Aliases for LILRA3 Gene
Previous GeneCards Identifiers for LILRA3 Gene
This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
GeneCards Summary for LILRA3 Gene
LILRA3 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 3) is a Protein Coding gene. Diseases associated with LILRA3 include ascariasis and trichuriasis. Among its related pathways are Osteoclast differentiation. GO annotations related to this gene include receptor activity and antigen binding.
UniProtKB/Swiss-Prot for LILRA3 Gene
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.