A6 Gene

Localization for SLC2A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A6 Gene

Cell membrane; Multi-pass membrane protein. Note=The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A6 Gene COMPARTMENTS Subcellular localization image for SLC2A6 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane NAS 10970791
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC2A6: view

Pathways for SLC2A6 Gene

genes like me logo Genes that share pathways with SLC2A6: view

Interacting Proteins for SLC2A6 Gene

Gene Ontology (GO) - Biological Process for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015758 glucose transport --
GO:0015992 proton transport IBA --
GO:0035428 hexose transmembrane transport IBA --
GO:0046323 glucose import IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC2A6: view

Compounds for SLC2A6 Gene

(11) Novoseek inferred chemical compound relationships for SLC2A6 Gene

Compound -log(P) Hits PubMed IDs
glucose 59.9 18
cytochalasin b 59 1
fructose 58.5 4
monosaccharide 56.2 1
xylose 54.8 1
genes like me logo Genes that share compounds with SLC2A6: view

Transcripts for SLC2A6 Gene

Unigene Clusters for SLC2A6 Gene

Solute carrier family 2 (facilitated glucose transporter), member 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: -
SP11:

Relevant External Links for SLC2A6 Gene

GeneLoc Exon Structure for
SLC2A6
ECgene alternative splicing isoforms for
SLC2A6

Expression for SLC2A6 Gene

mRNA expression in normal human tissues for SLC2A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A6 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A6 Gene

SOURCE GeneReport for Unigene cluster for SLC2A6 Gene Hs.244378

mRNA Expression by UniProt/SwissProt for SLC2A6 Gene

Q9UGQ3-GTR6_HUMAN
Tissue specificity: Highly expressed in brain, spleen and peripheral blood leukocytes
genes like me logo Genes that share expressions with SLC2A6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC2A6 Gene

Orthologs for SLC2A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A6 35
  • 99.54 (n)
  • 99.8 (a)
SLC2A6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A6 35
  • 87.31 (n)
  • 87.57 (a)
SLC2A6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A6 35
  • 87.77 (n)
  • 87.97 (a)
SLC2A6 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a6 35
  • 82.76 (n)
  • 83.64 (a)
Slc2a6 16
Slc2a6 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A6 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A6 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A6 35
  • 68.77 (n)
  • 66.47 (a)
SLC2A6 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A6 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a6 35
  • 61.84 (n)
  • 59.47 (a)
zebrafish
(Danio rerio)
Actinopterygii slc2a6 35
  • 58.46 (n)
  • 57.02 (a)
slc2a6 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TRET1_ANOGA 35
  • 48.16 (n)
  • 33.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10960 36
  • 25 (a)
ManyToMany
CG1208 36
  • 27 (a)
ManyToMany
CG1213 36
  • 28 (a)
ManyToMany
CG14605 36
  • 23 (a)
ManyToMany
CG14606 36
  • 25 (a)
ManyToMany
CG15406 36
  • 24 (a)
ManyToMany
CG15408 36
  • 21 (a)
ManyToMany
CG31100 36
  • 18 (a)
ManyToMany
CG3285 36
  • 22 (a)
ManyToMany
CG33281 36
  • 24 (a)
ManyToMany
CG33282 36
  • 21 (a)
ManyToMany
CG4607 36
  • 23 (a)
ManyToMany
CG4797 36
  • 20 (a)
ManyToMany
CG6484 36
  • 28 (a)
ManyToMany
CG8249 36
  • 24 (a)
ManyToMany
CG8837 36
  • 20 (a)
ManyToMany
Glut3 36
  • 22 (a)
ManyToMany
sut4 36
  • 29 (a)
ManyToMany
Tret1-1 35
  • 48.23 (n)
  • 34.56 (a)
Tret1-1 36
  • 17 (a)
ManyToMany
Tret1-2 36
  • 30 (a)
ManyToMany
CG15406 37
  • 26 (a)
CG1213 37
  • 29 (a)
CG1208 37
  • 29 (a)
CG8234 37
  • 32 (a)
sut4 37
  • 30 (a)
CG4797 37
  • 24 (a)
CG6484 37
  • 29 (a)
CG8249 37
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL2 36
  • 19 (a)
ManyToMany
HXT1 36
  • 19 (a)
ManyToMany
HXT10 36
  • 20 (a)
ManyToMany
HXT11 36
  • 19 (a)
ManyToMany
HXT13 36
  • 19 (a)
ManyToMany
HXT14 36
  • 20 (a)
ManyToMany
HXT15 36
  • 18 (a)
ManyToMany
HXT16 36
  • 18 (a)
ManyToMany
HXT17 36
  • 18 (a)
ManyToMany
HXT2 36
  • 21 (a)
ManyToMany
HXT3 36
  • 19 (a)
ManyToMany
HXT4 36
  • 19 (a)
ManyToMany
HXT5 36
  • 20 (a)
ManyToMany
HXT6 36
  • 19 (a)
ManyToMany
HXT7 36
  • 19 (a)
ManyToMany
HXT8 36
  • 19 (a)
ManyToMany
HXT9 36
  • 19 (a)
ManyToMany
RGT2 36
  • 15 (a)
ManyToMany
SNF3 36
  • 12 (a)
ManyToMany
STL1 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
CSA.10291 36
  • 32 (a)
ManyToMany
Species with no ortholog for SLC2A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A6 Gene

ENSEMBL:
Gene Tree for SLC2A6 (if available)
TreeFam:
Gene Tree for SLC2A6 (if available)

Paralogs for SLC2A6 Gene

Paralogs for SLC2A6 Gene

Selected SIMAP similar genes for SLC2A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC2A6: view

Variants for SLC2A6 Gene

Sequence variations from dbSNP and Humsavar for SLC2A6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs968471 -- 133,479,491(-) AGGTG(A/C/G/T)GCATT upstream-variant-2KB
rs2073935 -- 133,475,078(-) GCCCC(A/C)CACGT reference, synonymous-codon, nc-transcript-variant
rs3094326 -- 133,478,525(+) CAGGC(C/G)TCCCT intron-variant
rs3094378 - 133,472,046(-) CCGCA(C/T)GGGGA reference, missense, nc-transcript-variant
rs3124757 -- 133,480,981(-) CTATA(C/T)TTAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC2A6 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894081 CNV Loss 21882294
dgv8328n71 CNV Loss 21882294
nsv894086 CNV Gain 21882294
nsv894094 CNV Loss 21882294
nsv894096 CNV Loss 21882294
nsv894097 CNV Loss 21882294
dgv8330n71 CNV Loss 21882294

Relevant External Links for SLC2A6 Gene

HapMap Linkage Disequilibrium report
SLC2A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A6 Gene

Disorders for SLC2A6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC2A6 Gene including...

Search for SLC2A6 Gene in MalaCards »

(3) University of Copenhagen DISEASES for SLC2A6 Gene

(2) Novoseek inferred disease relationships for SLC2A6 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
cancer 0 2

Relevant External Links for SLC2A6

Genetic Association Database (GAD)
SLC2A6
Human Genome Epidemiology (HuGE) Navigator
SLC2A6
genes like me logo Genes that share disorders with SLC2A6: view

No data available for UniProtKB/Swiss-Prot for SLC2A6 Gene

Publications for SLC2A6 Gene

  1. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. (PMID: 10970791) Doege H. … Schuermann A. (Biochem. J. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for SLC2A6 Gene

  • antibodies-online peptides for SLC2A6
  • antibodies-online antibodies for SLC2A6
  • antibodies-online kits for SLC2A6

Sources for SLC2A6 Gene

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