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Aliases for TRIOBP Gene

Aliases for TRIOBP Gene

  • TRIO And F-Actin Binding Protein 2 3
  • Trio-Associated Repeat On Actin 3 4
  • Protein Tara 3 4
  • KIAA1662 4 6
  • TARA 3 4
  • TRIO And F-Actin-Binding Protein 3
  • Tara-Like Protein 3
  • EC 3.6.3.14 64
  • HRIHFB2122 3
  • EC 6.3.5.5 64
  • EC 6.1.1.4 64
  • DJ37E16.4 3
  • DFNB28 3
  • TAP68 3

External Ids for TRIOBP Gene

Previous Symbols for TRIOBP Gene

  • DFNB28

Summaries for TRIOBP Gene

Entrez Gene Summary for TRIOBP Gene

  • This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]

GeneCards Summary for TRIOBP Gene

TRIOBP (TRIO And F-Actin Binding Protein) is a Protein Coding gene. Diseases associated with TRIOBP include autosomal recessive non-syndromic sensorineural deafness type dfnb and deafness, autosomal recessive 28. GO annotations related to this gene include phospholipid binding and actin filament binding. An important paralog of this gene is MPRIP.

UniProtKB/Swiss-Prot for TRIOBP Gene

  • May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

Gene Wiki entry for TRIOBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIOBP Gene

Genomics for TRIOBP Gene

Genomic Location for TRIOBP Gene

Start:
37,696,988 bp from pter
End:
37,776,556 bp from pter
Size:
79,569 bases
Orientation:
Plus strand

Genomic View for TRIOBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIOBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIOBP Gene

Regulatory Elements for TRIOBP Gene

Proteins for TRIOBP Gene

  • Protein details for TRIOBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2D6-TARA_HUMAN
    Recommended name:
    TRIO and F-actin-binding protein
    Protein Accession:
    Q9H2D6
    Secondary Accessions:
    • B1AHD4
    • B1AHD7
    • F2Z2W0
    • F8W6V6
    • O94797
    • Q2PZW8
    • Q2Q3Z9
    • Q2Q400
    • Q5R3M6
    • Q96DW1
    • Q9BT77
    • Q9BTL7
    • Q9BY98
    • Q9Y3L4

    Protein attributes for TRIOBP Gene

    Size:
    2365 amino acids
    Molecular mass:
    261376 Da
    Quaternary structure:
    • Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3.
    Miscellaneous:
    • Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted protein
    SequenceCaution:
    • Sequence=BAA34800.1; Type=Frameshift; Positions=478; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIOBP Gene

neXtProt entry for TRIOBP Gene

Proteomics data for TRIOBP Gene at MOPED

Selected DME Specific Peptides for TRIOBP Gene

Post-translational modifications for TRIOBP Gene

  • Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.
  • Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for TRIOBP Gene

Gene Families for TRIOBP Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for TRIOBP Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TARA_HUMAN
Domain:
  • Contains at least 2 actin-binding sites per coiled-coil dimer:
    • Q9H2D6
  • Contains 1 PH domain.:
    • Q9H2D6
genes like me logo Genes that share domains with TRIOBP: view

Function for TRIOBP Gene

Molecular function for TRIOBP Gene

UniProtKB/Swiss-Prot Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

Enzyme Numbers (IUBMB) for TRIOBP Gene

Gene Ontology (GO) - Molecular Function for TRIOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017049 GTP-Rho binding NAS 11148140
GO:0031625 ubiquitin protein ligase binding IPI 18194665
GO:0045159 myosin II binding NAS 11148140
GO:0051015 actin filament binding IDA 11148140
genes like me logo Genes that share ontologies with TRIOBP: view

Phenotypes for TRIOBP Gene

genes like me logo Genes that share phenotypes with TRIOBP: view

miRNA for TRIOBP Gene

miRTarBase miRNAs that target TRIOBP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIOBP Gene

Localization for TRIOBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIOBP Gene

Nucleus. Cytoplasm, cytoskeleton. Note=Localized to F-actin in a periodic pattern.
Isoform 1: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIOBP Gene COMPARTMENTS Subcellular localization image for TRIOBP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton NAS 11148140
genes like me logo Genes that share ontologies with TRIOBP: view

Pathways for TRIOBP Gene

SuperPathways for TRIOBP Gene

No Data Available

Interacting Proteins for TRIOBP Gene

Gene Ontology (GO) - Biological Process for TRIOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0030047 actin modification NAS 11148140
GO:0051016 barbed-end actin filament capping NAS 11148140
GO:0051301 cell division IEA --
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading IDA 11148140
genes like me logo Genes that share ontologies with TRIOBP: view

No data available for Pathways by source for TRIOBP Gene

Transcripts for TRIOBP Gene

Unigene Clusters for TRIOBP Gene

TRIO and F-actin binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIOBP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - -
SP11: - - -
SP12: - - - - - -
SP13:

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d ^ 22a · 22b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - -
SP12:
SP13: -

Relevant External Links for TRIOBP Gene

GeneLoc Exon Structure for
TRIOBP
ECgene alternative splicing isoforms for
TRIOBP

Expression for TRIOBP Gene

mRNA expression in normal human tissues for TRIOBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIOBP Gene

SOURCE GeneReport for Unigene cluster for TRIOBP Gene Hs.533030

mRNA Expression by UniProt/SwissProt for TRIOBP Gene

Q9H2D6-TARA_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.
genes like me logo Genes that share expressions with TRIOBP: view

Orthologs for TRIOBP Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIOBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIOBP 37
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIOBP 36
  • 89.56 (n)
  • 94.12 (a)
TRIOBP 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIOBP 36
  • 84.79 (n)
  • 81.77 (a)
TRIOBP 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Triobp 36
  • 79.69 (n)
  • 76.25 (a)
Triobp 16
Triobp 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIOBP 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIOBP 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Triobp 36
  • 79.98 (n)
  • 77.28 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 56 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
LOC100859397 36
  • 74.98 (n)
  • 73.06 (a)
lizard
(Anolis carolinensis)
Reptilia TRIOBP 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12480 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1356 36
triobp 36
  • 62.99 (n)
  • 66.35 (a)
zebrafish
(Danio rerio)
Actinopterygii triobp 37
  • 39 (a)
OneToMany
TRIOBP (2 of 2) 37
  • 24 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta osp 37
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10G8.8 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for TRIOBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIOBP Gene

ENSEMBL:
Gene Tree for TRIOBP (if available)
TreeFam:
Gene Tree for TRIOBP (if available)

Paralogs for TRIOBP Gene

Paralogs for TRIOBP Gene

Selected SIMAP similar genes for TRIOBP Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TRIOBP: view

Variants for TRIOBP Gene

Sequence variations from dbSNP and Humsavar for TRIOBP Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs15691 -- 37,776,373(-) AGCTG(C/G/T)TCAGT utr-variant-3-prime
rs739137 -- 37,726,441(+) AGCAG(C/T)GGGGG reference, synonymous-codon
rs739138 - 37,726,455(+) CACCC(A/G)CAGCC reference, missense
rs739140 -- 37,719,549(+) TTACT(A/G)CCCAC intron-variant
rs743833 -- 37,735,801(+) GCTCA(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIOBP Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834191 CNV Loss 17160897
nsv471197 CNV Loss 18288195
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
esv2724218 CNV Deletion 23290073
esv2724219 CNV Deletion 23290073
nsv915039 CNV Gain 21882294
nsv9903 CNV Loss 18304495
esv1471410 CNV Deletion 17803354
esv2658988 CNV Deletion 23128226
esv2660524 CNV Deletion 23128226
dgv4966n71 CNV Loss 21882294
nsv9904 CNV Gain+Loss 18304495

Relevant External Links for TRIOBP Gene

HapMap Linkage Disequilibrium report
TRIOBP
Human Gene Mutation Database (HGMD)
TRIOBP

Disorders for TRIOBP Gene

(1) OMIM Diseases for TRIOBP Gene (609761)

UniProtKB/Swiss-Prot

TARA_HUMAN
  • Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:16385457, ECO:0000269 PubMed:16385458}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TRIOBP Gene

Relevant External Links for TRIOBP

Genetic Association Database (GAD)
TRIOBP
Human Genome Epidemiology (HuGE) Navigator
TRIOBP
genes like me logo Genes that share disorders with TRIOBP: view

Publications for TRIOBP Gene

  1. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. (PMID: 16385457) Riazuddin S. … Friedman T.B. (Am. J. Hum. Genet. 2006) 2 3 4 23
  2. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. (PMID: 11148140) Seipel K. … Streuli M. (J. Cell Sci. 2001) 2 3 4
  3. Mutations in a novel isoform of TRIOBP that encodes a filamentous- actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. (PMID: 16385458) Shahin H. … Kanaan M. (Am. J. Hum. Genet. 2006) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 3 4

Products for TRIOBP Gene

Sources for TRIOBP Gene

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