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Aliases for SLC38A3 Gene

Aliases for SLC38A3 Gene

  • Solute Carrier Family 38, Member 3 2 3
  • G17 3 4 6
  • SN1 3 4 6
  • Na(+)-Coupled Neutral Amino Acid Transporter 3 3 4
  • System N Amino Acid Transporter 1 3 4
  • N-System Amino Acid Transporter 1 3 4
  • SNAT3 3 4
  • NAT1 3 4
  • System N1 Na+ And H+-Coupled Glutamine Transporter 3
  • Sodium-Coupled Neutral Amino Acid Transporter 3 3
  • Solute Carrier Family 38 Member 3 4

External Ids for SLC38A3 Gene

Summaries for SLC38A3 Gene

GeneCards Summary for SLC38A3 Gene

SLC38A3 (Solute Carrier Family 38, Member 3) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include symporter activity and L-alanine transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC38A3 Gene

  • Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Gene Wiki entry for SLC38A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A3 Gene

Genomics for SLC38A3 Gene

Genomic Location for SLC38A3 Gene

Start:
50,205,246 bp from pter
End:
50,221,486 bp from pter
Size:
16,241 bases
Orientation:
Plus strand

Genomic View for SLC38A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC38A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A3 Gene

Regulatory Elements for SLC38A3 Gene

Proteins for SLC38A3 Gene

  • Protein details for SLC38A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99624-S38A3_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 3
    Protein Accession:
    Q99624
    Secondary Accessions:
    • B2R8Q0
    • Q6IB34

    Protein attributes for SLC38A3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55773 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC38A3 Gene

Proteomics data for SLC38A3 Gene at MOPED

Post-translational modifications for SLC38A3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn74, Asn247, Asn248, Asn252, and Asn323

Other Protein References for SLC38A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC38A3 Gene

Domains for SLC38A3 Gene

Gene Families for SLC38A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC38A3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S38A3_HUMAN
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.:
    • Q99624
genes like me logo Genes that share domains with SLC38A3: view

Function for SLC38A3 Gene

Molecular function for SLC38A3 Gene

UniProtKB/Swiss-Prot Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Gene Ontology (GO) - Molecular Function for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005290 L-histidine transmembrane transporter activity IDA 10823827
GO:0015180 L-alanine transmembrane transporter activity IDA 10823827
GO:0015182 L-asparagine transmembrane transporter activity IDA 10823827
GO:0015186 L-glutamine transmembrane transporter activity IDA 10823827
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC38A3: view

miRNA for SLC38A3 Gene

miRTarBase miRNAs that target SLC38A3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC38A3 Gene

Localization for SLC38A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
genes like me logo Genes that share ontologies with SLC38A3: view

Pathways for SLC38A3 Gene

genes like me logo Genes that share pathways with SLC38A3: view

Interacting Proteins for SLC38A3 Gene

Selected Interacting proteins: Q99624-S38A3_HUMAN for SLC38A3 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport TAS --
GO:0006867 asparagine transport IDA 10823827
GO:0006868 glutamine transport IDA 10823827
genes like me logo Genes that share ontologies with SLC38A3: view

Compounds for SLC38A3 Gene

(5) HMDB Compounds for SLC38A3 Gene

Compound Synonyms Cas Number PubMed IDs
L-Alanine
  • (2S)-2-Aminopropanoate
56-41-7
L-Asparagine
  • (-)-Asparagine
70-47-3
L-Glutamine
  • (2S)-2,5-diamino-5-oxopentanoic acid
56-85-9
L-Histidine
  • (S)-1H-Imidazole-4-alanine
71-00-1
Sodium
  • Sodium
7440-23-5

(3) Drugbank Compounds for SLC38A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Asparagine
  • (-)-Asparagine
70-47-3 target
L-Glutamine
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 transporter substrate
L-Histidine
  • (S)-4-(2-Amino-2-carboxyethyl)imidazole
71-00-1 target

(2) IUPHAR Ligand for SLC38A3 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]glutamine None None
[3H]glutamine None None

(1) Novoseek inferred chemical compound relationships for SLC38A3 Gene

Compound -log(P) Hits PubMed IDs
glutamine 54.5 3
genes like me logo Genes that share compounds with SLC38A3: view

Transcripts for SLC38A3 Gene

Unigene Clusters for SLC38A3 Gene

Solute carrier family 38, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for SLC38A3 Gene

GeneLoc Exon Structure for
SLC38A3
ECgene alternative splicing isoforms for
SLC38A3

Expression for SLC38A3 Gene

mRNA expression in normal human tissues for SLC38A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A3 Gene

This gene is overexpressed in Liver (23.8) and Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC38A3 Gene

SOURCE GeneReport for Unigene cluster for SLC38A3 Gene Hs.76460

genes like me logo Genes that share expressions with SLC38A3: view

Orthologs for SLC38A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC38A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A3 36
  • 99.6 (n)
  • 99.21 (a)
cow
(Bos Taurus)
Mammalia SLC38A3 36
  • 89.09 (n)
  • 89.68 (a)
dog
(Canis familiaris)
Mammalia SLC38A3 36
  • 90.54 (n)
  • 92.26 (a)
mouse
(Mus musculus)
Mammalia Slc38a3 36
  • 87.21 (n)
  • 90.26 (a)
Slc38a3 16
rat
(Rattus norvegicus)
Mammalia Slc38a3 36
  • 87.81 (n)
  • 90.06 (a)
chicken
(Gallus gallus)
Aves SLC38A3 36
  • 78.33 (n)
  • 79.4 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a3 36
  • 72.45 (n)
  • 77.02 (a)
zebrafish
(Danio rerio)
Actinopterygii slc38a5b 36
  • 65.73 (n)
  • 67.17 (a)
wufc48a10 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G38820 36
  • 41.05 (n)
  • 32.32 (a)
rice
(Oryza sativa)
Liliopsida Os06g0275800 36
  • 44.68 (n)
  • 32.71 (a)
Species with no ortholog for SLC38A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A3 Gene

ENSEMBL:
Gene Tree for SLC38A3 (if available)
TreeFam:
Gene Tree for SLC38A3 (if available)

Paralogs for SLC38A3 Gene

Selected SIMAP similar genes for SLC38A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC38A3: view

No data available for Paralogs for SLC38A3 Gene

Variants for SLC38A3 Gene

Sequence variations from dbSNP and Humsavar for SLC38A3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs739430 -- 50,218,042(+) AGCTG(C/G)TTTGG intron-variant
rs739431 -- 50,217,873(+) GCCCA(A/G)TGAGA intron-variant
rs886075 -- 50,219,496(-) GAGAA(C/T)GAAGA intron-variant
rs1858828 -- 50,204,954(-) GCTTC(A/C)GCCAA upstream-variant-2KB
rs2006199 -- 50,204,188(-) CCTGG(C/T)GTACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC38A3 Gene

Variant ID Type Subtype PubMed ID
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680
nsv876768 CNV Gain 21882294
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv602n27 CNV Loss 19166990
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv876771 CNV Loss 21882294
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294

Relevant External Links for SLC38A3 Gene

HapMap Linkage Disequilibrium report
SLC38A3

Disorders for SLC38A3 Gene

Relevant External Links for SLC38A3

Genetic Association Database (GAD)
SLC38A3
genes like me logo Genes that share disorders with SLC38A3: view

No data available for UniProtKB/Swiss-Prot for SLC38A3 Gene

Publications for SLC38A3 Gene

  1. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. (PMID: 10619430) Chaudhry F.A. … Edwards R.H. (Cell 1999) 2 3 23
  2. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+- coupled glutamine transporter. (PMID: 10823827) Fei Y.-J. … Ganapathy V. (J. Biol. Chem. 2000) 2 3 4
  3. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PMID: 16432833) Kholodnyuk I.D. … Imreh S. (Int. J. Cancer 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4

Products for SLC38A3 Gene

Sources for SLC38A3 Gene

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