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Aliases for ADAMTS5 Gene

Aliases for ADAMTS5 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 2 3 5
  • Aggrecanase-2 2 3 4
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2) 2 3
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11 3 4
  • ADAM-TS 11 3 4
  • ADAM-TS 5 3 4
  • ADAMTS-11 3 4
  • ADAM-TS5 3 4
  • ADAMTS-5 3 4
  • ADAMTS11 3 4
  • ADMP-2 3 4
  • EC 3.4.24.14 63
  • EC 3.4.24.82 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • ADMP2 4

External Ids for ADAMTS5 Gene

Previous GeneCards Identifiers for ADAMTS5 Gene

  • GC21M024872
  • GC21M027200
  • GC21M027215
  • GC21M028290
  • GC21M013695

Summaries for ADAMTS5 Gene

Entrez Gene Summary for ADAMTS5 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS5 Gene

ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include osteoarthritis and bone inflammation disease. Among its related pathways are Degradation of the extracellular matrix and O-linked glycosylation. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS20.

UniProtKB/Swiss-Prot for ADAMTS5 Gene

  • Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Gene Wiki entry for ADAMTS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS5 Gene

Genomics for ADAMTS5 Gene

Regulatory Elements for ADAMTS5 Gene

Promoters for ADAMTS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAMTS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS5 Gene

Chromosome:
21
Start:
26,917,912 bp from pter
End:
26,967,120 bp from pter
Size:
49,209 bases
Orientation:
Minus strand

Genomic View for ADAMTS5 Gene

Genes around ADAMTS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS5 Gene

Proteins for ADAMTS5 Gene

  • Protein details for ADAMTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNA0-ATS5_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 5
    Protein Accession:
    Q9UNA0
    Secondary Accessions:
    • Q52LV4
    • Q9UKP2

    Protein attributes for ADAMTS5 Gene

    Size:
    930 amino acids
    Molecular mass:
    101718 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADAMTS5 Gene

neXtProt entry for ADAMTS5 Gene

Proteomics data for ADAMTS5 Gene at MOPED

Selected DME Specific Peptides for ADAMTS5 Gene

Post-translational modifications for ADAMTS5 Gene

  • C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Thr 36, Ser 208, Ser 214, Thr 215, Asn 498, Trp 570, Trp 573, Ser 582, Asn 728, Asn 802, and Asn 807
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADAMTS5 Gene

Gene Families for ADAMTS5 Gene

Suggested Antigen Peptide Sequences for ADAMTS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNA0

UniProtKB/Swiss-Prot:

ATS5_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 2 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS5: view

Function for ADAMTS5 Gene

Molecular function for ADAMTS5 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 2,with thrombospondin type 1 motif 5,highly expressed in the peri-implantation period in mouse embryo and trophoblast and in adult tissues,extracellular matrix protein
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves aggrecan at the 392-Glu- -Ala-393 site.
UniProtKB/Swiss-Prot Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Enzyme Numbers (IUBMB) for ADAMTS5 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0005178 integrin binding TAS 10438522
GO:0005515 protein binding IPI 22406378
genes like me logo Genes that share ontologies with ADAMTS5: view
genes like me logo Genes that share phenotypes with ADAMTS5: view

Animal Models for ADAMTS5 Gene

MGI Knock Outs for ADAMTS5:

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAMTS5 Gene

Localization for ADAMTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS5 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS5 Gene COMPARTMENTS Subcellular localization image for ADAMTS5 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADAMTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with ADAMTS5: view

Pathways & Interactions for ADAMTS5 Gene

genes like me logo Genes that share pathways with ADAMTS5: view

Pathways by source for ADAMTS5 Gene

Gene Ontology (GO) - Biological Process for ADAMTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0036066 protein O-linked fucosylation TAS --
genes like me logo Genes that share ontologies with ADAMTS5: view

No data available for SIGNOR curated interactions for ADAMTS5 Gene

Drugs & Compounds for ADAMTS5 Gene

(5) Drugs for ADAMTS5 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide Experimental Pharma Target 0
Batimastat Experimental Pharma Target 0
N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide Experimental Pharma Target 0

(2) Additional Compounds for ADAMTS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAMTS5: view

Transcripts for ADAMTS5 Gene

mRNA/cDNA for ADAMTS5 Gene

Unigene Clusters for ADAMTS5 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS5 Gene

No ASD Table

Relevant External Links for ADAMTS5 Gene

GeneLoc Exon Structure for
ADAMTS5
ECgene alternative splicing isoforms for
ADAMTS5

Expression for ADAMTS5 Gene

mRNA expression in normal human tissues for ADAMTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS5 Gene

This gene is overexpressed in Adipose - Subcutaneous (x6.0).

Protein differential expression in normal tissues from HIPED for ADAMTS5 Gene

This gene is overexpressed in Amniocyte (47.6) and Heart (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS5 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS5 Gene Hs.58324

mRNA Expression by UniProt/SwissProt for ADAMTS5 Gene

Q9UNA0-ATS5_HUMAN
Tissue specificity: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
genes like me logo Genes that share expression patterns with ADAMTS5: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ADAMTS5 Gene

Orthologs for ADAMTS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS5 35
  • 87.53 (n)
  • 91.94 (a)
ADAMTS5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS5 35
  • 88.81 (n)
  • 93.09 (a)
ADAMTS5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts5 35
  • 85.86 (n)
  • 90.8 (a)
Adamts5 16
Adamts5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS5 35
  • 99.64 (n)
  • 99.68 (a)
ADAMTS5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts5 35
  • 85.97 (n)
  • 91.65 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS5 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS5 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS5 35
  • 78.85 (n)
  • 85.52 (a)
ADAMTS5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS5 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts5 35
  • 71.49 (n)
  • 76.46 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts5 35
  • 66.83 (n)
  • 70.62 (a)
Species with no ortholog for ADAMTS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS5 Gene

ENSEMBL:
Gene Tree for ADAMTS5 (if available)
TreeFam:
Gene Tree for ADAMTS5 (if available)

Paralogs for ADAMTS5 Gene

(9) SIMAP similar genes for ADAMTS5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS5: view

Variants for ADAMTS5 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS5 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_021849 -
rs457947 - 26,965,979(+) GACTA(C/G)CGTCC reference, missense
VAR_028200 -
rs395709 -- 26,968,745(-) TTTCA(A/G)AATCT upstream-variant-2KB
rs162501 -- 26,961,235(-) TGTAA(C/T)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS5 Gene

Variant ID Type Subtype PubMed ID
nsv834068 CNV Loss 17160897
esv2659668 CNV Deletion 23128226

Variation tolerance for ADAMTS5 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS5 Gene

HapMap Linkage Disequilibrium report
ADAMTS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS5 Gene

Disorders for ADAMTS5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADAMTS5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteoarthritis
  • arthropathy
bone inflammation disease
  • bone inflammatory disease
bone structure disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAMTS5

Genetic Association Database (GAD)
ADAMTS5
Human Genome Epidemiology (HuGE) Navigator
ADAMTS5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS5
genes like me logo Genes that share disorders with ADAMTS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS5 Gene

Publications for ADAMTS5 Gene

  1. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. (PMID: 10438522) Abbaszade I. … Burn T.C. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. (PMID: 19643179) Troeberg L. … Nagase H. (Matrix Biol. 2009) 3 23
  3. High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2). (PMID: 17991750) Shieh H.S. … Tomasselli A. (J. Biol. Chem. 2008) 3 23
  4. Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. (PMID: 18156631) Fushimi K. … Nagase H. (J. Biol. Chem. 2008) 3 23
  5. Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (PMID: 18240210) Rodriguez-Lopez J. … Gonzalez A. (Arthritis Rheum. 2008) 3 23

Products for ADAMTS5 Gene

Sources for ADAMTS5 Gene

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