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Aliases for SLC27A3 Gene

Aliases for SLC27A3 Gene

  • Solute Carrier Family 27 Member 3 2 3 4
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 3 2 3 5
  • Very Long-Chain Acyl-CoA Synthetase Homolog 3 3 4
  • Fatty Acid Transport Protein 3 3 4
  • ACSVL3 3 4
  • VLCS-3 3 4
  • FATP3 3 4
  • EC 6.2.1.7 63
  • EC 6.2.1.- 4
  • EC 6.2.1 63
  • FATP-3 4

External Ids for SLC27A3 Gene

Previous GeneCards Identifiers for SLC27A3 Gene

  • GC01U990233
  • GC01P149478
  • GC01P150523
  • GC01P150964
  • GC01P150963
  • GC01P150559
  • GC01P152014
  • GC01P125110

Summaries for SLC27A3 Gene

GeneCards Summary for SLC27A3 Gene

SLC27A3 (Solute Carrier Family 27 Member 3) is a Protein Coding gene. Among its related pathways are Translation Insulin regulation of translation. GO annotations related to this gene include nucleotide binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A3 Gene

  • Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).

Gene Wiki entry for SLC27A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A3 Gene

Genomics for SLC27A3 Gene

Regulatory Elements for SLC27A3 Gene

Enhancers for SLC27A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC27A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC27A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC27A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC27A3 Gene

Chromosome:
1
Start:
153,774,354 bp from pter
End:
153,780,157 bp from pter
Size:
5,804 bases
Orientation:
Plus strand

Genomic View for SLC27A3 Gene

Genes around SLC27A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A3 Gene

Proteins for SLC27A3 Gene

  • Protein details for SLC27A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5K4L6-S27A3_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 3
    Protein Accession:
    Q5K4L6
    Secondary Accessions:
    • Q5VUQ7
    • Q5VUQ8
    • Q5VUR3
    • Q6ZV16
    • Q8N2X7
    • Q8TEJ0
    • Q96SW5
    • Q9BTJ5
    • Q9BTY5

    Protein attributes for SLC27A3 Gene

    Size:
    730 amino acids
    Molecular mass:
    78644 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29792.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55156.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86050.1; Type=Frameshift; Positions=540; Evidence={ECO:0000305}; Sequence=CAE12159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71420.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC27A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A3 Gene

Proteomics data for SLC27A3 Gene at MOPED

Selected DME Specific Peptides for SLC27A3 Gene

Post-translational modifications for SLC27A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A3 Gene

Domains & Families for SLC27A3 Gene

Protein Domains for SLC27A3 Gene

Suggested Antigen Peptide Sequences for SLC27A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5K4L6

UniProtKB/Swiss-Prot:

S27A3_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A3: view

Function for SLC27A3 Gene

Molecular function for SLC27A3 Gene

UniProtKB/Swiss-Prot Function:
Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).

Enzyme Numbers (IUBMB) for SLC27A3 Gene

Gene Ontology (GO) - Molecular Function for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with SLC27A3: view

Phenotypes for SLC27A3 Gene

genes like me logo Genes that share phenotypes with SLC27A3: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC27A3 Gene

Localization for SLC27A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A3 Gene COMPARTMENTS Subcellular localization image for SLC27A3 gene
Compartment Confidence
mitochondrion 3
peroxisome 3
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLC27A3 Gene

Pathways & Interactions for SLC27A3 Gene

SuperPathways for SLC27A3 Gene

genes like me logo Genes that share pathways with SLC27A3: view

Pathways by source for SLC27A3 Gene

1 KEGG pathway for SLC27A3 Gene

Interacting Proteins for SLC27A3 Gene

Gene Ontology (GO) - Biological Process for SLC27A3 Gene

None

No data available for SIGNOR curated interactions for SLC27A3 Gene

Drugs & Compounds for SLC27A3 Gene

(6) Drugs for SLC27A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Propionyl-CoA Experimental Pharma 0
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(34) Additional Compounds for SLC27A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with SLC27A3: view

Transcripts for SLC27A3 Gene

Unigene Clusters for SLC27A3 Gene

Solute carrier family 27 (fatty acid transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for SLC27A3 Gene

GeneLoc Exon Structure for
SLC27A3
ECgene alternative splicing isoforms for
SLC27A3

Expression for SLC27A3 Gene

mRNA expression in normal human tissues for SLC27A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC27A3 Gene

This gene is overexpressed in Fetal testis (9.8), Stomach (7.8), and Fetal ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC27A3 Gene



SOURCE GeneReport for Unigene cluster for SLC27A3 Gene Hs.438723

genes like me logo Genes that share expression patterns with SLC27A3: view

Protein tissue co-expression partners for SLC27A3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC27A3 Gene

Orthologs for SLC27A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC27A3 35
  • 86.8 (n)
  • 86.29 (a)
SLC27A3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A3 35
  • 85.36 (n)
  • 86.1 (a)
SLC27A3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a3 35
  • 83.77 (n)
  • 86.05 (a)
Slc27a3 16
Slc27a3 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC27A3 35
  • 96.68 (n)
  • 95.71 (a)
SLC27A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a3 35
  • 83.62 (n)
  • 86.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC27A3 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20896 35
zebrafish
(Danio rerio)
Actinopterygii SLC27A3 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SLC27A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A3 Gene

ENSEMBL:
Gene Tree for SLC27A3 (if available)
TreeFam:
Gene Tree for SLC27A3 (if available)

Paralogs for SLC27A3 Gene

Paralogs for SLC27A3 Gene

(6) SIMAP similar genes for SLC27A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC27A3: view

Variants for SLC27A3 Gene

Sequence variations from dbSNP and Humsavar for SLC27A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_048241 -
VAR_048242 -

Structural Variations from Database of Genomic Variants (DGV) for SLC27A3 Gene

Variant ID Type Subtype PubMed ID
nsv515962 CNV Loss 19592680

Variation tolerance for SLC27A3 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC27A3 Gene

Disorders for SLC27A3 Gene

Relevant External Links for SLC27A3

Genetic Association Database (GAD)
SLC27A3
Human Genome Epidemiology (HuGE) Navigator
SLC27A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC27A3

No disorders were found for SLC27A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC27A3 Gene

Publications for SLC27A3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. A family of fatty acid transporters conserved from mycobacterium to man. (PMID: 9671728) Hirsch D. … Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity. (PMID: 24893952) Sun P. … Laterra J. (BMC Cancer 2014) 3

Products for SLC27A3 Gene

Sources for SLC27A3 Gene

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