Aliases for CHD1 Gene
Aliases for CHD1 Gene
External Ids for CHD1 Gene
- HGNC: 1915
- Entrez Gene: 1105
- Ensembl: ENSG00000153922
- OMIM: 602118
- UniProtKB: O14646
Previous GeneCards Identifiers for CHD1 Gene
- GC05M097537
- GC05M098601
- GC05M098222
- GC05M098267
- GC05M098219
- GC05M093378
- GC05M098190
Summaries for CHD1 Gene
-
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHD1 Gene
CHD1 (Chromodomain Helicase DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with CHD1 include Pilarowski-Bjornsson Syndrome. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include methylated histone binding and ATP-dependent DNA helicase activity. An important paralog of this gene is CHD2.
UniProtKB/Swiss-Prot for CHD1 Gene
-
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD1 Gene
Genomics for CHD1 Gene
GeneHancer (GH) Regulatory Elements for CHD1 Gene
Promoters and enhancers for CHD1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I098925 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 563 | +0.1 | 88 | 6.5 | FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 MEF2D | CHD1 LOC100289230 LINC02062 RGMB-AS1 RNU6-402P | |
| GH05I098767 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 39.6 | +156.4 | 156415 | 10.3 | HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 | RGMB-AS1 RGMB CHD1 | |
| GH05I098917 | Enhancer | 0.5 | FANTOM5 dbSUPER | 30.4 | +11.1 | 11126 | 0.4 | CHD1 RNU6-402P | ||
| GH05I099019 | Enhancer | 1.2 | Ensembl ENCODE | 11.4 | -92.0 | -91953 | 3.3 | PKNOX1 ATF1 FEZF1 ZNF2 ZNF213 ATF7 FOS KLF13 YY2 REST | RGMB-AS1 LINC02062 CHD1 RGMB PIR38453 GC05P099011 PIR33197 | |
| GH05I099032 | Enhancer | 1.1 | Ensembl ENCODE | 11.3 | -104.4 | -104407 | 2.5 | RB1 ARNT RAD21 ZBTB40 RARA RFX5 YY1 EGR1 ARID2 SCRT2 | RGMB-AS1 LINC02062 CHD1 RGMB GC05P099011 PIR38453 PIR33197 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CHD1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CHD1 gene promoter:
Regulatory Element Products
Genomic Locations for CHD1 Gene
Genomic Locations for CHD1 Gene
- chr5:98,853,985-98,928,957
- (GRCh38/hg38)
- Size:
- 74,973 bases
- Orientation:
- Minus strand
- chr5:98,190,908-98,262,240
- (GRCh37/hg19)
Genomic View for CHD1 Gene
Genes around CHD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q21.1 by Ensembl
- 5q15-q21.1 by Entrez Gene
- 5q15-q21.1 by HGNC
CHD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHD1 Gene
Proteins for CHD1 Gene
-
Protein details for CHD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14646-CHD1_HUMAN
- Recommended name:
- Chromodomain-helicase-DNA-binding protein 1
- Protein Accession:
- O14646
- Q17RZ3
Protein attributes for CHD1 Gene
- Size:
- 1710 amino acids
- Molecular mass:
- 196688 Da
- Quaternary structure:
-
- Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1.
Three dimensional structures from OCA and Proteopedia for CHD1 Gene
Protein Expression for CHD1 Gene
Selected DME Specific Peptides for CHD1 Gene
- O14646:
-
- VLIFSQMVR
- DSDWNPQ
- IFDSDWNP
- FLLSTRA
- DEMGLGKT
- ERMRPVK
- AGGLGINL
- DEAHRLK
- TGTPLQN
- RVLIFSQM
- RAHRIGQ
- LLHFIMP
- LSTRAGGLG
- MGLGKTIQ
Post-translational modifications for CHD1 Gene
- Ubiquitination at posLast=364364
Other Protein References for CHD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CHD1 (CHD1)
- Cell Signaling Technology (CST) Antibodies for CHD1 (CHD-1)
- Novus Biologicals Antibodies for CHD1
- Invitrogen Antibodies for CHD1
- Search GeneTex for Antibodies for CHD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHD1
- Sino Biological Antibodies for CHD1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CHD1
- Origene Custom Protein Services for CHD1
- Novus Biologicals proteins for CHD1
- antibodies-online: Search results for available CHD1 related products ranked by validation data
- Search GeneTex for Proteins for CHD1
-
Abcam proteins for CHD1
Assay Products
- antibodies-online: Search results for available CHD1 related products ranked by validation data
Domains & Families for CHD1 Gene
Gene Families for CHD1 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for CHD1 Gene
Suggested Antigen Peptide Sequences for CHD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14646UniProtKB/Swiss-Prot:
CHD1_HUMAN :- The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
- Belongs to the SNF2/RAD54 helicase family.
- Domain:
-
- The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
- Family:
-
- Belongs to the SNF2/RAD54 helicase family.
Function for CHD1 Gene
Molecular function for CHD1 Gene
- GENATLAS Biochemistry:
- DNA binding protein with two chromatin organization (chromo) domains and a helicase ATPase domain,1,binding A.T tracts, released into cytoplasm during mitosis,component of the chromatin remodeling complex
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot Function:
- ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Enzyme Numbers (IUBMB) for CHD1 Gene
Phenotypes From GWAS Catalog for CHD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | 9326634 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22419161 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CHD1 Gene
- MGI mutant phenotypes for CHD1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CHD1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHD1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
- Search ViGene Biosciences for CHD1
CRISPR Products
-
OriGene CRISPR knockouts for CHD1
- genomics-online: gRNA clones - Search results for 97 available CHD1 gene related products
- Overview of 97 available CHD1 gene related products
- Applied Biological Materials CRISPR for CHD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHD1
- GenScript: Design CRISPR guide RNA sequences for CHD1
miRNA for CHD1 Gene
- miRTarBase miRNAs that target CHD1
-
- hsa-mir-30a-5p (MIRT005127)
- hsa-mir-30b-5p (MIRT023406)
- hsa-mir-98-5p (MIRT027799)
- hsa-let-7b-5p (MIRT032461)
- hsa-mir-130b-5p (MIRT038317)
- hsa-mir-30c-5p (MIRT047842)
- hsa-let-7c-5p (MIRT051818)
- hsa-mir-26a-5p (MIRT052903)
- hsa-mir-4503 (MIRT497838)
- hsa-mir-6792-5p (MIRT497839)
- hsa-mir-3194-5p (MIRT497840)
- hsa-mir-4691-3p (MIRT497841)
- hsa-mir-570-3p (MIRT548834)
- hsa-mir-3613-3p (MIRT548835)
- hsa-mir-7849-3p (MIRT548836)
- hsa-mir-8054 (MIRT548837)
- hsa-mir-548k (MIRT548838)
- hsa-mir-548av-5p (MIRT548839)
- hsa-mir-548n (MIRT548840)
- hsa-mir-501-5p (MIRT624361)
- hsa-mir-4700-3p (MIRT624362)
- hsa-mir-500b-5p (MIRT624363)
- hsa-mir-362-5p (MIRT624364)
- hsa-mir-30e-5p (MIRT728001)
- hsa-mir-30d-5p (MIRT728002)
- hsa-mir-194-5p (MIRT735079)
- mmu-mir-194-5p (MIRT735080)
miRNA Products
- Search ViGene Biosciences for CHD1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CHD1
- Browse OriGene Inhibitory RNA Products For CHD1
- genomics-online: shRNA clones - Search results for 97 available CHD1 gene related products
- Overview of 97 available CHD1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
Clone Products
- Sino Biological Human cDNA Clone for CHD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHD1
- Applied Biological Materials Clones for CHD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CHD1
-
ViGene Biosciences adenoviral particle packaged cDNA for CHD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHD1 Gene
Localization for CHD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHD1 Gene
- Nucleus. Cytoplasm. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250 UniProtKB:P40201}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoli fibrillar center (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IDA | 22046413 |
| GO:0005737 | cytoplasm | IDA | 22046413 |
Pathways & Interactions for CHD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin Regulation / Acetylation | ||
Pathways by source for CHD1 Gene
1 Cell Signaling Technology pathway for CHD1 Gene
Interacting Proteins for CHD1 Gene
Selected Interacting proteins:
ENSP00000284049
O14646-CHD1_HUMAN
for CHD1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006338 | chromatin remodeling | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 9326634 |
| GO:0016569 | covalent chromatin modification | IEA,IMP | 28866611 |
No data available for SIGNOR curated interactions for CHD1 Gene
Drugs & Compounds for CHD1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for CHD1 Gene
mRNA/cDNA for CHD1 Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHD1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHD1
- genomics-online: gRNA clones - Search results for 97 available CHD1 gene related products
- Overview of 97 available CHD1 gene related products
- Applied Biological Materials CRISPR for CHD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHD1
- GenScript: Design CRISPR guide RNA sequences for CHD1
miRNA Products
- Search ViGene Biosciences for CHD1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CHD1
- Browse OriGene Inhibitory RNA Products For CHD1
- genomics-online: shRNA clones - Search results for 97 available CHD1 gene related products
- Overview of 97 available CHD1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHD1 gene
Clone Products
- Sino Biological Human cDNA Clone for CHD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHD1
- Applied Biological Materials Clones for CHD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP2: | - | - | |||||||||||||||||||||||||||||||||
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| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||||||||||||||||
| SP14: |
Expression for CHD1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (19.3), Breast (12.3), Lung (9.5), and Adrenal (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHD1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHD1 Gene:
CHD1SOURCE GeneReport for Unigene cluster for CHD1 Gene:
Hs.643465Evidence on tissue expression from TISSUES for CHD1 Gene
- Lung(5)
- Liver(4.3)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CHD1
- genomics-online: primer clones - Search results for 97 available CHD1 gene related products
- Overview of 97 available CHD1 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHD1 Gene
Orthologs for CHD1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHD1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHD1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CHD1 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHD1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CHD1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chd1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Chd1 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | CHDZ 34 34 |
|
OneToMany | |
| CHD1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | CHD1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17448 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CHD1 34 |
|
OneToOne | |
| zgc:173506 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Chd1 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | H06O01.2 35 |
|
|
|
| chd-1 34 |
|
OneToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C17578g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR123C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CHD1 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hrp1 33 |
|
- Species where no ortholog for CHD1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CHD1 Gene
(3) SIMAP similar genes for CHD1 Gene using alignment to 5 proteins:
Variants for CHD1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1064795875 | uncertain-significance, pathogenic, not specified, PILAROWSKI-BJORNSSON SYNDROME | 98,902,916(-) | T/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1000040891 | -- | 98,904,357(-) | T/A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000048149 | -- | 98,892,234(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000062578 | -- | 98,910,352(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000140444 | -- | 98,913,486(-) | A/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1161270 | CNV | duplication | 26073780 |
| nsv507277 | OTHER | sequence alteration | 20534489 |
Residual Variation Intolerance Score:
1.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.72;
83.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHD1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD1 Gene
Disorders for CHD1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pilarowski-bjornsson syndrome |
|
Search CHD1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CHD1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CHD1 Gene
Publications for CHD1 Gene
- Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. (PMID: 16263726) Sims RJ … Reinberg D (The Journal of biological chemistry 2005) 3 4 22 58
- Characterization of the CHD family of proteins. (PMID: 9326634) Woodage T … Collins FS (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 58
- Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians. (PMID: 20363151) Won HH … Lee KA (Cytokine 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Structural polymorphism of chromodomains in Chd1. (PMID: 17098252) Okuda M … Nishimura Y (Journal of molecular biology 2007) 3 22 58
Products for CHD1 Gene
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- Mammalian expression: PiggyBac
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Sources for CHD1 Gene
- (1) GeneCards
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- (3) EntrezGene
- (4) Swiss-Prot
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- (66) GenScript
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
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- (84) Vector BioLabs
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