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Aliases for ADAMTS8 Gene

Aliases for ADAMTS8 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 8 2 3
  • ADAM-TS 8 3 4
  • ADAM-TS8 3 4
  • ADAMTS-8 3 4
  • METH-2 3 4
  • METH-8 3 4
  • METH2 3 4
  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 8 3
  • EC 3.4.24.82 63
  • EC 3.4.24.14 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ADAMTS8 Gene

Previous GeneCards Identifiers for ADAMTS8 Gene

  • GC11M132275
  • GC11M131787
  • GC11M129812
  • GC11M129780
  • GC11M126229

Summaries for ADAMTS8 Gene

Entrez Gene Summary for ADAMTS8 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS8 Gene

ADAMTS8 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8) is a Protein Coding gene. Among its related pathways are Infectious disease and Diseases associated with O-glycosylation of proteins. GO annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is ADAMTS20.

UniProtKB/Swiss-Prot for ADAMTS8 Gene

  • Has anti-angiogenic properties.

Gene Wiki entry for ADAMTS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS8 Gene

Genomics for ADAMTS8 Gene

Regulatory Elements for ADAMTS8 Gene

Enhancers for ADAMTS8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS8 Gene

Chromosome:
11
Start:
130,404,923 bp from pter
End:
130,428,993 bp from pter
Size:
24,071 bases
Orientation:
Minus strand

Genomic View for ADAMTS8 Gene

Genes around ADAMTS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS8 Gene

Proteins for ADAMTS8 Gene

  • Protein details for ADAMTS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UP79-ATS8_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 8
    Protein Accession:
    Q9UP79
    Secondary Accessions:
    • Q9NZS0

    Protein attributes for ADAMTS8 Gene

    Size:
    889 amino acids
    Molecular mass:
    96460 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS8 Gene

Proteomics data for ADAMTS8 Gene at MOPED

Selected DME Specific Peptides for ADAMTS8 Gene

Post-translational modifications for ADAMTS8 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 344, Asn 400, Asn 465, Asn 490, and Asn 599
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADAMTS8 Gene

Gene Families for ADAMTS8 Gene

Suggested Antigen Peptide Sequences for ADAMTS8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UP79

UniProtKB/Swiss-Prot:

ATS8_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 2 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS8: view

Function for ADAMTS8 Gene

Molecular function for ADAMTS8 Gene

UniProtKB/Swiss-Prot Function:
Has anti-angiogenic properties.

Enzyme Numbers (IUBMB) for ADAMTS8 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 10438512
genes like me logo Genes that share ontologies with ADAMTS8: view
genes like me logo Genes that share phenotypes with ADAMTS8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS8 Gene

Localization for ADAMTS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS8 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS8 Gene COMPARTMENTS Subcellular localization image for ADAMTS8 gene
Compartment Confidence
extracellular 4
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ADAMTS8 Gene

Drugs & Compounds for ADAMTS8 Gene

No Compound Related Data Available

Transcripts for ADAMTS8 Gene

mRNA/cDNA for ADAMTS8 Gene

Unigene Clusters for ADAMTS8 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - - - - - - - - -
SP3: -
SP4:

Relevant External Links for ADAMTS8 Gene

GeneLoc Exon Structure for
ADAMTS8
ECgene alternative splicing isoforms for
ADAMTS8

Expression for ADAMTS8 Gene

mRNA expression in normal human tissues for ADAMTS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS8 Gene

This gene is overexpressed in Lung (x8.5) and Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for ADAMTS8 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS8 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS8 Gene Hs.271605

mRNA Expression by UniProt/SwissProt for ADAMTS8 Gene

Q9UP79-ATS8_HUMAN
Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney.
genes like me logo Genes that share expression patterns with ADAMTS8: view

Protein tissue co-expression partners for ADAMTS8 Gene

Primer Products

Orthologs for ADAMTS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS8 35
  • 82.92 (n)
  • 76.7 (a)
ADAMTS8 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS8 35
  • 88.15 (n)
  • 90.12 (a)
ADAMTS8 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts8 35
  • 83.72 (n)
  • 82.44 (a)
Adamts8 16
Adamts8 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS8 35
  • 99.1 (n)
  • 98.83 (a)
ADAMTS8 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts8 35
  • 82.94 (n)
  • 82.55 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS8 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS8 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS8 35
  • 76.94 (n)
  • 78.02 (a)
ADAMTS8 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS8 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts8 35
  • 58.75 (n)
  • 58.35 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts8a 35
  • 61.77 (n)
  • 58.4 (a)
adamts15b 36
  • 50 (a)
OneToMany
adamts8a 36
  • 53 (a)
OneToMany
Species with no ortholog for ADAMTS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS8 Gene

ENSEMBL:
Gene Tree for ADAMTS8 (if available)
TreeFam:
Gene Tree for ADAMTS8 (if available)

Paralogs for ADAMTS8 Gene

(12) SIMAP similar genes for ADAMTS8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS8: view

Variants for ADAMTS8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS8 Gene

Variant ID Type Subtype PubMed ID
dgv446e1 CNV Complex 17122850
nsv508660 CNV Loss 20534489
nsv550 CNV Insertion 18451855

Variation tolerance for ADAMTS8 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.82; 94.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ADAMTS8 Gene

Disorders for ADAMTS8 Gene

Relevant External Links for ADAMTS8

Genetic Association Database (GAD)
ADAMTS8
Human Genome Epidemiology (HuGE) Navigator
ADAMTS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS8

No disorders were found for ADAMTS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS8 Gene

Publications for ADAMTS8 Gene

  1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PMID: 10438512) Vazquez F. … Iruela-Arispe M.L. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PMID: 15296936) Collins-Racie L.A. … LaVallie E.R. (Matrix Biol. 2004) 3 23
  3. METH-2 silencing and promoter hypermethylation in NSCLC. (PMID: 15328519) Dunn J.R. … Liloglou T. (Br. J. Cancer 2004) 3 23
  4. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PMID: 10610729) Georgiadis K.E. … Apte S.S. (Genomics 1999) 3 23
  5. The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation. (PMID: 24184540) Choi G.C. … Tao Q. (Mol. Cancer Res. 2014) 3

Products for ADAMTS8 Gene

Sources for ADAMTS8 Gene

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