Aliases for BTN3A1 Gene
Aliases for BTN3A1 Gene
External Ids for BTN3A1 Gene
- HGNC: 1138
- Entrez Gene: 11119
- Ensembl: ENSG00000026950
- OMIM: 613593
- UniProtKB: O00481
Previous GeneCards Identifiers for BTN3A1 Gene
- GC06P026460
- GC06P026465
- GC06P026510
- GC06P026345
Summaries for BTN3A1 Gene
-
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
GeneCards Summary for BTN3A1 Gene
BTN3A1 (Butyrophilin Subfamily 3 Member A1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Butyrophilin (BTN) family interactions. An important paralog of this gene is BTN3A3.
UniProtKB/Swiss-Prot for BTN3A1 Gene
-
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Additional gene information for BTN3A1 Gene
- Monarch Initiative
- Search for BTN3A1 at DataMed
- Search for BTN3A1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN3A1 Gene
Genomics for BTN3A1 Gene
GeneHancer (GH) Regulatory Elements for BTN3A1 Gene
- Top Transcription factor binding sites by QIAGEN in the BTN3A1 gene promoter:
Regulatory Element Products
Genomic Locations for BTN3A1 Gene
- chr6:26,402,237-26,415,216
- (GRCh38/hg38)
- Size:
- 12,980 bases
- Orientation:
- Plus strand
- chr6:26,402,465-26,415,444
- (GRCh37/hg19)
Genomic View for BTN3A1 Gene
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC


RefSeq DNA sequence for BTN3A1 Gene
Proteins for BTN3A1 Gene
-
Protein details for BTN3A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00481-BT3A1_HUMAN
- Recommended name:
- Butyrophilin subfamily 3 member A1
- Protein Accession:
- O00481
- A2A278
- A8K2C8
- B4DIQ1
- B4DRM2
- E9PGB4
- E9PHG8
- Q0P515
- Q147X5
- Q53F15
- Q99420
- Q9HCY1
Protein attributes for BTN3A1 Gene
- Size:
- 513 amino acids
- Molecular mass:
- 57677 Da
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=CAA69164.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BTN3A1 Gene
Protein Expression for BTN3A1 Gene
Post-translational modifications for BTN3A1 Gene
- N-glycosylated.
- Glycosylation at Asn115
Other Protein References for BTN3A1 Gene
Antibody Products
- R&D Systems Antibodies for BTN3A1 (CD277/BTN3A1)
-
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Protein Products
- R&D Systems Proteins and Enzymes for BTN3A1 (CD277/BTN3A1)
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- Search GeneTex for Proteins for BTN3A1
-
ProSci Proteins for BTN3A1
Assay Products
No data available for DME Specific Peptides for BTN3A1 Gene
Domains & Families for BTN3A1 Gene
Gene Families for BTN3A1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for BTN3A1 Gene
Suggested Antigen Peptide Sequences for BTN3A1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00481- Family:
-
- Belongs to the immunoglobulin superfamily. BTN/MOG family.
Function for BTN3A1 Gene
Molecular function for BTN3A1 Gene
- GENATLAS Biochemistry:
- butyrophilin subfamily 3,member A1,B box family of proteins,involved in cell proliferation and development
- UniProtKB/Swiss-Prot Function:
- Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Phenotypes From GWAS Catalog for BTN3A1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21982860 |
Phenotypes for BTN3A1 Gene
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CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
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miRNA for BTN3A1 Gene
- miRTarBase miRNAs that target BTN3A1
miRNA Products
- Search ViGene Biosciences for BTN3A1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BTN3A1
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Clone Products
- Sino Biological Human cDNA Clone for BTN3A1
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VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for BTN3A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN3A1 Gene
Localization for BTN3A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BTN3A1 Gene
- Cell membrane; Single-pass type I membrane protein.
- Vesicles (1)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for BTN3A1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | T Cell Co-Signaling Pathway: Ligand-Receptor Interactions | ||
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Butyrophilin (BTN) family interactions | ||
4 | Innate Immune System |
.61
|
Pathways by source for BTN3A1 Gene
3 Reactome pathways for BTN3A1 Gene
1 R&D Systems pathway for BTN3A1 Gene
Interacting Proteins for BTN3A1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0050663 | cytokine secretion | IDA | 21918970 |
GO:0050798 | activated T cell proliferation | IMP | 21918970 |
GO:0050852 | T cell receptor signaling pathway | IDA | 21918970 |
No data available for SIGNOR curated interactions for BTN3A1 Gene
Transcripts for BTN3A1 Gene
mRNA/cDNA for BTN3A1 Gene
- (7) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BTN3A1 Gene
- Butyrophilin, subfamily 3, member A1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for BTN3A1
- genomics-online: gRNA clones - Search results for 67 available BTN3A1 gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
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- GenScript: Design CRISPR guide RNA sequences for BTN3A1
miRNA Products
- Search ViGene Biosciences for BTN3A1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BTN3A1
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ViGene Biosciences ready-to-package AAV shRNAs for BTN3A1 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for BTN3A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BTN3A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for BTN3A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BTN3A1 (CD277/BTN3A1)
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||
SP2: | |||||||||||||||
SP3: | |||||||||||||||
SP4: | - | - |
Expression for BTN3A1 Gene
mRNA differential expression in normal tissues according to GTEx for BTN3A1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN3A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of BTN3A1 Gene:
BTN3A1SOURCE GeneReport for Unigene cluster for BTN3A1 Gene:
Hs.191510mRNA Expression by UniProt/SwissProt for BTN3A1 Gene:
O00481-BT3A1_HUMANEvidence on tissue expression from TISSUES for BTN3A1 Gene
- Nervous system(4.6)
- Blood(2.5)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for BTN3A1
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTN3A1 Gene
Orthologs for BTN3A1 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | BTN3A1 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
mouse (Mus musculus) |
Mammalia | Btnl6 34 |
|
ManyToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany |
- Species where no ortholog for BTN3A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for BTN3A1 Gene
Paralogs for BTN3A1 Gene
(15) SIMAP similar genes for BTN3A1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for BTN3A1 Gene
Variants for BTN3A1 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000508885 | -- | 26,410,854(+) | T/C | genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
rs1000573713 | -- | 26,414,921(+) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
rs1000981828 | -- | 26,402,447(+) | A/C | intron_variant | |
rs1001110201 | -- | 26,409,263(+) | T/C | intron_variant, non_coding_transcript_variant | |
rs1001601096 | -- | 26,405,504(+) | C/T | 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2731728 | CNV | deletion | 23290073 |
esv2731730 | CNV | deletion | 23290073 |
esv3608402 | CNV | loss | 21293372 |
esv3608403 | CNV | loss | 21293372 |
esv3608404 | CNV | gain | 21293372 |
esv3890802 | CNV | loss | 25118596 |
nsv1023453 | CNV | gain | 25217958 |
nsv1030863 | CNV | gain+loss | 25217958 |
nsv601184 | CNV | gain | 21841781 |
nsv981113 | CNV | duplication | 23825009 |
Additional Variant Information for BTN3A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BTN3A1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN3A1 Gene
Disorders for BTN3A1 Gene
Additional Disease Information for BTN3A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BTN3A1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN3A1 Gene
Publications for BTN3A1 Gene
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy DA … Feder JN (Genome research 1997) 2 3 4 58
- Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PMID: 9382921) Tazi-Ahnini R … Pontarotti P (Immunogenetics 1997) 3 4 22 58
- Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. (PMID: 22767497) Harly C … Scotet E (Blood 2012) 3 4 58
- The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. (PMID: 22846996) Palakodeti A … Adams EJ (The Journal of biological chemistry 2012) 3 4 58
- Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. (PMID: 21918970) Messal N … Olive D (European journal of immunology 2011) 3 4 58
Products for BTN3A1 Gene
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- VectorBuilder custom plasmid, inducible vectors for BTN3A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BTN3A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 56 available BTN3A1 Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for 67 available BTN3A1 gene related products
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Sources for BTN3A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
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