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Aliases for ADCY3 Gene

Aliases for ADCY3 Gene

  • Adenylate Cyclase 3 2 3 5
  • Adenylate Cyclase, Olfactive Type 3 4
  • Adenylate Cyclase Type III 3 4
  • ATP Pyrophosphate-Lyase 3 3 4
  • Adenylyl Cyclase 3 3 4
  • EC 4.6.1.1 4 63
  • AC-III 3 4
  • AC3 3 4
  • Adenylyl Cyclase, Type III 3
  • KIAA0511 4
  • EC 4.6.1 63

External Ids for ADCY3 Gene

Previous GeneCards Identifiers for ADCY3 Gene

  • GC02M024963
  • GC02M025134
  • GC02M024999
  • GC02M025016
  • GC02M024953
  • GC02M025042
  • GC02M024779

Summaries for ADCY3 Gene

Entrez Gene Summary for ADCY3 Gene

  • This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADCY3 Gene

ADCY3 (Adenylate Cyclase 3) is a Protein Coding gene. Diseases associated with ADCY3 include restrictive cardiomyopathy. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include nucleotide binding and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY3 Gene

  • Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Tocris Summary for ADCY3 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY3 Gene

Genomics for ADCY3 Gene

Regulatory Elements for ADCY3 Gene

Promoters for ADCY3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADCY3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCY3 Gene

Chromosome:
2
Start:
24,819,169 bp from pter
End:
24,919,839 bp from pter
Size:
100,671 bases
Orientation:
Minus strand

Genomic View for ADCY3 Gene

Genes around ADCY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY3 Gene

Proteins for ADCY3 Gene

  • Protein details for ADCY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60266-ADCY3_HUMAN
    Recommended name:
    Adenylate cyclase type 3
    Protein Accession:
    O60266
    Secondary Accessions:
    • B3KT86
    • Q53T54
    • Q9UDB1

    Protein attributes for ADCY3 Gene

    Size:
    1144 amino acids
    Molecular mass:
    128960 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADCY3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY3 Gene

Proteomics data for ADCY3 Gene at MOPED

Selected DME Specific Peptides for ADCY3 Gene

Post-translational modifications for ADCY3 Gene

  • N-glycosylated.
  • Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.
  • Sumoylated. Sumoylation is required for targeting ot olfactory cilia.
  • Ubiquitination at Lys 1046, Lys 1111, and Lys 1120
  • Glycosylation at Asn 736
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for ADCY3

Domains & Families for ADCY3 Gene

Gene Families for ADCY3 Gene

Protein Domains for ADCY3 Gene

Graphical View of Domain Structure for InterPro Entry

O60266

UniProtKB/Swiss-Prot:

ADCY3_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
  • Contains 2 guanylate cyclase domains.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY3: view

Function for ADCY3 Gene

Molecular function for ADCY3 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type III,calmodulin sensitive,olfactory sensory neurons,brain,spinal and retina,heart,kidney,liver,lung,pancreas,placenta,skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forskolin. After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Enzyme Numbers (IUBMB) for ADCY3 Gene

genes like me logo Genes that share phenotypes with ADCY3: view

Animal Models for ADCY3 Gene

MGI Knock Outs for ADCY3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCY3

miRNA for ADCY3 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY3 Gene

Localization for ADCY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY3 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus. Note=Also detected in the cytoplasm, close to lipid droplets. {ECO:0000269 PubMed:11549699}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY3 Gene COMPARTMENTS Subcellular localization image for ADCY3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
nucleus 4

Gene Ontology (GO) - Cellular Components for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11549699
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with ADCY3: view

Pathways & Interactions for ADCY3 Gene

SuperPathways for ADCY3 Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin-3, 5 and GM-CSF signaling
3 Circadian entrainment
4 Aquaporin-mediated transport
5 G-Beta Gamma Signaling
genes like me logo Genes that share pathways with ADCY3: view

SIGNOR curated interactions for ADCY3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006833 water transport TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
genes like me logo Genes that share ontologies with ADCY3: view

Drugs & Compounds for ADCY3 Gene

(12) Drugs for ADCY3 Gene - From: HMDB, Novoseek, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
Forskolin Experimental Pharma Adenylyl cyclase activator 0
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0

(8) Additional Compounds for ADCY3 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
NKH 477
138605-00-2
PACAP 1-27
127317-03-7
PACAP 1-38
137061-48-4
SQ 22536
17318-31-9
genes like me logo Genes that share compounds with ADCY3: view

Transcripts for ADCY3 Gene

Unigene Clusters for ADCY3 Gene

Adenylate cyclase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11: - -
SP12: -
SP13:
SP14:
SP15:

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1:
SP2:
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ADCY3 Gene

GeneLoc Exon Structure for
ADCY3
ECgene alternative splicing isoforms for
ADCY3

Expression for ADCY3 Gene

mRNA expression in normal human tissues for ADCY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADCY3 Gene

This gene is overexpressed in Lung (44.6), Esophagus (10.8), and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY3 Gene



SOURCE GeneReport for Unigene cluster for ADCY3 Gene Hs.467898

mRNA Expression by UniProt/SwissProt for ADCY3 Gene

O60266-ADCY3_HUMAN
Tissue specificity: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
genes like me logo Genes that share expression patterns with ADCY3: view

Protein tissue co-expression partners for ADCY3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADCY3 Gene

Orthologs for ADCY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY3 36
  • 100 (a)
OneToOne
ADCY3 35
  • 99.53 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia ADCY3 35
  • 90.62 (n)
  • 94.76 (a)
ADCY3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY3 36
  • 93 (a)
OneToOne
ADCY3 35
  • 90.36 (n)
  • 93.88 (a)
mouse
(Mus musculus)
Mammalia Adcy3 36
  • 94 (a)
OneToOne
Adcy3 16
Adcy3 35
  • 89.99 (n)
  • 94.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCY3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy3 35
  • 89.34 (n)
  • 94.65 (a)
chicken
(Gallus gallus)
Aves ADCY3 35
  • 79.14 (n)
  • 80.44 (a)
ADCY3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc27 35
  • 75.25 (n)
  • 80.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ADCY3 36
  • 77 (a)
OneToOne
adcy3l 35
  • 73.85 (n)
  • 77.34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009315 35
  • 55.35 (n)
  • 43.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac3 36
  • 38 (a)
OneToOne
Ac3 35
  • 51.2 (n)
  • 43.95 (a)
Ac3 37
  • 37 (a)
Ac78C 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-4 37
  • 45 (a)
Species with no ortholog for ADCY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY3 Gene

ENSEMBL:
Gene Tree for ADCY3 (if available)
TreeFam:
Gene Tree for ADCY3 (if available)

Paralogs for ADCY3 Gene

Paralogs for ADCY3 Gene

genes like me logo Genes that share paralogs with ADCY3: view

Variants for ADCY3 Gene

Sequence variations from dbSNP and Humsavar for ADCY3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11676272 - 24,918,669(+) GAGGG(A/G)AGCCA reference, missense
rs916484 -- 24,859,719(-) CTTCA(G/T)GCCGG intron-variant
rs916485 -- 24,859,404(-) CCACC(A/G)TGCCA intron-variant
rs753529 -- 24,831,392(+) CTGCC(A/G)TACTC intron-variant
rs934608 -- 24,840,273(+) TTCCC(A/G)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY3 Gene

Variant ID Type Subtype PubMed ID
nsv508831 CNV Insertion 20534489
nsv873742 CNV Loss 21882294
esv2678377 CNV Deletion 23128226
nsv2645 CNV Loss 18451855
esv2666034 CNV Deletion 23128226
esv2668898 CNV Deletion 23128226
esv2673418 CNV Deletion 23128226
nsv2646 CNV Insertion 18451855
esv989967 CNV Deletion 20482838
nsv524979 CNV Loss 19592680

Variation tolerance for ADCY3 Gene

Residual Variation Intolerance Score: 3.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY3 Gene

HapMap Linkage Disequilibrium report
ADCY3
Human Gene Mutation Database (HGMD)
ADCY3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY3 Gene

Disorders for ADCY3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADCY3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
restrictive cardiomyopathy
  • cardiomyopathy, familial restrictive, 1
- elite association - COSMIC cancer census association via MalaCards
Search ADCY3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADCY3

Genetic Association Database (GAD)
ADCY3
Human Genome Epidemiology (HuGE) Navigator
ADCY3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY3
genes like me logo Genes that share disorders with ADCY3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY3 Gene

Publications for ADCY3 Gene

  1. Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. (PMID: 9920776) Yang B. … Hillert J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Adenylate cyclase regulates elongation of mammalian primary cilia. (PMID: 19576885) Ou Y. … van der Hoorn F.A. (Exp. Cell Res. 2009) 3 23
  3. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. (PMID: 17895882) Nordman S. … Gu H.F. (Int J Obes (Lond) 2008) 3 23
  4. Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets. (PMID: 12623444) Katsel P.L. … Maayani S. (Platelets 2003) 3 23
  5. Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules. (PMID: 12782409) Celano M. … Russo D. (Mol. Cell. Endocrinol. 2003) 3 23

Products for ADCY3 Gene

Sources for ADCY3 Gene

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