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Aliases for PNRC1 Gene

Aliases for PNRC1 Gene

  • Proline-Rich Nuclear Receptor Coactivator 1 2 3
  • PROL2 3 4 6
  • Proline-Rich Protein 2 3 4
  • Protein B4-2 3 4
  • Proline-Rich Protein With Nuclear Targeting Signal 3
  • Proline-Rich Polypeptide 2 3
  • Proline Rich 2 Protein 3
  • Proline Rich 2 2
  • PNAS-145 3
  • PRR2 3
  • B4-2 3

External Ids for PNRC1 Gene

Previous Symbols for PNRC1 Gene

  • PROL2

Summaries for PNRC1 Gene

GeneCards Summary for PNRC1 Gene

PNRC1 (Proline-Rich Nuclear Receptor Coactivator 1) is a Protein Coding gene. An important paralog of this gene is PNRC2.

UniProtKB/Swiss-Prot for PNRC1 Gene

  • Nuclear receptor coactivator. May play a role in signal transduction.

Gene Wiki entry for PNRC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNRC1 Gene

Genomics for PNRC1 Gene

Genomic Location for PNRC1 Gene

Start:
89,080,710 bp from pter
End:
89,085,160 bp from pter
Size:
4,451 bases
Orientation:
Plus strand

Genomic View for PNRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNRC1 Gene

Regulatory Elements for PNRC1 Gene

Proteins for PNRC1 Gene

  • Protein details for PNRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12796-PNRC1_HUMAN
    Recommended name:
    Proline-rich nuclear receptor coactivator 1
    Protein Accession:
    Q12796
    Secondary Accessions:
    • B2R6Q0
    • E1P515
    • Q5T7J6
    • Q7Z5N0

    Protein attributes for PNRC1 Gene

    Size:
    327 amino acids
    Molecular mass:
    35225 Da
    Quaternary structure:
    • Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2.
    SequenceCaution:
    • Sequence=CAI16244.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PNRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNRC1 Gene

Proteomics data for PNRC1 Gene at MOPED

Post-translational modifications for PNRC1 Gene

No Post-translational modifications

Other Protein References for PNRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNRC1 Gene

Domains for PNRC1 Gene

Protein Domains for PNRC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PNRC1_HUMAN
Domain:
  • The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif:
    • Q12796
Family:
  • Belongs to the PNRC family. PNRC1 subfamily.:
    • Q12796
genes like me logo Genes that share domains with PNRC1: view

No data available for Gene Families for PNRC1 Gene

Function for PNRC1 Gene

Molecular function for PNRC1 Gene

UniProtKB/Swiss-Prot Function: Nuclear receptor coactivator. May play a role in signal transduction.

Gene Ontology (GO) - Molecular Function for PNRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17612402
genes like me logo Genes that share ontologies with PNRC1: view

Phenotypes for PNRC1 Gene

GenomeRNAi human phenotypes for PNRC1:
genes like me logo Genes that share phenotypes with PNRC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PNRC1 Gene

Localization for PNRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNRC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNRC1 Gene COMPARTMENTS Subcellular localization image for PNRC1 gene
Compartment Confidence
nucleus 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PNRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PNRC1: view

Pathways for PNRC1 Gene

SuperPathways for PNRC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PNRC1: view

No data available for Pathways by source for PNRC1 Gene

Transcripts for PNRC1 Gene

mRNA/cDNA for PNRC1 Gene

Unigene Clusters for PNRC1 Gene

Proline-rich nuclear receptor coactivator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNRC1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for PNRC1 Gene

GeneLoc Exon Structure for
PNRC1
ECgene alternative splicing isoforms for
PNRC1

Expression for PNRC1 Gene

mRNA expression in normal human tissues for PNRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNRC1 Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNRC1 Gene

SOURCE GeneReport for Unigene cluster for PNRC1 Gene Hs.75969

mRNA Expression by UniProt/SwissProt for PNRC1 Gene

Q12796-PNRC1_HUMAN
Tissue specificity: Expressed in liver, lung, fat and NK/T cells.
genes like me logo Genes that share expressions with PNRC1: view

Orthologs for PNRC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PNRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNRC1 36
  • 99.49 (n)
  • 99.39 (a)
PNRC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PNRC1 36
  • 88.38 (n)
  • 88.69 (a)
PNRC1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNRC1 36
  • 89.91 (n)
  • 89.91 (a)
PNRC1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnrc1 36
  • 81.59 (n)
  • 83.5 (a)
Pnrc1 16
Pnrc1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNRC1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pnrc1 36
  • 80.71 (n)
  • 81.89 (a)
chicken
(Gallus gallus)
Aves PNRC1 36
  • 67.3 (n)
  • 61.74 (a)
PNRC1 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNRC1 37
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pnrc1 37
  • 29 (a)
OneToOne
Species with no ortholog for PNRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNRC1 Gene

ENSEMBL:
Gene Tree for PNRC1 (if available)
TreeFam:
Gene Tree for PNRC1 (if available)

Paralogs for PNRC1 Gene

Paralogs for PNRC1 Gene

Selected SIMAP similar genes for PNRC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNRC1: view

Variants for PNRC1 Gene

Sequence variations from dbSNP and Humsavar for PNRC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs12445 -- 89,084,677(+) GATTT(C/G)TAATC utr-variant-3-prime
rs1130809 -- 89,084,175(+) AAAAC(C/G)CTCCT synonymous-codon, reference
rs1574008 -- 89,083,005(-) AAAAA(A/C)AACAA intron-variant
rs2231263 -- 89,080,312(+) GCAGC(G/T)GAGGA upstream-variant-2KB
rs2231264 -- 89,080,423(+) CCGCC(C/G)GGACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PNRC1 Gene

Variant ID Type Subtype PubMed ID
nsv886336 CNV Loss 21882294
nsv886337 CNV Loss 21882294

Relevant External Links for PNRC1 Gene

HapMap Linkage Disequilibrium report
PNRC1

Disorders for PNRC1 Gene

Relevant External Links for PNRC1

Genetic Association Database (GAD)
PNRC1
Human Genome Epidemiology (HuGE) Navigator
PNRC1
genes like me logo Genes that share disorders with PNRC1: view

No data available for UniProtKB/Swiss-Prot for PNRC1 Gene

Publications for PNRC1 Gene

  1. Cloning a cDNA from human NK/T cells which codes for a protein with high proline content. (PMID: 7578250) Chen J. … Pohajdak B. (Biochim. Biophys. Acta 1995) 2 3 4
  2. PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1). (PMID: 10894149) Zhou D. … Chen S. (Mol. Endocrinol. 2000) 3 4
  3. PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PMID: 11574675) Zhou D. … Chen S. (Nucleic Acids Res. 2001) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PNRC1 Gene

Sources for PNRC1 Gene

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