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Aliases for CAPN10 Gene

Aliases for CAPN10 Gene

  • Calpain 10 2 3 5
  • Calcium-Activated Neutral Proteinase 10 3 4
  • Calpain-Like Protease CAPN10 3
  • EC 3.4.22.- 4
  • KIAA1845 4
  • CANP 10 4
  • CANP10 3
  • NIDDM1 3

External Ids for CAPN10 Gene

Previous GeneCards Identifiers for CAPN10 Gene

  • GC02M239919
  • GC02M240764
  • GC02P241545
  • GC02P241846
  • GC02P241246
  • GC02P241174
  • GC02P233282
  • GC02P241526

Summaries for CAPN10 Gene

Entrez Gene Summary for CAPN10 Gene

  • Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for CAPN10 Gene

CAPN10 (Calpain 10) is a Protein Coding gene. Diseases associated with CAPN10 include diabetes mellitus, noninsulin-dependent 1 and polycystic ovary syndrome. Among its related pathways are Apoptosis Pathway and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include cytoskeletal protein binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN10 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Tocris Summary for CAPN10 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Gene Wiki entry for CAPN10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN10 Gene

Genomics for CAPN10 Gene

Regulatory Elements for CAPN10 Gene

Enhancers for CAPN10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAPN10 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPN10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAPN10 gene promoter:

Genomic Location for CAPN10 Gene

Chromosome:
2
Start:
240,586,716 bp from pter
End:
240,617,705 bp from pter
Size:
30,990 bases
Orientation:
Plus strand

Genomic View for CAPN10 Gene

Genes around CAPN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN10 Gene

Proteins for CAPN10 Gene

  • Protein details for CAPN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC96-CAN10_HUMAN
    Recommended name:
    Calpain-10
    Protein Accession:
    Q9HC96
    Secondary Accessions:
    • A8MVS7
    • Q4ZFV1
    • Q8NCD4
    • Q96IG4
    • Q96JI2
    • Q9HC89
    • Q9HC90
    • Q9HC91
    • Q9HC92
    • Q9HC93
    • Q9HC94
    • Q9HC95

    Protein attributes for CAPN10 Gene

    Size:
    672 amino acids
    Molecular mass:
    74952 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAPN10 Gene

neXtProt entry for CAPN10 Gene

Proteomics data for CAPN10 Gene at MOPED

Post-translational modifications for CAPN10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPN10 Gene

Domains & Families for CAPN10 Gene

Gene Families for CAPN10 Gene

Suggested Antigen Peptide Sequences for CAPN10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC96

UniProtKB/Swiss-Prot:

CAN10_HUMAN :
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
Domain:
  • Contains 1 calpain catalytic domain.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN10: view

Function for CAPN10 Gene

Molecular function for CAPN10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Enzyme Numbers (IUBMB) for CAPN10 Gene

genes like me logo Genes that share phenotypes with CAPN10: view

Animal Models for CAPN10 Gene

MGI Knock Outs for CAPN10:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN10

miRNA for CAPN10 Gene

miRTarBase miRNAs that target CAPN10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN10 Gene

Localization for CAPN10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN10 Gene COMPARTMENTS Subcellular localization image for CAPN10 gene
Compartment Confidence
cytosol 5
mitochondrion 5
plasma membrane 4
nucleus 3
endoplasmic reticulum 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16790502
genes like me logo Genes that share ontologies with CAPN10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN10 Gene

Pathways & Interactions for CAPN10 Gene

genes like me logo Genes that share pathways with CAPN10: view

Pathways by source for CAPN10 Gene

Interacting Proteins for CAPN10 Gene

Gene Ontology (GO) - Biological Process for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IMP 15044459
GO:0031532 actin cytoskeleton reorganization ISS 12974673
GO:0032024 positive regulation of insulin secretion IMP 15471947
GO:0032388 positive regulation of intracellular transport ISS 12974673
GO:0046326 positive regulation of glucose import IMP 17572128
genes like me logo Genes that share ontologies with CAPN10: view

No data available for SIGNOR curated interactions for CAPN10 Gene

Drugs & Compounds for CAPN10 Gene

(7) Drugs for CAPN10 Gene - From: PharmGKB, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1668
calcium Nutra 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(7) Additional Compounds for CAPN10 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Acetyl-Calpastatin (184-210) (human)
123714-50-1
Calpeptin
117591-20-5
MG 132
133407-82-6
PD 150606
179528-45-1

(5) Tocris Compounds for CAPN10 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
PD 150606 Cell permeable calpain inhibitor 179528-45-1
genes like me logo Genes that share compounds with CAPN10: view

Transcripts for CAPN10 Gene

Unigene Clusters for CAPN10 Gene

Calpain 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - -
SP15:
SP16: -
SP17:

ExUns: 16c ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11: - -
SP12: -
SP13: - - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CAPN10 Gene

GeneLoc Exon Structure for
CAPN10
ECgene alternative splicing isoforms for
CAPN10

Expression for CAPN10 Gene

mRNA expression in normal human tissues for CAPN10 Gene

Protein differential expression in normal tissues from HIPED for CAPN10 Gene

This gene is overexpressed in Serum (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN10 Gene



SOURCE GeneReport for Unigene cluster for CAPN10 Gene Hs.728234

mRNA Expression by UniProt/SwissProt for CAPN10 Gene

Q9HC96-CAN10_HUMAN
Tissue specificity: Detected in primary skeletal muscle cells (at protein level). Ubiquitous.
genes like me logo Genes that share expression patterns with CAPN10: view

Protein tissue co-expression partners for CAPN10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAPN10 Gene

Orthologs for CAPN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC789674 35
  • 85.03 (n)
  • 84.75 (a)
CAPN10 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN10 35
  • 84.74 (n)
  • 82.18 (a)
CAPN10 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn10 35
  • 82.41 (n)
  • 81.95 (a)
Capn10 16
Capn10 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAPN10 35
  • 98.31 (n)
  • 97.7 (a)
CAPN10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn10 35
  • 82.56 (n)
  • 81.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPN10 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves CAPN10 35
  • 65.55 (n)
  • 66.16 (a)
lizard
(Anolis carolinensis)
Reptilia CAPN10 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn10 35
  • 56.05 (n)
  • 52.77 (a)
zebrafish
(Danio rerio)
Actinopterygii capn10 35
  • 57.69 (n)
  • 52.9 (a)
capn10 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CalpC 36
  • 22 (a)
OneToOne
Species with no ortholog for CAPN10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPN10 Gene

ENSEMBL:
Gene Tree for CAPN10 (if available)
TreeFam:
Gene Tree for CAPN10 (if available)

Paralogs for CAPN10 Gene

Paralogs for CAPN10 Gene

(1) SIMAP similar genes for CAPN10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN10: view

Variants for CAPN10 Gene

Sequence variations from dbSNP and Humsavar for CAPN10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3792268 - 240,592,060(+) ACAGG(A/C)CNGGC reference, missense
VAR_014438 -
VAR_014439 -
rs7607759 - 240,596,709(+) ACACC(A/G)CCCCC intron-variant, reference, missense
VAR_014441 -

Structural Variations from Database of Genomic Variants (DGV) for CAPN10 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
nsv834586 CNV Loss 17160897
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876148 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv876160 CNV Loss 21882294
nsv470529 CNV Loss 18288195
dgv4477n71 CNV Loss 21882294

Variation tolerance for CAPN10 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN10 Gene

HapMap Linkage Disequilibrium report
CAPN10
Human Gene Mutation Database (HGMD)
CAPN10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN10 Gene

Disorders for CAPN10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CAPN10 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent 1
  • diabetes mellitus, non-insulin-dependent, 1
polycystic ovary syndrome
  • multicystic ovaries
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
calpainopathy
  • limb-girdle muscular dystrophy type 2a
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CAN10_HUMAN
  • Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:11017071, ECO:0000269 PubMed:16721485}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CAPN10

Genetic Association Database (GAD)
CAPN10
Human Genome Epidemiology (HuGE) Navigator
CAPN10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN10
genes like me logo Genes that share disorders with CAPN10: view

No data available for Genatlas for CAPN10 Gene

Publications for CAPN10 Gene

  1. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PMID: 11017071) Horikawa Y. … Bell G.I. (Nat. Genet. 2000) 2 3 4 23 48 67
  2. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. (PMID: 11018080) Baier L.J. … Bogardus C. (J. Clin. Invest. 2000) 2 3 23
  3. Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus. (PMID: 19752882) Kurzawski M. … Drozdzik M. (Pharmacogenomics J. 2010) 3 23
  4. Co-existence of risk and protective haplotypes of Calpain 10 gene to type 2 diabetes in the eastern Indian population. (PMID: 20368234) Adak S. … Bhattacharyya M. (Diab Vasc Dis Res 2010) 3 23
  5. 111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women. (PMID: 18701098) Lee J.Y. … Chung H.W. (Fertil. Steril. 2009) 3 23

Products for CAPN10 Gene

Sources for CAPN10 Gene

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