Aliases for TRIOBP Gene
External Ids for TRIOBP Gene
Previous HGNC Symbols for TRIOBP Gene
Previous GeneCards Identifiers for TRIOBP Gene
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
GeneCards Summary for TRIOBP Gene
TRIOBP (TRIO And F-Actin Binding Protein) is a Protein Coding gene. Diseases associated with TRIOBP include deafness, autosomal recessive 28 and dfnb28 nonsyndromic hearing loss and deafness. GO annotations related to this gene include ubiquitin protein ligase binding and GTP-Rho binding. An important paralog of this gene is MPRIP.
UniProtKB/Swiss-Prot for TRIOBP Gene
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.