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Aliases for PAPOLA Gene

Aliases for PAPOLA Gene

  • Poly(A) Polymerase Alpha 2 3
  • PAP 3 4 6
  • Polynucleotide Adenylyltransferase Alpha 3 4
  • EC 2.7.7.19 4 63
  • Pap-Alpha 3 4
  • EC 2.7.7 63

External Ids for PAPOLA Gene

Previous GeneCards Identifiers for PAPOLA Gene

  • GC14P094479
  • GC14P090785
  • GC14P094958
  • GC14P096038
  • GC14P096969
  • GC14P077153

Summaries for PAPOLA Gene

Entrez Gene Summary for PAPOLA Gene

  • The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PAPOLA Gene

PAPOLA (Poly(A) Polymerase Alpha) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and manganese ion binding. An important paralog of this gene is PAPOLG.

UniProtKB/Swiss-Prot for PAPOLA Gene

  • Polymerase that creates the 3-poly(A) tail of mRNAs. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus

Gene Wiki entry for PAPOLA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPOLA Gene

Genomics for PAPOLA Gene

Regulatory Elements for PAPOLA Gene

Genomic Location for PAPOLA Gene

Start:
96,501,433 bp from pter
End:
96,567,116 bp from pter
Size:
65,684 bases
Orientation:
Plus strand

Genomic View for PAPOLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAPOLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPOLA Gene

Proteins for PAPOLA Gene

  • Protein details for PAPOLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51003-PAPOA_HUMAN
    Recommended name:
    Poly(A) polymerase alpha
    Protein Accession:
    P51003
    Secondary Accessions:
    • Q86SX4
    • Q86TV0
    • Q8IYF5
    • Q9BVU2

    Protein attributes for PAPOLA Gene

    Size:
    745 amino acids
    Molecular mass:
    82843 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium ions. Also active with manganese.;
    Quaternary structure:
    • Monomer. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1 (By similarity). Interacts with NUDT21; the interaction is diminished by acetylation. Interacts with KPNB1; the interaction promotes PAP nuclear import and is inhibited by acetylation of PAP (By similarity).

    Alternative splice isoforms for PAPOLA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAPOLA Gene

Proteomics data for PAPOLA Gene at MOPED

Post-translational modifications for PAPOLA Gene

  • Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity).
  • Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF (By similarity).
  • Polysumoylated. Varying sumolyation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity (By similarity).
  • Ubiquitination at Lys67, Lys110, and Lys360
  • Modification sites at PhosphoSitePlus

Domains for PAPOLA Gene

Suggested Antigen Peptide Sequences for PAPOLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51003

UniProtKB/Swiss-Prot:

PAPOA_HUMAN :
  • P51003
Family:
  • Belongs to the poly(A) polymerase family.
genes like me logo Genes that share domains with PAPOLA: view

No data available for Gene Families for PAPOLA Gene

Function for PAPOLA Gene

Molecular function for PAPOLA Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + RNA(n) = diphosphate + RNA(n+1)
UniProtKB/Swiss-Prot Function: Polymerase that creates the 3-poly(A) tail of mRNAs. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus

Enzyme Numbers (IUBMB) for PAPOLA Gene

Gene Ontology (GO) - Molecular Function for PAPOLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0003723 RNA binding IEA --
GO:0004652 polynucleotide adenylyltransferase activity ISS --
GO:0005524 ATP binding ISS --
GO:0016779 nucleotidyltransferase activity --
genes like me logo Genes that share ontologies with PAPOLA: view

Phenotypes for PAPOLA Gene

GenomeRNAi human phenotypes for PAPOLA:
genes like me logo Genes that share phenotypes with PAPOLA: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PAPOLA Gene

Localization for PAPOLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPOLA Gene

Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAPOLA Gene COMPARTMENTS Subcellular localization image for PAPOLA gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PAPOLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8302877
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 8302877
genes like me logo Genes that share ontologies with PAPOLA: view

Pathways for PAPOLA Gene

genes like me logo Genes that share pathways with PAPOLA: view

Gene Ontology (GO) - Biological Process for PAPOLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with PAPOLA: view

Compounds for PAPOLA Gene

(3) HMDB Compounds for PAPOLA Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(3) Drugbank Compounds for PAPOLA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Sulfinoalanine
1115-65-7 target
Cordycepin Triphosphate
73-04-1 target
Triphospate
target

(1) Novoseek inferred chemical compound relationships for PAPOLA Gene

Compound -log(P) Hits PubMed IDs
adenylate 69 11
genes like me logo Genes that share compounds with PAPOLA: view

Transcripts for PAPOLA Gene

Unigene Clusters for PAPOLA Gene

Poly(A) polymerase alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAPOLA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6: - - - -
SP7: -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - -
SP11:
SP12:
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ·
SP1: - - - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14: - - - -
SP15: - - -
SP16: -
SP17: - - -
SP18: -
SP19:
SP20:
SP21:
SP22:

ExUns: 25d · 25e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for PAPOLA Gene

GeneLoc Exon Structure for
PAPOLA
ECgene alternative splicing isoforms for
PAPOLA

Expression for PAPOLA Gene

mRNA expression in normal human tissues for PAPOLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PAPOLA Gene

SOURCE GeneReport for Unigene cluster for PAPOLA Gene Hs.253726

genes like me logo Genes that share expressions with PAPOLA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAPOLA Gene

Orthologs for PAPOLA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PAPOLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAPOLA 35
  • 99.96 (n)
  • 100 (a)
PAPOLA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAPOLA 35
  • 96.89 (n)
  • 98.24 (a)
PAPOLA 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAPOLA 35
  • 97.56 (n)
  • 98.65 (a)
PAPOLA 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Papola 35
  • 93.82 (n)
  • 96.21 (a)
Papola 16
Papola 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
ManyToMany
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Papola 35
  • 93.46 (n)
  • 95.81 (a)
chicken
(Gallus gallus)
Aves PAPOLA 35
  • 88.5 (n)
  • 91.17 (a)
PAPOLA 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68746 35
tropical clawed frog
(Silurana tropicalis)
Amphibia papola 35
  • 78.73 (n)
  • 84.29 (a)
Str.10813 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5723 35
zebrafish
(Danio rerio)
Actinopterygii papola 35
  • 68.38 (n)
  • 75.46 (a)
papola 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hrg 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F43G6.5 36
  • 47 (a)
ManyToMany
pap-1 36
  • 41 (a)
ManyToMany
T15H9.6 35
  • 57.55 (n)
  • 54.04 (a)
T15H9.6 36
  • 46 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAP1 36
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons nPAP 35
  • 50.8 (n)
  • 46.56 (a)
rice
(Oryza sativa)
Liliopsida Os.32564 35
Os06g0558700 35
  • 52.14 (n)
  • 47.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2725 36
  • 64 (a)
OneToMany
Species with no ortholog for PAPOLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAPOLA Gene

ENSEMBL:
Gene Tree for PAPOLA (if available)
TreeFam:
Gene Tree for PAPOLA (if available)

Paralogs for PAPOLA Gene

Paralogs for PAPOLA Gene

Selected SIMAP similar genes for PAPOLA Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PAPOLA: view

Variants for PAPOLA Gene

Sequence variations from dbSNP and Humsavar for PAPOLA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1280456 -- 96,509,432(-) GTATA(C/T)ATTTT intron-variant
rs1292503 -- 96,559,581(+) tctct(A/C)tatat intron-variant
rs1484251 -- 96,537,430(+) AACTC(A/G)TTAAT intron-variant
rs2150312 -- 96,507,375(+) CTCCG(C/T)CTTCC intron-variant
rs2274795 -- 96,528,345(+) AGTAA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAPOLA Gene

Variant ID Type Subtype PubMed ID
nsv902211 CNV Loss 21882294

Relevant External Links for PAPOLA Gene

HapMap Linkage Disequilibrium report
PAPOLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPOLA Gene

Disorders for PAPOLA Gene

Relevant External Links for PAPOLA

Genetic Association Database (GAD)
PAPOLA
genes like me logo Genes that share disorders with PAPOLA: view

No data available for UniProtKB/Swiss-Prot for PAPOLA Gene

Publications for PAPOLA Gene

  1. Multiple forms of poly(A) polymerases in human cells. (PMID: 8302877) Thuresson A.-C. … Virtanen A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Assignment of the human poly(A) polymerase (PAP) gene to chromosome 14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence. (PMID: 10429366) Yamauchi T. … Isobe M. (J. Hum. Genet. 1999) 2 3
  5. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (PMID: 7590244) Murthy K.G. … Manley J.L. (Genes Dev. 1995) 3 23

Products for PAPOLA Gene

  • antibodies-online proteins for PAPOLA
  • antibodies-online antibodies for PAPOLA
  • antibodies-online kits for PAPOLA

Sources for PAPOLA Gene

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