Aliases for PAPOLA Gene
External Ids for PAPOLA Gene
Previous GeneCards Identifiers for PAPOLA Gene
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for PAPOLA Gene
PAPOLA (Poly(A) Polymerase Alpha) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include RNA binding and manganese ion binding. An important paralog of this gene is PAPOLB.
UniProtKB/Swiss-Prot for PAPOLA Gene
Polymerase that creates the 3-poly(A) tail of mRNAs. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.