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Aliases for EHD1 Gene

Aliases for EHD1 Gene

  • EH Domain Containing 1 2 3 5
  • Testilin 2 3 4
  • PAST Homolog 1 3 4
  • HPAST1 3 4
  • PAST1 3 4
  • PAST 3 4
  • EH Domain-Containing Protein 1 3
  • H-PAST 3

External Ids for EHD1 Gene

Previous HGNC Symbols for EHD1 Gene

  • PAST1

Previous GeneCards Identifiers for EHD1 Gene

  • GC11M067135
  • GC11M066301
  • GC11M064395
  • GC11M064376
  • GC11M064619
  • GC11M060947

Summaries for EHD1 Gene

Entrez Gene Summary for EHD1 Gene

  • This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for EHD1 Gene

EHD1 (EH Domain Containing 1) is a Protein Coding gene. Diseases associated with EHD1 include Photoallergic Dermatitis and Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Endocytosis. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is EHD3.

UniProtKB/Swiss-Prot for EHD1 Gene

  • ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).

Gene Wiki entry for EHD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EHD1 Gene

Genomics for EHD1 Gene

Regulatory Elements for EHD1 Gene

Enhancers for EHD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064846 1.9 FANTOM5 Ensembl ENCODE 55.4 +28.0 28025 27.0 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 EHD1 NEAT1 KAT5 MAP4K2 SNX15 MIR192 MEN1 SSSCA1-AS1 EHBP1L1 FAU
GH11F065307 1.5 FANTOM5 Ensembl ENCODE 24.4 -421.7 -421705 4.8 BRCA1 RAD21 RFX5 ZNF121 GLIS2 ZNF143 RCOR1 DEK SMAD5 CEBPB LOC728975 POLA2 EHD1 BATF2 DPF2 RELA CDC42EP2 EHBP1L1 AP5B1 SPDYC
GH11F065288 1.7 FANTOM5 Ensembl ENCODE 20.8 -407.5 -407502 14.5 HDGF PKNOX1 ARID4B DMAP1 YY1 SLC30A9 FOS ZNF263 SP5 JUNB POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11F064884 1.5 FANTOM5 ENCODE 12.2 +2.5 2496 1.7 HDGF ARNT MLX ARID4B DMAP1 ZNF2 ZNF143 FOS DEK ZNF263 ATG2A EHD1 SF1 CDC42BPG TIGD3 RASGRP2 MAP4K2 PYGM RPS16P6
GH11F064841 1.1 ENCODE 12.5 +44.6 44601 4.3 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF143 ZNF548 FOS ZNF263 EHD1 MEN1 MAP4K2 POLA2 NEAT1 KAT5 SSSCA1-AS1 PLCB3 ZFPL1 FAU
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EHD1 on UCSC Golden Path with GeneCards custom track

Promoters for EHD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769233 296 401 HDGF ARID4B SIN3A ZNF48 ZNF2 GLIS2 ZNF143 ZNF207 KLF7 SP3

Transcription factor binding sites by QIAGEN in the EHD1 gene promoter:

Genomic Location for EHD1 Gene

Chromosome:
11
Start:
64,851,642 bp from pter
End:
64,888,296 bp from pter
Size:
36,655 bases
Orientation:
Minus strand

Genomic View for EHD1 Gene

Genes around EHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EHD1 Gene

Proteins for EHD1 Gene

  • Protein details for EHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4M9-EHD1_HUMAN
    Recommended name:
    EH domain-containing protein 1
    Protein Accession:
    Q9H4M9
    Secondary Accessions:
    • O14611
    • Q2M3Q4
    • Q9UNR3

    Protein attributes for EHD1 Gene

    Size:
    534 amino acids
    Molecular mass:
    60627 Da
    Quaternary structure:
    • Homooligomer, and heterooligomer with EHD2, EHD3 and EHD4, ATP-binding is required for heterooligomerization (PubMed:16251358, PubMed:17233914, PubMed:18331452). Interacts (via EH domain) with MICALL1 (via NPF1 motif); the interaction is direct and recruits EHD1 to membranes (PubMed:19864458, PubMed:20106972). Interacts with RAB35; the interaction is indirect through MICALL1 and recruits EHD1 to membranes (By similarity). Interacts (via EH domain) with PACSIN2 (via NPF motifs); regulates localization to tubular recycling endosome membranes (PubMed:23596323). Interacts with PACSIN1 (By similarity). Interacts with RAB8A (PubMed:19864458). Interacts with FER1L5 (via second C2 domain) (By similarity). Interacts with MYOF (By similarity). Interacts with ZFYVE20 (PubMed:15020713). Interacts (via EH domain) with RAB11FIP2 (PubMed:16251358).

    Three dimensional structures from OCA and Proteopedia for EHD1 Gene

neXtProt entry for EHD1 Gene

Post-translational modifications for EHD1 Gene

  • Ubiquitination at Lys 32
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for EHD1

No data available for DME Specific Peptides for EHD1 Gene

Domains & Families for EHD1 Gene

Gene Families for EHD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4M9

UniProtKB/Swiss-Prot:

EHD1_HUMAN :
  • The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
Domain:
  • The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 EF-hand domain.
  • Contains 1 EH domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
genes like me logo Genes that share domains with EHD1: view

Function for EHD1 Gene

Molecular function for EHD1 Gene

GENATLAS Biochemistry:
EPS15 homology (EH) domain family member 1 with three alternatively spliced isoforms,the smallest expressed in testis,the larger more widely,located in endocytic vesicles and potentially participating in clathrin-coated pit-mediated endocytosis of IGF1 receptor after binding to its ligand
UniProtKB/Swiss-Prot Function:
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).

Gene Ontology (GO) - Molecular Function for EHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12121420
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0017137 Rab GTPase binding IPI 19864458
genes like me logo Genes that share ontologies with EHD1: view
genes like me logo Genes that share phenotypes with EHD1: view

Animal Models for EHD1 Gene

MGI Knock Outs for EHD1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EHD1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EHD1 Gene

Localization for EHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EHD1 Gene

Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250 UniProtKB:Q9WVK4, ECO:0000269 PubMed:15020713, ECO:0000269 PubMed:17233914, ECO:0000269 PubMed:19864458, ECO:0000269 PubMed:23596323, ECO:0000269 PubMed:25686250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EHD1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005811 lipid particle IEA,ISS --
GO:0005886 plasma membrane IEA,ISS --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with EHD1: view

Pathways & Interactions for EHD1 Gene

genes like me logo Genes that share pathways with EHD1: view

Pathways by source for EHD1 Gene

1 BioSystems pathway for EHD1 Gene
1 KEGG pathway for EHD1 Gene
1 GeneGo (Thomson Reuters) pathway for EHD1 Gene

Gene Ontology (GO) - Biological Process for EHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IMP 15020713
GO:0006897 endocytosis IEA,IMP 20801876
GO:0007596 blood coagulation TAS --
GO:0010886 positive regulation of cholesterol storage IEA,ISS --
genes like me logo Genes that share ontologies with EHD1: view

No data available for SIGNOR curated interactions for EHD1 Gene

Transcripts for EHD1 Gene

Unigene Clusters for EHD1 Gene

EH-domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EHD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EHD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -
SP9:
SP10: - - -

Relevant External Links for EHD1 Gene

GeneLoc Exon Structure for
EHD1
ECgene alternative splicing isoforms for
EHD1

Expression for EHD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EHD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EHD1 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for EHD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EHD1 Gene



Protein tissue co-expression partners for EHD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EHD1 Gene:

EHD1

SOURCE GeneReport for Unigene cluster for EHD1 Gene:

Hs.523774

mRNA Expression by UniProt/SwissProt for EHD1 Gene:

Q9H4M9-EHD1_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with EHD1: view

Primer Products

Orthologs for EHD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EHD1 34 35
  • 99.27 (n)
oppossum
(Monodelphis domestica)
Mammalia EHD1 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EHD1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EHD1 34 35
  • 93.26 (n)
dog
(Canis familiaris)
Mammalia EHD1 34 35
  • 92.05 (n)
mouse
(Mus musculus)
Mammalia Ehd1 34 16 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Ehd1 34
  • 89.45 (n)
lizard
(Anolis carolinensis)
Reptilia EHD1 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ehd1 34
  • 79.71 (n)
Str.611 34
zebrafish
(Danio rerio)
Actinopterygii EHD1 (3 of 3) 35
  • 85 (a)
OneToMany
ehd1a 35
  • 85 (a)
OneToMany
ehd1b 34 35
  • 76.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta Past1 36 34
  • 71.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004593 34
  • 64.27 (n)
worm
(Caenorhabditis elegans)
Secernentea rme-1 36 34
  • 62.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EHD1 34
  • 53.99 (n)
rice
(Oryza sativa)
Liliopsida Os04g0669300 34
  • 54.21 (n)
Species where no ortholog for EHD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EHD1 Gene

ENSEMBL:
Gene Tree for EHD1 (if available)
TreeFam:
Gene Tree for EHD1 (if available)

Paralogs for EHD1 Gene

Paralogs for EHD1 Gene

(4) SIMAP similar genes for EHD1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EHD1: view

Variants for EHD1 Gene

Sequence variations from dbSNP and Humsavar for EHD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10591826 -- 64,880,210(+) TTTTT(-/TT)GGTGT upstream-variant-2KB
rs10674960 -- 64,858,190(+) TTTTC(-/TTTTT)TTTTT intron-variant
rs10897533 -- 64,855,397(+) TCTCC(C/G)AGGTT reference, synonymous-codon
rs10897534 -- 64,855,952(+) CTCCG(C/T)TCAAC intron-variant
rs111248978 -- 64,869,286(+) CTGAG(A/G)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EHD1 Gene

Variant ID Type Subtype PubMed ID
nsv957903 CNV deletion 24416366
nsv832189 CNV loss 17160897
nsv555208 CNV loss 21841781
nsv555207 CNV loss 21841781
nsv528506 CNV loss 19592680
nsv526181 CNV gain 19592680
nsv469962 CNV loss 18288195
nsv39166 CNV deletion 16902084
nsv360 CNV deletion 18451855
nsv1130657 CNV deletion 24896259
nsv1069592 CNV deletion 25765185
esv992888 CNV deletion 20482838
esv989116 CNV deletion 20482838
esv3653 CNV loss 18987735
esv2744629 CNV deletion 23290073
esv2744628 CNV deletion 23290073
esv2224954 CNV deletion 18987734
esv1447546 CNV deletion 17803354
dgv141e201 CNV deletion 23290073

Variation tolerance for EHD1 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EHD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EHD1 Gene

Disorders for EHD1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for EHD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
photoallergic dermatitis
  • photoallergic contact dermatitis
cerebellar ataxia, mental retardation and dysequlibrium syndrome
  • camrq
venous hemangioma
bardet-biedl syndrome 1
  • bardet-biedl syndrome 1, modifier of
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search EHD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EHD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EHD1
genes like me logo Genes that share disorders with EHD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EHD1 Gene

Publications for EHD1 Gene

  1. EHD1 -- an EH-domain-containing protein with a specific expression pattern. (PMID: 10395801) Mintz L. … Horowitz M. (Genomics 1999) 2 3 4 22 64
  2. MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. (PMID: 19864458) Sharma M. … Caplan S. (Mol. Biol. Cell 2009) 3 4 22 64
  3. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. (PMID: 10673336) Pohl U. … Louis D.N. (Genomics 2000) 2 3 22 64
  4. Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. (PMID: 25686250) Lu Q. … Westlake C.J. (Nat. Cell Biol. 2015) 3 4 64
  5. Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. (PMID: 23596323) Giridharan S.S. … Caplan S. (Mol. Biol. Cell 2013) 3 4 64

Products for EHD1 Gene

Sources for EHD1 Gene

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