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Aliases for HNRNPA0 Gene

Aliases for HNRNPA0 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A0 2 3 5
  • HnRNP A0 3 4
  • HNRPA0 3 4
  • HnRNA Binding Protein 3

External Ids for HNRNPA0 Gene

Previous HGNC Symbols for HNRNPA0 Gene

  • HNRPA0

Previous GeneCards Identifiers for HNRNPA0 Gene

  • GC05M137114
  • GC05M132277

Summaries for HNRNPA0 Gene

Entrez Gene Summary for HNRNPA0 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA0 Gene

HNRNPA0 (Heterogeneous Nuclear Ribonucleoprotein A0) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA3.

UniProtKB/Swiss-Prot for HNRNPA0 Gene

  • mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Wiki entry for HNRNPA0 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA0 Gene

Genomics for HNRNPA0 Gene

Regulatory Elements for HNRNPA0 Gene

Enhancers for HNRNPA0 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G138463 1.8 FANTOM5 ENCODE dbSUPER 25.4 -710.9 -710873 4.1 CREB3L1 AGO1 YY1 ZNF143 ZNF263 SP3 SSRP1 ZNF610 ZNF585B GLIS1 HNRNPA0 EGR1 CDC23 KDM3B FAM53C REEP2 LRRTM2 CDC25C ETF1 FAM13B
GH05G137751 1.4 ENCODE dbSUPER 32 +0.9 944 4.6 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 HNRNPA0 KDM3B RPL7P19 CDC23 FAM13B PKD2L2 GC05M137746
GH05G137759 0.9 ENCODE 28.4 -6.4 -6433 2.5 TBP FOXA2 ZNF473 INSM2 KLF17 BMI1 BRCA1 GTF3C2 ZSCAN5C FOS HNRNPA0 CDC23 KDM3B MYOT ENSG00000270697 PIR60264
GH05G138635 0.8 Ensembl ENCODE 31.9 -881.0 -880953 1.4 ZNF791 ZNF366 ZNF512 FEZF1 ZNF514 ZNF507 HNRNPA0 CDC23 RPL7P19 KDM3B LOC105379194 ENSG00000238745
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPA0 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187427 776 3601 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for HNRNPA0 Gene

137,745,651 bp from pter
137,754,376 bp from pter
8,726 bases
Minus strand

Genomic View for HNRNPA0 Gene

Genes around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA0 Gene

Proteins for HNRNPA0 Gene

  • Protein details for HNRNPA0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A0
    Protein Accession:
    Secondary Accessions:
    • Q6IB18

    Protein attributes for HNRNPA0 Gene

    305 amino acids
    Molecular mass:
    30841 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA0 Gene

Post-translational modifications for HNRNPA0 Gene

  • Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
  • Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
  • Ubiquitination at isoforms=45, posLast=8080, posLast=106106, posLast=133133, and posLast=172172
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA0 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA0 Gene

Domains & Families for HNRNPA0 Gene

Gene Families for HNRNPA0 Gene

Protein Domains for HNRNPA0 Gene

Suggested Antigen Peptide Sequences for HNRNPA0 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPA0: view

No data available for UniProtKB/Swiss-Prot for HNRNPA0 Gene

Function for HNRNPA0 Gene

Molecular function for HNRNPA0 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Ontology (GO) - Molecular Function for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,TAS 22658674
GO:0017091 AU-rich element binding IDA 20932473
GO:0019901 protein kinase binding IPI 20932473
genes like me logo Genes that share ontologies with HNRNPA0: view
genes like me logo Genes that share phenotypes with HNRNPA0: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA0 Gene

miRTarBase miRNAs that target HNRNPA0

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA0 Gene

Localization for HNRNPA0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA0 gene
Compartment Confidence
nucleus 5
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7585247
GO:0005654 nucleoplasm TAS --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPA0: view

Pathways & Interactions for HNRNPA0 Gene

genes like me logo Genes that share pathways with HNRNPA0: view

Pathways by source for HNRNPA0 Gene

Gene Ontology (GO) - Biological Process for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 7585247
GO:0006954 inflammatory response ISS,IEA --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPA0: view

No data available for SIGNOR curated interactions for HNRNPA0 Gene

Drugs & Compounds for HNRNPA0 Gene

No Compound Related Data Available

Transcripts for HNRNPA0 Gene

mRNA/cDNA for HNRNPA0 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(628) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNRNPA0 Gene

Heterogeneous nuclear ribonucleoprotein A0:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA0 Gene

No ASD Table

Relevant External Links for HNRNPA0 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPA0 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPA0 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPA0 Gene

This gene is overexpressed in Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA0 Gene

Protein tissue co-expression partners for HNRNPA0 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPA0 Gene:


SOURCE GeneReport for Unigene cluster for HNRNPA0 Gene:


Evidence on tissue expression from TISSUES for HNRNPA0 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Muscle(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Skin(4.4)
  • Stomach(2.3)
  • Heart(2.2)
  • Intestine(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with HNRNPA0: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA0 Gene

Orthologs for HNRNPA0 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPA0 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HNRNPA0 35
  • 100 (a)
(Bos Taurus)
Mammalia HNRPA0 35
  • 98 (a)
  • 94.3 (n)
(Canis familiaris)
Mammalia HNRNPA0 35
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPA0 35
  • 94 (a)
(Rattus norvegicus)
Mammalia LOC681410 34
  • 85.19 (n)
(Mus musculus)
Mammalia Hnrnpa0 34 16 35
  • 83.21 (n)
(Monodelphis domestica)
Mammalia HNRNPA0 35
  • 71 (a)
(Gallus gallus)
Aves HNRNPA0 34 35
  • 78.86 (n)
(Anolis carolinensis)
Reptilia HNRNPA0 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpa0 34
  • 68.43 (n)
MGC75874 34
African clawed frog
(Xenopus laevis)
Amphibia hnrpa0-prov 34
(Danio rerio)
Actinopterygii hnrnpa0a 35
  • 60 (a)
hnrnpa0b 35
  • 59 (a)
hnrnpa0l 35
  • 58 (a)
wufc01g05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6239 34
fruit fly
(Drosophila melanogaster)
Insecta Hrb87F 35
  • 36 (a)
Hrb98DE 35
  • 35 (a)
Rb97D 35
  • 23 (a)
(Caenorhabditis elegans)
Secernentea hrp-1 35
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10370 35
  • 27 (a)
Species where no ortholog for HNRNPA0 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPA0 Gene

Gene Tree for HNRNPA0 (if available)
Gene Tree for HNRNPA0 (if available)

Paralogs for HNRNPA0 Gene

(17) SIMAP similar genes for HNRNPA0 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA0: view

Variants for HNRNPA0 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA0 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000328463 -- 137,755,130(+) CCCGA(C/T)GTGCG upstream-variant-2KB
rs1000408900 -- 137,756,220(+) CCATA(C/T)GGTAA upstream-variant-2KB
rs1000803343 -- 137,751,838(+) AGCTA(C/T)GCATA utr-variant-3-prime
rs1000828489 -- 137,751,439(+) TCTTA(C/G)TATAG utr-variant-3-prime
rs1000902001 -- 137,751,119(+) TGTAC(-/AACT)ATTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA0 Gene

Variant ID Type Subtype PubMed ID
nsv819360 CNV gain 19587683
nsv830500 CNV loss 17160897

Variation tolerance for HNRNPA0 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA0 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Disorders for HNRNPA0 Gene

Relevant External Links for HNRNPA0

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HNRNPA0 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA0 Gene

Publications for HNRNPA0 Gene

  1. Isolation and characterization of a novel, low abundance hnRNP protein: A0. (PMID: 7585247) Myer V.E. … Steitz J.A. (RNA 1995) 2 3 4 64
  2. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt H.C. … Yaffe M.B. (Mol. Cell 2010) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP- K2 and its interaction with cytokine mRNAs. (PMID: 12456657) Rousseau S. … Cohen P. (EMBO J. 2002) 3 4 64
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64

Products for HNRNPA0 Gene

Sources for HNRNPA0 Gene

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