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Aliases for CHI3L1 Gene

Aliases for CHI3L1 Gene

  • Chitinase 3-Like 1 (Cartilage Glycoprotein-39) 2 3
  • Cartilage Glycoprotein 39 3 4
  • 39 KDa Synovial Protein 3 4
  • HCGP-39 3 4
  • CGP-39 3 4
  • YKL-40 3 4
  • ASRT7 3 6
  • YKL40 3 6
  • GP-39 3 4
  • Gp39 3 6
  • Chitinase-3-Like Protein 1 3
  • HC-Gp39 3
  • HCGP-3P 3
  • YYL-40 3

External Ids for CHI3L1 Gene

Previous GeneCards Identifiers for CHI3L1 Gene

  • GC01M200831
  • GC01M198577
  • GC01M199614
  • GC01M200436
  • GC01M199879
  • GC01M201414
  • GC01M174313

Summaries for CHI3L1 Gene

Entrez Gene Summary for CHI3L1 Gene

  • Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

GeneCards Summary for CHI3L1 Gene

CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39)) is a Protein Coding gene. Diseases associated with CHI3L1 include asthma-related traits 7 and schizophrenia. GO annotations related to this gene include extracellular matrix structural constituent and chitin binding. An important paralog of this gene is CHI3L2.

UniProtKB/Swiss-Prot for CHI3L1 Gene

  • Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Gene Wiki entry for CHI3L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHI3L1 Gene

Genomics for CHI3L1 Gene

Regulatory Elements for CHI3L1 Gene

Genomic Location for CHI3L1 Gene

Start:
203,178,931 bp from pter
End:
203,186,794 bp from pter
Size:
7,864 bases
Orientation:
Minus strand

Genomic View for CHI3L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHI3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHI3L1 Gene

Proteins for CHI3L1 Gene

  • Protein details for CHI3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36222-CH3L1_HUMAN
    Recommended name:
    Chitinase-3-like protein 1
    Protein Accession:
    P36222
    Secondary Accessions:
    • B2R7B0
    • P30923
    • Q8IVA4
    • Q96HI7

    Protein attributes for CHI3L1 Gene

    Size:
    383 amino acids
    Molecular mass:
    42625 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CHI3L1 Gene

neXtProt entry for CHI3L1 Gene

Proteomics data for CHI3L1 Gene at MOPED

Post-translational modifications for CHI3L1 Gene

Other Protein References for CHI3L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHI3L1 Gene

Domains for CHI3L1 Gene

Suggested Antigen Peptide Sequences for CHI3L1 Gene

Graphical View of Domain Structure for InterPro Entry

P36222

UniProtKB/Swiss-Prot:

CH3L1_HUMAN :
  • P36222
Family:
  • Belongs to the glycosyl hydrolase 18 family.
genes like me logo Genes that share domains with CHI3L1: view

No data available for Gene Families for CHI3L1 Gene

Function for CHI3L1 Gene

Molecular function for CHI3L1 Gene

GENATLAS Biochemistry: chitinase 3-like 1
UniProtKB/Swiss-Prot Function: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
UniProtKB/Swiss-Prot Induction: Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.

Gene Ontology (GO) - Molecular Function for CHI3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004568 NOT chitinase activity IDA 8245017
GO:0005201 extracellular matrix structural constituent NAS 8245017
GO:0008061 chitin binding IDA 12775711
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHI3L1: view

Phenotypes for CHI3L1 Gene

genes like me logo Genes that share phenotypes with CHI3L1: view

Animal Models for CHI3L1 Gene

MGI Knock Outs for CHI3L1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CHI3L1 Gene

Localization for CHI3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHI3L1 Gene

Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHI3L1 Gene COMPARTMENTS Subcellular localization image for CHI3L1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHI3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 8245017
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CHI3L1: view

Pathways for CHI3L1 Gene

SuperPathways for CHI3L1 Gene

No Data Available

Interacting Proteins for CHI3L1 Gene

Gene Ontology (GO) - Biological Process for CHI3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006032 NOT chitin catabolic process IBA --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEP 16234240
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CHI3L1: view

No data available for Pathways by source for CHI3L1 Gene

Compounds for CHI3L1 Gene

(2) Drugbank Compounds for CHI3L1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Beta-D-Mannose
7322-31-8 target

(6) Novoseek inferred chemical compound relationships for CHI3L1 Gene

Compound -log(P) Hits PubMed IDs
chitin 64.4 8
hyaluronic acid 41.3 10
p003 27.2 2
nitric oxide 0 5
estrogen 0 3
genes like me logo Genes that share compounds with CHI3L1: view

Transcripts for CHI3L1 Gene

Unigene Clusters for CHI3L1 Gene

Chitinase 3-like 1 (cartilage glycoprotein-39):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHI3L1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -
SP13: - - - - - -
SP14:
SP15: - -
SP16:
SP17: - - -
SP18:

ExUns: 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for CHI3L1 Gene

GeneLoc Exon Structure for
CHI3L1
ECgene alternative splicing isoforms for
CHI3L1

Expression for CHI3L1 Gene

mRNA expression in normal human tissues for CHI3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHI3L1 Gene

This gene is overexpressed in Liver (12.9) and Pituitary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHI3L1 Gene

SOURCE GeneReport for Unigene cluster for CHI3L1 Gene Hs.382202

mRNA Expression by UniProt/SwissProt for CHI3L1 Gene

P36222-CH3L1_HUMAN
Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
genes like me logo Genes that share expressions with CHI3L1: view

Orthologs for CHI3L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHI3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHI3L1 35
  • 99.56 (n)
  • 99.48 (a)
CHI3L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHI3L1 35
  • 85.65 (n)
  • 83.46 (a)
CHI3L1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHI3L1 35
  • 84.38 (n)
  • 82.72 (a)
CHI3L1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chi3l1 16
Chi3l1 36
  • 72 (a)
OneToOne
Chil1 35
  • 78.86 (n)
  • 73.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CHI3L1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHI3L1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chi3l1 35
  • 81.84 (n)
  • 80.49 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cht7 36
  • 16 (a)
OneToMany
Cht3 37
  • 36 (a)
CG10531 37
  • 39 (a)
CG9357 37
  • 41 (a)
Idgf3 37
  • 29 (a)
CG3044 37
  • 30 (a)
CG9307 37
  • 35 (a)
Idgf4 37
  • 27 (a)
Cht1 37
  • 37 (a)
Cht2 37
  • 37 (a)
CG2989 37
  • 40 (a)
CG1869 37
  • 45 (a)
Idgf2 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea cht-1 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTS2 36
  • 21 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04883 35
  • 49.33 (n)
  • 38.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8046 36
  • 22 (a)
OneToMany
Species with no ortholog for CHI3L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CHI3L1 Gene

ENSEMBL:
Gene Tree for CHI3L1 (if available)
TreeFam:
Gene Tree for CHI3L1 (if available)

Paralogs for CHI3L1 Gene

Paralogs for CHI3L1 Gene

Selected SIMAP similar genes for CHI3L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHI3L1: view

Variants for CHI3L1 Gene

Sequence variations from dbSNP and Humsavar for CHI3L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs880633 - 203,183,673(+) GTCTC(C/T)CCGTC reference, missense
rs903357 -- 203,178,482(-) TCATG(C/T)ACCCT downstream-variant-500B
rs946259 -- 203,183,049(+) CTAAT(C/T)TTCTC intron-variant
rs946260 -- 203,183,192(+) CTGGT(A/G)CATGA intron-variant
rs946261 -- 203,188,745(+) GGAGC(C/T)CAGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHI3L1 Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV Loss 17160897
nsv873110 CNV Loss 21882294

Relevant External Links for CHI3L1 Gene

HapMap Linkage Disequilibrium report
CHI3L1
Human Gene Mutation Database (HGMD)
CHI3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHI3L1 Gene

Disorders for CHI3L1 Gene

(2) OMIM Diseases for CHI3L1 Gene (601525)

UniProtKB/Swiss-Prot

CH3L1_HUMAN
  • Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CHI3L1 Gene

(36) Novoseek inferred disease relationships for CHI3L1 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 65.1 21
osteoarthritis 62.9 7
rheumatoid arthritis 61.7 21
inflammation 50.5 31
liver fibrosis 48.8 10

Relevant External Links for CHI3L1

Genetic Association Database (GAD)
CHI3L1
Human Genome Epidemiology (HuGE) Navigator
CHI3L1
genes like me logo Genes that share disorders with CHI3L1: view

Publications for CHI3L1 Gene

  1. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. (PMID: 8245017) Hakala B.E. … Recklies A.D. (J. Biol. Chem. 1993) 2 3 4 23
  2. Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. (PMID: 9492324) Renkema G.H. … Aerts J.M.F.G. (Eur. J. Biochem. 1998) 3 4 23
  3. Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes. (PMID: 12775711) Houston D.R. … van Aalten D.M.F. (J. Biol. Chem. 2003) 3 4 23
  4. Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. (PMID: 12851408) Fusetti F. … Dijkstra B.W. (J. Biol. Chem. 2003) 3 4 23
  5. Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. (PMID: 17160890) Zhao X. … He L. (Am. J. Hum. Genet. 2007) 3 23 48

Products for CHI3L1 Gene

Sources for CHI3L1 Gene

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