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Aliases for DUS4L Gene

Aliases for DUS4L Gene

  • Dihydrouridine Synthase 4 Like 2 3
  • Protein Similar To E.Coli Yhdg And R. Capsulatus NifR3 2 3
  • Dihydrouridine Synthase 4-Like 3 5
  • PP35 3 4
  • Dihydrouridine Synthase 4-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 4-Like 4
  • EC 1.3.1.- 4
  • DUS4 3

External Ids for DUS4L Gene

Previous GeneCards Identifiers for DUS4L Gene

  • GC07P106799
  • GC07P106991
  • GC07P107203
  • GC07P101565

Summaries for DUS4L Gene

GeneCards Summary for DUS4L Gene

DUS4L (Dihydrouridine Synthase 4 Like) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and FMN binding.

UniProtKB/Swiss-Prot for DUS4L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS4L Gene

Genomics for DUS4L Gene

Regulatory Elements for DUS4L Gene

Enhancers for DUS4L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUS4L on UCSC Golden Path with GeneCards custom track

Promoters for DUS4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUS4L on UCSC Golden Path with GeneCards custom track

Genomic Location for DUS4L Gene

107,563,484 bp from pter
107,578,523 bp from pter
15,040 bases
Plus strand

Genomic View for DUS4L Gene

Genes around DUS4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS4L Gene

Proteins for DUS4L Gene

  • Protein details for DUS4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
    Protein Accession:
    Secondary Accessions:
    • B4DLX0
    • Q2NKK1

    Protein attributes for DUS4L Gene

    317 amino acids
    Molecular mass:
    35816 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available
    • Sequence=AAD00100.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for DUS4L Gene


neXtProt entry for DUS4L Gene

Proteomics data for DUS4L Gene at MOPED

Post-translational modifications for DUS4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUS4L Gene

No data available for DME Specific Peptides for DUS4L Gene

Domains & Families for DUS4L Gene

Protein Domains for DUS4L Gene

Suggested Antigen Peptide Sequences for DUS4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Dus family. Dus4 subfamily.
  • Belongs to the Dus family. Dus4 subfamily.
genes like me logo Genes that share domains with DUS4L: view

No data available for Gene Families for DUS4L Gene

Function for DUS4L Gene

Molecular function for DUS4L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS4L Gene

genes like me logo Genes that share phenotypes with DUS4L: view

Animal Model Products

miRNA for DUS4L Gene

miRTarBase miRNAs that target DUS4L

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS4L Gene

Localization for DUS4L Gene

Subcellular locations from

Jensen Localization Image for DUS4L Gene COMPARTMENTS Subcellular localization image for DUS4L gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS4L Gene

Pathways & Interactions for DUS4L Gene

SuperPathways for DUS4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS4L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS4L Gene

Drugs & Compounds for DUS4L Gene

(1) Drugs for DUS4L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS4L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5,6-Dihydrouridine
  • Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydrouridine
genes like me logo Genes that share compounds with DUS4L: view

Transcripts for DUS4L Gene

Unigene Clusters for DUS4L Gene

Dihydrouridine synthase 4-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUS4L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP7: - -
SP8: - - - - - -

Relevant External Links for DUS4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUS4L Gene

mRNA expression in normal human tissues for DUS4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUS4L Gene

This gene is overexpressed in Placenta (52.3) and Fetal Brain (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS4L Gene

SOURCE GeneReport for Unigene cluster for DUS4L Gene Hs.97627

genes like me logo Genes that share expression patterns with DUS4L: view

Protein tissue co-expression partners for DUS4L Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUS4L Gene

Orthologs for DUS4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUS4L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia DUS4L 35
  • 93.06 (n)
  • 93.69 (a)
DUS4L 36
  • 94 (a)
(Mus musculus)
Mammalia Dus4l 35
  • 88.61 (n)
  • 90.51 (a)
Dus4l 16
Dus4l 36
  • 88 (a)
(Pan troglodytes)
Mammalia DUS4L 35
  • 99.79 (n)
  • 100 (a)
DUS4L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dus4l 35
  • 88.19 (n)
  • 90.19 (a)
(Bos Taurus)
Mammalia DUS4L 36
  • 89 (a)
(Monodelphis domestica)
Mammalia DUS4L 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia DUS4L 36
  • 81 (a)
(Gallus gallus)
Aves DUS4L 35
  • 78.33 (n)
  • 78.85 (a)
DUS4L 36
  • 76 (a)
(Anolis carolinensis)
Reptilia DUS4L 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dus4l 35
  • 75.24 (n)
  • 76.21 (a)
(Danio rerio)
Actinopterygii dus4l 35
  • 69.02 (n)
  • 70.47 (a)
dus4l 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002791 35
  • 51.76 (n)
  • 51.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10495 35
  • 49.45 (n)
  • 45.07 (a)
CG10495 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C45G9.2 35
  • 54.17 (n)
  • 49.29 (a)
C45G9.2 36
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER075W 35
  • 47.75 (n)
  • 41.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02959g 35
  • 50.72 (n)
  • 42.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS4 35
  • 50.39 (n)
  • 43.43 (a)
DUS4 36
  • 34 (a)
DUS4 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC777.15 35
  • 52.6 (n)
  • 43.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for DUS4L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS4L Gene

Gene Tree for DUS4L (if available)
Gene Tree for DUS4L (if available)

Paralogs for DUS4L Gene

(2) SIMAP similar genes for DUS4L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DUS4L: view

No data available for Paralogs for DUS4L Gene

Variants for DUS4L Gene

Sequence variations from dbSNP and Humsavar for DUS4L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6957510 - 107,576,575(+) GTGGC(A/G)GATTA nc-transcript-variant, reference, missense
rs6956789 - 107,576,418(+) AAGCA(A/G)CAGGA nc-transcript-variant, reference, missense
rs1468335 -- 107,567,673(+) ctcga(C/T)cattt intron-variant
rs1468336 -- 107,567,805(+) gttcc(C/T)cacag intron-variant
rs34611940 -- 107,570,251(+) ATGTA(-/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUS4L Gene

Variant ID Type Subtype PubMed ID
nsv888940 CNV Loss 21882294

Variation tolerance for DUS4L Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUS4L Gene

Disorders for DUS4L Gene

Relevant External Links for DUS4L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUS4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS4L Gene

Publications for DUS4L Gene

  1. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E. … Spector T.D. (Ann. Rheum. Dis. 2011) 3 48 67
  2. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3

Products for DUS4L Gene

Sources for DUS4L Gene