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Aliases for ADCY5 Gene

Aliases for ADCY5 Gene

  • Adenylate Cyclase 5 2 3
  • ATP Pyrophosphate-Lyase 5 3 4
  • Adenylate Cyclase Type V 3 4
  • Adenylyl Cyclase 5 3 4
  • EC 4.6.1.1 4 64
  • FDFM 3 6
  • Adenylate Cyclase Type 5 3
  • AC5 3

External Ids for ADCY5 Gene

Summaries for ADCY5 Gene

Entrez Gene Summary for ADCY5 Gene

  • This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for ADCY5 Gene

ADCY5 (Adenylate Cyclase 5) is a Protein Coding gene. Diseases associated with ADCY5 include dyskinesia, familial, with facial myokymia and adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and adenylate cyclase binding. An important paralog of this gene is NPR2.

UniProtKB/Swiss-Prot for ADCY5 Gene

  • This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Tocris Summary for ADCY5 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5-triphosphate (ATP) into 3,5-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY5 Gene

Genomics for ADCY5 Gene

Genomic Location for ADCY5 Gene

Start:
123,282,296 bp from pter
End:
123,449,758 bp from pter
Size:
167,463 bases
Orientation:
Minus strand

Genomic View for ADCY5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY5 Gene

Regulatory Elements for ADCY5 Gene

Proteins for ADCY5 Gene

  • Protein details for ADCY5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95622-ADCY5_HUMAN
    Recommended name:
    Adenylate cyclase type 5
    Protein Accession:
    O95622
    Secondary Accessions:
    • B7Z8A6
    • Q7RTV7
    • Q8NFM3

    Protein attributes for ADCY5 Gene

    Size:
    1261 amino acids
    Molecular mass:
    138908 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1.

    Alternative splice isoforms for ADCY5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY5 Gene

Proteomics data for ADCY5 Gene at MOPED

Post-translational modifications for ADCY5 Gene

Other Protein References for ADCY5 Gene

Domains for ADCY5 Gene

Gene Families for ADCY5 Gene

HGNC:
  • ADCY :Adenylate cyclases
IUPHAR :

Protein Domains for ADCY5 Gene

UniProtKB/Swiss-Prot:

ADCY5_HUMAN
Domain:
  • Contains 2 guanylate cyclase domains.:
    • O95622
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • O95622
genes like me logo Genes that share domains with ADCY5: view

Function for ADCY5 Gene

Molecular function for ADCY5 Gene

GENATLAS Biochemistry: adenylyl cyclase,type V,ubiquitous
UniProtKB/Swiss-Prot CatalyticActivity: ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation by RAF1 results in its activation.
UniProtKB/Swiss-Prot Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Enzyme Numbers (IUBMB) for ADCY5 Gene

Gene Ontology (GO) - Molecular Function for ADCY5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004016 adenylate cyclase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008179 adenylate cyclase binding ISS --
genes like me logo Genes that share ontologies with ADCY5: view
genes like me logo Genes that share phenotypes with ADCY5: view

Animal Models for ADCY5 Gene

MGI Knock Outs for ADCY5:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ADCY5 Gene

Localization for ADCY5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY5 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY5 Gene COMPARTMENTS Subcellular localization image for ADCY5 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADCY5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0072372 primary cilium ISS --
genes like me logo Genes that share ontologies with ADCY5: view

Pathways for ADCY5 Gene

SuperPathways for ADCY5 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY5: view

Gene Ontology (GO) - Biological Process for ADCY5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
genes like me logo Genes that share ontologies with ADCY5: view

Compounds for ADCY5 Gene

(5) Tocris Compounds for ADCY5 Gene

Compound Action Cas Number
KH 7 Selective soluble adenylyl cyclase inhibitor [330676-02-3]
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Drugbank Compounds for ADCY5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
target
Forskolin
64657-11-0 target

(1) IUPHAR Ligand for ADCY5 Gene

Ligand Type Action Affinity Pubmed IDs
NKY80 Inhibitor Inhibition

(3) Novoseek inferred chemical compound relationships for ADCY5 Gene

Compound -log(P) Hits PubMed IDs
adenylate 58.2 7
dopamine 11.1 1
nitric oxide 1.2 1
genes like me logo Genes that share compounds with ADCY5: view

Transcripts for ADCY5 Gene

Unigene Clusters for ADCY5 Gene

Adenylate cyclase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY5 Gene

No ASD Table

Relevant External Links for ADCY5 Gene

GeneLoc Exon Structure for
ADCY5
ECgene alternative splicing isoforms for
ADCY5

Expression for ADCY5 Gene

mRNA expression in normal human tissues for ADCY5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY5 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY5 Gene

SOURCE GeneReport for Unigene cluster for ADCY5 Gene Hs.593292

genes like me logo Genes that share expressions with ADCY5: view

Orthologs for ADCY5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY5 36
  • 99.29 (n)
  • 99.26 (a)
ADCY5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY5 36
  • 92.53 (n)
  • 97.06 (a)
ADCY5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY5 36
  • 91.22 (n)
  • 93.94 (a)
ADCY5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy5 36
  • 89.48 (n)
  • 94.29 (a)
Adcy5 16
Adcy5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY5 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adcy5 36
  • 89.51 (n)
  • 94.37 (a)
chicken
(Gallus gallus)
Aves ADCY5 36
  • 75.77 (n)
  • 82.01 (a)
ADCY5 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY5 37
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adcy5 36
  • 74.08 (n)
  • 79.29 (a)
adcy5 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002998 36
  • 59.17 (n)
  • 52.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43373 36
  • 59.8 (n)
  • 52.68 (a)
CG43373 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acy-4 36
  • 49.31 (n)
  • 42.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for ADCY5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADCY5 Gene

ENSEMBL:
Gene Tree for ADCY5 (if available)
TreeFam:
Gene Tree for ADCY5 (if available)

Paralogs for ADCY5 Gene

Selected SIMAP similar genes for ADCY5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY5: view

Variants for ADCY5 Gene

Sequence variations from dbSNP and Humsavar for ADCY5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs726835 -- 123,440,727(+) CCAGA(C/T)GAATG intron-variant
rs730521 -- 123,391,378(+) GGGGA(C/T)GGCAA intron-variant
rs764032 -- 123,440,769(+) TTCTA(C/T)TAACC intron-variant
rs903571 -- 123,382,403(-) gactt(G/T)ctgaa intron-variant
rs903572 -- 123,382,297(-) GGTTC(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY5 Gene

Variant ID Type Subtype PubMed ID
nsv3976 CNV Insertion 18451855
nsv877395 CNV Gain 21882294
esv272701 CNV Insertion 20981092
nsv829707 CNV Loss 17160897
nsv822229 CNV Gain 20364138
esv2627675 CNV Insertion 19546169
nsv877396 CNV Gain 21882294
esv21931 CNV Loss 19812545

Relevant External Links for ADCY5 Gene

HapMap Linkage Disequilibrium report
ADCY5
Human Gene Mutation Database (HGMD)
ADCY5

Disorders for ADCY5 Gene

(1) OMIM Diseases for ADCY5 Gene (600293)

UniProtKB/Swiss-Prot

ADCY5_HUMAN
  • Dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]: A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages. {ECO:0000269 PubMed:22782511}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ADCY5 Gene

Relevant External Links for ADCY5

Genetic Association Database (GAD)
ADCY5
Human Genome Epidemiology (HuGE) Navigator
ADCY5
genes like me logo Genes that share disorders with ADCY5: view

Publications for ADCY5 Gene

  1. Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. (PMID: 10481931) Raimundo S. … Wisser H. (Clin. Chim. Acta 1999) 2 3 4
  2. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PMID: 12503609) Ludwig M.G. … Seuwen K. (J. Recept. Signal Transduct. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  5. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PMID: 20081857) Saxena R. … Watanabe R.M. (Nat. Genet. 2010) 3 49

Products for ADCY5 Gene

Sources for ADCY5 Gene

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