Aliases for KAT7 Gene
External Ids for KAT7 Gene
Previous HGNC Symbols for KAT7 Gene
Previous GeneCards Identifiers for KAT7 Gene
The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
GeneCards Summary for KAT7 Gene
KAT7 (Lysine Acetyltransferase 7) is a Protein Coding gene. Among its related pathways are Chromatin organization and CCR5 Pathway in Macrophages. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is KAT6B.
UniProtKB/Swiss-Prot for KAT7 Gene
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.