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Aliases for FASTK Gene

Aliases for FASTK Gene

  • Fas-Activated Serine/Threonine Kinase 2 3
  • FAST Kinase 3 4
  • EC 2.7.11.8 4
  • FAST 3

External Ids for FASTK Gene

Previous GeneCards Identifiers for FASTK Gene

  • GC07M149020
  • GC07M150088
  • GC07M150165
  • GC07M150211
  • GC07M150404
  • GC07M150773
  • GC07M144586

Summaries for FASTK Gene

Entrez Gene Summary for FASTK Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASTK Gene

FASTK (Fas-Activated Serine/Threonine Kinase) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity and Fas-activated serine/threonine kinase activity. An important paralog of this gene is FASTKD1.

UniProtKB/Swiss-Prot for FASTK Gene

  • Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

Gene Wiki entry for FASTK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTK Gene

Genomics for FASTK Gene

Regulatory Elements for FASTK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FASTK Gene

Chromosome:
7
Start:
151,076,593 bp from pter
End:
151,080,883 bp from pter
Size:
4,291 bases
Orientation:
Minus strand

Genomic View for FASTK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTK Gene

Proteins for FASTK Gene

  • Protein details for FASTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14296-FASTK_HUMAN
    Recommended name:
    Fas-activated serine/threonine kinase
    Protein Accession:
    Q14296
    Secondary Accessions:
    • A8K867
    • F8VTW9
    • Q59EM8
    • Q8IVA0

    Protein attributes for FASTK Gene

    Size:
    549 amino acids
    Molecular mass:
    61104 Da
    Quaternary structure:
    • Interacts with TIA-1 and TIAR.
    SequenceCaution:
    • Sequence=BAD93020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASTK Gene

Proteomics data for FASTK Gene at MOPED

Post-translational modifications for FASTK Gene

  • Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FASTK Gene

Antibody Products

No data available for DME Specific Peptides for FASTK Gene

Domains & Families for FASTK Gene

Protein Domains for FASTK Gene

Suggested Antigen Peptide Sequences for FASTK Gene

Graphical View of Domain Structure for InterPro Entry

Q14296

UniProtKB/Swiss-Prot:

FASTK_HUMAN :
  • Contains 1 RAP domain.
  • Belongs to the FAST protein kinase family.
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST protein kinase family.
genes like me logo Genes that share domains with FASTK: view

No data available for Gene Families for FASTK Gene

Function for FASTK Gene

Molecular function for FASTK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
UniProtKB/Swiss-Prot Function:
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

Enzyme Numbers (IUBMB) for FASTK Gene

Gene Ontology (GO) - Molecular Function for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 7544399
GO:0005515 protein binding IPI 7544399
GO:0005524 ATP binding IEA --
GO:0033867 Fas-activated serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with FASTK: view
genes like me logo Genes that share phenotypes with FASTK: view

Animal Models for FASTK Gene

MGI Knock Outs for FASTK:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for FASTK Gene

Localization for FASTK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTK Gene COMPARTMENTS Subcellular localization image for FASTK gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with FASTK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FASTK Gene

Pathways & Interactions for FASTK Gene

SuperPathways for FASTK Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 7544399
GO:0043484 regulation of RNA splicing IMP 17592127
GO:0097190 apoptotic signaling pathway TAS 7544399
genes like me logo Genes that share ontologies with FASTK: view

No data available for Pathways by source and SIGNOR curated interactions for FASTK Gene

Drugs & Compounds for FASTK Gene

(2) Drugs for FASTK Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420
threonine Nutra 16
genes like me logo Genes that share compounds with FASTK: view

Transcripts for FASTK Gene

Unigene Clusters for FASTK Gene

Fas-activated serine/threonine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FASTK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - - -
SP16:
SP17: - -
SP18:
SP19:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for FASTK Gene

GeneLoc Exon Structure for
FASTK
ECgene alternative splicing isoforms for
FASTK

Expression for FASTK Gene

mRNA expression in normal human tissues for FASTK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FASTK Gene

This gene is overexpressed in Liver (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASTK Gene



SOURCE GeneReport for Unigene cluster for FASTK Gene Hs.647094

mRNA Expression by UniProt/SwissProt for FASTK Gene

Q14296-FASTK_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expression patterns with FASTK: view

Protein tissue co-expression partners for FASTK Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FASTK Gene

Orthologs for FASTK Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASTK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FASTK 35
  • 90.34 (n)
  • 92.25 (a)
FASTK 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASTK 35
  • 91.2 (n)
  • 93.99 (a)
FASTK 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fastk 35
  • 86.67 (n)
  • 89.54 (a)
Fastk 16
Fastk 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FASTK 35
  • 99.7 (n)
  • 99.82 (a)
FASTK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fastk 35
  • 87.41 (n)
  • 90.82 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FASTK 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FASTK 35
  • 62.83 (n)
  • 54 (a)
FASTK 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASTK 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.13216 35
fastk 35
  • 54.87 (n)
  • 47.13 (a)
fastk 36
  • 25 (a)
OneToOne
Species with no ortholog for FASTK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTK Gene

ENSEMBL:
Gene Tree for FASTK (if available)
TreeFam:
Gene Tree for FASTK (if available)

Paralogs for FASTK Gene

Paralogs for FASTK Gene

(1) SIMAP similar genes for FASTK Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FASTK: view

Variants for FASTK Gene

Sequence variations from dbSNP and Humsavar for FASTK Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1049365 -- 151,079,816(-) TGTTT(A/C/G)GGGCC synonymous-codon, missense, reference, intron-variant
rs1130560 -- 151,077,103(-) GCCCA(A/G)AGGGT synonymous-codon, reference, intron-variant
rs2288648 - 151,077,221(+) TGCTG(A/G)CGCAC reference, missense, intron-variant
rs2303942 -- 151,078,219(+) CCTCC(A/G)GCCTC intron-variant
rs3793334 -- 151,080,519(-) CGCGC(C/T)CTGCG intron-variant, utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FASTK Gene

Variant ID Type Subtype PubMed ID
nsv889465 CNV Loss 21882294
nsv526410 CNV Loss 19592680
nsv889476 CNV Loss 21882294
nsv889477 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897
dgv7546n71 CNV Loss 21882294
nsv517508 CNV Loss 19592680
nsv465215 CNV Loss 19166990
nsv6004 CNV Insertion 18451855
dgv7547n71 CNV Loss 21882294
dgv7548n71 CNV Loss 21882294

Variation tolerance for FASTK Gene

Residual Variation Intolerance Score: 46.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASTK Gene

HapMap Linkage Disequilibrium report
FASTK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTK Gene

Disorders for FASTK Gene

Relevant External Links for FASTK

Genetic Association Database (GAD)
FASTK
Human Genome Epidemiology (HuGE) Navigator
FASTK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASTK
genes like me logo Genes that share disorders with FASTK: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTK Gene

Publications for FASTK Gene

  1. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. (PMID: 15572676) Li W. … Anderson P. (Mol. Cell. Biol. 2004) 2 23 67
  2. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (PMID: 7544399) Tian Q. … Anderson P. (J. Exp. Med. 1995) 2 23 67
  3. Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left ventricular dysfunction. (PMID: 18649053) ZohlnhAPfer D. … Schwaiger M. (Heart Vessels 2008) 23 67
  4. Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. (PMID: 17592127) Simarro M. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 2007) 23 67
  5. The AP-2alpha transcription factor regulates tumor cell migration and apoptosis. (PMID: 17695722) Orso F. … Taverna D. (Adv. Exp. Med. Biol. 2007) 23 67

Products for FASTK Gene

Sources for FASTK Gene

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