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Aliases for ADAMTS5 Gene

Aliases for ADAMTS5 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 5 2 3
  • Aggrecanase-2 2 3 4
  • ADAMTS11 3 4 6
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2) 2 3
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11 3 4
  • ADAM-TS 11 3 4
  • ADAM-TS 5 3 4
  • ADAMTS-11 3 4
  • ADAM-TS5 3 4
  • ADAMTS-5 3 4
  • ADMP-2 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 3
  • EC 3.4.24.14 64
  • EC 3.4.24.82 64
  • EC 3.4.24.- 4
  • EC 3.4.24 64
  • ADMP2 4

External Ids for ADAMTS5 Gene

Summaries for ADAMTS5 Gene

Entrez Gene Summary for ADAMTS5 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS5 Gene

ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 5) is a Protein Coding gene. Among its related pathways are Endochondral Ossification and Degradation of the extracellular matrix. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS5 Gene

  • Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period

Gene Wiki entry for ADAMTS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS5 Gene

Genomics for ADAMTS5 Gene

Genomic Location for ADAMTS5 Gene

Start:
26,917,912 bp from pter
End:
26,967,120 bp from pter
Size:
49,209 bases
Orientation:
Minus strand

Genomic View for ADAMTS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS5 Gene

Regulatory Elements for ADAMTS5 Gene

Proteins for ADAMTS5 Gene

  • Protein details for ADAMTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNA0-ATS5_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 5
    Protein Accession:
    Q9UNA0
    Secondary Accessions:
    • Q52LV4
    • Q9UKP2

    Protein attributes for ADAMTS5 Gene

    Size:
    930 amino acids
    Molecular mass:
    101718 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADAMTS5 Gene

neXtProt entry for ADAMTS5 Gene

Proteomics data for ADAMTS5 Gene at MOPED

Selected DME Specific Peptides for ADAMTS5 Gene

Post-translational modifications for ADAMTS5 Gene

  • C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr36, Ser208, Ser214, Thr215, Asn498, Trp570, Trp573, Ser582, Asn728, Asn802, and Asn807

Other Protein References for ADAMTS5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADAMTS5 Gene

Gene Families for ADAMTS5 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

UniProtKB/Swiss-Prot:

ATS5_HUMAN
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix:
    • Q9UNA0
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9UNA0
  • Contains 1 disintegrin domain.:
    • Q9UNA0
  • Contains 1 peptidase M12B domain.:
    • Q9UNA0
  • Contains 2 TSP type-1 domains.:
    • Q9UNA0
genes like me logo Genes that share domains with ADAMTS5: view

Function for ADAMTS5 Gene

Molecular function for ADAMTS5 Gene

GENATLAS Biochemistry: a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 2,with thrombospondin type 1 motif 5,highly expressed in the peri-implantation period in mouse embryo and trophoblast and in adult tissues,extracellular matrix protein
UniProtKB/Swiss-Prot CatalyticActivity: Cleaves aggrecan at the 392-Glu- -Ala-393 site
UniProtKB/Swiss-Prot Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period

Enzyme Numbers (IUBMB) for ADAMTS5 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 10438522
GO:0005515 protein binding IPI 22406378
GO:0008237 metallopeptidase activity TAS 10438522
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS5: view
genes like me logo Genes that share phenotypes with ADAMTS5: view

Animal Models for ADAMTS5 Gene

MGI Knock Outs for ADAMTS5:

miRNA for ADAMTS5 Gene

miRTarBase miRNAs that target ADAMTS5

No data available for Transcription Factor Targeting and HOMER Transcription for ADAMTS5 Gene

Localization for ADAMTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS5 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS5 Gene COMPARTMENTS Subcellular localization image for ADAMTS5 gene
Compartment Confidence
cytosol 4
extracellular 4
nucleus 4
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAMTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTS5: view

Pathways for ADAMTS5 Gene

genes like me logo Genes that share pathways with ADAMTS5: view

Pathways by source for ADAMTS5 Gene

1 Sino Biological pathway for ADAMTS5 Gene
1 BioSystems pathway for ADAMTS5 Gene

Gene Ontology (GO) - Biological Process for ADAMTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0036066 protein O-linked fucosylation TAS --
genes like me logo Genes that share ontologies with ADAMTS5: view

Compounds for ADAMTS5 Gene

(4) Novoseek inferred chemical compound relationships for ADAMTS5 Gene

Compound -log(P) Hits PubMed IDs
glycosaminoglycan 61 4
retinoic acid 21.3 1
heparin 11.4 3
zinc 9.64 3
genes like me logo Genes that share compounds with ADAMTS5: view

Transcripts for ADAMTS5 Gene

mRNA/cDNA for ADAMTS5 Gene

Unigene Clusters for ADAMTS5 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS5 Gene

No ASD Table

Relevant External Links for ADAMTS5 Gene

GeneLoc Exon Structure for
ADAMTS5
ECgene alternative splicing isoforms for
ADAMTS5

Expression for ADAMTS5 Gene

mRNA expression in normal human tissues for ADAMTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS5 Gene

This gene is overexpressed in Adipose - Subcutaneous (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAMTS5 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS5 Gene Hs.58324

mRNA Expression by UniProt/SwissProt for ADAMTS5 Gene

Q9UNA0-ATS5_HUMAN
Tissue specificity: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient
genes like me logo Genes that share expressions with ADAMTS5: view

Orthologs for ADAMTS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS5 36
  • 99.64 (n)
  • 99.68 (a)
ADAMTS5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS5 36
  • 87.53 (n)
  • 91.94 (a)
ADAMTS5 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS5 36
  • 88.81 (n)
  • 93.09 (a)
ADAMTS5 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts5 36
  • 85.86 (n)
  • 90.8 (a)
Adamts5 16
Adamts5 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMTS5 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS5 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts5 36
  • 85.97 (n)
  • 91.65 (a)
chicken
(Gallus gallus)
Aves ADAMTS5 36
  • 78.85 (n)
  • 85.52 (a)
ADAMTS5 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS5 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts5 36
  • 71.49 (n)
  • 76.46 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts5 36
  • 66.83 (n)
  • 70.62 (a)
Species with no ortholog for ADAMTS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS5 Gene

ENSEMBL:
Gene Tree for ADAMTS5 (if available)
TreeFam:
Gene Tree for ADAMTS5 (if available)

Paralogs for ADAMTS5 Gene

Selected SIMAP similar genes for ADAMTS5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS5: view

Variants for ADAMTS5 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS5 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs149415 -- 26,949,233(-) GTGAT(A/G)CAGCA intron-variant
rs149416 -- 26,930,854(-) ATATT(C/T)TACTT intron-variant
rs150940 -- 26,939,916(-) TGGGA(C/G)CCCCC intron-variant
rs151056 -- 26,931,204(+) ACCAC(A/G)CCCAG intron-variant
rs151057 -- 26,938,720(+) AGACT(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS5 Gene

Variant ID Type Subtype PubMed ID
nsv834068 CNV Loss 17160897
esv2659668 CNV Deletion 23128226

Relevant External Links for ADAMTS5 Gene

HapMap Linkage Disequilibrium report
ADAMTS5

Disorders for ADAMTS5 Gene

(1) University of Copenhagen DISEASES for ADAMTS5 Gene

(6) Novoseek inferred disease relationships for ADAMTS5 Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 79.2 13
arthritis 51.5 3
necrosis 31.5 4
glioblastoma 12.7 7
rheumatoid arthritis 7.63 1

Relevant External Links for ADAMTS5

Genetic Association Database (GAD)
ADAMTS5
Human Genome Epidemiology (HuGE) Navigator
ADAMTS5
genes like me logo Genes that share disorders with ADAMTS5: view

No data available for UniProtKB/Swiss-Prot for ADAMTS5 Gene

Publications for ADAMTS5 Gene

  1. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. (PMID: 10438522) Abbaszade I. … Burn T.C. (J. Biol. Chem. 1999) 2 3 4 23
  2. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PMID: 10464288) Hurskainen T.L. … Apte S.S. (J. Biol. Chem. 1999) 3 4 23
  3. Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (PMID: 18240210) Rodriguez-Lopez J. … Gonzalez A. (Arthritis Rheum. 2008) 3 23 49
  4. Expression of ADAMTS-5 in deformed human temporomandibular joint discs. (PMID: 18830934) Matsumoto T. … Fujita S. (Histol. Histopathol. 2008) 3 23
  5. Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter. (PMID: 17211519) Thirunavukkarasu K. … Wei T. (Mol. Biol. Rep. 2007) 3 23

Products for ADAMTS5 Gene

Sources for ADAMTS5 Gene

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