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Aliases for ABHD2 Gene

Aliases for ABHD2 Gene

  • Abhydrolase Domain Containing 2 2 3 5
  • Lung Alpha/Beta Hydrolase 2 3 4
  • Protein PHPS1-2 3 4
  • LABH2 3 4
  • Alpha/Beta Hydrolase Domain Containing Protein 2 3
  • Testicular Tissue Protein Li 6 3
  • EC 3.1.1.- 4
  • EC 3.1.1 63
  • PHPS1-2 3
  • HS1-2 3

External Ids for ABHD2 Gene

Previous GeneCards Identifiers for ABHD2 Gene

  • GC15P085970
  • GC15P082997
  • GC15P087218
  • GC15P087361
  • GC15P087432
  • GC15P089631
  • GC15P065743

Summaries for ABHD2 Gene

Entrez Gene Summary for ABHD2 Gene

  • This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD2 Gene

ABHD2 (Abhydrolase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ABHD1.

UniProtKB/Swiss-Prot for ABHD2 Gene

  • May play a role in smooth muscle cells migration.

Gene Wiki entry for ABHD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD2 Gene

Genomics for ABHD2 Gene

Regulatory Elements for ABHD2 Gene

Enhancers for ABHD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABHD2 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABHD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD2 Gene

89,087,459 bp from pter
89,202,360 bp from pter
114,902 bases
Plus strand

Genomic View for ABHD2 Gene

Genes around ABHD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD2 Gene

Proteins for ABHD2 Gene

  • Protein details for ABHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Abhydrolase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q53G48
    • Q53GU0
    • Q5FVD9
    • Q8TC79

    Protein attributes for ABHD2 Gene

    425 amino acids
    Molecular mass:
    48315 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD2 Gene

Proteomics data for ABHD2 Gene at MOPED

Post-translational modifications for ABHD2 Gene

  • Ubiquitination at Lys 36, Lys 57, and Lys 152
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD2 Gene

Antibody Products

  • Abcam antibodies for ABHD2

Domains & Families for ABHD2 Gene

Gene Families for ABHD2 Gene

Protein Domains for ABHD2 Gene

Suggested Antigen Peptide Sequences for ABHD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
genes like me logo Genes that share domains with ABHD2: view

Function for ABHD2 Gene

Molecular function for ABHD2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in smooth muscle cells migration.

Enzyme Numbers (IUBMB) for ABHD2 Gene

Gene Ontology (GO) - Molecular Function for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IDA 26989199
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD2: view
genes like me logo Genes that share phenotypes with ABHD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD2

miRNA for ABHD2 Gene

miRTarBase miRNAs that target ABHD2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD2 Gene

Localization for ABHD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ABHD2 Gene COMPARTMENTS Subcellular localization image for ABHD2 gene
Compartment Confidence
extracellular 3
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ABHD2 Gene

Pathways & Interactions for ABHD2 Gene

SuperPathways for ABHD2 Gene

No Data Available

Interacting Proteins for ABHD2 Gene

Gene Ontology (GO) - Biological Process for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0009611 response to wounding IEA --
GO:0030336 negative regulation of cell migration IEA --
GO:0048240 sperm capacitation IDA 26989199
genes like me logo Genes that share ontologies with ABHD2: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD2 Gene

Drugs & Compounds for ABHD2 Gene

No Compound Related Data Available

Transcripts for ABHD2 Gene

Unigene Clusters for ABHD2 Gene

Abhydrolase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - -
SP11: - - - -

ExUns: 17

Relevant External Links for ABHD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD2 Gene

mRNA expression in normal human tissues for ABHD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABHD2 Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for ABHD2 Gene

This gene is overexpressed in Heart (41.4) and Liver (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABHD2 Gene

SOURCE GeneReport for Unigene cluster for ABHD2 Gene Hs.122337

genes like me logo Genes that share expression patterns with ABHD2: view

Protein tissue co-expression partners for ABHD2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ABHD2 Gene

Orthologs for ABHD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABHD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABHD2 35
  • 92 (n)
  • 98.82 (a)
ABHD2 36
  • 99 (a)
(Canis familiaris)
Mammalia ABHD2 35
  • 92.16 (n)
  • 99.06 (a)
ABHD2 36
  • 99 (a)
(Mus musculus)
Mammalia Abhd2 35
  • 91.53 (n)
  • 98.82 (a)
Abhd2 16
Abhd2 36
  • 99 (a)
(Pan troglodytes)
Mammalia ABHD2 35
  • 99.53 (n)
  • 99.76 (a)
ABHD2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Abhd2 35
  • 91.06 (n)
  • 98.82 (a)
(Monodelphis domestica)
Mammalia ABHD2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
-- 36
  • 90 (a)
(Gallus gallus)
Aves ABHD2 35
  • 80.47 (n)
  • 89.88 (a)
ABHD2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia ABHD2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd2 35
  • 73.84 (n)
  • 82.51 (a)
(Danio rerio)
Actinopterygii zgc55722 35
abhd2a 36
  • 75 (a)
abhd2b 36
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5024 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008542 35
  • 50.36 (n)
  • 38.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hydr2 35
  • 53.54 (n)
  • 44.36 (a)
Hydr2 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 18 (a)
EEB1 36
  • 17 (a)
EHT1 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9408 36
  • 42 (a)
Species with no ortholog for ABHD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD2 Gene

Gene Tree for ABHD2 (if available)
Gene Tree for ABHD2 (if available)

Paralogs for ABHD2 Gene

Paralogs for ABHD2 Gene

genes like me logo Genes that share paralogs with ABHD2: view

Variants for ABHD2 Gene

Sequence variations from dbSNP and Humsavar for ABHD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs17851730 - 89,185,459(+) GTGCC(A/G/T)GCGGT reference, missense
rs9550 -- 89,200,437(+) ggctc(C/G)cggga utr-variant-3-prime
rs182394 -- 89,117,756(-) ATTCA(C/T)CCAGT intron-variant
rs186052 -- 89,117,684(-) CACCA(C/T)TGGGT intron-variant
rs4932210 -- 89,171,846(+) gtaga(A/C)gaaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD2 Gene

Variant ID Type Subtype PubMed ID
nsv523275 CNV Loss 19592680
nsv507795 CNV Insertion 20534489

Variation tolerance for ABHD2 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ABHD2 Gene

Disorders for ABHD2 Gene

Relevant External Links for ABHD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABHD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD2 Gene

Publications for ABHD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. (PMID: 26989199) Miller M.R. … Lishko P.V. (Science 2016) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. (PMID: 20007591) Giambra V. … Frezza D. (J. Immunol. 2009) 3
  5. Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. (PMID: 17980156) Miyata K. … Yamamura K. (Biochem. Biophys. Res. Commun. 2008) 3

Products for ABHD2 Gene

Sources for ABHD2 Gene