Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUB1 Gene

Aliases for SUB1 Gene

  • SUB1 Homolog, Transcriptional Regulator 2 3 5
  • Positive Cofactor 4 2 3 4
  • SUB1 Homolog 3 4
  • P14 3 4
  • PC4 3 4
  • Activated RNA Polymerase II Transcription Cofactor 4 3
  • SUB1 Homolog (S. Cerevisiae) 2
  • RPO2TC1 4
  • P15 3

External Ids for SUB1 Gene

Previous GeneCards Identifiers for SUB1 Gene

  • GC05P032622

Summaries for SUB1 Gene

GeneCards Summary for SUB1 Gene

SUB1 (SUB1 Homolog, Transcriptional Regulator) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot for SUB1 Gene

  • General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Gene Wiki entry for SUB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUB1 Gene

Genomics for SUB1 Gene

Regulatory Elements for SUB1 Gene

Enhancers for SUB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUB1 on UCSC Golden Path with GeneCards custom track

Promoters for SUB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUB1 Gene

Chromosome:
5
Start:
32,531,633 bp from pter
End:
32,604,079 bp from pter
Size:
72,447 bases
Orientation:
Plus strand

Genomic View for SUB1 Gene

Genes around SUB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUB1 Gene

Proteins for SUB1 Gene

  • Protein details for SUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53999-TCP4_HUMAN
    Recommended name:
    Activated RNA polymerase II transcriptional coactivator p15
    Protein Accession:
    P53999
    Secondary Accessions:
    • Q96L29

    Protein attributes for SUB1 Gene

    Size:
    127 amino acids
    Molecular mass:
    14395 Da
    Quaternary structure:
    • Homodimer. Interacts with CSTF2.

    Three dimensional structures from OCA and Proteopedia for SUB1 Gene

neXtProt entry for SUB1 Gene

Proteomics data for SUB1 Gene at MOPED

Post-translational modifications for SUB1 Gene

  • Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
  • Ubiquitination at Lys 53 and Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for SUB1 Gene

No data available for DME Specific Peptides for SUB1 Gene

Domains & Families for SUB1 Gene

Suggested Antigen Peptide Sequences for SUB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53999

UniProtKB/Swiss-Prot:

TCP4_HUMAN :
  • Belongs to the transcriptional coactivator PC4 family.
Family:
  • Belongs to the transcriptional coactivator PC4 family.
genes like me logo Genes that share domains with SUB1: view

No data available for Gene Families for SUB1 Gene

Function for SUB1 Gene

Molecular function for SUB1 Gene

UniProtKB/Swiss-Prot Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Gene Ontology (GO) - Molecular Function for SUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IDA 8062391
GO:0005515 protein binding IPI 9847329
genes like me logo Genes that share ontologies with SUB1: view
genes like me logo Genes that share phenotypes with SUB1: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUB1 Gene

Localization for SUB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUB1 Gene COMPARTMENTS Subcellular localization image for SUB1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for SUB1 Gene

Pathways & Interactions for SUB1 Gene

SuperPathways for SUB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SUB1: view

No data available for Pathways by source and SIGNOR curated interactions for SUB1 Gene

Drugs & Compounds for SUB1 Gene

No Compound Related Data Available

Transcripts for SUB1 Gene

Unigene Clusters for SUB1 Gene

SUB1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for SUB1 Gene

GeneLoc Exon Structure for
SUB1
ECgene alternative splicing isoforms for
SUB1

Expression for SUB1 Gene

mRNA expression in normal human tissues for SUB1 Gene

Protein differential expression in normal tissues from HIPED for SUB1 Gene

This gene is overexpressed in Bone (12.7) and Tlymphocyte (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUB1 Gene



SOURCE GeneReport for Unigene cluster for SUB1 Gene Hs.229641

genes like me logo Genes that share expression patterns with SUB1: view

Protein tissue co-expression partners for SUB1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUB1 Gene

Orthologs for SUB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUB1 35
  • 93.18 (n)
  • 99.21 (a)
SUB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUB1 35
  • 94.23 (n)
  • 99.21 (a)
SUB1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sub1 35
  • 87.93 (n)
  • 93.7 (a)
Sub1 16
Sub1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUB1 35
  • 99.21 (n)
  • 100 (a)
SUB1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sub1 35
  • 88.98 (n)
  • 93.7 (a)
oppossum
(Monodelphis domestica)
Mammalia SUB1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUB1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUB1 35
  • 85.98 (n)
  • 90.48 (a)
-- 36
  • 46 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
SUB1 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SUB1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3149 35
sub1 35
  • 77.25 (n)
  • 80.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21992 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15428 35
sub1a 35
  • 71.54 (n)
  • 78.05 (a)
sub1a 36
  • 83 (a)
OneToMany
sub1b 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8767 35
worm
(Caenorhabditis elegans)
Secernentea T13F2.2 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUB1 36
  • 13 (a)
OneToOne
SUB1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for SUB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUB1 Gene

ENSEMBL:
Gene Tree for SUB1 (if available)
TreeFam:
Gene Tree for SUB1 (if available)

Paralogs for SUB1 Gene

(1) SIMAP similar genes for SUB1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SUB1 Gene

genes like me logo Genes that share paralogs with SUB1: view

No data available for Paralogs for SUB1 Gene

Variants for SUB1 Gene

Sequence variations from dbSNP and Humsavar for SUB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17850527 - 32,588,543(+) CTTCA(A/G)GCTCT reference, missense
rs15075 -- 32,601,268(+) TCAAC(C/T)TTATT utr-variant-3-prime
rs1046680 -- 32,602,840(+) CATCA(A/T)GCTTG utr-variant-3-prime
rs1049398 -- 32,601,066(+) GATGA(C/T)GCAGT reference, synonymous-codon
rs3204139 -- 32,602,604(+) GCCAC(A/G/T)TAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SUB1 Gene

Variant ID Type Subtype PubMed ID
dgv1792e1 CNV Complex 17122850

Variation tolerance for SUB1 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SUB1 Gene

Disorders for SUB1 Gene

Relevant External Links for SUB1

Human Genome Epidemiology (HuGE) Navigator
SUB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUB1

No disorders were found for SUB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUB1 Gene

Publications for SUB1 Gene

  1. A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. (PMID: 8062392) Kretzschmar M. … Meisterernst M. (Cell 1994) 2 3 4 67
  2. Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications. (PMID: 17785449) Batta K. … Kundu T.K. (Mol. Cell. Biol. 2007) 3 23
  3. Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. (PMID: 16982701) Das C. … Kundu T.K. (Mol. Cell. Biol. 2006) 3 23
  4. Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. (PMID: 15893730) Lewis B.A. … Reinberg D. (Mol. Cell 2005) 3 23
  5. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PMID: 11389848) Calvo O. … Manley J.L. (Mol. Cell 2001) 3 23

Products for SUB1 Gene

Sources for SUB1 Gene

Content