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Aliases for SLC27A5 Gene

Aliases for SLC27A5 Gene

  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 5 2 3
  • Very Long-Chain Acyl-CoA Synthetase-Related Protein 3 4
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 3 3 4
  • Very Long-Chain Acyl-CoA Synthetase Homolog 2 3 4
  • Solute Carrier Family 27 Member 5 3 4
  • Fatty Acid Transport Protein 5 3 4
  • Bile Acid-CoA Ligase 3 4
  • Cholate--CoA Ligase 3 4
  • BA-CoA Ligase 3 4
  • VLACS-Related 3 4
  • VLCS-H2 3 4
  • ACSVL6 3 4
  • FACVL3 3 4
  • FATP-5 3 4
  • VLACSR 3 4
  • VLCSH2 3 4
  • FATP5 3 4
  • ACSB 3 4
  • BACS 3 4
  • BAL 3 4
  • Fatty-Acid-Coenzyme A Ligase 2
  • Very Long-Chain 3 2
  • EC 6.2.1.7 4

External Ids for SLC27A5 Gene

Previous GeneCards Identifiers for SLC27A5 Gene

  • GC19U990162
  • GC19M059463
  • GC19M063666
  • GC19M063701
  • GC19M059009
  • GC19M055319
  • GC19M058990

Summaries for SLC27A5 Gene

Entrez Gene Summary for SLC27A5 Gene

  • The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC27A5 Gene

SLC27A5 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 5) is a Protein Coding gene. Diseases associated with SLC27A5 include amusia and schizophreniform disorder. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Metabolism. GO annotations related to this gene include protein complex binding and very long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A5 Gene

  • Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Gene Wiki entry for SLC27A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A5 Gene

Genomics for SLC27A5 Gene

Regulatory Elements for SLC27A5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC27A5 Gene

Chromosome:
19
Start:
58,479,512 bp from pter
End:
58,512,413 bp from pter
Size:
32,902 bases
Orientation:
Minus strand

Genomic View for SLC27A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC27A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A5 Gene

Proteins for SLC27A5 Gene

  • Protein details for SLC27A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P5-S27A5_HUMAN
    Recommended name:
    Bile acyl-CoA synthetase
    Protein Accession:
    Q9Y2P5
    Secondary Accessions:
    • B3KVP6
    • B4DPQ1

    Protein attributes for SLC27A5 Gene

    Size:
    690 amino acids
    Molecular mass:
    75385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC27A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A5 Gene

Proteomics data for SLC27A5 Gene at MOPED

Post-translational modifications for SLC27A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A5 Gene

Antibody Products

No data available for DME Specific Peptides for SLC27A5 Gene

Domains & Families for SLC27A5 Gene

Protein Domains for SLC27A5 Gene

Suggested Antigen Peptide Sequences for SLC27A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2P5

UniProtKB/Swiss-Prot:

S27A5_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A5: view

Function for SLC27A5 Gene

Molecular function for SLC27A5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
UniProtKB/Swiss-Prot Function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Enzyme Numbers (IUBMB) for SLC27A5 Gene

Gene Ontology (GO) - Molecular Function for SLC27A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0005524 ATP binding IEA --
GO:0015245 fatty acid transporter activity IEA --
GO:0031957 very long-chain fatty acid-CoA ligase activity IDA 10479480
genes like me logo Genes that share ontologies with SLC27A5: view
genes like me logo Genes that share phenotypes with SLC27A5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC27A5 Gene

Localization for SLC27A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A5 Gene COMPARTMENTS Subcellular localization image for SLC27A5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC27A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 10479480
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0009925 basal plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 11980911
genes like me logo Genes that share ontologies with SLC27A5: view

Pathways & Interactions for SLC27A5 Gene

genes like me logo Genes that share pathways with SLC27A5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC27A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 10479480
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006642 triglyceride mobilization IEA --
GO:0006699 bile acid biosynthetic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with SLC27A5: view

No data available for SIGNOR curated interactions for SLC27A5 Gene

Drugs & Compounds for SLC27A5 Gene

(8) Drugs for SLC27A5 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chenodeoxycholic acid Approved Pharma Antagonist 23
cholic acid Approved Pharma Full agonist, Agonist 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(42) Additional Compounds for SLC27A5 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oyl-CoA
(25R)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
genes like me logo Genes that share compounds with SLC27A5: view

Transcripts for SLC27A5 Gene

Unigene Clusters for SLC27A5 Gene

Solute carrier family 27 (fatty acid transporter), member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SLC27A5 Gene

GeneLoc Exon Structure for
SLC27A5
ECgene alternative splicing isoforms for
SLC27A5

Expression for SLC27A5 Gene

mRNA expression in normal human tissues for SLC27A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC27A5 Gene

This gene is overexpressed in Liver (x39.8).

Protein differential expression in normal tissues from HIPED for SLC27A5 Gene

This gene is overexpressed in Gallbladder (42.9) and Liver (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC27A5 Gene



SOURCE GeneReport for Unigene cluster for SLC27A5 Gene Hs.292177

mRNA Expression by UniProt/SwissProt for SLC27A5 Gene

Q9Y2P5-S27A5_HUMAN
Tissue specificity: Predominantly expressed in liver.
genes like me logo Genes that share expression patterns with SLC27A5: view

Protein tissue co-expression partners for SLC27A5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC27A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC27A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC27A5 35
  • 79.95 (n)
  • 76.67 (a)
SLC27A5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a5 35
  • 75.89 (n)
  • 71.73 (a)
Slc27a5 16
Slc27a5 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC27A5 35
  • 99.42 (n)
  • 99.28 (a)
SLC27A5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a5 35
  • 75.89 (n)
  • 71.59 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC27A5 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC27A5 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC27A5 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc27a2a 36
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 27 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6780 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for SLC27A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A5 Gene

ENSEMBL:
Gene Tree for SLC27A5 (if available)
TreeFam:
Gene Tree for SLC27A5 (if available)

Paralogs for SLC27A5 Gene

Paralogs for SLC27A5 Gene

(6) SIMAP similar genes for SLC27A5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC27A5: view

Variants for SLC27A5 Gene

Sequence variations from dbSNP and Humsavar for SLC27A5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7245675 -- 58,510,986(+) TGCGA(A/G)GCGGG intron-variant
rs16988781 -- 58,512,209(-) GCAGA(G/T)ACCTG upstream-variant-2KB
rs34415062 - 58,511,799(+) GGGCC(A/G)TGCTA reference, missense
rs35350976 - 58,511,807(+) CTAAC(A/G)TGGCC missense, reference
rs113221451 -- 58,510,574(+) CCTCG(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A5 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
esv2669488 CNV Deletion 23128226
esv2667957 CNV Deletion 23128226
nsv912546 CNV Loss 21882294

Variation tolerance for SLC27A5 Gene

Residual Variation Intolerance Score: 73.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC27A5 Gene

HapMap Linkage Disequilibrium report
SLC27A5
Human Gene Mutation Database (HGMD)
SLC27A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A5 Gene

Disorders for SLC27A5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC27A5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amusia
  • receptive amusia
schizophreniform disorder
  • schizophreniform disorders
schizophrenia
  • schizophrenia 12
- elite association

Relevant External Links for SLC27A5

Genetic Association Database (GAD)
SLC27A5
Human Genome Epidemiology (HuGE) Navigator
SLC27A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC27A5
genes like me logo Genes that share disorders with SLC27A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC27A5 Gene

Publications for SLC27A5 Gene

  1. Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. (PMID: 19054139) Mitsuyoshi H. … Yoshikawa T. (Hepatol. Res. 2009) 23 67
  2. Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. (PMID: 16399361) Shonsey E.M. … Barnes S. (Meth. Enzymol. 2005) 23 67
  3. Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization. (PMID: 12951368) He D. … Falany C.N. (J. Lipid Res. 2003) 23 67
  4. Farnesoid X receptor regulates bile acid-amino acid conjugation. (PMID: 12754200) Pircher P.C. … Westin S.K. (J. Biol. Chem. 2003) 23 67
  5. Molecular cloning and expression of rat liver bile acid CoA ligase. (PMID: 12454267) Falany C.N. … Barnes S. (J. Lipid Res. 2002) 23 67

Products for SLC27A5 Gene

Sources for SLC27A5 Gene

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