Aliases for ADAMTS8 Gene
External Ids for ADAMTS8 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS8 Gene
ADAMTS8 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 8) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is ADAMTS16.
UniProtKB/Swiss-Prot for ADAMTS8 Gene
Has anti-angiogenic properties