Aliases for JTB Gene
Aliases for JTB Gene
External Ids for JTB Gene
- HGNC: 6201
- Entrez Gene: 10899
- Ensembl: ENSG00000143543
- OMIM: 604671
- UniProtKB: O76095
Previous GeneCards Identifiers for JTB Gene
- GC01M151763
- GC01M149677
- GC01M150722
- GC01M151163
- GC01M150759
- GC01M152213
- GC01M153946
- GC01M125309
Summaries for JTB Gene
GeneCards Summary for JTB Gene
JTB (Jumping Translocation Breakpoint) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot for JTB Gene
-
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JTB Gene
Genomics for JTB Gene
GeneHancer (GH) Regulatory Elements for JTB Gene
- Top Transcription factor binding sites by QIAGEN in the JTB gene promoter:
Regulatory Element Products
Genomic Locations for JTB Gene
- chr1:153,974,269-153,977,975
- (GRCh38/hg38)
- Size:
- 3,707 bases
- Orientation:
- Minus strand
- chr1:153,946,745-153,950,451
- (GRCh37/hg19)
Genomic View for JTB Gene
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC


RefSeq DNA sequence for JTB Gene
Proteins for JTB Gene
-
Protein details for JTB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O76095-JTB_HUMAN
- Recommended name:
- Protein JTB
- Protein Accession:
- O76095
- O95442
- Q6IB19
- Q9P0Q4
Protein attributes for JTB Gene
- Size:
- 146 amino acids
- Molecular mass:
- 16358 Da
- Quaternary structure:
-
- Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.
Protein Expression for JTB Gene
Post-translational modifications for JTB Gene
- Ubiquitination at isoforms=2, 1, 269
Other Protein References for JTB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for JTB
-
Abcam antibodies for JTB
- Invitrogen Antibodies for JTB
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Protein Products
-
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- ProSpec Recombinant Proteins for JTB
- antibodies-online: Search results for 7 available JTB Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for JTB
Assay Products
-
Cloud-Clone Corp. Assay Kits for JTB
- antibodies-online: Search results for 5 available JTB Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for JTB Gene
Domains & Families for JTB Gene
Gene Families for JTB Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for JTB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for JTB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O76095- Family:
-
- Belongs to the JTB family.
Function for JTB Gene
Molecular function for JTB Gene
- GENATLAS Biochemistry:
- jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
- UniProtKB/Swiss-Prot Function:
- Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0019901 | protein kinase binding | IDA | 21225229 |
Phenotypes for JTB Gene
- MGI mutant phenotypes for JTB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for JTB:
Animal Models for JTB Gene
- MGI Knock Outs for JTB:
-
- Jtb tm1b(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for JTB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
- Search ViGene Biosciences for JTB
CRISPR Products
-
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- genomics-online: gRNA clones - Search results for available JTB gene related products
- Applied Biological Materials CRISPR for JTB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for JTB
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miRNA for JTB Gene
- miRTarBase miRNAs that target JTB
miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available JTB gene related products
-
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Clone Products
- Sino Biological Human cDNA Clone for JTB
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available JTB gene related products
- orf clones - Search results for available JTB gene related products
- Applied Biological Materials Clones for JTB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
-
Horizon Cell Lines for JTB
-
ViGene Biosciences adenoviral particle packaged cDNA for JTB gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JTB Gene
Localization for JTB Gene
Subcellular locations from UniProtKB/Swiss-Prot for JTB Gene
- Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
- Actin filaments (2)
- Vesicles (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IDA | 21225229 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005813 | colocalizes_with centrosome | IDA | 21225229 |
GO:0005815 | microtubule organizing center | IEA | -- |
GO:0005819 | colocalizes_with spindle | IDA,IEA | 21225229 |
Pathways & Interactions for JTB Gene
Interacting Proteins for JTB Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IMP | 21225229 |
GO:0000281 | mitotic cytokinesis | IMP | 21225229 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0008637 | apoptotic mitochondrial changes | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for JTB Gene
Transcripts for JTB Gene
mRNA/cDNA for JTB Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (930) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for JTB Gene
CRISPR Products
-
OriGene CRISPR knockouts for JTB
- genomics-online: gRNA clones - Search results for available JTB gene related products
- Applied Biological Materials CRISPR for JTB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for JTB
- GenScript: Design CRISPR guide RNA sequences for JTB
miRNA Products
- Search ViGene Biosciences for JTB
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for JTB
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- genomics-online: shRNA clones - Search results for available JTB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for JTB gene
Clone Products
- Sino Biological Human cDNA Clone for JTB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for JTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available JTB gene related products
- orf clones - Search results for available JTB gene related products
- Applied Biological Materials Clones for JTB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for JTB
Expression for JTB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JTB Gene
NURSA nuclear receptor signaling pathways regulating expression of JTB Gene:
JTBSOURCE GeneReport for Unigene cluster for JTB Gene:
Hs.6396mRNA Expression by UniProt/SwissProt for JTB Gene:
O76095-JTB_HUMANEvidence on tissue expression from TISSUES for JTB Gene
- Lung(4.8)
- Nervous system(4.8)
- Blood(4.3)
- Skin(4.3)
- Pancreas(3)
- Intestine(2.8)
- Liver(2.2)
Primer Products
-
OriGene qPCR primer pairs for JTB
-
OriGene qPCR primer pairs and template standards for JTB
- genomics-online: primer clones - Search results for available JTB gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JTB Gene
Orthologs for JTB Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | JTB 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | JTB 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | JTB 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Jtb 33 |
|
||
mouse (Mus musculus) |
Mammalia | Jtb 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | JTB 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | JTB 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | jtb 34 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for JTB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for JTB Gene
Pseudogenes.org Pseudogenes for JTB Gene
No data available for Paralogs for JTB Gene
Variants for JTB Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001417388 | -- | 153,975,162(-) | C/G | intron_variant | |
rs1002434171 | -- | 153,974,501(-) | A/C | 3_prime_UTR_variant | |
rs1002740228 | -- | 153,975,607(-) | A/G | intron_variant | |
rs1002811548 | -- | 153,974,044(-) | G/A | downstream_transcript_variant | |
rs1003180750 | -- | 153,975,876(-) | T/A | coding_sequence_variant, synonymous_variant |
Additional Variant Information for JTB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- JTB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JTB Gene
Disorders for JTB Gene
Additional Disease Information for JTB
No disorders were found for JTB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JTB Gene
Publications for JTB Gene
- JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PMID: 10321732) Hatakeyama S … Ishikawa F (Oncogene 1999) 2 3 4 58
- The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. (PMID: 22079049) Rousseau F … Lingel A (Journal of molecular biology 2012) 3 4 58
- PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PMID: 21225229) Platica M … Platica O (International journal of oncology 2011) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PMID: 10762645) Platica O … Platica M (International journal of oncology 2000) 3 4 58
Products for JTB Gene
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for JTB
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- Cyagen custom Knockout/knockin (KOKI) mouse models for JTB
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JTB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 20 available JTB Antibodies ranked by validation data
- Compare Top JTB Antibodies
- antibodies-online: Search results for 5 available JTB Elisa Kits ranked by validation data
- Compare Top JTB Elisa Kits
- Quality Products:
- antibodies-online: Search results for 7 available JTB Proteins ranked by validation data
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- genomics-online: cdna clones - Search results for available JTB gene related products
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Sources for JTB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew