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Aliases for SLC27A3 Gene

Aliases for SLC27A3 Gene

  • Solute Carrier Family 27 Member 3 2 3 4 5
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 3 2 3
  • Very Long-Chain Acyl-CoA Synthetase Homolog 3 3 4
  • ACSVL3 3 4
  • VLCS-3 3 4
  • FATP3 3 4
  • Long-Chain Fatty Acid Transport Protein 3 3
  • Fatty Acid Transport Protein 3 4
  • EC 61
  • EC 6.2.1.- 4
  • EC 6.2.1 61
  • FATP-3 4

External Ids for SLC27A3 Gene

Previous GeneCards Identifiers for SLC27A3 Gene

  • GC01U990233
  • GC01P149478
  • GC01P150523
  • GC01P150964
  • GC01P150963
  • GC01P150559
  • GC01P152014
  • GC01P125110

Summaries for SLC27A3 Gene

Entrez Gene Summary for SLC27A3 Gene

  • This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for SLC27A3 Gene

SLC27A3 (Solute Carrier Family 27 Member 3) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. GO annotations related to this gene include nucleotide binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A6.

UniProtKB/Swiss-Prot for SLC27A3 Gene

  • Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).

Gene Wiki entry for SLC27A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A3 Gene

Genomics for SLC27A3 Gene

Regulatory Elements for SLC27A3 Gene

Enhancers for SLC27A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G154324 1.7 FANTOM5 ENCODE dbSUPER 30.1 +552.8 552762 5.7 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 CHTOP SLC27A3 THBS3 INTS3 RUSC1-AS1 LOC101928120 ENSG00000238279 PYGO2 RPS27 CHRNB2
GH01G154351 1.7 Ensembl ENCODE dbSUPER 28.2 +578.8 578830 3.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 CHTOP RUSC1-AS1 SLC27A3 THBS3 INTS3 EFNA4 ENSG00000272030 KRTCAP2 ENSG00000238279 DPM3
GH01G153696 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -76.0 -75986 3.2 CREB3L1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 SSRP1 ZNF610 S100A1 SLC27A3 INTS3 CHTOP S100A12 S100A9 RN7SL372P MIR8083
GH01G153727 1.3 ENCODE dbSUPER 17.4 -44.9 -44875 4.2 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 S100A1 SLC27A3 ILF2 NPR1 ENSG00000233222 ENSG00000243613 CHTOP SNAPIN DENND4B C1orf189
GH01G153677 1.5 Ensembl ENCODE dbSUPER 12.5 -95.1 -95107 3.3 HDGF ARID4B GLI4 ZNF2 ZBTB7B GLIS2 ZNF143 ZNF548 DEK TSHZ1 SLC27A3 CHTOP S100A13 NPR1 MIR8083
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC27A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC27A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013844 508 1201 HDGF AGO1 SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNF121 GLIS2

Genomic Location for SLC27A3 Gene

153,774,354 bp from pter
153,780,157 bp from pter
5,804 bases
Plus strand

Genomic View for SLC27A3 Gene

Genes around SLC27A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A3 Gene

Proteins for SLC27A3 Gene

  • Protein details for SLC27A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Long-chain fatty acid transport protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5VUQ7
    • Q5VUQ8
    • Q5VUR3
    • Q6ZV16
    • Q8N2X7
    • Q8TEJ0
    • Q96SW5
    • Q9BTJ5
    • Q9BTY5

    Protein attributes for SLC27A3 Gene

    730 amino acids
    Molecular mass:
    78644 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH29792.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55156.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86050.1; Type=Frameshift; Positions=540; Evidence={ECO:0000305}; Sequence=CAE12159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71420.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC27A3 Gene


neXtProt entry for SLC27A3 Gene

Selected DME Specific Peptides for SLC27A3 Gene


Post-translational modifications for SLC27A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A3 Gene

Domains & Families for SLC27A3 Gene

Protein Domains for SLC27A3 Gene

Suggested Antigen Peptide Sequences for SLC27A3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP-dependent AMP-binding enzyme family.
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A3: view

Function for SLC27A3 Gene

Molecular function for SLC27A3 Gene

UniProtKB/Swiss-Prot Function:
Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).

Enzyme Numbers (IUBMB) for SLC27A3 Gene

Gene Ontology (GO) - Molecular Function for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0016874 ligase activity IEA --
GO:0031957 very long-chain fatty acid-CoA ligase activity IEA,TAS --
genes like me logo Genes that share ontologies with SLC27A3: view
genes like me logo Genes that share phenotypes with SLC27A3: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC27A3 Gene

Localization for SLC27A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC27A3 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 4
plasma membrane 3
peroxisome 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC27A3: view

Pathways & Interactions for SLC27A3 Gene

genes like me logo Genes that share pathways with SLC27A3: view

Gene Ontology (GO) - Biological Process for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with SLC27A3: view

No data available for SIGNOR curated interactions for SLC27A3 Gene

Drugs & Compounds for SLC27A3 Gene

(6) Drugs for SLC27A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Propionyl-CoA Experimental Pharma 0
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(34) Additional Compounds for SLC27A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with SLC27A3: view

Transcripts for SLC27A3 Gene

Unigene Clusters for SLC27A3 Gene

Solute carrier family 27 (fatty acid transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - -
SP2: - - - -
SP3: - - -
SP7: -

Relevant External Links for SLC27A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC27A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC27A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC27A3 Gene

This gene is overexpressed in Fetal testis (9.8), Stomach (7.8), and Fetal ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC27A3 Gene

Protein tissue co-expression partners for SLC27A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC27A3 Gene:


SOURCE GeneReport for Unigene cluster for SLC27A3 Gene:


Evidence on tissue expression from TISSUES for SLC27A3 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Lung(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with SLC27A3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC27A3 Gene

Orthologs for SLC27A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC27A3 34 35
  • 96.68 (n)
(Bos Taurus)
Mammalia SLC27A3 34 35
  • 86.8 (n)
(Canis familiaris)
Mammalia SLC27A3 34 35
  • 85.36 (n)
(Mus musculus)
Mammalia Slc27a3 34 16 35
  • 83.77 (n)
(Rattus norvegicus)
Mammalia Slc27a3 34
  • 83.62 (n)
(Monodelphis domestica)
Mammalia SLC27A3 35
  • 74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20896 34
(Danio rerio)
Actinopterygii SLC27A3 35
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
Species where no ortholog for SLC27A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A3 Gene

Gene Tree for SLC27A3 (if available)
Gene Tree for SLC27A3 (if available)

Paralogs for SLC27A3 Gene

Paralogs for SLC27A3 Gene

(6) SIMAP similar genes for SLC27A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC27A3: view

Variants for SLC27A3 Gene

Sequence variations from dbSNP and Humsavar for SLC27A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34527123 --
rs35102232 --

Structural Variations from Database of Genomic Variants (DGV) for SLC27A3 Gene

Variant ID Type Subtype PubMed ID
nsv515962 CNV loss 19592680
nsv547941 CNV loss 21841781

Variation tolerance for SLC27A3 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC27A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A3 Gene

Disorders for SLC27A3 Gene

Relevant External Links for SLC27A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC27A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC27A3 Gene

Publications for SLC27A3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. A family of fatty acid transporters conserved from mycobacterium to man. (PMID: 9671728) Hirsch D. … Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 64

Products for SLC27A3 Gene

Sources for SLC27A3 Gene

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