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Aliases for OGFR Gene

Aliases for OGFR Gene

  • Opioid Growth Factor Receptor 2 3
  • Zeta-Type Opioid Receptor 4
  • Protein 7-60 4
  • OGFr 4

External Ids for OGFR Gene

Summaries for OGFR Gene

Entrez Gene Summary for OGFR Gene

  • The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for OGFR Gene

OGFR (Opioid Growth Factor Receptor) is a Protein Coding gene. Diseases associated with OGFR include pancreatic cancer. Among its related pathways are RhoGDI Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include opioid receptor activity. An important paralog of this gene is OGFRL1.

UniProtKB/Swiss-Prot for OGFR Gene

  • Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation

Gene Wiki entry for OGFR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFR Gene

Genomics for OGFR Gene

Genomic Location for OGFR Gene

Start:
62,804,825 bp from pter
End:
62,814,000 bp from pter
Size:
9,176 bases
Orientation:
Plus strand

Genomic View for OGFR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFR Gene

Proteins for OGFR Gene

  • Protein details for OGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZT2-OGFR_HUMAN
    Recommended name:
    Opioid growth factor receptor
    Protein Accession:
    Q9NZT2
    Secondary Accessions:
    • O96029
    • Q4VXW5
    • Q96CM2
    • Q9BQW1
    • Q9H4H0
    • Q9H7J5
    • Q9NZT3
    • Q9NZT4

    Protein attributes for OGFR Gene

    Size:
    677 amino acids
    Molecular mass:
    73325 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=AAD03745.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=CAC28882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFR Gene

Proteomics data for OGFR Gene at MOPED

Post-translational modifications for OGFR Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys158, Lys218, and Lys291

Other Protein References for OGFR Gene

No data available for DME Specific Peptides for OGFR Gene

Domains for OGFR Gene

Protein Domains for OGFR Gene

UniProtKB/Swiss-Prot:

OGFR_HUMAN
Family:
  • Belongs to the opioid growth factor receptor family.:
    • Q9NZT2
genes like me logo Genes that share domains with OGFR: view

No data available for Gene Families for OGFR Gene

Function for OGFR Gene

Molecular function for OGFR Gene

UniProtKB/Swiss-Prot Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation

Gene Ontology (GO) - Molecular Function for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0004985 opioid receptor activity NAS 10677613
genes like me logo Genes that share ontologies with OGFR: view

Phenotypes for OGFR Gene

genes like me logo Genes that share phenotypes with OGFR: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OGFR Gene

Localization for OGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFR Gene

Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGFR Gene COMPARTMENTS Subcellular localization image for OGFR gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFR: view

Pathways for OGFR Gene

genes like me logo Genes that share pathways with OGFR: view

Gene Ontology (GO) - Biological Process for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10677613
GO:0038003 opioid receptor signaling pathway NAS 10677613
genes like me logo Genes that share ontologies with OGFR: view

Compounds for OGFR Gene

(1) Novoseek inferred chemical compound relationships for OGFR Gene

Compound -log(P) Hits PubMed IDs
naltrexone 80 4
genes like me logo Genes that share compounds with OGFR: view

Transcripts for OGFR Gene

Unigene Clusters for OGFR Gene

Opioid growth factor receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGFR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6: -

Relevant External Links for OGFR Gene

GeneLoc Exon Structure for
OGFR
ECgene alternative splicing isoforms for
OGFR

Expression for OGFR Gene

mRNA expression in normal human tissues for OGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGFR Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGFR Gene

SOURCE GeneReport for Unigene cluster for OGFR Gene Hs.67896

mRNA Expression by UniProt/SwissProt for OGFR Gene

Q9NZT2-OGFR_HUMAN
Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney
genes like me logo Genes that share expressions with OGFR: view

Orthologs for OGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFR 36
  • 97.08 (n)
  • 95.29 (a)
OGFR 37
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OGFR 36
  • 77.73 (n)
  • 67.59 (a)
OGFR 37
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFR 36
  • 85.89 (n)
  • 84.23 (a)
OGFR 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfr 36
  • 71.27 (n)
  • 64.27 (a)
Ogfr 16
Ogfr 37
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OGFR 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfr 36
  • 71.23 (n)
  • 63.14 (a)
chicken
(Gallus gallus)
Aves OGFR 36
  • 51.18 (n)
  • 45.75 (a)
OGFR 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFR 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17622 36
zebrafish
(Danio rerio)
Actinopterygii ogfr 37
  • 33 (a)
OneToMany
OGFR (3 of 4) 37
  • 39 (a)
OneToMany
OGFR (4 of 4) 37
  • 28 (a)
OneToMany
ogfrl2 37
  • 31 (a)
OneToMany
Species with no ortholog for OGFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFR Gene

ENSEMBL:
Gene Tree for OGFR (if available)
TreeFam:
Gene Tree for OGFR (if available)

Paralogs for OGFR Gene

Paralogs for OGFR Gene

Selected SIMAP similar genes for OGFR Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OGFR Gene

genes like me logo Genes that share paralogs with OGFR: view

Variants for OGFR Gene

Sequence variations from dbSNP and Humsavar for OGFR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs741759 -- 62,814,091(+) CCGGC(G/T)ACCGC downstream-variant-500B
rs760276 -- 62,808,356(+) CCGGC(A/G)CTTCC intron-variant
rs760277 -- 62,808,475(+) GAGGG(A/C)ATCCA intron-variant
rs760279 -- 62,809,136(+) TGCAC(A/G)AAACA intron-variant
rs1048792 -- 62,809,619(+) TGGAC(A/G)GACAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for OGFR Gene

Variant ID Type Subtype PubMed ID
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
nsv428380 CNV Loss 18775914
dgv4614n71 CNV Loss 21882294
nsv470558 CNV Loss 18288195
nsv834027 CNV Loss 17160897
nsv9825 CNV Gain 18304495
nsv913124 CNV Loss 21882294
nsv913125 CNV Loss 21882294
nsv913126 CNV Loss 21882294
esv2722837 CNV Deletion 23290073

Relevant External Links for OGFR Gene

HapMap Linkage Disequilibrium report
OGFR

Disorders for OGFR Gene

(1) MalaCards Diseases for OGFR Gene

Search for OGFR Gene in MalaCards »

(6) Novoseek inferred disease relationships for OGFR Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 57.7 14
pancreatic cancer 44 7
tumors 35.6 31
cancer 29.3 6
colon cancer 22.3 4
genes like me logo Genes that share disorders with OGFR: view

No data available for UniProtKB/Swiss-Prot for OGFR Gene

Publications for OGFR Gene

  1. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PMID: 10677613) Zagon I.S. … McLaughlin P.J. (Brain Res. 2000) 2 3 4 23
  2. The biology of the opioid growth factor receptor (OGFr). (PMID: 11890982) Zagon I.S. … McLaughlin P.J. (Brain Res. Brain Res. Rev. 2002) 3 4 23
  3. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers. (PMID: 16820893) Zagon I.S. … McLaughlin P.J. (Int. J. Oncol. 2006) 3 23
  4. Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck. (PMID: 17273790) McLaughlin P.J. … Zagon I.S. (Int. J. Mol. Med. 2007) 3 23
  5. Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. (PMID: 16685459) McLaughlin P.J. … Zagon I.S. (Int. J. Oncol. 2006) 3 23

Products for OGFR Gene

Sources for OGFR Gene

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