Aliases for CHD1 Gene
Aliases for CHD1 Gene
External Ids for CHD1 Gene
- HGNC: 1915
- Entrez Gene: 1105
- Ensembl: ENSG00000153922
- OMIM: 602118
- UniProtKB: O14646
Previous GeneCards Identifiers for CHD1 Gene
- GC05M097537
- GC05M098601
- GC05M098222
- GC05M098267
- GC05M098219
- GC05M093378
- GC05M098190
Summaries for CHD1 Gene
-
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHD1 Gene
CHD1 (Chromodomain Helicase DNA Binding Protein 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include methylated histone binding and ATP-dependent DNA helicase activity. An important paralog of this gene is CHD2.
UniProtKB/Swiss-Prot for CHD1 Gene
-
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD1 Gene
Genomics for CHD1 Gene
Regulatory Elements for CHD1 Gene
Enhancers for CHD1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G098925 | 1.8 | FANTOM5 ENCODE dbSUPER | 13 | +0.1 | 88 | 6.5 | CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 TBX21 | CHD1 RGMB-AS1 RNU6-402P |
| GH05G098917 | 0.7 | FANTOM5 dbSUPER | 30.4 | +11.1 | 11126 | 0.4 | RBFOX2 | CHD1 RNU6-402P |
| GH05G098767 | 1.4 | ENCODE dbSUPER | 11.9 | +156.4 | 156415 | 10.3 | HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 | RGMB-AS1 CHD1 RGMB |
| GH05G099019 | 1.3 | Ensembl ENCODE | 11.3 | -92.0 | -91954 | 3.3 | PKNOX1 ATF1 FEZF1 ZNF2 FOS YY2 REST TSHZ1 PPARG ZNF518A | RGMB-AS1 CHD1 LINC02062 RGMB PIR38453 GC05P099011 PIR33197 |
| GH05G099032 | 1.2 | Ensembl ENCODE | 11.3 | -104.4 | -104408 | 2.5 | FOXA2 CBX3 RB1 TBL1XR1 ARNT WRNIP1 RAD21 RARA RFX5 YY1 | RGMB-AS1 LINC02062 CHD1 RGMB PIR38453 GC05P099011 PIR33197 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CHD1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CHD1 gene promoter:
Regulatory Element Products
Genomic Location for CHD1 Gene
- Chromosome:
- 5
- Start:
- 98,853,985 bp from pter
- End:
- 98,928,957 bp from pter
- Size:
- 74,973 bases
- Orientation:
- Minus strand
Genomic View for CHD1 Gene
Genes around CHD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q21.1 by Ensembl
- 5q15-q21.1 by Entrez Gene
- 5q15-q21.1 by HGNC
CHD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHD1 Gene
Proteins for CHD1 Gene
-
Protein details for CHD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14646-CHD1_HUMAN
- Recommended name:
- Chromodomain-helicase-DNA-binding protein 1
- Protein Accession:
- O14646
- Q17RZ3
Protein attributes for CHD1 Gene
- Size:
- 1710 amino acids
- Molecular mass:
- 196688 Da
- Quaternary structure:
-
- Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1.
Three dimensional structures from OCA and Proteopedia for CHD1 Gene
Protein Expression for CHD1 Gene
Selected DME Specific Peptides for CHD1 Gene
- O14646:
-
- VLIFSQMVR
- DSDWNPQ
- IFDSDWNP
- FLLSTRA
- DEMGLGKT
- ERMRPVK
- AGGLGINL
- DEAHRLK
- TGTPLQN
- RVLIFSQM
- RAHRIGQ
- LLHFIMP
- LSTRAGGLG
- MGLGKTIQ
Post-translational modifications for CHD1 Gene
Other Protein References for CHD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CHD1
- R&D Systems Antibodies for CHD1 (CHD1)
- Cell Signaling Technology (CST) Antibodies for CHD1 (CHD-1)
- Novus Biologicals Antibodies for CHD1
- Invitrogen Antibodies for CHD1
- antibodies-online Antibodies for CHD1: See all 52
- Search GeneTex for Antibodies for CHD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHD1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CHD1
- Origene Custom Protein Services for CHD1
- Novus Biologicals proteins for CHD1
- Search GeneTex for Proteins for CHD1
Assay Products
- antibodies-online Kits for CHD1: See all 3
Domains & Families for CHD1 Gene
Protein Domains for CHD1 Gene
Suggested Antigen Peptide Sequences for CHD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14646UniProtKB/Swiss-Prot:
CHD1_HUMAN :- The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
- Belongs to the SNF2/RAD54 helicase family.
- Domain:
-
- The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
- Family:
-
- Belongs to the SNF2/RAD54 helicase family.
No data available for Gene Families for CHD1 Gene
Function for CHD1 Gene
Molecular function for CHD1 Gene
- GENATLAS Biochemistry:
- DNA binding protein with two chromatin organization (chromo) domains and a helicase ATPase domain,1,binding A.T tracts, released into cytoplasm during mitosis,component of the chromatin remodeling complex
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot Function:
- ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Enzyme Numbers (IUBMB) for CHD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | 9326634 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22419161 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CHD1 Gene
- MGI mutant phenotypes for CHD1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CHD1:
Animal Model Products
-
Taconic Biosciences Mouse Models for CHD1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHD1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
- Search ViGene Biosciences for CHD1
CRISPR Products
-
OriGene CRISPR knockouts for CHD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHD1
- GenScript: Design CRISPR guide RNA sequences for CHD1
miRNA for CHD1 Gene
- miRTarBase miRNAs that target CHD1
-
- hsa-mir-30a-5p (MIRT005127)
- hsa-mir-30b-5p (MIRT023406)
- hsa-mir-98-5p (MIRT027799)
- hsa-let-7b-5p (MIRT032461)
- hsa-mir-130b-5p (MIRT038317)
- hsa-mir-30c-5p (MIRT047842)
- hsa-let-7c-5p (MIRT051818)
- hsa-mir-26a-5p (MIRT052903)
- hsa-mir-4503 (MIRT497838)
- hsa-mir-6792-5p (MIRT497839)
- hsa-mir-3194-5p (MIRT497840)
- hsa-mir-4691-3p (MIRT497841)
- hsa-mir-570-3p (MIRT548834)
- hsa-mir-3613-3p (MIRT548835)
- hsa-mir-7849-3p (MIRT548836)
- hsa-mir-8054 (MIRT548837)
- hsa-mir-548k (MIRT548838)
- hsa-mir-548av-5p (MIRT548839)
- hsa-mir-548n (MIRT548840)
- hsa-mir-501-5p (MIRT624361)
- hsa-mir-4700-3p (MIRT624362)
- hsa-mir-500b-5p (MIRT624363)
- hsa-mir-362-5p (MIRT624364)
- hsa-mir-30e-5p (MIRT728001)
- hsa-mir-30d-5p (MIRT728002)
miRNA Products
- Search ViGene Biosciences for CHD1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHD1
- Browse OriGene Inhibitory RNA Products For CHD1
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
Clone Products
-
OriGene ORF clones in human for CHD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CHD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CHD1
-
ViGene Biosciences adenoviral particle packaged cDNA for CHD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHD1 Gene
Localization for CHD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHD1 Gene
- Nucleus. Cytoplasm. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250 UniProtKB:P40201}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IEA,IDA | 22046413 |
| GO:0005737 | cytoplasm | IEA,IDA | 22046413 |
Pathways & Interactions for CHD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin Regulation / Acetylation | ||
Pathways by source for CHD1 Gene
1 Cell Signaling Technology pathway for CHD1 Gene
Interacting Proteins for CHD1 Gene
Selected Interacting proteins:
ENSP00000284049
O14646-CHD1_HUMAN
for CHD1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006338 | chromatin remodeling | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 9326634 |
| GO:0016569 | covalent chromatin modification | IEA | -- |
No data available for SIGNOR curated interactions for CHD1 Gene
Drugs & Compounds for CHD1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for CHD1 Gene
mRNA/cDNA for CHD1 Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHD1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHD1
- GenScript: Design CRISPR guide RNA sequences for CHD1
miRNA Products
- Search ViGene Biosciences for CHD1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHD1
- Browse OriGene Inhibitory RNA Products For CHD1
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
Clone Products
-
OriGene ORF clones in human for CHD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CHD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
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| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||||||||||||||||
| SP14: |
Expression for CHD1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (19.3), Breast (12.3), Lung (9.5), and Adrenal (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHD1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHD1 Gene:
CHD1SOURCE GeneReport for Unigene cluster for CHD1 Gene:
Hs.643465Evidence on tissue expression from TISSUES for CHD1 Gene
- Lung(5)
- Liver(4.3)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CHD1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHD1 Gene
Orthologs for CHD1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHD1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHD1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CHD1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHD1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CHD1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chd1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Chd1 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | CHDZ 35 35 |
|
OneToMany | |
| CHD1 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | CHD1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17448 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CHD1 35 |
|
OneToOne | |
| zgc:173506 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Chd1 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | H06O01.2 36 |
|
|
|
| chd-1 35 |
|
OneToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C17578g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR123C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CHD1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hrp1 34 |
|
- Species where no ortholog for CHD1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CHD1 Gene
(3) SIMAP similar genes for CHD1 Gene using alignment to 5 proteins:
Variants for CHD1 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040891 | -- | 98,904,357(+) | TCTTA(A/T)CTCAT | intron-variant | |
| rs1000048149 | -- | 98,892,234(+) | ATTAT(C/T)GTGGA | intron-variant | |
| rs1000062578 | -- | 98,910,352(+) | TTTCA(A/G)GAATA | intron-variant | |
| rs1000140444 | -- | 98,913,486(+) | AGGGG(A/T)GGCAG | intron-variant | |
| rs1000178679 | -- | 98,910,162(+) | ATTCA(C/T)GTAAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1161270 | CNV | duplication | 26073780 |
| nsv507277 | OTHER | sequence alteration | 20534489 |
Residual Variation Intolerance Score:
1.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.72;
83.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CHD1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD1 Gene
Disorders for CHD1 Gene
Relevant External Links for CHD1
No disorders were found for CHD1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHD1 Gene
Publications for CHD1 Gene
- Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. (PMID: 16263726) Sims R.J. III … Reinberg D. (J. Biol. Chem. 2005) 3 4 22 64
- Characterization of the CHD family of proteins. (PMID: 9326634) Woodage T. … Collins F.S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians. (PMID: 20363151) Won H.H. … Lee K.A. (Cytokine 2010) 3 46 64
- Structural polymorphism of chromodomains in Chd1. (PMID: 17098252) Okuda M. … Nishimura Y. (J. Mol. Biol. 2007) 3 22 64
Products for CHD1 Gene
- R&D Systems Antibodies for CHD1 (CHD1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CHD1
- Origene Custom Protein Services for CHD1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHD1
- Browse OriGene Inhibitory RNA Products For CHD1
- OriGene qPCR primer pairs for CHD1
- OriGene CRISPR knockouts for CHD1
- OriGene ORF clones in human for CHD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CHD1
- GenScript: Next-day shipping cDNA ORF clone for CHD1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CHD1
- GenScript Custom Assay Services for CHD1
- GenScript Custom overexpressing Cell Line Services for CHD1
- GenScript: Design CRISPR guide RNA sequences for CHD1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CHD1
- Cell Signaling Technology (CST) Antibodies for CHD1 (CHD-1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CHD1
- Browse Sino Biological Cell Lysates
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- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CHD1
- Novus Biologicals proteins for CHD1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CHD1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for CHD1: See all 52
- antibodies-online Kits for CHD1: See all 3
- Search antibodies-online for proteins
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- Search GeneTex for Antibodies for CHD1
- Search GeneTex for Proteins for CHD1
- ViGene Biosciences adenoviral particle packaged cDNA for CHD1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CHD1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
- Search ViGene Biosciences for CHD1
- Santa Cruz Biotechnology (SCBT) Antibodies for CHD1
- Search Santa Cruz Biotechnology (SCBT) for CHD1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CHD1
- Horizon Cell Lines for CHD1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHD1
- VectorBuilder custom plasmid, inducible vectors for CHD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHD1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (26) UniGene
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- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer