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Aliases for WWP1 Gene

Aliases for WWP1 Gene

  • WW Domain Containing E3 Ubiquitin Protein Ligase 1 2 3
  • Tiul1 3 4 6
  • TGIF-Interacting Ubiquitin Ligase 1 3 4
  • Atrophin-1-Interacting Protein 5 3 4
  • WW Domain-Containing Protein 1 3 4
  • AIP5 3 4
  • NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1 3
  • Nedd-4-Like Ubiquitin-Protein Ligase 3
  • Atrophin-1 Interacting Protein 5 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • HSDRP1 3

External Ids for WWP1 Gene

Previous GeneCards Identifiers for WWP1 Gene

  • GC08P085970
  • GC08P087113
  • GC08P087337
  • GC08P087311
  • GC08P087424
  • GC08P082564

Summaries for WWP1 Gene

Entrez Gene Summary for WWP1 Gene

  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WWP1 Gene

WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for WWP1 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene Wiki entry for WWP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWP1 Gene

Genomics for WWP1 Gene

Regulatory Elements for WWP1 Gene

Genomic Location for WWP1 Gene

Start:
86,342,736 bp from pter
End:
86,478,420 bp from pter
Size:
135,685 bases
Orientation:
Plus strand

Genomic View for WWP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WWP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWP1 Gene

Proteins for WWP1 Gene

  • Protein details for WWP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0M0-WWP1_HUMAN
    Recommended name:
    NEDD4-like E3 ubiquitin-protein ligase WWP1
    Protein Accession:
    Q9H0M0
    Secondary Accessions:
    • O00307
    • Q5YLC1
    • Q96BP4

    Protein attributes for WWP1 Gene

    Size:
    922 amino acids
    Molecular mass:
    105202 Da
    Quaternary structure:
    • Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase. Interacts with TGIF.

    Three dimensional structures from OCA and Proteopedia for WWP1 Gene

    Alternative splice isoforms for WWP1 Gene

neXtProt entry for WWP1 Gene

Proteomics data for WWP1 Gene at MOPED

Post-translational modifications for WWP1 Gene

  • Auto-ubiquitinated and ubiquitinated by RNF11.
  • Ubiquitination at Lys464, Lys684, and Lys900
  • Modification sites at PhosphoSitePlus

Other Protein References for WWP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for WWP1 Gene

Suggested Antigen Peptide Sequences for WWP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0M0

UniProtKB/Swiss-Prot:

WWP1_HUMAN :
  • Q9H0M0
Domain:
  • Contains 1 C2 domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 4 WW domains.
genes like me logo Genes that share domains with WWP1: view

No data available for Gene Families for WWP1 Gene

Function for WWP1 Gene

Molecular function for WWP1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activated by NDFIP1- and NDFIP2-binding
UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Enzyme Numbers (IUBMB) for WWP1 Gene

Gene Ontology (GO) - Molecular Function for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 9169421
GO:0005515 protein binding IPI 16189514
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with WWP1: view

Phenotypes for WWP1 Gene

genes like me logo Genes that share phenotypes with WWP1: view

Animal Models for WWP1 Gene

MGI Knock Outs for WWP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWP1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for WWP1 Gene

Localization for WWP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WWP1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWP1 Gene COMPARTMENTS Subcellular localization image for WWP1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3
mitochondrion 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 9169421
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with WWP1: view

Pathways for WWP1 Gene

genes like me logo Genes that share pathways with WWP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9H0M0-WWP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9169421
GO:0007417 central nervous system development NAS 9647693
GO:0016567 protein ubiquitination TAS 12535537
GO:0034220 ion transmembrane transport TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with WWP1: view

Compounds for WWP1 Gene

(1) Novoseek inferred chemical compound relationships for WWP1 Gene

Compound -log(P) Hits PubMed IDs
sodium 13.5 1
genes like me logo Genes that share compounds with WWP1: view

Transcripts for WWP1 Gene

Unigene Clusters for WWP1 Gene

WW domain containing E3 ubiquitin protein ligase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WWP1 Gene

No ASD Table

Relevant External Links for WWP1 Gene

GeneLoc Exon Structure for
WWP1
ECgene alternative splicing isoforms for
WWP1

Expression for WWP1 Gene

mRNA expression in normal human tissues for WWP1 Gene

mRNA differential expression in normal tissues according to GTEx for WWP1 Gene

This gene is overexpressed in Muscle - Skeletal (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWP1 Gene

SOURCE GeneReport for Unigene cluster for WWP1 Gene Hs.655189

mRNA Expression by UniProt/SwissProt for WWP1 Gene

Q9H0M0-WWP1_HUMAN
Tissue specificity: Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.
genes like me logo Genes that share expressions with WWP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WWP1 Gene

Orthologs for WWP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WWP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WWP1 35
  • 99.89 (n)
  • 99.89 (a)
WWP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WWP1 35
  • 91.49 (n)
  • 93.59 (a)
WWP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWP1 35
  • 93.82 (n)
  • 95.23 (a)
WWP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wwp1 35
  • 90.27 (n)
  • 90.96 (a)
Wwp1 16
Wwp1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WWP1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WWP1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wwp1 35
  • 89.47 (n)
  • 90.85 (a)
chicken
(Gallus gallus)
Aves WWP1 35
  • 79.91 (n)
  • 84.28 (a)
WWP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWP1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19332 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wwp1 35
  • 73 (n)
  • 80.66 (a)
zebrafish
(Danio rerio)
Actinopterygii WWP1 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009074 35
  • 55.65 (n)
  • 59.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Su(dx) 35
  • 56.08 (n)
  • 57.01 (a)
Su(dx) 36
  • 53 (a)
OneToMany
Su(dx) 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea wwp-1 35
  • 60.43 (n)
  • 65.16 (a)
wwp-1 36
  • 55 (a)
OneToMany
Y65B4BR.4a 37
  • 64 (a)
Y65B4BR.4b 37
  • 64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSP5 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9326 36
  • 72 (a)
OneToMany
Species with no ortholog for WWP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WWP1 Gene

ENSEMBL:
Gene Tree for WWP1 (if available)
TreeFam:
Gene Tree for WWP1 (if available)

Paralogs for WWP1 Gene

Paralogs for WWP1 Gene

Selected SIMAP similar genes for WWP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WWP1 Gene

genes like me logo Genes that share paralogs with WWP1: view

Variants for WWP1 Gene

Sequence variations from dbSNP and Humsavar for WWP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1865864 -- 86,446,845(-) GTGTG(C/T)GTGCT intron-variant
rs2917554 -- 86,360,474(-) CAGGA(C/G)TAACA intron-variant
rs2917558 -- 86,433,250(+) ttttg(G/T)taact intron-variant
rs2953527 -- 86,404,725(-) TTCAA(A/G)GAGTT intron-variant
rs2953528 -- 86,394,983(-) GTTTT(C/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WWP1 Gene

Variant ID Type Subtype PubMed ID
nsv397543 CNV Insertion 16902084
esv2658378 CNV Deletion 23128226
esv1003777 CNV Insertion 20482838

Relevant External Links for WWP1 Gene

HapMap Linkage Disequilibrium report
WWP1

PCR Panel Products

  • Copy Number PCR Panels: for WWP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWP1 Gene

Disorders for WWP1 Gene

(1) Novoseek inferred disease relationships for WWP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for WWP1

Human Genome Epidemiology (HuGE) Navigator
WWP1
genes like me logo Genes that share disorders with WWP1: view

No data available for UniProtKB/Swiss-Prot for WWP1 Gene

Publications for WWP1 Gene

  1. Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). (PMID: 15221015) Komuro A. … Miyazawa K. (Oncogene 2004) 3 4 23
  2. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. (PMID: 15359284) Seo S.R. … Atfi A. (EMBO J. 2004) 3 4 23
  3. Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. (PMID: 11779188) Flasza M. … Baron M. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  4. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PMID: 12450395) Galinier R. … Chroboczek J. (Biochemistry 2002) 3 4 23
  5. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PMID: 18724389) Chen C. … Seth A.K. (Oncogene 2008) 3 4 23

Products for WWP1 Gene

Sources for WWP1 Gene

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