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Aliases for CDC37 Gene

Aliases for CDC37 Gene

  • Cell Division Cycle 37 2 3
  • CDC37 (Cell Division Cycle 37, S. Cerevisiae, Homolog) 2 3
  • Hsp90 Chaperone Protein Kinase-Targeting Subunit 3 4
  • CDC37 Cell Division Cycle 37 Homolog 2 3
  • Hsp90 Co-Chaperone Cdc37 2 3
  • P50CDC37 3 4
  • CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 37 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 37 Homolog 3
  • CDC37 (Cell Division Cycle 37 2
  • S. Cerevisiae 2
  • Homolog) 2
  • CDC37A 4

External Ids for CDC37 Gene

Summaries for CDC37 Gene

Entrez Gene Summary for CDC37 Gene

  • The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC37 Gene

CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is CDC37L1.

UniProtKB/Swiss-Prot for CDC37 Gene

  • Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.

Gene Wiki entry for CDC37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC37 Gene

Genomics for CDC37 Gene

Genomic Location for CDC37 Gene

Start:
10,391,133 bp from pter
End:
10,420,121 bp from pter
Size:
28,989 bases
Orientation:
Minus strand

Genomic View for CDC37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC37 Gene

Regulatory Elements for CDC37 Gene

Proteins for CDC37 Gene

  • Protein details for CDC37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16543-CDC37_HUMAN
    Recommended name:
    Hsp90 co-chaperone Cdc37
    Protein Accession:
    Q16543
    Secondary Accessions:
    • Q53YA2

    Protein attributes for CDC37 Gene

    Size:
    378 amino acids
    Molecular mass:
    44468 Da
    Quaternary structure:
    • Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.

    Three dimensional structures from OCA and Proteopedia for CDC37 Gene

neXtProt entry for CDC37 Gene

Proteomics data for CDC37 Gene at MOPED

Post-translational modifications for CDC37 Gene

Other Protein References for CDC37 Gene

No data available for DME Specific Peptides for CDC37 Gene

Domains for CDC37 Gene

Protein Domains for CDC37 Gene

UniProtKB/Swiss-Prot:

CDC37_HUMAN
Family:
  • Belongs to the CDC37 family.:
    • Q16543
genes like me logo Genes that share domains with CDC37: view

No data available for Gene Families for CDC37 Gene

Function for CDC37 Gene

Molecular function for CDC37 Gene

GENATLAS Biochemistry: cell division cycle 37,S cerevisiae homolog,protein kinase targetting subunit of HSP90 that binds and stabilizes CDK4 (HSPC*),potential regulator of cell cycle
UniProtKB/Swiss-Prot Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.

Gene Ontology (GO) - Molecular Function for CDC37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11036079
GO:0019900 kinase binding IPI 21855797
GO:0019901 protein kinase binding --
GO:0031072 heat shock protein binding IPI 9660753
GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA --
genes like me logo Genes that share ontologies with CDC37: view

Phenotypes for CDC37 Gene

GenomeRNAi human phenotypes for CDC37:
genes like me logo Genes that share phenotypes with CDC37: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC37 Gene

Localization for CDC37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC37 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC37 Gene COMPARTMENTS Subcellular localization image for CDC37 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CDC37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0032587 ruffle membrane IEA --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CDC37: view

Pathways for CDC37 Gene

genes like me logo Genes that share pathways with CDC37: view

Pathways by source for CDC37 Gene

1 Qiagen pathway for CDC37 Gene
3 Cell Signaling Technology pathways for CDC37 Gene

Gene Ontology (GO) - Biological Process for CDC37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8666233
GO:0006457 protein folding IBA --
GO:0006605 protein targeting TAS 8666233
GO:0050821 protein stabilization IBA --
GO:0051726 regulation of cell cycle --
genes like me logo Genes that share ontologies with CDC37: view

Compounds for CDC37 Gene

(1) HMDB Compounds for CDC37 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8

(10) Novoseek inferred chemical compound relationships for CDC37 Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 86.4 8
17-(allylamino)-17-demethoxygeldanamycin 85.3 1
alpha e 74.4 1
molybdate 66 4
novobiocin 57.2 2
genes like me logo Genes that share compounds with CDC37: view

Transcripts for CDC37 Gene

Unigene Clusters for CDC37 Gene

Cell division cycle 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - -
SP2:
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11: -

Relevant External Links for CDC37 Gene

GeneLoc Exon Structure for
CDC37
ECgene alternative splicing isoforms for
CDC37

Expression for CDC37 Gene

mRNA expression in normal human tissues for CDC37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC37 Gene

SOURCE GeneReport for Unigene cluster for CDC37 Gene Hs.160958

genes like me logo Genes that share expressions with CDC37: view

Orthologs for CDC37 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC37 36
  • 94 (n)
  • 93.14 (a)
CDC37 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC37 36
  • 91.62 (n)
  • 97.09 (a)
CDC37 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC37 36
  • 91.71 (n)
  • 96.83 (a)
CDC37 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc37 36
  • 88.27 (n)
  • 95.24 (a)
Cdc37 16
Cdc37 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC37 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC37 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc37 36
  • 85.98 (n)
  • 92.59 (a)
lizard
(Anolis carolinensis)
Reptilia CDC37 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cdc37-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc37 36
  • 72.73 (n)
  • 76.86 (a)
Str.7392 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01043370.1 37
  • 63 (a)
OneToOne
cdc37 36
  • 75.99 (n)
  • 75.99 (a)
zgc56210 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001914 36
  • 64.03 (n)
  • 56.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdc37 36
  • 63.18 (n)
  • 53.39 (a)
Cdc37 37
  • 49 (a)
OneToMany
Cdc37 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea cdc-37 36
  • 53.95 (n)
  • 41.24 (a)
cdc-37 37
  • 34 (a)
OneToMany
W08F4.8 38
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3576 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for CDC37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC37 Gene

ENSEMBL:
Gene Tree for CDC37 (if available)
TreeFam:
Gene Tree for CDC37 (if available)

Paralogs for CDC37 Gene

Paralogs for CDC37 Gene

Selected SIMAP similar genes for CDC37 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CDC37 Gene

genes like me logo Genes that share paralogs with CDC37: view

Variants for CDC37 Gene

Sequence variations from dbSNP and Humsavar for CDC37 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs280528 - 10,391,609(+) GGTCC(C/T)CAGGA missense, reference
rs1057482 -- 10,391,403(-) GGCCT(C/T)TCCAC utr-variant-3-prime
rs1057487 -- 10,391,387(-) CCACT(C/T)TCCAG utr-variant-3-prime
rs1057521 -- 10,391,286(-) GGGCA(A/G)AGGTC utr-variant-3-prime
rs1802887 -- 10,393,273(-) TCTAC(G/T)AGTCC reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for CDC37 Gene

Variant ID Type Subtype PubMed ID
dgv3725n71 CNV Loss 21882294
nsv518008 CNV Gain 19592680
esv24860 CNV Gain 19812545
nsv911041 CNV Loss 21882294

Relevant External Links for CDC37 Gene

HapMap Linkage Disequilibrium report
CDC37

Disorders for CDC37 Gene

(5) Novoseek inferred disease relationships for CDC37 Gene

Disease -log(P) Hits PubMed IDs
shock 57.2 11
cancer 19.4 10
tumors 3.34 4
prostate cancer 0 4
hyperplasia 0 1

Relevant External Links for CDC37

Human Genome Epidemiology (HuGE) Navigator
CDC37
genes like me logo Genes that share disorders with CDC37: view

No data available for UniProtKB/Swiss-Prot for CDC37 Gene

Publications for CDC37 Gene

  1. Interaction between Cdc37 and Cdk4 in human cells. (PMID: 9150368) Lamphere L. … Gyuris J. (Oncogene 1997) 3 4 23
  2. Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase. (PMID: 11036079) Shao J. … Matts R.L. (J. Biol. Chem. 2001) 3 4 23
  3. Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. (PMID: 11085988) Rao J. … Caplan A.J. (J. Biol. Chem. 2001) 3 4 23
  4. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. (PMID: 8666233) Stepanova L. … Harper J.W. (Genes Dev. 1996) 2 3 4
  5. Physical interaction of mammalian CDC37 with CDK4. (PMID: 8703009) Dai K. … Beach D. (J. Biol. Chem. 1996) 2 3 4

Products for CDC37 Gene

Sources for CDC37 Gene

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