Aliases for JTB Gene
Aliases for JTB Gene
External Ids for JTB Gene
- HGNC: 6201
- Entrez Gene: 10899
- Ensembl: ENSG00000143543
- OMIM: 604671
- UniProtKB: O76095
Previous GeneCards Identifiers for JTB Gene
- GC01M151763
- GC01M149677
- GC01M150722
- GC01M151163
- GC01M150759
- GC01M152213
- GC01M153946
- GC01M125309
Summaries for JTB Gene
GeneCards Summary for JTB Gene
JTB (Jumping Translocation Breakpoint) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot for JTB Gene
-
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JTB Gene
Genomics for JTB Gene
Regulatory Elements for JTB Gene
Enhancers for JTB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around JTB on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the JTB gene promoter:
Regulatory Element Products
Genomic Location for JTB Gene
- Chromosome:
- 1
- Start:
- 153,974,269 bp from pter
- End:
- 153,977,975 bp from pter
- Size:
- 3,707 bases
- Orientation:
- Minus strand
Genomic View for JTB Gene
Genes around JTB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
JTB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for JTB Gene
Proteins for JTB Gene
-
Protein details for JTB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O76095-JTB_HUMAN
- Recommended name:
- Protein JTB
- Protein Accession:
- O76095
- O95442
- Q6IB19
- Q9P0Q4
Protein attributes for JTB Gene
- Size:
- 146 amino acids
- Molecular mass:
- 16358 Da
- Quaternary structure:
-
- Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.
Protein Expression for JTB Gene
Post-translational modifications for JTB Gene
Other Protein References for JTB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for JTB
-
Abcam antibodies for JTB
- Invitrogen Antibodies for JTB
- antibodies-online Antibodies for JTB: See all 23
- Search GeneTex for Antibodies for JTB
Protein Products
-
OriGene Purified Proteins for JTB
- Search Origene for MassSpec and Protein Over-expression Lysates for JTB
- Origene Custom Protein Services for JTB
- Sino Biological Cell Lysates for JTB
- Sino Biological Recombinant Proteins for JTB
- ProSpec Recombinant Proteins for JTB
- antibodies-online Proteins for JTB: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for JTB
-
Abcam proteins for JTB
Assay Products
- antibodies-online Kits for JTB: See all 5
No data available for DME Specific Peptides for JTB Gene
Domains & Families for JTB Gene
Protein Domains for JTB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for JTB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O76095- Family:
-
- Belongs to the JTB family.
No data available for Gene Families for JTB Gene
Function for JTB Gene
Molecular function for JTB Gene
- GENATLAS Biochemistry:
- jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
- UniProtKB/Swiss-Prot Function:
- Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019901 | protein kinase binding | IDA | 21225229 |
Phenotypes for JTB Gene
- MGI mutant phenotypes for JTB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for JTB:
Animal Models for JTB Gene
- MGI Knock Outs for JTB:
-
- Jtb tm1b(EUCOMM)Hmgu
Animal Model Products
-
Taconic Biosciences Mouse Models for JTB
- Cyagen custom Knockout/knockin (KOKI) mouse models for JTB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for JTB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
- Search ViGene Biosciences for JTB
CRISPR Products
-
OriGene CRISPR knockouts for JTB
-
Santa Cruz Biotechnology (SCBT) CRISPR for JTB
- GenScript: Design CRISPR guide RNA sequences for JTB
miRNA for JTB Gene
- miRTarBase miRNAs that target JTB
miRNA Products
- Search ViGene Biosciences for JTB
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for JTB
- Browse OriGene Inhibitory RNA Products For JTB
-
ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
Clone Products
- Sino Biological Human cDNA Clone for JTB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for JTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for JTB
-
ViGene Biosciences adenoviral particle packaged cDNA for JTB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for JTB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JTB Gene
Localization for JTB Gene
Subcellular locations from UniProtKB/Swiss-Prot for JTB Gene
- Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| extracellular | 3 |
| mitochondrion | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 21225229 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005813 | colocalizes_with centrosome | IDA | 21225229 |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005819 | colocalizes_with spindle | IDA,IEA | 21225229 |
Pathways & Interactions for JTB Gene
No Data Available
Interacting Proteins for JTB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | IMP | 21225229 |
| GO:0000910 | cytokinesis | IMP | 21225229 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | IMP | -- |
No data available for Pathways by source and SIGNOR curated interactions for JTB Gene
Transcripts for JTB Gene
mRNA/cDNA for JTB Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (930) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for JTB Gene
CRISPR Products
-
OriGene CRISPR knockouts for JTB
-
Santa Cruz Biotechnology (SCBT) CRISPR for JTB
- GenScript: Design CRISPR guide RNA sequences for JTB
miRNA Products
- Search ViGene Biosciences for JTB
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for JTB
- Browse OriGene Inhibitory RNA Products For JTB
-
ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
Clone Products
- Sino Biological Human cDNA Clone for JTB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for JTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for JTB Gene
This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Pancreas (10.9), Bone (10.4), and Colon (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JTB Gene
NURSA nuclear receptor signaling pathways regulating expression of JTB Gene:
JTBSOURCE GeneReport for Unigene cluster for JTB Gene:
Hs.6396mRNA Expression by UniProt/SwissProt for JTB Gene:
O76095-JTB_HUMAN
Tissue specificity:
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
Evidence on tissue expression from TISSUES for JTB Gene
- Lung(4.8)
- Nervous system(4.8)
- Blood(4.3)
- Skin(4.3)
- Pancreas(3)
- Intestine(2.8)
- Liver(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for JTB
-
OriGene qPCR primer pairs for JTB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JTB Gene
Orthologs for JTB Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | JTB 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | JTB 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | JTB 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Jtb 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Jtb 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | JTB 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | JTB 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | jtb 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for JTB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for JTB Gene
Pseudogenes.org Pseudogenes for JTB Gene
No data available for Paralogs for JTB Gene
Variants for JTB Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001417388 | -- | 153,975,162(+) | TGTCA(C/G)CCAGA | intron-variant | |
| rs1002434171 | -- | 153,974,501(+) | TACAG(A/C)AGGGA | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1002740228 | -- | 153,975,607(+) | TAGAG(A/G)TGGGG | intron-variant | |
| rs1002811548 | -- | 153,974,044(+) | TCCGT(A/G)CTGCA | nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon | |
| rs1003180750 | -- | 153,975,876(+) | ACATA(A/T)CCTGT | reference, synonymous-codon |
Residual Variation Intolerance Score:
55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.00;
49.89% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for JTB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- JTB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JTB Gene
Disorders for JTB Gene
Relevant External Links for JTB
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- JTB
No disorders were found for JTB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JTB Gene
Publications for JTB Gene
- JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PMID: 10321732) Hatakeyama S. … Ishikawa F. (Oncogene 1999) 2 3 4 64
- The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. (PMID: 22079049) Rousseau F. … Lingel A. (J. Mol. Biol. 2012) 3 4 64
- PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PMID: 21225229) Platica M. … Platica O. (Int. J. Oncol. 2011) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PMID: 10762645) Platica O. … Platica M. (Int. J. Oncol. 2000) 3 4 64
Products for JTB Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- OriGene Purified Proteins for JTB
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- OriGene qPCR primer pairs and template standards for JTB
- OriGene qPCR primer pairs for JTB
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- GenScript: Next-day shipping cDNA ORF clone for JTB in any vector
- GenScript Custom Purified and Recombinant Proteins Services for JTB
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- GenScript: Design CRISPR guide RNA sequences for JTB
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Novus Biologicals Antibodies for JTB
- Novus Biologicals proteins and lysates for JTB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for JTB
- Abcam proteins for JTB
- Find your target
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- Taconic Biosciences Mouse Models for JTB
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for JTB
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- antibodies-online Antibodies for JTB: See all 23
- antibodies-online Kits for JTB: See all 5
- antibodies-online Proteins for JTB: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for JTB
- Search GeneTex for Proteins for JTB
- ViGene Biosciences adenoviral particle packaged cDNA for JTB gene
- ViGene Biosciences lentiviral particle packaged cDNA for JTB gene
- ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
- Search ViGene Biosciences for JTB
- Horizon Cell Lines for JTB
- Cyagen custom Knockout/knockin (KOKI) mouse models for JTB
- VectorBuilder custom plasmid, inducible vectors for JTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JTB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for JTB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer