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Aliases for SLC27A5 Gene

Aliases for SLC27A5 Gene

  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 5 2 3
  • VLACSR 3 4 6
  • VLCSH2 3 4 6
  • FATP5 3 4 6
  • Very Long-Chain Acyl-CoA Synthetase-Related Protein 3 4
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 3 3 4
  • Very Long-Chain Acyl-CoA Synthetase Homolog 2 3 4
  • Solute Carrier Family 27 Member 5 3 4
  • Fatty Acid Transport Protein 5 3 4
  • Bile Acid-CoA Ligase 3 4
  • Cholate--CoA Ligase 3 4
  • BA-CoA Ligase 3 4
  • VLACS-Related 3 4
  • VLCS-H2 3 4
  • ACSVL6 3 4
  • FACVL3 3 4
  • FATP-5 3 4
  • ACSB 3 4
  • BACS 3 4
  • BAL 3 4
  • Fatty-Acid-Coenzyme A Ligase 2
  • Bile Acyl-CoA Synthetase 3
  • Very Long-Chain 3 2
  • EC 6.2.1.7 4

External Ids for SLC27A5 Gene

Summaries for SLC27A5 Gene

Entrez Gene Summary for SLC27A5 Gene

  • The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC27A5 Gene

SLC27A5 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 5) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Metabolism. GO annotations related to this gene include protein complex binding and fatty acid transporter activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A5 Gene

  • Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Gene Wiki entry for SLC27A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A5 Gene

Genomics for SLC27A5 Gene

Genomic Location for SLC27A5 Gene

Start:
58,479,512 bp from pter
End:
58,512,413 bp from pter
Size:
32,902 bases
Orientation:
Minus strand

Genomic View for SLC27A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC27A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A5 Gene

Regulatory Elements for SLC27A5 Gene

Proteins for SLC27A5 Gene

  • Protein details for SLC27A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P5-S27A5_HUMAN
    Recommended name:
    Bile acyl-CoA synthetase
    Protein Accession:
    Q9Y2P5
    Secondary Accessions:
    • B3KVP6
    • B4DPQ1

    Protein attributes for SLC27A5 Gene

    Size:
    690 amino acids
    Molecular mass:
    75385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC27A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A5 Gene

Proteomics data for SLC27A5 Gene at MOPED

Post-translational modifications for SLC27A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC27A5 Gene

Domains for SLC27A5 Gene

Gene Families for SLC27A5 Gene

HGNC:
  • SLC :Solute carriers
  • ACS :Acyl-CoA synthetase family
IUPHAR :

Protein Domains for SLC27A5 Gene

UniProtKB/Swiss-Prot:

S27A5_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • Q9Y2P5
genes like me logo Genes that share domains with SLC27A5: view

Function for SLC27A5 Gene

Molecular function for SLC27A5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA
UniProtKB/Swiss-Prot CatalyticActivity: ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
UniProtKB/Swiss-Prot Function: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Enzyme Numbers (IUBMB) for SLC27A5 Gene

Gene Ontology (GO) - Molecular Function for SLC27A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0005524 ATP binding IEA --
GO:0015245 fatty acid transporter activity IEA --
GO:0031957 very long-chain fatty acid-CoA ligase activity IDA 10479480
genes like me logo Genes that share ontologies with SLC27A5: view
genes like me logo Genes that share phenotypes with SLC27A5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC27A5 Gene

Localization for SLC27A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A5 Gene COMPARTMENTS Subcellular localization image for SLC27A5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 2
extracellular 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC27A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 10479480
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0009925 basal plasma membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 11980911
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with SLC27A5: view

Pathways for SLC27A5 Gene

genes like me logo Genes that share pathways with SLC27A5: view

Gene Ontology (GO) - Biological Process for SLC27A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 10479480
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006642 triglyceride mobilization IEA --
GO:0006699 bile acid biosynthetic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with SLC27A5: view

Compounds for SLC27A5 Gene

(45) HMDB Compounds for SLC27A5 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(2) Novoseek inferred chemical compound relationships for SLC27A5 Gene

Compound -log(P) Hits PubMed IDs
taurine 56.5 1
fatty acid 41 2
genes like me logo Genes that share compounds with SLC27A5: view

Transcripts for SLC27A5 Gene

Unigene Clusters for SLC27A5 Gene

Solute carrier family 27 (fatty acid transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SLC27A5 Gene

GeneLoc Exon Structure for
SLC27A5
ECgene alternative splicing isoforms for
SLC27A5

Expression for SLC27A5 Gene

mRNA expression in normal human tissues for SLC27A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC27A5 Gene

This gene is overexpressed in Liver (39.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC27A5 Gene

SOURCE GeneReport for Unigene cluster for SLC27A5 Gene Hs.292177

mRNA Expression by UniProt/SwissProt for SLC27A5 Gene

Q9Y2P5-S27A5_HUMAN
Tissue specificity: Predominantly expressed in liver.
genes like me logo Genes that share expressions with SLC27A5: view

Orthologs for SLC27A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC27A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A5 36
  • 99.42 (n)
  • 99.28 (a)
SLC27A5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC27A5 36
  • 79.95 (n)
  • 76.67 (a)
SLC27A5 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc27a5 36
  • 75.89 (n)
  • 71.73 (a)
Slc27a5 16
Slc27a5 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC27A5 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC27A5 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a5 36
  • 75.89 (n)
  • 71.59 (a)
chicken
(Gallus gallus)
Aves SLC27A5 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc27a2a 37
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 37
  • 27 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6780 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for SLC27A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A5 Gene

ENSEMBL:
Gene Tree for SLC27A5 (if available)
TreeFam:
Gene Tree for SLC27A5 (if available)

Paralogs for SLC27A5 Gene

Paralogs for SLC27A5 Gene

Selected SIMAP similar genes for SLC27A5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC27A5: view

Variants for SLC27A5 Gene

Sequence variations from dbSNP and Humsavar for SLC27A5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs880162 -- 58,501,767(-) GAACC(C/T)GGGAG intron-variant
rs1317920 -- 58,501,624(-) GGCAC(A/G)GAGCT intron-variant
rs2003103 -- 58,509,246(-) ACCAC(A/G)CCCGG intron-variant
rs2003104 -- 58,509,230(-) ttttg(A/T)agttt intron-variant
rs2003105 -- 58,509,215(-) agaga(C/T)gggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A5 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
esv2669488 CNV Deletion 23128226
esv2667957 CNV Deletion 23128226
nsv912546 CNV Loss 21882294

Relevant External Links for SLC27A5 Gene

HapMap Linkage Disequilibrium report
SLC27A5
Human Gene Mutation Database (HGMD)
SLC27A5

Disorders for SLC27A5 Gene

Relevant External Links for SLC27A5

Genetic Association Database (GAD)
SLC27A5
Human Genome Epidemiology (HuGE) Navigator
SLC27A5
genes like me logo Genes that share disorders with SLC27A5: view

No data available for UniProtKB/Swiss-Prot for SLC27A5 Gene

Publications for SLC27A5 Gene

  1. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PMID: 10479480) Steinberg S.J. … Watkins P.A. (Mol. Genet. Metab. 1999) 2 3 4
  2. The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase. (PMID: 10749848) Steinberg S.J. … Watkins P.A. (J. Biol. Chem. 2000) 2 3 4
  3. Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. (PMID: 11980911) Mihalik S.J. … Watkins P.A. (J. Biol. Chem. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PMID: 17266179) Fisher E. … DAPring F. (Mol Nutr Food Res 2007) 3 49

Products for SLC27A5 Gene

Sources for SLC27A5 Gene

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