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Aliases for SLC27A3 Gene

Aliases for SLC27A3 Gene

  • Solute Carrier Family 27 Member 3 2 3 4 5
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 3 2 3
  • Very Long-Chain Acyl-CoA Synthetase Homolog 3 3 4
  • ACSVL3 3 4
  • VLCS-3 3 4
  • FATP3 3 4
  • Long-Chain Fatty Acid Transport Protein 3 3
  • Fatty Acid Transport Protein 3 4
  • EC 6.2.1.7 56
  • EC 6.2.1.- 4
  • EC 6.2.1 56
  • FATP-3 4

External Ids for SLC27A3 Gene

Previous GeneCards Identifiers for SLC27A3 Gene

  • GC01U990233
  • GC01P149478
  • GC01P150523
  • GC01P150964
  • GC01P150963
  • GC01P150559
  • GC01P152014
  • GC01P125110

Summaries for SLC27A3 Gene

Entrez Gene Summary for SLC27A3 Gene

  • This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for SLC27A3 Gene

SLC27A3 (Solute Carrier Family 27 Member 3) is a Protein Coding gene. Diseases associated with SLC27A3 include Autism. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A2.

UniProtKB/Swiss-Prot for SLC27A3 Gene

  • Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).

Gene Wiki entry for SLC27A3 Gene

Additional gene information for SLC27A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A3 Gene

Genomics for SLC27A3 Gene

GeneHancer (GH) Regulatory Elements for SLC27A3 Gene

Promoters and enhancers for SLC27A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I153772 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 558 +0.3 307 4.6 HDGF PKNOX1 SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNF121 GLIS2 SLC27A3 PIR62645 ENSG00000279767 CHTOP ATP8B2 GC01M153786 ENSG00000207039 INTS3
GH01I153989 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.4 +217.2 217237 3.2 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 RPS27 GC01P153990 GC01P153994 CREB3L4 CRTC2 UBAP2L SLC27A3 CHTOP SHC1 INTS3
GH01I154177 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.9 +406.5 406526 6.8 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TPM3 UBAP2L CRTC2 CHTOP LOC101928120 SLC27A3 FLAD1 ILF2 INTS3 CREB3L4
GH01I154626 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.1 +853.1 853118 2.6 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ADAR UBAP2L ENSG00000271267 CLK2 INTS3 LOC101928120 SLC27A3 CHTOP MSTO1 ATP8B2
GH01I153919 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.6 +147.4 147438 5.4 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC101928059 GATAD2B UBAP2L CRTC2 ILF2 INTS3 CHTOP CREB3L4 SLC27A3 ENSG00000272654
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC27A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC27A3 gene promoter:

Genomic Locations for SLC27A3 Gene

Genomic Locations for SLC27A3 Gene
chr1:153,774,354-153,780,157
(GRCh38/hg38)
Size:
5,804 bases
Orientation:
Plus strand
chr1:153,746,830-153,752,633
(GRCh37/hg19)

Genomic View for SLC27A3 Gene

Genes around SLC27A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A3 Gene

Proteins for SLC27A3 Gene

  • Protein details for SLC27A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5K4L6-S27A3_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 3
    Protein Accession:
    Q5K4L6
    Secondary Accessions:
    • Q5VUQ7
    • Q5VUQ8
    • Q5VUR3
    • Q6ZV16
    • Q8N2X7
    • Q8TEJ0
    • Q96SW5
    • Q9BTJ5
    • Q9BTY5

    Protein attributes for SLC27A3 Gene

    Size:
    730 amino acids
    Molecular mass:
    78644 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29792.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55156.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86050.1; Type=Frameshift; Positions=540; Evidence={ECO:0000305}; Sequence=CAE12159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71420.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC27A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A3 Gene

Selected DME Specific Peptides for SLC27A3 Gene

Q5K4L6:
  • EGRAGMAA
  • TSGTTGLPKA
  • QYIGELCRYL
  • RWKGENV

Post-translational modifications for SLC27A3 Gene

No Post-translational modifications

Other Protein References for SLC27A3 Gene

Domains & Families for SLC27A3 Gene

Gene Families for SLC27A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC27A3 Gene

Suggested Antigen Peptide Sequences for SLC27A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5K4L6

UniProtKB/Swiss-Prot:

S27A3_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A3: view

Function for SLC27A3 Gene

Molecular function for SLC27A3 Gene

UniProtKB/Swiss-Prot Function:
Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).

Enzyme Numbers (IUBMB) for SLC27A3 Gene

Phenotypes From GWAS Catalog for SLC27A3 Gene

Gene Ontology (GO) - Molecular Function for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0016874 ligase activity IEA --
GO:0031957 very long-chain fatty acid-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with SLC27A3: view
genes like me logo Genes that share phenotypes with SLC27A3: view

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC27A3 Gene

Localization for SLC27A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC27A3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 3
peroxisome 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SLC27A3: view

Pathways & Interactions for SLC27A3 Gene

genes like me logo Genes that share pathways with SLC27A3: view

Gene Ontology (GO) - Biological Process for SLC27A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SLC27A3: view

No data available for SIGNOR curated interactions for SLC27A3 Gene

Drugs & Compounds for SLC27A3 Gene

(7) Drugs for SLC27A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0
Hexanoyl-CoA Experimental Pharma 0
Myristic acid Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(33) Additional Compounds for SLC27A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with SLC27A3: view

Transcripts for SLC27A3 Gene

Unigene Clusters for SLC27A3 Gene

Solute carrier family 27 (fatty acid transporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for SLC27A3 Gene

GeneLoc Exon Structure for
SLC27A3
ECgene alternative splicing isoforms for
SLC27A3

Expression for SLC27A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC27A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC27A3 Gene

This gene is overexpressed in Fetal testis (9.8), Stomach (7.8), and Fetal ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC27A3 Gene



Protein tissue co-expression partners for SLC27A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC27A3 Gene:

SLC27A3

SOURCE GeneReport for Unigene cluster for SLC27A3 Gene:

Hs.438723

Evidence on tissue expression from TISSUES for SLC27A3 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Lung(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with SLC27A3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC27A3 Gene

Orthologs for SLC27A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A3 33 34
  • 96.68 (n)
cow
(Bos Taurus)
Mammalia SLC27A3 33 34
  • 86.8 (n)
dog
(Canis familiaris)
Mammalia SLC27A3 33 34
  • 85.36 (n)
mouse
(Mus musculus)
Mammalia Slc27a3 33 16 34
  • 83.77 (n)
rat
(Rattus norvegicus)
Mammalia Slc27a3 33
  • 83.62 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC27A3 34
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20896 33
zebrafish
(Danio rerio)
Actinopterygii SLC27A3 34
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for SLC27A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A3 Gene

ENSEMBL:
Gene Tree for SLC27A3 (if available)
TreeFam:
Gene Tree for SLC27A3 (if available)

Paralogs for SLC27A3 Gene

Paralogs for SLC27A3 Gene

(6) SIMAP similar genes for SLC27A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC27A3: view

Variants for SLC27A3 Gene

Sequence variations from dbSNP and Humsavar for SLC27A3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs140194614 not-provided, not provided 153,776,188(+) C/T intron_variant
rs142223071 not-provided, not provided 153,778,554(+) G/A/T splice_donor_variant
rs143973304 not-provided, not provided 153,776,494(+) C/A/T intron_variant
rs146145258 not-provided, not provided 153,778,572(+) G/A intron_variant
rs146389904 not-provided, not provided 153,779,488(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A3 Gene

Variant ID Type Subtype PubMed ID
nsv515962 CNV loss 19592680
nsv547941 CNV loss 21841781

Variation tolerance for SLC27A3 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC27A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC27A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A3 Gene

Disorders for SLC27A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC27A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC27A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC27A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC27A3 Gene

Publications for SLC27A3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. A family of fatty acid transporters conserved from mycobacterium to man. (PMID: 9671728) Hirsch D … Lodish HF (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 58

Products for SLC27A3 Gene

Sources for SLC27A3 Gene

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