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Aliases for PIM2 Gene

Aliases for PIM2 Gene

  • Pim-2 Proto-Oncogene, Serine/Threonine Kinase 2 3
  • Pim-2 Oncogene 2 3
  • EC 2.7.11.1 4 63
  • Pim-2h 3 4
  • Proto-Oncogene Pim-2 (Serine Threonine Kinase) 3
  • Serine/Threonine Protein Kinase Pim-2 3
  • Serine/Threonine-Protein Kinase Pim-2 3

External Ids for PIM2 Gene

Previous GeneCards Identifiers for PIM2 Gene

  • GC0XM047573
  • GC0XM047031
  • GC0XM047816
  • GC0XM048526
  • GC0XM048655
  • GC0XM048770
  • GC0XM046426

Summaries for PIM2 Gene

Entrez Gene Summary for PIM2 Gene

  • This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

GeneCards Summary for PIM2 Gene

PIM2 (Pim-2 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM2 include colorectal adenocarcinoma and mantle cell lymphoma. Among its related pathways are Endometrial cancer and Apoptosis and Autophagy. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PIM1.

UniProtKB/Swiss-Prot for PIM2 Gene

  • Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Gene Wiki entry for PIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIM2 Gene

Genomics for PIM2 Gene

Regulatory Elements for PIM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIM2 Gene

Start:
48,913,182 bp from pter
End:
48,919,136 bp from pter
Size:
5,955 bases
Orientation:
Minus strand

Genomic View for PIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIM2 Gene

Proteins for PIM2 Gene

  • Protein details for PIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1W9-PIM2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase pim-2
    Protein Accession:
    Q9P1W9
    Secondary Accessions:
    • A8K4G6
    • Q99739

    Protein attributes for PIM2 Gene

    Size:
    311 amino acids
    Molecular mass:
    34190 Da
    Quaternary structure:
    • Interacts with MYC.
    SequenceCaution:
    • Sequence=AAC78506.1; Type=Frameshift; Positions=293; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIM2 Gene

neXtProt entry for PIM2 Gene

Proteomics data for PIM2 Gene at MOPED

Selected DME Specific Peptides for PIM2 Gene

Post-translational modifications for PIM2 Gene

Other Protein References for PIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIM2 (Pim2)

Domains for PIM2 Gene

Gene Families for PIM2 Gene

Suggested Antigen Peptide Sequences for PIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1W9

UniProtKB/Swiss-Prot:

PIM2_HUMAN :
  • Q9P1W9
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
genes like me logo Genes that share domains with PIM2: view

Function for PIM2 Gene

Molecular function for PIM2 Gene

GENATLAS Biochemistry: pim-2 oncogene murine otholog,with a large transcript,expressed in hematopoietic tissues and leukemia and lymphoma cell lines,testis (primary germ cells),small intestine,colon and colorectal adenocarcinoma cells. A short transcript can be detected only in spleen,tissue,small intestine and colon,potentially involved in proliferating cells as well as during meiosis
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
UniProtKB/Swiss-Prot Induction: Down-regulated in response to enterovirus 71 (EV71) infection.

Enzyme Numbers (IUBMB) for PIM2 Gene

Gene Ontology (GO) - Molecular Function for PIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 18593906
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PIM2: view
genes like me logo Genes that share phenotypes with PIM2: view

Animal Models for PIM2 Gene

MGI Knock Outs for PIM2:

Animal Model Products

CRISPR Products

miRNA for PIM2 Gene

miRTarBase miRNAs that target PIM2

No data available for Transcription Factor Targeting and HOMER Transcription for PIM2 Gene

Localization for PIM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIM2 Gene COMPARTMENTS Subcellular localization image for PIM2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PIM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIM2 Gene

Pathways for PIM2 Gene

genes like me logo Genes that share pathways with PIM2: view

Pathways by source for PIM2 Gene

2 Cell Signaling Technology pathways for PIM2 Gene
1 KEGG pathway for PIM2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 20307683
GO:0006468 protein phosphorylation ISS --
GO:0007140 male meiosis TAS 9804974
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0008283 cell proliferation TAS 9804974
genes like me logo Genes that share ontologies with PIM2: view

Compounds for PIM2 Gene

(8) ApexBio Compounds for PIM2 Gene

Compound Action Cas Number
AZD1208 novel, orally bioavailable, highly selective PIM kinase inhibitor. [1204144-28-4]
CX-6258 potent, orally efficacious pan-Pim kinases Inhibitor.
LKB1 (AAK1 dual inhibitor) Pim-1 kinase inhibitor. [1093222-27-5]
PIM-1 Inhibitor 2 Potent Pim-1 kinase inhibitor [477845-12-8]
R8-T198wt Cell-permeable peptide inhibitor of Pim-1 kinase
SGI-1776 free base potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase [1025065-69-3]
SMI-4a potent inhibitor of Pim1 [438190-29-5]
TCS PIM-1 1 ATP-competitive Pim-1 kinase inhibitor. [491871-58-0]

(2) HMDB Compounds for PIM2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for PIM2 Gene

Compound -log(P) Hits PubMed IDs
threonine 61.8 3
serine 53.7 3
genes like me logo Genes that share compounds with PIM2: view

Transcripts for PIM2 Gene

mRNA/cDNA for PIM2 Gene

Unigene Clusters for PIM2 Gene

Pim-2 oncogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIM2

Clone Products

  • Addgene plasmids for PIM2
  • Addgene plasmids for PIM2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - -

Relevant External Links for PIM2 Gene

GeneLoc Exon Structure for
PIM2
ECgene alternative splicing isoforms for
PIM2

Expression for PIM2 Gene

mRNA expression in normal human tissues for PIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIM2 Gene

This gene is overexpressed in Whole Blood (7.3) and Spleen (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIM2 Gene

SOURCE GeneReport for Unigene cluster for PIM2 Gene Hs.727148

mRNA Expression by UniProt/SwissProt for PIM2 Gene

Q9P1W9-PIM2_HUMAN
Tissue specificity: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
genes like me logo Genes that share expressions with PIM2: view

In Situ Assay Products

Orthologs for PIM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIM2 35
  • 99.57 (n)
  • 99.68 (a)
PIM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIM2 35
  • 90.89 (n)
  • 91.96 (a)
PIM2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIM2 35
  • 90.68 (n)
  • 93.57 (a)
PIM2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pim2 35
  • 86.39 (n)
  • 89.39 (a)
Pim2 16
Pim2 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIM2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pim2 35
  • 87.25 (n)
  • 89.71 (a)
lizard
(Anolis carolinensis)
Reptilia PIM2 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pim1 35
  • 59.45 (n)
  • 57.84 (a)
worm
(Caenorhabditis elegans)
Secernentea prk-1 37
  • 37 (a)
prk-2 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for PIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIM2 Gene

ENSEMBL:
Gene Tree for PIM2 (if available)
TreeFam:
Gene Tree for PIM2 (if available)

Paralogs for PIM2 Gene

Paralogs for PIM2 Gene

genes like me logo Genes that share paralogs with PIM2: view

Variants for PIM2 Gene

Sequence variations from dbSNP and Humsavar for PIM2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1050790 -- 48,915,285(-) CAGGA(A/C/G)GGCTT synonymous-codon, missense, reference
rs2239452 -- 48,918,295(-) GGCAG(C/G)GGGCT intron-variant
rs2283734 -- 48,916,279(-) ACAGA(C/T)ATAAT intron-variant
rs3027511 -- 48,919,356(-) TTAAG(G/T)GTAAA upstream-variant-2KB
rs3027512 -- 48,918,995(-) GGCGA(A/G)TCTCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PIM2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv6894 CNV Insertion 18451855

Relevant External Links for PIM2 Gene

HapMap Linkage Disequilibrium report
PIM2
Locus Specific Mutation Databases (LSDB)
PIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIM2 Gene

Disorders for PIM2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PIM2 Gene including...

Search for PIM2 Gene in MalaCards »

(2) Novoseek inferred disease relationships for PIM2 Gene

Disease -log(P) Hits PubMed IDs
lymphoma 52.8 2
cancer 0 1
genes like me logo Genes that share disorders with PIM2: view

No data available for UniProtKB/Swiss-Prot for PIM2 Gene

Publications for PIM2 Gene

  1. The human Pim-2 proto-oncogene and its testicular expression. (PMID: 9804974) Baytel D. … Don J. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell. (PMID: 18675992) Gong J. … Shi Y. (J. Surg. Res. 2009) 3 4 23
  3. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. (PMID: 16403219) Macdonald A. … Arthur J.S. (BMC Cell Biol. 2006) 3 23
  4. Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma. (PMID: 15291354) Cohen A.M. … Don J. (Leuk. Lymphoma 2004) 3 23
  5. Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells. (PMID: 20307683) Wang Z. … Magnuson N.S. (Int. J. Biochem. Cell Biol. 2010) 3 4

Products for PIM2 Gene

  • Addgene plasmids for PIM2
  • Addgene plasmids for PIM2

Sources for PIM2 Gene

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