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Aliases for ABHD2 Gene

Aliases for ABHD2 Gene

  • Abhydrolase Domain Containing 2 2 3
  • LABH2 3 4 6
  • Lung Alpha/Beta Hydrolase 2 3 4
  • Protein PHPS1-2 3 4
  • Alpha/Beta Hydrolase Domain Containing Protein 2 3
  • Abhydrolase Domain-Containing Protein 2 3
  • EC 3.1.1.- 4
  • EC 3.1.1 64
  • PHPS1-2 3
  • HS1-2 3

External Ids for ABHD2 Gene

Summaries for ABHD2 Gene

Entrez Gene Summary for ABHD2 Gene

  • This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD2 Gene

ABHD2 (Abhydrolase Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ABHD1.

UniProtKB/Swiss-Prot for ABHD2 Gene

  • May play a role in smooth muscle cells migration.

Gene Wiki entry for ABHD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD2 Gene

Genomics for ABHD2 Gene

Genomic Location for ABHD2 Gene

Start:
89,087,459 bp from pter
End:
89,202,360 bp from pter
Size:
114,902 bases
Orientation:
Plus strand

Genomic View for ABHD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD2 Gene

Regulatory Elements for ABHD2 Gene

Proteins for ABHD2 Gene

  • Protein details for ABHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08910-ABHD2_HUMAN
    Recommended name:
    Abhydrolase domain-containing protein 2
    Protein Accession:
    P08910
    Secondary Accessions:
    • Q53G48
    • Q53GU0
    • Q5FVD9
    • Q8TC79

    Protein attributes for ABHD2 Gene

    Size:
    425 amino acids
    Molecular mass:
    48315 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD2 Gene

Proteomics data for ABHD2 Gene at MOPED

Post-translational modifications for ABHD2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36, Lys57, and Lys152

Other Protein References for ABHD2 Gene

Domains for ABHD2 Gene

Gene Families for ABHD2 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

UniProtKB/Swiss-Prot:

ABHD2_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.:
    • P08910
genes like me logo Genes that share domains with ABHD2: view

Function for ABHD2 Gene

Molecular function for ABHD2 Gene

UniProtKB/Swiss-Prot Function: May play a role in smooth muscle cells migration.

Enzyme Numbers (IUBMB) for ABHD2 Gene

Gene Ontology (GO) - Molecular Function for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD2: view
genes like me logo Genes that share phenotypes with ABHD2: view

miRNA for ABHD2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD2 Gene

Localization for ABHD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD2 Gene COMPARTMENTS Subcellular localization image for ABHD2 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABHD2: view

Pathways for ABHD2 Gene

SuperPathways for ABHD2 Gene

No Data Available

Interacting Proteins for ABHD2 Gene

Gene Ontology (GO) - Biological Process for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0009611 response to wounding IEA --
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with ABHD2: view

No data available for Pathways by source for ABHD2 Gene

Transcripts for ABHD2 Gene

Unigene Clusters for ABHD2 Gene

Abhydrolase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - -
SP11: - - - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ABHD2 Gene

GeneLoc Exon Structure for
ABHD2
ECgene alternative splicing isoforms for
ABHD2

Expression for ABHD2 Gene

mRNA expression in normal human tissues for ABHD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABHD2 Gene

This gene is overexpressed in Liver (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD2 Gene

SOURCE GeneReport for Unigene cluster for ABHD2 Gene Hs.122337

genes like me logo Genes that share expressions with ABHD2: view

Orthologs for ABHD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABHD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD2 36
  • 99.53 (n)
  • 99.76 (a)
ABHD2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD2 36
  • 92 (n)
  • 98.82 (a)
ABHD2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD2 36
  • 92.16 (n)
  • 99.06 (a)
ABHD2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd2 36
  • 91.53 (n)
  • 98.82 (a)
Abhd2 16
Abhd2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 93 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Abhd2 36
  • 91.06 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves ABHD2 36
  • 80.47 (n)
  • 89.88 (a)
ABHD2 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd2 36
  • 73.84 (n)
  • 82.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5024 36
zebrafish
(Danio rerio)
Actinopterygii abhd2a 37
  • 75 (a)
OneToMany
abhd2b 37
  • 76 (a)
OneToMany
zgc55722 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008542 36
  • 50.36 (n)
  • 38.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hydr2 36
  • 53.54 (n)
  • 44.36 (a)
Hydr2 37
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 18 (a)
ManyToMany
EEB1 37
  • 17 (a)
ManyToMany
EHT1 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9408 37
  • 42 (a)
OneToOne
Species with no ortholog for ABHD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD2 Gene

ENSEMBL:
Gene Tree for ABHD2 (if available)
TreeFam:
Gene Tree for ABHD2 (if available)

Paralogs for ABHD2 Gene

Paralogs for ABHD2 Gene

genes like me logo Genes that share paralogs with ABHD2: view

Variants for ABHD2 Gene

Sequence variations from dbSNP and Humsavar for ABHD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9550 -- 89,200,437(+) ggctc(C/G)cggga utr-variant-3-prime
rs182394 -- 89,117,756(-) ATTCA(C/T)CCAGT intron-variant
rs186052 -- 89,117,684(-) CACCA(C/T)TGGGT intron-variant
rs293369 -- 89,087,901(-) AGAAG(G/T)GTCGT upstream-variant-2KB
rs293370 -- 89,087,245(-) GAACA(A/G)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ABHD2 Gene

Variant ID Type Subtype PubMed ID
nsv523275 CNV Loss 19592680
nsv507795 CNV Insertion 20534489

Relevant External Links for ABHD2 Gene

HapMap Linkage Disequilibrium report
ABHD2

Disorders for ABHD2 Gene

No disorders were found for ABHD2 Gene.

No data available for UniProtKB/Swiss-Prot for ABHD2 Gene

Publications for ABHD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family. (PMID: 2843827) Rapiejko P.J. … Malbon C.C. (Nucleic Acids Res. 1988) 3 4
  3. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  4. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. (PMID: 11922611) Edgar A.J. … Polak J.M. (Biochem. Biophys. Res. Commun. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ABHD2 Gene

Sources for ABHD2 Gene

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