Aliases for CBX1 Gene
External Ids for CBX1 Gene
Previous GeneCards Identifiers for CBX1 Gene
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBX1 Gene
CBX1 (Chromobox Homolog 1) is a Protein Coding gene. Diseases associated with CBX1 include mandibuloacral dysplasia. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include protein homodimerization activity and chromatin binding. An important paralog of this gene is CBX5.
UniProtKB/Swiss-Prot for CBX1 Gene
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane