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Aliases for SOX21 Gene

Aliases for SOX21 Gene

  • SRY (Sex Determining Region Y)-Box 21 2 3
  • SRY-Box 21 2 3
  • SOX-A 3 4
  • SOX25 3 4
  • Transcription Factor SOX-21 3
  • SOXA 4

External Ids for SOX21 Gene

Summaries for SOX21 Gene

Entrez Gene Summary for SOX21 Gene

  • SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

GeneCards Summary for SOX21 Gene

SOX21 (SRY (Sex Determining Region Y)-Box 21) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX21 Gene

  • May play a role as an activator of transcription of OPRM1.

Gene Wiki entry for SOX21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX21 Gene

Genomics for SOX21 Gene

Genomic Location for SOX21 Gene

94,709,622 bp from pter
94,712,399 bp from pter
2,778 bases
Minus strand

Genomic View for SOX21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX21 Gene

Regulatory Elements for SOX21 Gene

Proteins for SOX21 Gene

  • Protein details for SOX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor SOX-21
    Protein Accession:
    Secondary Accessions:
    • P35715
    • Q15504
    • Q5TBS1

    Protein attributes for SOX21 Gene

    276 amino acids
    Molecular mass:
    28580 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX21 Gene

Proteomics data for SOX21 Gene at MOPED

Post-translational modifications for SOX21 Gene

No Post-translational modifications

Other Protein References for SOX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX21 Gene

Domains for SOX21 Gene

Gene Families for SOX21 Gene

  • SOX :SRY (sex determining region Y)-boxes

Protein Domains for SOX21 Gene



  • Contains 1 HMG box DNA-binding domain.:
    • Q9Y651
genes like me logo Genes that share domains with SOX21: view

Function for SOX21 Gene

Molecular function for SOX21 Gene

GENATLAS Biochemistry: SRY related HMG box gene 221,involved in embryonic CNS development,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function: May play a role as an activator of transcription of OPRM1.

Gene Ontology (GO) - Molecular Function for SOX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity NAS 10441749
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
genes like me logo Genes that share ontologies with SOX21: view

Phenotypes for SOX21 Gene

genes like me logo Genes that share phenotypes with SOX21: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SOX21 Gene

Localization for SOX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX21 Gene

Subcellular locations from

Jensen Localization Image for SOX21 Gene COMPARTMENTS Subcellular localization image for SOX21 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SOX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SOX21: view

Pathways for SOX21 Gene

SuperPathways for SOX21 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX21: view

Pathways by source for SOX21 Gene

1 Qiagen pathway for SOX21 Gene

Interacting Proteins for SOX21 Gene

Gene Ontology (GO) - Biological Process for SOX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription from RNA polymerase II promoter NAS 10441749
GO:0006366 transcription from RNA polymerase II promoter NAS 10441749
GO:0042633 hair cycle --
genes like me logo Genes that share ontologies with SOX21: view

Transcripts for SOX21 Gene

mRNA/cDNA for SOX21 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX21 Gene

SRY (sex determining region Y)-box 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX21 Gene

No ASD Table

Relevant External Links for SOX21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOX21 Gene

mRNA expression in normal human tissues for SOX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX21 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (5.6), Skin - Not Sun Exposed (Suprapubic) (5.4), Brain - Amygdala (4.4), Esophagus - Mucosa (4.2), and Brain - Caudate (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SOX21 Gene

SOURCE GeneReport for Unigene cluster for SOX21 Gene Hs.187577

genes like me logo Genes that share expressions with SOX21: view

Orthologs for SOX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOX21 37
  • 99 (a)
(Mus musculus)
Mammalia Sox21 36
  • 93.36 (n)
  • 99.64 (a)
Sox21 16
Sox21 37
  • 100 (a)
(Monodelphis domestica)
Mammalia SOX21 37
  • 97 (a)
(Rattus norvegicus)
Mammalia Sox21 36
  • 95.93 (n)
  • 100 (a)
(Anolis carolinensis)
Reptilia SOX21 37
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sox21 36
  • 74.03 (n)
  • 86.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3288 36
(Danio rerio)
Actinopterygii sox21a 37
  • 60 (a)
sox21b 36
  • 71.33 (n)
  • 80.93 (a)
sox21b 37
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010922 36
  • 77.54 (n)
  • 82.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sox21a 37
  • 25 (a)
D 38
  • 87 (a)
Sox21b 38
  • 91 (a)
Sox21a 38
  • 91 (a)
(Caenorhabditis elegans)
Secernentea sox-3 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
Species with no ortholog for SOX21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX21 Gene

Gene Tree for SOX21 (if available)
Gene Tree for SOX21 (if available)

Paralogs for SOX21 Gene

Selected SIMAP similar genes for SOX21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX21: view

Variants for SOX21 Gene

Sequence variations from dbSNP and Humsavar for SOX21 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs35383846 -- 94,710,654(+) AAACA(-/G)GGGAG utr-variant-3-prime
rs189144824 -- 94,710,546(+) CGTGA(A/T)CATCT utr-variant-3-prime
rs536039267 -- 94,710,618(+) CTTGA(C/G)AGAAC utr-variant-3-prime
rs570200640 -- 94,710,603(+) TGGTT(C/G)GGAGT utr-variant-3-prime
VAR_049562 -

Structural Variations from Database of Genomic Variants (DGV) for SOX21 Gene

Variant ID Type Subtype PubMed ID
esv34004 CNV Loss 18971310
nsv832686 CNV Gain 17160897
nsv826750 CNV Gain 20364138
esv28079 CNV Loss 19812545

Relevant External Links for SOX21 Gene

HapMap Linkage Disequilibrium report

Disorders for SOX21 Gene

No disorders were found for SOX21 Gene.

No data available for UniProtKB/Swiss-Prot for SOX21 Gene

Publications for SOX21 Gene

  1. The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PMID: 10441749) Malas S. … Episkopou V. (Mamm. Genome 1999) 2 3 4
  2. A conserved family of genes related to the testis determining gene, SRY. (PMID: 1614875) Denny P. … Ashworth A. (Nucleic Acids Res. 1992) 3 4
  3. SOX3 is an X-linked gene related to SRY. (PMID: 8111369) Stevanovic M. … Goodfellow P.N. (Hum. Mol. Genet. 1993) 3
  4. Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR. (PMID: 9827568) Cremazy F. … Jay P. (FEBS Lett. 1998) 3
  5. Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells. (PMID: 9027483) Tani M. … Yokota J. (Genomics 1997) 23

Products for SOX21 Gene

Sources for SOX21 Gene

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