Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PNRC1 Gene

Aliases for PNRC1 Gene

  • Proline Rich Nuclear Receptor Coactivator 1 2 3 5
  • Proline-Rich Nuclear Receptor Coactivator 1 2 3
  • Proline-Rich Protein 2 3 4
  • Protein B4-2 3 4
  • PROL2 3 4
  • Proline-Rich Protein With Nuclear Targeting Signal 3
  • Proline-Rich Polypeptide 2 3
  • Proline Rich 2 Protein 3
  • Proline Rich 2 2
  • PNAS-145 3
  • PRR2 3
  • B4-2 3

External Ids for PNRC1 Gene

Previous HGNC Symbols for PNRC1 Gene

  • PROL2

Previous GeneCards Identifiers for PNRC1 Gene

  • GC06P089740
  • GC06P089786
  • GC06P089847
  • GC06P089790
  • GC06P087006

Summaries for PNRC1 Gene

GeneCards Summary for PNRC1 Gene

PNRC1 (Proline Rich Nuclear Receptor Coactivator 1) is a Protein Coding gene. Diseases associated with PNRC1 include Uremic Neuropathy. An important paralog of this gene is PNRC2.

UniProtKB/Swiss-Prot for PNRC1 Gene

  • Nuclear receptor coactivator. May play a role in signal transduction.

Gene Wiki entry for PNRC1 Gene

Additional gene information for PNRC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNRC1 Gene

Genomics for PNRC1 Gene

Regulatory Elements for PNRC1 Gene

Enhancers for PNRC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H089033 1.7 FANTOM5 Ensembl ENCODE 15.5 -44.8 -44804 4.2 PKNOX1 FOXA2 ATF1 ARNT ARID4B SIN3A FEZF1 DMAP1 BRCA1 YY1 PNRC1 SRSF12 RNGTT UBE2J1 RRAGD GC06M089046 PIR60881
GH06H089044 1 FANTOM5 Ensembl ENCODE 14.8 -35.6 -35647 1.6 SPI1 TCF7L2 PNRC1 UBE2J1 RNGTT RRAGD GC06M089046 PIR60881
GH06H089072 1.4 Ensembl ENCODE dbSUPER 5.9 -7.6 -7621 1.8 HDAC1 ATF1 ARNT TCF12 GATA2 ATF7 CREM ZNF680 ZBTB2 CEBPB SRSF12 GABRR1 PNRC1 ENSG00000271931 RNU2-61P GC06M089064
GH06H089321 1.4 FANTOM5 Ensembl ENCODE 5.3 +241.0 240991 1 HDAC1 PKNOX1 ATF1 TBL1XR1 CHAMP1 TCF12 CBX5 GATA2 ETV6 RUNX3 SRSF12 PNRC1 UBE2J1 GC06M089320
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PNRC1 on UCSC Golden Path with GeneCards custom track

Promoters for PNRC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for PNRC1 Gene

Genomic Locations for PNRC1 Gene
4,451 bases
Plus strand

Genomic View for PNRC1 Gene

Genes around PNRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNRC1 Gene

Proteins for PNRC1 Gene

  • Protein details for PNRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich nuclear receptor coactivator 1
    Protein Accession:
    Secondary Accessions:
    • B2R6Q0
    • E1P515
    • Q5T7J6
    • Q7Z5N0

    Protein attributes for PNRC1 Gene

    327 amino acids
    Molecular mass:
    35225 Da
    Quaternary structure:
    • Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2.
    • Sequence=CAI16244.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PNRC1 Gene


neXtProt entry for PNRC1 Gene

Post-translational modifications for PNRC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNRC1 Gene

Domains & Families for PNRC1 Gene

Gene Families for PNRC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PNRC1 Gene


Suggested Antigen Peptide Sequences for PNRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif.
  • Belongs to the PNRC family. PNRC1 subfamily.
  • The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif.
  • Belongs to the PNRC family. PNRC1 subfamily.
genes like me logo Genes that share domains with PNRC1: view

Function for PNRC1 Gene

Molecular function for PNRC1 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coactivator. May play a role in signal transduction.

Gene Ontology (GO) - Molecular Function for PNRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17612402
genes like me logo Genes that share ontologies with PNRC1: view
genes like me logo Genes that share phenotypes with PNRC1: view

Animal Model Products

miRNA for PNRC1 Gene

miRTarBase miRNAs that target PNRC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNRC1 Gene

Localization for PNRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNRC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNRC1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PNRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA --
GO:0005634 nucleus IBA,TAS --
genes like me logo Genes that share ontologies with PNRC1: view

Pathways & Interactions for PNRC1 Gene

SuperPathways for PNRC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA --
genes like me logo Genes that share ontologies with PNRC1: view

No data available for Pathways by source and SIGNOR curated interactions for PNRC1 Gene

Drugs & Compounds for PNRC1 Gene

No Compound Related Data Available

Transcripts for PNRC1 Gene

mRNA/cDNA for PNRC1 Gene

Unigene Clusters for PNRC1 Gene

Proline-rich nuclear receptor coactivator 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNRC1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP2: - -
SP3: -

Relevant External Links for PNRC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PNRC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNRC1 Gene

mRNA differential expression in normal tissues according to GTEx for PNRC1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNRC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PNRC1 Gene:


SOURCE GeneReport for Unigene cluster for PNRC1 Gene:


mRNA Expression by UniProt/SwissProt for PNRC1 Gene:

Tissue specificity: Expressed in liver, lung, fat and NK/T cells.

Evidence on tissue expression from TISSUES for PNRC1 Gene

  • Skin(4.3)
  • Nervous system(3.5)
  • Blood(2.7)
  • Bone marrow(2.5)
  • Lung(2.5)
  • Muscle(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PNRC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNRC1 Gene

Orthologs for PNRC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PNRC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PNRC1 33 34
  • 99.49 (n)
(Canis familiaris)
Mammalia PNRC1 33 34
  • 89.91 (n)
(Bos Taurus)
Mammalia PNRC1 33 34
  • 88.38 (n)
(Mus musculus)
Mammalia Pnrc1 33 16 34
  • 81.59 (n)
(Rattus norvegicus)
Mammalia Pnrc1 33
  • 80.71 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
-- 34
  • 80 (a)
(Monodelphis domestica)
Mammalia PNRC1 34
  • 74 (a)
(Gallus gallus)
Aves PNRC1 33 34
  • 67.3 (n)
(Anolis carolinensis)
Reptilia PNRC1 34
  • 49 (a)
(Danio rerio)
Actinopterygii pnrc1 34
  • 29 (a)
Species where no ortholog for PNRC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNRC1 Gene

Gene Tree for PNRC1 (if available)
Gene Tree for PNRC1 (if available)

Paralogs for PNRC1 Gene

Paralogs for PNRC1 Gene

(2) SIMAP similar genes for PNRC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNRC1: view

Variants for PNRC1 Gene

Sequence variations from dbSNP and Humsavar for PNRC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000545109 -- 89,081,796(+) CGTCA(A/G)CGCGC intron-variant, nc-transcript-variant
rs1000610051 -- 89,082,490(+) CTTTT(A/G)AAATA intron-variant
rs1001227809 -- 89,080,752(+) ATTTG(G/T)TGCTG nc-transcript-variant, utr-variant-5-prime
rs1001596882 -- 89,083,000(+) GTTTT(-/TTG)TTGTT intron-variant
rs1001712011 -- 89,085,627(+) TATGT(C/T)CAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PNRC1 Gene

Variant ID Type Subtype PubMed ID
nsv1122134 CNV deletion 24896259
nsv1073994 CNV deletion 25765185

Variation tolerance for PNRC1 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNRC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNRC1 Gene

Disorders for PNRC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNRC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uremic neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search PNRC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNRC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PNRC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNRC1 Gene

Publications for PNRC1 Gene

  1. Cloning a cDNA from human NK/T cells which codes for a protein with high proline content. (PMID: 7578250) Chen J … Pohajdak B (Biochimica et biophysica acta 1995) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PMID: 11574675) Zhou D … Chen S (Nucleic acids research 2001) 3 4 60
  5. PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1). (PMID: 10894149) Zhou D … Chen S (Molecular endocrinology (Baltimore, Md.) 2000) 3 4 60

Products for PNRC1 Gene

Sources for PNRC1 Gene

Loading form....