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Aliases for ADCY3 Gene

Aliases for ADCY3 Gene

  • Adenylate Cyclase 3 2 3 5
  • Adenylate Cyclase, Olfactive Type 3 4
  • Adenylate Cyclase Type III 3 4
  • ATP Pyrophosphate-Lyase 3 3 4
  • Adenylyl Cyclase 3 3 4
  • EC 4.6.1.1 4 61
  • AC-III 3 4
  • AC3 3 4
  • Adenylyl Cyclase, Type III 3
  • Adenylate Cyclase Type 3 3
  • KIAA0511 4
  • EC 4.6.1 61

External Ids for ADCY3 Gene

Previous GeneCards Identifiers for ADCY3 Gene

  • GC02M024963
  • GC02M025134
  • GC02M024999
  • GC02M025016
  • GC02M024953
  • GC02M025042
  • GC02M024779

Summaries for ADCY3 Gene

Entrez Gene Summary for ADCY3 Gene

  • This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADCY3 Gene

ADCY3 (Adenylate Cyclase 3) is a Protein Coding gene. Among its related pathways are Signaling in Gap Junctions and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include nucleotide binding and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY8.

UniProtKB/Swiss-Prot for ADCY3 Gene

  • Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Tocris Summary for ADCY3 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY3 Gene

Genomics for ADCY3 Gene

Regulatory Elements for ADCY3 Gene

Enhancers for ADCY3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G024871 1.6 FANTOM5 Ensembl ENCODE dbSUPER 57.4 +46.3 46261 5.0 ESRRA MAX KLF17 ZNF384 ZIC2 RARA YY1 TEAD3 ZNF121 CTBP1 ADCY3 CENPO LOC105377626
GH02G024885 1.2 FANTOM5 Ensembl ENCODE 65.4 +33.4 33439 2.8 SCRT1 PKNOX1 SMARCA4 POLR2A BHLHE40 NR2F1 FOS CHD2 ADCY3 DNAJC27 DNAJC27-AS1 ENSG00000202479 RPS13P5 PTRHD1 LOC105377626
GH02G024854 1.5 Ensembl ENCODE dbSUPER 51 +64.1 64105 3.2 SIN3A FEZF1 TCF12 GLIS2 GATA2 FOS ZNF263 SP3 TSHZ1 SREBF1 ADCY3 LOC105377626
GH02G024970 1.4 ENCODE dbSUPER 37.7 -52.4 -52397 3.6 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC GLIS1 RCOR2 ADCY3 EFR3B LINC01381 POMC DNAJC27 PTRHD1 GC02M025008 ENSG00000207069
GH02G024893 0.6 ENCODE 64.1 +25.9 25854 0.8 SOX5 FOXA2 MIER1 FOS DPF2 FOXA1 ADCY3 RPS13P5 ENSG00000202479 DNAJC27 DNAJC27-AS1 LOC105377626
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADCY3 on UCSC Golden Path with GeneCards custom track

Promoters for ADCY3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114102 -261 1801 HDGF CREB3L1 SIN3A SP3 ZNF592 GLIS1 NBN KDM1A WT1 SP7

Genomic Location for ADCY3 Gene

Chromosome:
2
Start:
24,819,169 bp from pter
End:
24,919,839 bp from pter
Size:
100,671 bases
Orientation:
Minus strand

Genomic View for ADCY3 Gene

Genes around ADCY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY3 Gene

Proteins for ADCY3 Gene

  • Protein details for ADCY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60266-ADCY3_HUMAN
    Recommended name:
    Adenylate cyclase type 3
    Protein Accession:
    O60266
    Secondary Accessions:
    • B3KT86
    • Q53T54
    • Q9UDB1

    Protein attributes for ADCY3 Gene

    Size:
    1144 amino acids
    Molecular mass:
    128960 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADCY3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY3 Gene

Selected DME Specific Peptides for ADCY3 Gene

O60266:
  • RIKILGDCYYC
  • ADIVGFT
  • TVNVASR
  • AGVIGARKP
  • WQYDVWS
  • ASRMEST
  • MRVGVHTGTVL

Post-translational modifications for ADCY3 Gene

  • N-glycosylated.
  • Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.
  • Sumoylated. Sumoylation is required for targeting ot olfactory cilia.
  • Ubiquitination at Lys1046, posLast=11111111, and posLast=11201120
  • Glycosylation at Asn736
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for ADCY3

Domains & Families for ADCY3 Gene

Gene Families for ADCY3 Gene

Protein Domains for ADCY3 Gene

Graphical View of Domain Structure for InterPro Entry

O60266

UniProtKB/Swiss-Prot:

ADCY3_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY3: view

Function for ADCY3 Gene

Molecular function for ADCY3 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type III,calmodulin sensitive,olfactory sensory neurons,brain,spinal and retina,heart,kidney,liver,lung,pancreas,placenta,skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forskolin. After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Enzyme Numbers (IUBMB) for ADCY3 Gene

Gene Ontology (GO) - Molecular Function for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IEA,TAS --
GO:0004383 guanylate cyclase activity IBA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with ADCY3: view
genes like me logo Genes that share phenotypes with ADCY3: view

Animal Models for ADCY3 Gene

MGI Knock Outs for ADCY3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCY3

miRNA for ADCY3 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY3 Gene

Localization for ADCY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY3 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus. Note=Also detected in the cytoplasm, close to lipid droplets. {ECO:0000269 PubMed:11549699}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA,IEA 11549699
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9920776
genes like me logo Genes that share ontologies with ADCY3: view

Pathways & Interactions for ADCY3 Gene

SuperPathways for ADCY3 Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
2 RET signaling
3 Vascular smooth muscle contraction
4 Development Endothelin-1/EDNRA signaling
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY3: view

SIGNOR curated interactions for ADCY3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process IEA,ISS --
GO:0006182 cGMP biosynthetic process IBA --
GO:0007165 signal transduction TAS 9920776
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADCY3: view

Drugs & Compounds for ADCY3 Gene

(21) Drugs for ADCY3 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0

(4) Additional Compounds for ADCY3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(5) Tocris Compounds for ADCY3 Gene

Compound Action Cas Number
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(8) ApexBio Compounds for ADCY3 Gene

Compound Action Cas Number
1,9-Dideoxyforskolin 64657-18-7
Forskolin 66575-29-9
KH 7 330676-02-3
MDL 12330A hydrochloride adenylate cyclase inhibitor 40297-09-4
N6-methyladenosine (m6A) adenylate cyclase regulator 1867-73-8
NKH 477 138605-00-2
NKY 80 299442-43-6
SQ 22536 17318-31-9
genes like me logo Genes that share compounds with ADCY3: view

Transcripts for ADCY3 Gene

Unigene Clusters for ADCY3 Gene

Adenylate cyclase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11: - -
SP12: -
SP13:
SP14:
SP15:

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1:
SP2:
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ADCY3 Gene

GeneLoc Exon Structure for
ADCY3
ECgene alternative splicing isoforms for
ADCY3

Expression for ADCY3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADCY3 Gene

This gene is overexpressed in Lung (44.6), Esophagus (10.8), and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY3 Gene



Protein tissue co-expression partners for ADCY3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCY3 Gene:

ADCY3

SOURCE GeneReport for Unigene cluster for ADCY3 Gene:

Hs.467898

mRNA Expression by UniProt/SwissProt for ADCY3 Gene:

O60266-ADCY3_HUMAN
Tissue specificity: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).

Evidence on tissue expression from TISSUES for ADCY3 Gene

  • Nervous system(4.8)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with ADCY3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY3 Gene

Orthologs for ADCY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY3 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia ADCY3 34 35
  • 90.62 (n)
dog
(Canis familiaris)
Mammalia ADCY3 34 35
  • 90.36 (n)
mouse
(Mus musculus)
Mammalia Adcy3 34 16 35
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Adcy3 34
  • 89.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ADCY3 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCY3 35 34
  • 79.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc27 34
  • 75.25 (n)
zebrafish
(Danio rerio)
Actinopterygii ADCY3 35
  • 77 (a)
OneToOne
adcy3l 34
  • 73.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009315 34
  • 55.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ac3 36 34 35
  • 51.2 (n)
Ac78C 36
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-4 36
  • 45 (a)
Species where no ortholog for ADCY3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY3 Gene

ENSEMBL:
Gene Tree for ADCY3 (if available)
TreeFam:
Gene Tree for ADCY3 (if available)

Paralogs for ADCY3 Gene

Paralogs for ADCY3 Gene

genes like me logo Genes that share paralogs with ADCY3: view

Variants for ADCY3 Gene

Sequence variations from dbSNP and Humsavar for ADCY3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000023937 -- 24,894,705(+) GCCTC(C/T)TCACT intron-variant
rs1000050121 -- 24,916,020(+) TCAGG(C/G)TCCCA intron-variant
rs1000082291 -- 24,915,787(+) CCGCC(C/T)GCCTC intron-variant
rs1000099284 -- 24,877,481(+) CTGAG(A/G)ACAGC intron-variant
rs1000111061 -- 24,839,460(+) GTAAT(C/T)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY3 Gene

Variant ID Type Subtype PubMed ID
esv2666034 CNV deletion 23128226
esv2668898 CNV deletion 23128226
esv2673418 CNV deletion 23128226
esv2678377 CNV deletion 23128226
esv3553955 CNV deletion 23714750
esv3590077 CNV loss 21293372
esv3590078 CNV loss 21293372
esv3590080 CNV loss 21293372
esv3590081 CNV loss 21293372
esv3590082 CNV loss 21293372
esv989967 CNV deletion 20482838
nsv1000020 CNV gain 25217958
nsv1004529 CNV loss 25217958
nsv1008732 CNV loss 25217958
nsv2645 CNV deletion 18451855
nsv2646 CNV insertion 18451855
nsv477077 CNV novel sequence insertion 20440878
nsv508831 CNV insertion 20534489
nsv524979 CNV loss 19592680
nsv997725 CNV gain 25217958

Variation tolerance for ADCY3 Gene

Residual Variation Intolerance Score: 3.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY3 Gene

Human Gene Mutation Database (HGMD)
ADCY3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY3 Gene

Disorders for ADCY3 Gene

Relevant External Links for ADCY3

Genetic Association Database (GAD)
ADCY3
Human Genome Epidemiology (HuGE) Navigator
ADCY3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY3

No disorders were found for ADCY3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY3 Gene

Publications for ADCY3 Gene

  1. Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. (PMID: 9920776) Yang B. … Hillert J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. (PMID: 17895882) Nordman S. … Gu H.F. (Int J Obes (Lond) 2008) 3 22 46 64
  3. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) CA'tAc M. … Gallo-Payet N. (J. Clin. Endocrinol. Metab. 2001) 3 4 22 64
  4. Meta-analysis identifies common variants associated with body mass index in east Asians. (PMID: 22344219) Wen W. … Shu X.O. (Nat. Genet. 2012) 3 46 64
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 46 64

Products for ADCY3 Gene

Sources for ADCY3 Gene

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