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Aliases for LILRA3 Gene

Aliases for LILRA3 Gene

  • Leukocyte Immunoglobulin Like Receptor A3 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 3 2 3
  • Leukocyte Immunoglobulin-Like Receptor 4 3 4
  • Monocyte Inhibitory Receptor HM43/HM31 3 4
  • CD85 Antigen-Like Family Member E 3 4
  • Immunoglobulin-Like Transcript 6 3 4
  • Leucocyte Ig-Like Receptor A3 2 3
  • ILT-6 3 4
  • LIR-4 3 4
  • ILT6 3 4
  • LIR4 3 4
  • Leukocyte Immunoglobulin-Like Receptor A3 3
  • CD85e Antigen 4
  • CD85E 3
  • HM31 3
  • HM43 3

External Ids for LILRA3 Gene

Previous GeneCards Identifiers for LILRA3 Gene

  • GC19M055680
  • GC19M055224
  • GC19M059475
  • GC19M059491
  • GC19M054798
  • GC19Mj00270

Summaries for LILRA3 Gene

Entrez Gene Summary for LILRA3 Gene

  • This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

GeneCards Summary for LILRA3 Gene

LILRA3 (Leukocyte Immunoglobulin Like Receptor A3) is a Protein Coding gene. Among its related pathways are Osteoclast differentiation and Immune System. GO annotations related to this gene include receptor activity and antigen binding.

UniProtKB/Swiss-Prot for LILRA3 Gene

  • Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Gene Wiki entry for LILRA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA3 Gene

Genomics for LILRA3 Gene

Regulatory Elements for LILRA3 Gene

Enhancers for LILRA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LILRA3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LILRA3 gene promoter:

Genomic Location for LILRA3 Gene

Chromosome:
19
Start:
270,735 bp from pter
End:
280,849 bp from pter
Size:
10,115 bases
Orientation:
Minus strand

Genomic View for LILRA3 Gene

Genes around LILRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LILRA3 Gene

Proteins for LILRA3 Gene

  • Protein details for LILRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6C8-LIRA3_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 3
    Protein Accession:
    Q8N6C8
    Secondary Accessions:
    • J3KPM2
    • O15469
    • O15470
    • O75016
    • Q8N151
    • Q8N154
    • Q8NHJ1
    • Q8NHJ2
    • Q8NHJ3
    • Q8NHJ4

    Protein attributes for LILRA3 Gene

    Size:
    439 amino acids
    Molecular mass:
    47472 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA3 Gene

    Alternative splice isoforms for LILRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA3 Gene

Proteomics data for LILRA3 Gene at MOPED

Post-translational modifications for LILRA3 Gene

  • N-glycosylation is required for ligand binding.
  • Glycosylation at Asn 140, Asn 281, Asn 302, Asn 341, and Asn 431
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA3 Gene

REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LILRA3 (LILRA3/CD85e)

No data available for DME Specific Peptides for LILRA3 Gene

Domains & Families for LILRA3 Gene

Suggested Antigen Peptide Sequences for LILRA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6C8

UniProtKB/Swiss-Prot:

LIRA3_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA3: view

Function for LILRA3 Gene

Molecular function for LILRA3 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily A,member 3,expressed on monocytes and B cells,secreted,acting potentially as a dominant negative soluble receptor that would suppress the function of other LIR molecules,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
UniProtKB/Swiss-Prot Function:
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Gene Ontology (GO) - Molecular Function for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9151699
GO:0004872 receptor activity TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view
genes like me logo Genes that share phenotypes with LILRA3: view

Animal Model Products

miRNA for LILRA3 Gene

miRTarBase miRNAs that target LILRA3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA3 Gene

Localization for LILRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRA3 Gene COMPARTMENTS Subcellular localization image for LILRA3 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view

Pathways & Interactions for LILRA3 Gene

genes like me logo Genes that share pathways with LILRA3: view

Pathways by source for LILRA3 Gene

Interacting Proteins for LILRA3 Gene

Selected Interacting proteins: Q8N6C8-LIRA3_HUMAN for LILRA3 Gene via I2D MINT

Gene Ontology (GO) - Biological Process for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006952 defense response TAS 9151699
GO:0007165 signal transduction TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view

No data available for SIGNOR curated interactions for LILRA3 Gene

Drugs & Compounds for LILRA3 Gene

No Compound Related Data Available

Transcripts for LILRA3 Gene

Unigene Clusters for LILRA3 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA3 Gene

No ASD Table

Relevant External Links for LILRA3 Gene

GeneLoc Exon Structure for
LILRA3
ECgene alternative splicing isoforms for
LILRA3

Expression for LILRA3 Gene

mRNA expression in normal human tissues for LILRA3 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA3 Gene

This gene is overexpressed in Whole Blood (x43.9) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for LILRA3 Gene

This gene is overexpressed in Serum (43.0), Monocytes (7.7), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA3 Gene



SOURCE GeneReport for Unigene cluster for LILRA3 Gene Hs.113277

mRNA Expression by UniProt/SwissProt for LILRA3 Gene

Q8N6C8-LIRA3_HUMAN
Tissue specificity: Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
genes like me logo Genes that share expression patterns with LILRA3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for LILRA3 Gene

Orthologs for LILRA3 Gene

No data available for Orthologs and Evolution for LILRA3 Gene

Paralogs for LILRA3 Gene

genes like me logo Genes that share paralogs with LILRA3: view

No data available for Paralogs for LILRA3 Gene

Variants for LILRA3 Gene

Sequence variations from dbSNP and Humsavar for LILRA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_016990 -
VAR_016991 -
VAR_016992 -
VAR_059397 -
rs78319071 -- 54,300,063(+) CCCCC(-/C)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LILRA3 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
dgv4003n71 CNV Loss 21882294
nsv912402 CNV Gain 21882294
esv2718860 CNV Deletion 23290073
dgv4004n71 CNV Loss 21882294
nsv912408 CNV Gain 21882294
nsv833878 CNV Loss 17160897
nsv912409 CNV Gain 21882294
esv2718864 CNV Deletion 23290073
nsv912410 CNV Gain 21882294
nsv527908 CNV Gain 19592680
nsv2549 CNV Loss 18451855
esv991182 CNV Deletion 20482838
dgv664e199 CNV Deletion 23128226
esv33839 CNV Loss 17666407
nsv9754 CNV Gain 18304495
nsv819942 CNV Loss 19587683
nsv828634 CNV Loss 20364138
nsv821486 CNV Deletion 20802225
nsv510775 CNV Loss 20534489
esv28827 CNV Gain+Loss 19812545
esv998993 CNV Loss 20482838
nsv828635 CNV Loss 20364138
esv8385 CNV Loss 19470904
dgv665e199 CNV Deletion 23128226
nsv498907 CNV Loss 21111241

Variation tolerance for LILRA3 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA3 Gene

HapMap Linkage Disequilibrium report
LILRA3
Human Gene Mutation Database (HGMD)
LILRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA3 Gene

Disorders for LILRA3 Gene

Relevant External Links for LILRA3

Genetic Association Database (GAD)
LILRA3
Human Genome Epidemiology (HuGE) Navigator
LILRA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA3

No disorders were found for LILRA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA3 Gene

Publications for LILRA3 Gene

  1. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PMID: 9278324) Arm J.P. … Austen K.F. (J. Immunol. 1997) 2 3 4 67
  2. Association of immunoglobulin-like transcript 6 deficiency with SjAPgren's syndrome. (PMID: 19790059) Kabalak G. … Witte T. (Arthritis Rheum. 2009) 3 23
  3. Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection. (PMID: 16501917) Hirayasu K. … Yabe T. (Hum. Genet. 2006) 3 23
  4. SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex. (PMID: 15185041) Norman P.J. … Vaughan R.W. (Immunogenetics 2004) 3 23
  5. Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. (PMID: 12651072) WiA9niewski A. … KuA9nierczyk P. (Hum. Immunol. 2003) 3 23

Products for LILRA3 Gene

Sources for LILRA3 Gene

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