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Aliases for HNRNPA0 Gene

Aliases for HNRNPA0 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A0 2 3
  • HNRPA0 3 4 6
  • HnRNP A0 3 4
  • HnRNA Binding Protein 3

External Ids for HNRNPA0 Gene

Previous Symbols for HNRNPA0 Gene

  • HNRPA0

Summaries for HNRNPA0 Gene

Entrez Gene Summary for HNRNPA0 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA0 Gene

HNRNPA0 (Heterogeneous Nuclear Ribonucleoprotein A0) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and protein kinase binding. An important paralog of this gene is HNRNPDL.

UniProtKB/Swiss-Prot for HNRNPA0 Gene

  • mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Wiki entry for HNRNPA0 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA0 Gene

Genomics for HNRNPA0 Gene

Genomic Location for HNRNPA0 Gene

Start:
137,750,427 bp from pter
End:
137,754,376 bp from pter
Size:
3,950 bases
Orientation:
Minus strand

Genomic View for HNRNPA0 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPA0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA0 Gene

Regulatory Elements for HNRNPA0 Gene

Proteins for HNRNPA0 Gene

  • Protein details for HNRNPA0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13151-ROA0_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A0
    Protein Accession:
    Q13151
    Secondary Accessions:
    • Q6IB18

    Protein attributes for HNRNPA0 Gene

    Size:
    305 amino acids
    Molecular mass:
    30841 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA0 Gene

Proteomics data for HNRNPA0 Gene at MOPED

Post-translational modifications for HNRNPA0 Gene

  • Arg-291 is dimethylated, probably to asymmetric dimethylarginine
  • Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys45, Lys80, Lys99, Lys106, Lys133, and Lys172

Other Protein References for HNRNPA0 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA0 Gene

Domains for HNRNPA0 Gene

Gene Families for HNRNPA0 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPA0 Gene

UniProtKB/Swiss-Prot:

ROA0_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q13151
genes like me logo Genes that share domains with HNRNPA0: view

Function for HNRNPA0 Gene

Molecular function for HNRNPA0 Gene

UniProtKB/Swiss-Prot Function: mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Ontology (GO) - Molecular Function for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 7585247
GO:0017091 AU-rich element binding IDA 20932473
GO:0019901 protein kinase binding IPI 20932473
genes like me logo Genes that share ontologies with HNRNPA0: view

Phenotypes for HNRNPA0 Gene

GenomeRNAi human phenotypes for HNRNPA0:
genes like me logo Genes that share phenotypes with HNRNPA0: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPA0 Gene

Localization for HNRNPA0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA0 Gene COMPARTMENTS Subcellular localization image for HNRNPA0 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7585247
GO:0005654 nucleoplasm TAS --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPA0: view

Pathways for HNRNPA0 Gene

genes like me logo Genes that share pathways with HNRNPA0: view

Pathways by source for HNRNPA0 Gene

Gene Ontology (GO) - Biological Process for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 7585247
GO:0006954 inflammatory response ISS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPA0: view

Transcripts for HNRNPA0 Gene

mRNA/cDNA for HNRNPA0 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(628) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNRNPA0 Gene

Heterogeneous nuclear ribonucleoprotein A0:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA0 Gene

No ASD Table

Relevant External Links for HNRNPA0 Gene

GeneLoc Exon Structure for
HNRNPA0
ECgene alternative splicing isoforms for
HNRNPA0

Expression for HNRNPA0 Gene

mRNA expression in normal human tissues for HNRNPA0 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPA0 Gene

SOURCE GeneReport for Unigene cluster for HNRNPA0 Gene Hs.96996

genes like me logo Genes that share expressions with HNRNPA0: view

Orthologs for HNRNPA0 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPA0 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA0 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPA0 36
  • 94.3 (n)
  • 99.67 (a)
HNRPA0 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPA0 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpa0 36
  • 83.21 (n)
  • 89.55 (a)
Hnrnpa0 16
Hnrnpa0 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPA0 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA0 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681410 36
  • 85.19 (n)
  • 91.67 (a)
chicken
(Gallus gallus)
Aves HNRNPA0 36
  • 78.86 (n)
  • 85.45 (a)
HNRNPA0 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPA0 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hnrpa0-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpa0 36
  • 68.43 (n)
  • 70.94 (a)
MGC75874 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6239 36
zebrafish
(Danio rerio)
Actinopterygii hnrnpa0a 37
  • 60 (a)
OneToMany
hnrnpa0b 37
  • 59 (a)
OneToMany
hnrnpa0l 37
  • 58 (a)
OneToMany
wufc01g05 36
fruit fly
(Drosophila melanogaster)
Insecta Hrb87F 37
  • 36 (a)
ManyToMany
Hrb98DE 37
  • 35 (a)
ManyToMany
Rb97D 37
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-1 37
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10370 37
  • 27 (a)
OneToMany
Species with no ortholog for HNRNPA0:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPA0 Gene

ENSEMBL:
Gene Tree for HNRNPA0 (if available)
TreeFam:
Gene Tree for HNRNPA0 (if available)

Paralogs for HNRNPA0 Gene

Paralogs for HNRNPA0 Gene

Selected SIMAP similar genes for HNRNPA0 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA0: view

Variants for HNRNPA0 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA0 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7875 -- 137,752,360(-) AGCGA(A/G)TTGTT utr-variant-3-prime
rs1050179 -- 137,751,634(-) CCTTT(C/T)TGGAT utr-variant-3-prime
rs1130987 -- 137,751,596(-) ATATC(A/C)CAAAT utr-variant-3-prime
rs3177854 -- 137,752,622(-) GTTTG(A/C)CCGTA utr-variant-3-prime
rs10064308 -- 137,750,916(+) ACCCA(A/G)ATCTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA0 Gene

Variant ID Type Subtype PubMed ID
nsv830500 CNV Loss 17160897
nsv819360 CNV Gain 19587683

Relevant External Links for HNRNPA0 Gene

HapMap Linkage Disequilibrium report
HNRNPA0

Disorders for HNRNPA0 Gene

No disorders were found for HNRNPA0 Gene.

No data available for UniProtKB/Swiss-Prot for HNRNPA0 Gene

Publications for HNRNPA0 Gene

  1. Isolation and characterization of a novel, low abundance hnRNP protein: A0. (PMID: 7585247) Myer V.E. … Steitz J.A. (RNA 1995) 2 3 4
  2. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP- K2 and its interaction with cytokine mRNAs. (PMID: 12456657) Rousseau S. … Cohen P. (EMBO J. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt H.C. … Yaffe M.B. (Mol. Cell 2010) 3 4
  5. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PMID: 21110914) Grant M.M. (BMB Rep 2010) 3

Products for HNRNPA0 Gene

Sources for HNRNPA0 Gene

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