Aliases for EHMT2 Gene
External Ids for EHMT2 Gene
Previous HGNC Symbols for EHMT2 Gene
Previous GeneCards Identifiers for EHMT2 Gene
This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for EHMT2 Gene
EHMT2 (Euchromatic Histone-Lysine N-Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Gene Expression. GO annotations related to this gene include p53 binding and protein-lysine N-methyltransferase activity. An important paralog of this gene is EHMT1.
UniProtKB/Swiss-Prot for EHMT2 Gene
Histone methyltransferase that specifically mono- and dimethylates Lys-9 of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of Lys-56 of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of Lys-373 of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Histone methyltransferases (HMTs) are a group of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to histones and are closely related in biological activity to the DNA methyltransferases. Histone methylation occurs predominantly on the side chains of lysine and arginine residues in histones H3 and H4, and multiple methyl groups may be added to each residue. Histone methyltransferases can be subdivided according to their target residue: those which methylate lysine residues on histone proteins are known as protein lysine methyltransferases (PKMTs) whereas those acting on arginine residues are known as protein arginine methyltransferases (PRMTs)