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JTB Gene(Protein Coding)

Jumping Translocation Breakpoint

GCID:
GC01M153974
GIFtS:
49
Genes Participants
UDN Logo

Aliases for JTB Gene

Aliases for JTB Gene

  • Jumping Translocation Breakpoint 2 3 5
  • Jumping Translocation Breakpoint Protein 3 4
  • Prostate Androgen-Regulated Protein 3 4
  • Prostate Androgen-Regulated Gene 2
  • PAR Protein 4
  • HSPC222 3
  • HJTB 3
  • PAR 3
  • HJT 3

External Ids for JTB Gene

Previous GeneCards Identifiers for JTB Gene

  • GC01M151763
  • GC01M149677
  • GC01M150722
  • GC01M151163
  • GC01M150759
  • GC01M152213
  • GC01M153946
  • GC01M125309

Summaries for JTB Gene

GeneCards Summary for JTB Gene

JTB (Jumping Translocation Breakpoint) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for JTB Gene

  • Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Gene Wiki entry for JTB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JTB Gene

Genomics for JTB Gene

Products:

  1. Regulatory Element

Regulatory Elements for JTB Gene

Enhancers for JTB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JTB on UCSC Golden Path with GeneCards custom track

Promoters for JTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JTB on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the JTB gene promoter:

Genomic Location for JTB Gene

Chromosome:
1
Start:
153,974,269 bp from pter
End:
153,977,975 bp from pter
Size:
3,707 bases
Orientation:
Minus strand

Genomic View for JTB Gene

Genes around JTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JTB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for JTB Gene

Proteins for JTB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for JTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76095-JTB_HUMAN
    Recommended name:
    Protein JTB
    Protein Accession:
    O76095
    Secondary Accessions:
    • O95442
    • Q6IB19
    • Q9P0Q4

    Protein attributes for JTB Gene

    Size:
    146 amino acids
    Molecular mass:
    16358 Da
    Quaternary structure:
    • Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.

    Three dimensional structures from OCA and Proteopedia for JTB Gene

    Alternative splice isoforms for JTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JTB Gene

Proteomics data for JTB Gene at MOPED

Protein Expression for JTB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for JTB Gene

  • Ubiquitination at Lys 69
  • Modification sites at PhosphoSitePlus

Other Protein References for JTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JTB Gene

Domains & Families for JTB Gene

Protein Domains for JTB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for JTB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76095

UniProtKB/Swiss-Prot:

JTB_HUMAN :
  • Belongs to the JTB family.
Family:
  • Belongs to the JTB family.
genes like me logo Genes that share domains with JTB: view

No data available for Gene Families for JTB Gene

Function for JTB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for JTB Gene

GENATLAS Biochemistry:
jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
UniProtKB/Swiss-Prot Function:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
UniProtKB/Swiss-Prot Induction:
Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.

Phenotypes for JTB Gene

GenomeRNAi human phenotypes for JTB:
genes like me logo Genes that share phenotypes with JTB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JTB

miRNA for JTB Gene

miRTarBase miRNAs that target JTB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JTB Gene

Localization for JTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JTB Gene

Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JTB Gene COMPARTMENTS Subcellular localization image for JTB gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
extracellular 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21225229
GO:0005819 colocalizes_with spindle IDA 21225229
GO:0016021 integral component of membrane IEA --
GO:0030496 midbody IDA 21225229
genes like me logo Genes that share ontologies with JTB: view

Pathways & Interactions for JTB Gene

SuperPathways for JTB Gene

PathCards logoMore details on SuperPathways for JTB
No Data Available

Gene Ontology (GO) - Biological Process for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008637 apoptotic mitochondrial changes IEA --
genes like me logo Genes that share ontologies with JTB: view

No data available for Pathways by source and SIGNOR curated interactions for JTB Gene

Drugs & Compounds for JTB Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for JTB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for JTB Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(930) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JTB Gene

Jumping translocation breakpoint:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JTB Gene

No ASD Table

Relevant External Links for JTB Gene

GeneLoc Exon Structure for
JTB
ECgene alternative splicing isoforms for
JTB

Expression for JTB Gene

Products:

  1. Primer

mRNA expression in normal human tissues for JTB Gene

mRNA expression in normal human tissues for JTB Gene
mRNA expression by BioGPS for JTB GenemRNA expression by GTEx for JTB Gene

Protein differential expression in normal tissues from HIPED for JTB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Pancreas (10.9), Bone (10.4), and Colon (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for JTB Gene



SOURCE GeneReport for Unigene cluster for JTB Gene Hs.6396

mRNA Expression by UniProt/SwissProt for JTB Gene

O76095-JTB_HUMAN
Tissue specificity: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
genes like me logo Genes that share expression patterns with JTB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for JTB Gene

Orthologs for JTB Gene

This gene was present in the common ancestor of chordates.

Orthologs for JTB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia JTB 35
  • 89.95 (n)
  • 89.73 (a)
JTB 36
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia JTB 35
  • 86.53 (n)
  • 87.67 (a)
mouse
(Mus musculus)
 Mammalia Jtb 35
  • 82.88 (n)
  • 85.62 (a)
Jtb 16
Jtb 36
  • 86 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia JTB 35
  • 99.54 (n)
  • 100 (a)
JTB 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Jtb 35
  • 84.02 (n)
  • 86.99 (a)
oppossum
(Monodelphis domestica)
 Mammalia JTB 36
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves JTB 36
  • 67 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii jtb 36
  • 24 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 32 (a)
 OneToOne
Species with no ortholog for JTB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JTB Gene

ENSEMBL:
Gene Tree for JTB (if available)
TreeFam:
Gene Tree for JTB (if available)

Paralogs for JTB Gene

Pseudogenes.org Pseudogenes for JTB Gene

genes like me logo Genes that share paralogs with JTB: view

No data available for Paralogs for JTB Gene

Variants for JTB Gene

Sequence variations from dbSNP and Humsavar for JTB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34686244 - 153,977,207(-) GCCAC(C/T)TCTGC reference, missense
rs1547766 -- 153,979,729(+) TATTA(A/C)ACATA upstream-variant-2KB
rs1547767 -- 153,979,744(+) AATTA(C/T)ATATA upstream-variant-2KB
rs3182946 -- 153,977,614(-) ACCGG(C/G)CCCCG utr-variant-5-prime
rs7527963 -- 153,975,745(+) CCCCA(A/G/T)ACCAG intron-variant

Variation tolerance for JTB Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for JTB Gene

Disorders for JTB Gene

Relevant External Links for JTB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JTB

No disorders were found for JTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JTB Gene

Publications for JTB Gene

  1. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PMID: 10321732) Hatakeyama S. … Ishikawa F. (Oncogene 1999) 2 3 4 67
  2. The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. (PMID: 22079049) Rousseau F. … Lingel A. (J. Mol. Biol. 2012) 3
  3. HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. (PMID: 22615844) Liu Y.P. … Ren J.L. (PLoS ONE 2012) 3
  4. [Downregulation of PAR expression induces the apoptosis of human prostate cancer PC3 cells and increases the Bcl-2/Bax ratio]. (PMID: 23297497) Xu X.F. … Gao J.P. (Zhonghua Nan Ke Xue 2012) 3
  5. PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PMID: 21225229) Platica M. … Platica O. (Int. J. Oncol. 2011) 3

Products for JTB Gene

Sources for JTB Gene

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