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JTB Gene(Protein Coding)

Jumping Translocation Breakpoint

GCID:
GC01M153974
GIFtS:
44
Genes Participants
UDN Logo

Aliases for JTB Gene

Aliases for JTB Gene

  • Jumping Translocation Breakpoint 2 3 5
  • Jumping Translocation Breakpoint Protein 3 4
  • Prostate Androgen-Regulated Protein 3 4
  • Prostate Androgen-Regulated Gene 2
  • Protein JTB 3
  • PAR Protein 4
  • HSPC222 3
  • HJTB 3
  • PAR 3
  • HJT 3

External Ids for JTB Gene

Previous GeneCards Identifiers for JTB Gene

  • GC01M151763
  • GC01M149677
  • GC01M150722
  • GC01M151163
  • GC01M150759
  • GC01M152213
  • GC01M153946
  • GC01M125309

Summaries for JTB Gene

GeneCards Summary for JTB Gene

JTB (Jumping Translocation Breakpoint) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for JTB Gene

  • Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Gene Wiki entry for JTB Gene

Additional gene information for JTB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JTB Gene

Genomics for JTB Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for JTB Gene

Promoters and enhancers for JTB Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I153975 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 496 3.4 HDGF FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 KLF13 ENSG00000272654 JTB GC01P153977 DENND4B GATAD2B CREB3L4 ENSG00000233222 ENSG00000243613 SLC39A1
GH01I153880 Enhancer 1.1 Ensembl ENCODE 10.9 +96.4 96422 2.7 PKNOX1 SMAD1 FEZF1 ZNF2 GLIS2 ZNF214 SP3 REST ZNF662 TSHZ1 UBAP2L CREB3L4 ENSG00000272654 INTS3 ATP8B2 GATAD2B CRTC2 SLC39A1 JTB CHTOP
GH01I153888 Enhancer 0.7 Ensembl ENCODE 10.8 +89.3 89335 1.1 ZNF121 IRF2 PRDM6 SOX6 BHLHE40 TAL1 CBFA2T3 ENSG00000236327 GATAD2B CREB3L4 SLC39A1 DENND4B CRTC2 JTB RAB13 RPS27 RPL34P5
GH01I153821 Enhancer 0.6 ENCODE 10.9 +156.5 156475 0.1 SMARCA5 CTCF ZNF654 ZBTB6 TRIM22 REST RAD21 ZNF664 ZNF143 SMC3 GATAD2B DENND4B CRTC2 RPS27 RAB13 RPL34P5 CREB3L4 SLC39A1 JTB UBAP2L
GH01I153961 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.7 +14.7 14680 4 HDGF PKNOX1 SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B MIR6737 SLC39A1 ENSG00000282386 ILF2 CREB3L4 UBAP2L RAB13 RPS27 RPL34P5 GATAD2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around JTB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JTB gene promoter:

Genomic Locations for JTB Gene

Genomic Locations for JTB Gene
chr1:153,974,269-153,977,975
(GRCh38/hg38)
Size:
3,707 bases
Orientation:
Minus strand
chr1:153,946,745-153,950,451
(GRCh37/hg19)

Genomic View for JTB Gene

Genes around JTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JTB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for JTB Gene

Proteins for JTB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for JTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76095-JTB_HUMAN
    Recommended name:
    Protein JTB
    Protein Accession:
    O76095
    Secondary Accessions:
    • O95442
    • Q6IB19
    • Q9P0Q4

    Protein attributes for JTB Gene

    Size:
    146 amino acids
    Molecular mass:
    16358 Da
    Quaternary structure:
    • Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.

    Three dimensional structures from OCA and Proteopedia for JTB Gene

    Alternative splice isoforms for JTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JTB Gene

Protein Expression for JTB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for JTB Gene

  • Ubiquitination at isoforms=2, 1, 269

Other Protein References for JTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JTB Gene

Domains & Families for JTB Gene

Gene Families for JTB Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for JTB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for JTB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76095

UniProtKB/Swiss-Prot:

JTB_HUMAN :
  • Belongs to the JTB family.
Family:
  • Belongs to the JTB family.
genes like me logo Genes that share domains with JTB: view

Function for JTB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for JTB Gene

GENATLAS Biochemistry:
jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
UniProtKB/Swiss-Prot Function:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
UniProtKB/Swiss-Prot Induction:
Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.

Gene Ontology (GO) - Molecular Function for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IDA 21225229
genes like me logo Genes that share ontologies with JTB: view
genes like me logo Genes that share phenotypes with JTB: view

Animal Models for JTB Gene

MGI Knock Outs for JTB:
  • Jtb tm1b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

miRNA for JTB Gene

miRTarBase miRNAs that target JTB

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JTB Gene

Localization for JTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JTB Gene

Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JTB gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
mitochondrion 4
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21225229
GO:0005739 mitochondrion IEA --
GO:0005813 colocalizes_with centrosome IDA 21225229
GO:0005815 microtubule organizing center IEA --
GO:0005819 colocalizes_with spindle IDA,IEA 21225229
genes like me logo Genes that share ontologies with JTB: view

Pathways & Interactions for JTB Gene

SuperPathways for JTB Gene

PathCards logo More details on SuperPathways for JTB
No Data Available

Gene Ontology (GO) - Biological Process for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 21225229
GO:0000281 mitotic cytokinesis IMP 21225229
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0008637 apoptotic mitochondrial changes IEA --
genes like me logo Genes that share ontologies with JTB: view

No data available for Pathways by source and SIGNOR curated interactions for JTB Gene

Drugs & Compounds for JTB Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for JTB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for JTB Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(930) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JTB Gene

Jumping translocation breakpoint:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JTB Gene

No ASD Table

Relevant External Links for JTB Gene

GeneLoc Exon Structure for
JTB
ECgene alternative splicing isoforms for
JTB

Expression for JTB Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JTB Gene

mRNA expression in normal human tissues for JTB Gene
mRNA expression by BioGPS for JTB GenemRNA expression by GTEx for JTB Gene

Protein differential expression in normal tissues from HIPED for JTB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Pancreas (10.9), Bone (10.4), and Colon (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JTB Gene



NURSA nuclear receptor signaling pathways regulating expression of JTB Gene:

JTB

SOURCE GeneReport for Unigene cluster for JTB Gene:

Hs.6396

mRNA Expression by UniProt/SwissProt for JTB Gene:

O76095-JTB_HUMAN
Tissue specificity: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.

Evidence on tissue expression from TISSUES for JTB Gene

  • Lung(4.8)
  • Nervous system(4.8)
  • Blood(4.3)
  • Skin(4.3)
  • Pancreas(3)
  • Intestine(2.8)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with JTB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JTB Gene

Orthologs for JTB Gene

This gene was present in the common ancestor of chordates.

Orthologs for JTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia JTB 33 34
  • 99.54 (n)
cow
(Bos Taurus)
 Mammalia JTB 33 34
  • 89.95 (n)
dog
(Canis familiaris)
 Mammalia JTB 33
  • 86.53 (n)
rat
(Rattus norvegicus)
 Mammalia Jtb 33
  • 84.02 (n)
mouse
(Mus musculus)
 Mammalia Jtb 33 16 34
  • 82.88 (n)
oppossum
(Monodelphis domestica)
 Mammalia JTB 34
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves JTB 34
  • 67 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii jtb 34
  • 24 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 32 (a)
 OneToOne
Species where no ortholog for JTB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JTB Gene

ENSEMBL:
Gene Tree for JTB (if available)
TreeFam:
Gene Tree for JTB (if available)

Paralogs for JTB Gene

Pseudogenes.org Pseudogenes for JTB Gene

genes like me logo Genes that share paralogs with JTB: view

No data available for Paralogs for JTB Gene

Variants for JTB Gene

Sequence variations from dbSNP and Humsavar for JTB Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001417388 -- 153,975,162(-) C/G intron_variant
rs1002434171 -- 153,974,501(-) A/C 3_prime_UTR_variant
rs1002740228 -- 153,975,607(-) A/G intron_variant
rs1002811548 -- 153,974,044(-) G/A downstream_transcript_variant
rs1003180750 -- 153,975,876(-) T/A coding_sequence_variant, synonymous_variant

Variation tolerance for JTB Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JTB Gene

Disorders for JTB Gene

Additional Disease Information for JTB

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for JTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JTB Gene

Publications for JTB Gene

  1. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PMID: 10321732) Hatakeyama S … Ishikawa F (Oncogene 1999) 2 3 4 58
  2. The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. (PMID: 22079049) Rousseau F … Lingel A (Journal of molecular biology 2012) 3 4 58
  3. PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PMID: 21225229) Platica M … Platica O (International journal of oncology 2011) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PMID: 10762645) Platica O … Platica M (International journal of oncology 2000) 3 4 58

Products for JTB Gene

Sources for JTB Gene

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