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Aliases for GADD45G Gene

Aliases for GADD45G Gene

  • Growth Arrest And DNA-Damage-Inducible, Gamma 2 3
  • DNA Damage-Inducible Transcript 2 Protein 3 4
  • Cytokine-Responsive Protein CR6 3 4
  • DDIT-2 3 4
  • GRP17 3 6
  • DDIT2 3 4
  • CR6 3 4
  • Growth Arrest And DNA Damage-Inducible Protein GADD45 Gamma 3
  • Growth Arrest And DNA-Damage-Inducible Gamma 2
  • Gadd-Related Protein, 17 KD 3
  • Gadd-Related Protein 2
  • GADD45-Gamma 3
  • GADD45gamma 3
  • 17 KD 2

External Ids for GADD45G Gene

Previous GeneCards Identifiers for GADD45G Gene

  • GC09P083195
  • GC09P084099
  • GC09P085804
  • GC09P087711
  • GC09P089449
  • GC09P091409
  • GC09P092219
  • GC09P062051

Summaries for GADD45G Gene

Entrez Gene Summary for GADD45G Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45G Gene

GADD45G (Growth Arrest And DNA-Damage-Inducible, Gamma) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Chks in Checkpoint Regulation. An important paralog of this gene is GADD45B.

UniProtKB/Swiss-Prot for GADD45G Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK

Gene Wiki entry for GADD45G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45G Gene

Genomics for GADD45G Gene

Regulatory Elements for GADD45G Gene

Genomic Location for GADD45G Gene

Start:
89,605,012 bp from pter
End:
89,606,555 bp from pter
Size:
1,544 bases
Orientation:
Plus strand

Genomic View for GADD45G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GADD45G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45G Gene

Proteins for GADD45G Gene

  • Protein details for GADD45G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95257-GA45G_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 gamma
    Protein Accession:
    O95257
    Secondary Accessions:
    • Q5VZ87
    • Q9C076

    Protein attributes for GADD45G Gene

    Size:
    159 amino acids
    Molecular mass:
    17121 Da
    Quaternary structure:
    • Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA.

    Three dimensional structures from OCA and Proteopedia for GADD45G Gene

neXtProt entry for GADD45G Gene

Proteomics data for GADD45G Gene at MOPED

Post-translational modifications for GADD45G Gene

No Post-translational modifications

Other Protein References for GADD45G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GADD45G Gene

Domains for GADD45G Gene

Protein Domains for GADD45G Gene

Graphical View of Domain Structure for InterPro Entry

O95257

UniProtKB/Swiss-Prot:

GA45G_HUMAN :
  • O95257
Domain:
  • Two central helices mediate homodimerization through parallel packing
Family:
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45G: view

No data available for Gene Families for GADD45G Gene

Function for GADD45G Gene

Molecular function for GADD45G Gene

GENATLAS Biochemistry: growth arrest and DNA-damage inducible,gamma,involved in negative control of cell growth
UniProtKB/Swiss-Prot Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK

Gene Ontology (GO) - Molecular Function for GADD45G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12716909
genes like me logo Genes that share ontologies with GADD45G: view
genes like me logo Genes that share phenotypes with GADD45G: view

Animal Models for GADD45G Gene

MGI Knock Outs for GADD45G:

miRNA for GADD45G Gene

miRTarBase miRNAs that target GADD45G

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GADD45G Gene

Localization for GADD45G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADD45G Gene COMPARTMENTS Subcellular localization image for GADD45G gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GADD45G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9827804
GO:0005737 cytoplasm IDA 9827804
genes like me logo Genes that share ontologies with GADD45G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GADD45G Gene

Pathways for GADD45G Gene

genes like me logo Genes that share pathways with GADD45G: view

Pathways by source for GADD45G Gene

Gene Ontology (GO) - Biological Process for GADD45G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0000186 activation of MAPKK activity IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with GADD45G: view

Transcripts for GADD45G Gene

mRNA/cDNA for GADD45G Gene

Unigene Clusters for GADD45G Gene

Growth arrest and DNA-damage-inducible, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for GADD45G Gene

GeneLoc Exon Structure for
GADD45G
ECgene alternative splicing isoforms for
GADD45G

Expression for GADD45G Gene

mRNA expression in normal human tissues for GADD45G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GADD45G Gene

This gene is overexpressed in Liver (5.6), Heart - Atrial Appendage (5.6), and Artery - Tibial (4.2).

SOURCE GeneReport for Unigene cluster for GADD45G Gene Hs.9701

genes like me logo Genes that share expressions with GADD45G: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for GADD45G Gene

Orthologs for GADD45G Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GADD45G 35
  • 99.58 (n)
  • 99.37 (a)
GADD45G 36
  • 68 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GADD45G 35
  • 89.1 (n)
  • 95.6 (a)
GADD45G 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45G 35
  • 88.89 (n)
  • 96.23 (a)
GADD45G 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45g 35
  • 88.26 (n)
  • 96.86 (a)
Gadd45g 16
Gadd45g 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GADD45G 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45g 35
  • 88.26 (n)
  • 96.23 (a)
chicken
(Gallus gallus)
Aves GADD45 36
  • 55 (a)
OneToOne
GADD45B 35
  • 76.1 (n)
  • 77.99 (a)
lizard
(Anolis carolinensis)
Reptilia GADD45G 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45g 35
  • 70.23 (n)
  • 76.73 (a)
Str.6981 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11828 35
gadd45g 35
  • 67.3 (n)
  • 67.09 (a)
gadd45g 36
  • 47 (a)
OneToMany
GADD45G (1 of 3) 36
  • 49 (a)
OneToMany
GADD45G (3 of 3) 36
  • 30 (a)
OneToMany
Species with no ortholog for GADD45G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45G Gene

ENSEMBL:
Gene Tree for GADD45G (if available)
TreeFam:
Gene Tree for GADD45G (if available)

Paralogs for GADD45G Gene

Paralogs for GADD45G Gene

Selected SIMAP similar genes for GADD45G Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GADD45G: view

Variants for GADD45G Gene

Sequence variations from dbSNP and Humsavar for GADD45G Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8252 -- 89,606,095(-) ACCAA(A/G)GTCCC utr-variant-3-prime
rs1329732 -- 89,603,794(-) CTGCC(C/G)GGCCG upstream-variant-2KB
rs2031968 -- 89,603,395(-) TGGCC(A/G)GGACA upstream-variant-2KB
rs2031969 -- 89,603,112(-) TCTAA(C/G)AATGA upstream-variant-2KB
rs2183297 -- 89,603,193(-) CCAAG(G/T)TGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GADD45G Gene

Variant ID Type Subtype PubMed ID
esv29434 CNV Gain+Loss 19812545
nsv893558 CNV Gain 21882294
nsv469563 CNV Complex 16826518
nsv471662 CNV Gain+Loss 15918152
nsv509309 CNV Insertion 20534489

Relevant External Links for GADD45G Gene

HapMap Linkage Disequilibrium report
GADD45G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45G Gene

Disorders for GADD45G Gene

(4) Novoseek inferred disease relationships for GADD45G Gene

Disease -log(P) Hits PubMed IDs
lung carcinoma 43.2 2
retinoblastoma 38.1 1
tumors 13.2 3
cancer 0 3

Relevant External Links for GADD45G

Genetic Association Database (GAD)
GADD45G
Human Genome Epidemiology (HuGE) Navigator
GADD45G
genes like me logo Genes that share disorders with GADD45G: view

No data available for UniProtKB/Swiss-Prot for GADD45G Gene

Publications for GADD45G Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M. … Saito H. (Cell 1998) 2 3 4 23
  2. Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. (PMID: 10496071) Suzuki M. … Tanigami A. (J. Hum. Genet. 1999) 2 3 23
  3. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. (PMID: 10597261) Fan W. … Smith K.A. (Oncogene 1999) 3 4 23
  4. Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. (PMID: 11022036) Azam N. … Liebermann D.A. (J. Biol. Chem. 2001) 3 23
  5. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. (PMID: 10490824) Zhang W. … Liebermann D.A. (Oncogene 1999) 3 23

Products for GADD45G Gene

Sources for GADD45G Gene

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