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Aliases for CHI3L1 Gene

Aliases for CHI3L1 Gene

  • Chitinase 3 Like 1 2 3 5
  • Chitinase 3-Like 1 (Cartilage Glycoprotein-39) 2 3
  • Cartilage Glycoprotein 39 3 4
  • 39 KDa Synovial Protein 3 4
  • HCGP-39 3 4
  • CGP-39 3 4
  • YKL-40 3 4
  • GP-39 3 4
  • Chitinase-3-Like Protein 1 3
  • Cartilage Glycoprotein-39 2
  • HC-Gp39 3
  • HCGP-3P 3
  • YYL-40 3
  • ASRT7 3
  • YKL40 3
  • Gp39 3

External Ids for CHI3L1 Gene

Previous GeneCards Identifiers for CHI3L1 Gene

  • GC01M200831
  • GC01M198577
  • GC01M199614
  • GC01M200436
  • GC01M199879
  • GC01M201414
  • GC01M174313

Summaries for CHI3L1 Gene

Entrez Gene Summary for CHI3L1 Gene

  • Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

GeneCards Summary for CHI3L1 Gene

CHI3L1 (Chitinase 3 Like 1) is a Protein Coding gene. Diseases associated with CHI3L1 include Asthma-Related Traits 7 and Schizophrenia. Among its related pathways are Innate Immune System. GO annotations related to this gene include carbohydrate binding and hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is CHIT1.

UniProtKB/Swiss-Prot for CHI3L1 Gene

  • Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Gene Wiki entry for CHI3L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHI3L1 Gene

Genomics for CHI3L1 Gene

Regulatory Elements for CHI3L1 Gene

Enhancers for CHI3L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G203035 1.7 Ensembl ENCODE dbSUPER 11 +148.8 148847 6.2 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D GLIS1 SNRPE MYOG ADORA1 PPFIA4 CYB5R1 MYBPH CHI3L1 ENSG00000224671 LOC100506672 ZBED6
GH01G203266 1.4 Ensembl ENCODE dbSUPER 10.3 -80.6 -80572 1.4 HDGF ZNF2 ZNF48 ZNF766 ZNF143 DEK REST TBX21 ZNF579 MAFF LINC01136 BTG2 RNU6-487P PPFIA4 FMOD LOC100131747 ADORA1 ENSG00000224671 OPTC CHI3L1
GH01G203068 1.3 Ensembl ENCODE dbSUPER 10.5 +117.6 117576 2.1 PKNOX1 ATF1 RB1 SIN3A ZNF2 RAD21 ZNF143 ZNF207 CREM DEK CHI3L1 PPFIA4 LOC105371687 MYOG
GH01G203263 1.3 FANTOM5 ENCODE dbSUPER 10.3 -77.3 -77325 1.9 HDGF EBF1 ZFHX2 IKZF2 EGR2 USF2 DPF2 GATAD2B ATF2 TBX21 RNU6-487P LINC01136 BTG2 FMOD LOC100131747 ADORA1 ENSG00000224671 OPTC CHI3L1 PRELP
GH01G203057 1.2 Ensembl ENCODE 10.7 +128.0 128003 2.9 HDAC1 HDGF ATF1 AGO1 ZSCAN4 DEAF1 SIN3A GLI4 NFXL1 ZBTB40 PPFIA4 MYOG ADORA1 CHI3L1 LOC100131747 FMOD LOC105371687
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHI3L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHI3L1 Gene

Chromosome:
1
Start:
203,178,931 bp from pter
End:
203,186,960 bp from pter
Size:
8,030 bases
Orientation:
Minus strand

Genomic View for CHI3L1 Gene

Genes around CHI3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHI3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHI3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHI3L1 Gene

Proteins for CHI3L1 Gene

  • Protein details for CHI3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36222-CH3L1_HUMAN
    Recommended name:
    Chitinase-3-like protein 1
    Protein Accession:
    P36222
    Secondary Accessions:
    • B2R7B0
    • P30923
    • Q8IVA4
    • Q96HI7

    Protein attributes for CHI3L1 Gene

    Size:
    383 amino acids
    Molecular mass:
    42625 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CHI3L1 Gene

neXtProt entry for CHI3L1 Gene

Post-translational modifications for CHI3L1 Gene

Other Protein References for CHI3L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHI3L1 (Chitinase 3-like 1)
  • Cloud-Clone Corp. Antibodies for CHI3L1

No data available for DME Specific Peptides for CHI3L1 Gene

Domains & Families for CHI3L1 Gene

Gene Families for CHI3L1 Gene

Suggested Antigen Peptide Sequences for CHI3L1 Gene

Graphical View of Domain Structure for InterPro Entry

P36222

UniProtKB/Swiss-Prot:

CH3L1_HUMAN :
  • Belongs to the glycosyl hydrolase 18 family.
Family:
  • Belongs to the glycosyl hydrolase 18 family.
genes like me logo Genes that share domains with CHI3L1: view

Function for CHI3L1 Gene

Molecular function for CHI3L1 Gene

GENATLAS Biochemistry:
chitinase 3-like 1
UniProtKB/Swiss-Prot Function:
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
UniProtKB/Swiss-Prot Induction:
Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.

Gene Ontology (GO) - Molecular Function for CHI3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004568 NOT chitinase activity IDA,IEA 8245017
GO:0005201 extracellular matrix structural constituent NAS 8245017
GO:0008061 chitin binding IEA,IDA 9492324
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHI3L1: view
genes like me logo Genes that share phenotypes with CHI3L1: view

Animal Models for CHI3L1 Gene

MGI Knock Outs for CHI3L1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHI3L1 Gene

Localization for CHI3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHI3L1 Gene

Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHI3L1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytoskeleton 2
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHI3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix NAS 8245017
GO:0005615 extracellular space IDA,IEA 8245017
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with CHI3L1: view

Pathways & Interactions for CHI3L1 Gene

genes like me logo Genes that share pathways with CHI3L1: view

Pathways by source for CHI3L1 Gene

3 Reactome pathways for CHI3L1 Gene

Gene Ontology (GO) - Biological Process for CHI3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006032 chitin catabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEP 16234240
GO:0007250 activation of NF-kappaB-inducing kinase activity ISS --
genes like me logo Genes that share ontologies with CHI3L1: view

No data available for SIGNOR curated interactions for CHI3L1 Gene

Drugs & Compounds for CHI3L1 Gene

(6) Drugs for CHI3L1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
N-Acetyl-D-glucosamine Approved Nutra 0

(2) Additional Compounds for CHI3L1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHI3L1: view

Transcripts for CHI3L1 Gene

Unigene Clusters for CHI3L1 Gene

Chitinase 3-like 1 (cartilage glycoprotein-39):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHI3L1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -
SP13: - - - - - -
SP14:
SP15: - -
SP16:
SP17: - - -
SP18:

ExUns: 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for CHI3L1 Gene

GeneLoc Exon Structure for
CHI3L1
ECgene alternative splicing isoforms for
CHI3L1

Expression for CHI3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHI3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHI3L1 Gene

This gene is overexpressed in Liver (x12.9) and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for CHI3L1 Gene

This gene is overexpressed in Vitreous humor (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHI3L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CHI3L1 Gene:

CHI3L1

SOURCE GeneReport for Unigene cluster for CHI3L1 Gene:

Hs.382202

mRNA Expression by UniProt/SwissProt for CHI3L1 Gene:

P36222-CH3L1_HUMAN
Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

Evidence on tissue expression from TISSUES for CHI3L1 Gene

  • Nervous system(4.9)
  • Blood(4.8)
  • Liver(3.6)
  • Intestine(2.8)
  • Lung(2.6)
  • Heart(2.5)
  • Bone marrow(2.3)
  • Lymph node(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CHI3L1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHI3L1 Gene

Orthologs for CHI3L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHI3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHI3L1 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia CHI3L1 34 35
  • 85.65 (n)
dog
(Canis familiaris)
Mammalia CHI3L1 34 35
  • 84.38 (n)
rat
(Rattus norvegicus)
Mammalia Chi3l1 34
  • 81.84 (n)
mouse
(Mus musculus)
Mammalia Chil1 34 16
  • 78.86 (n)
Chi3l1 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHI3L1 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHI3L1 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1869 36
  • 45 (a)
CG9357 36
  • 41 (a)
CG2989 36
  • 40 (a)
CG10531 36
  • 39 (a)
Cht1 36
  • 37 (a)
Cht2 36
  • 37 (a)
Cht3 36
  • 36 (a)
CG9307 36
  • 35 (a)
CG3044 36
  • 30 (a)
Idgf3 36
  • 29 (a)
Idgf2 36
  • 27 (a)
Idgf4 36
  • 27 (a)
Cht7 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cht-1 35
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTS2 35
  • 21 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04883 34
  • 49.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8046 35
  • 22 (a)
OneToMany
Species where no ortholog for CHI3L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CHI3L1 Gene

ENSEMBL:
Gene Tree for CHI3L1 (if available)
TreeFam:
Gene Tree for CHI3L1 (if available)

Paralogs for CHI3L1 Gene

Paralogs for CHI3L1 Gene

(5) SIMAP similar genes for CHI3L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHI3L1: view

Variants for CHI3L1 Gene

Sequence variations from dbSNP and Humsavar for CHI3L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4950928 other 203,186,754(+) TCCCC(A/C/G/T)ACGCG utr-variant-5-prime
rs1000050282 -- 203,182,124(+) CCTCC(C/T)TGGGA intron-variant
rs1000445136 -- 203,186,388(+) TCCTG(C/T)CCTTC intron-variant
rs1000652636 -- 203,179,910(+) GTGGG(A/G)AGTCG intron-variant
rs1000654536 -- 203,180,946(+) CATTC(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHI3L1 Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV loss 17160897
nsv952639 CNV deletion 24416366

Variation tolerance for CHI3L1 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.45; 94.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHI3L1 Gene

Human Gene Mutation Database (HGMD)
CHI3L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHI3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHI3L1 Gene

Disorders for CHI3L1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CHI3L1 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma-related traits 7
  • asrt7
schizophrenia
  • schizophrenia 12
pleural disease
  • disorder of pleura
pelvic inflammatory disease
  • pid
cellulitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CH3L1_HUMAN
  • Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:18403759}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CHI3L1

Genetic Association Database (GAD)
CHI3L1
Human Genome Epidemiology (HuGE) Navigator
CHI3L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHI3L1
genes like me logo Genes that share disorders with CHI3L1: view

No data available for Genatlas for CHI3L1 Gene

Publications for CHI3L1 Gene

  1. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. (PMID: 8245017) Hakala B.E. … Recklies A.D. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. (PMID: 20051317) Ohi K. … Takeda M. (Schizophr. Res. 2010) 3 22 46 64
  3. Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations. (PMID: 18767121) Yamada K. … Yoshikawa T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 64
  4. Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy. (PMID: 19106306) Sohn M.H. … Lee M.G. (Am. J. Respir. Crit. Care Med. 2009) 3 22 46 64
  5. No association of (-131C-->G) variant of CHI3L1 gene with risk of glioblastoma and prognosis. (PMID: 19255724) Boisselier B. … Sanson M. (J. Neurooncol. 2009) 3 22 46 64

Products for CHI3L1 Gene

Sources for CHI3L1 Gene

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