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Aliases for JTB Gene

Aliases for JTB Gene

  • Jumping Translocation Breakpoint 2 3
  • Jumping Translocation Breakpoint Protein 3 4
  • Prostate Androgen-Regulated Protein 3 4
  • PAR 3 6
  • Prostate Androgen-Regulated Gene 2
  • Protein JTB 3
  • PAR Protein 4
  • HSPC222 3
  • HJTB 3
  • HJT 3

External Ids for JTB Gene

Summaries for JTB Gene

GeneCards Summary for JTB Gene

JTB (Jumping Translocation Breakpoint) is a Protein Coding gene. Diseases associated with JTB include lymph node tuberculosis and tuberculosis. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for JTB Gene

  • Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Gene Wiki entry for JTB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JTB Gene

Genomics for JTB Gene

Genomic Location for JTB Gene

Start:
153,974,269 bp from pter
End:
153,977,975 bp from pter
Size:
3,707 bases
Orientation:
Minus strand

Genomic View for JTB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JTB Gene

Proteins for JTB Gene

  • Protein details for JTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76095-JTB_HUMAN
    Recommended name:
    Protein JTB
    Protein Accession:
    O76095
    Secondary Accessions:
    • O95442
    • Q6IB19
    • Q9P0Q4

    Protein attributes for JTB Gene

    Size:
    146 amino acids
    Molecular mass:
    16358 Da
    Quaternary structure:
    • Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.

    Three dimensional structures from OCA and Proteopedia for JTB Gene

    Alternative splice isoforms for JTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JTB Gene

Proteomics data for JTB Gene at MOPED

Post-translational modifications for JTB Gene

Other Protein References for JTB Gene

No data available for DME Specific Peptides for JTB Gene

Domains for JTB Gene

Protein Domains for JTB Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

JTB_HUMAN
Family:
  • Belongs to the JTB family.:
    • O76095
genes like me logo Genes that share domains with JTB: view

No data available for Gene Families for JTB Gene

Function for JTB Gene

Molecular function for JTB Gene

GENATLAS Biochemistry: jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
UniProtKB/Swiss-Prot Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
UniProtKB/Swiss-Prot Induction: Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.

Gene Ontology (GO) - Molecular Function for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IDA 21225229
genes like me logo Genes that share ontologies with JTB: view

Phenotypes for JTB Gene

GenomeRNAi human phenotypes for JTB:
genes like me logo Genes that share phenotypes with JTB: view

miRNA for JTB Gene

miRTarBase miRNAs that target JTB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for JTB Gene

Localization for JTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JTB Gene

Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JTB Gene COMPARTMENTS Subcellular localization image for JTB gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
extracellular 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21225229
GO:0005739 mitochondrion IEA --
GO:0005813 colocalizes_with centrosome IDA 21225229
GO:0005819 colocalizes_with spindle IDA 21225229
GO:0005887 integral component of plasma membrane TAS 10321732
genes like me logo Genes that share ontologies with JTB: view

Pathways for JTB Gene

SuperPathways for JTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for JTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 21225229
GO:0007067 mitotic nuclear division IMP 21225229
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0042127 regulation of cell proliferation IEA --
GO:0045860 positive regulation of protein kinase activity IMP 21225229
genes like me logo Genes that share ontologies with JTB: view

No data available for Pathways by source for JTB Gene

Transcripts for JTB Gene

Unigene Clusters for JTB Gene

Jumping translocation breakpoint:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JTB Gene

No ASD Table

Relevant External Links for JTB Gene

GeneLoc Exon Structure for
JTB
ECgene alternative splicing isoforms for
JTB

Expression for JTB Gene

mRNA expression in normal human tissues for JTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JTB Gene

SOURCE GeneReport for Unigene cluster for JTB Gene Hs.6396

mRNA Expression by UniProt/SwissProt for JTB Gene

O76095-JTB_HUMAN
Tissue specificity: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
genes like me logo Genes that share expressions with JTB: view

Orthologs for JTB Gene

This gene was present in the common ancestor of chordates.

Orthologs for JTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JTB 36
  • 99.54 (n)
  • 100 (a)
JTB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JTB 36
  • 89.95 (n)
  • 89.73 (a)
JTB 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JTB 36
  • 86.53 (n)
  • 87.67 (a)
mouse
(Mus musculus)
Mammalia Jtb 36
  • 82.88 (n)
  • 85.62 (a)
Jtb 16
Jtb 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JTB 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jtb 36
  • 84.02 (n)
  • 86.99 (a)
chicken
(Gallus gallus)
Aves JTB 37
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii jtb 37
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToOne
Species with no ortholog for JTB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JTB Gene

ENSEMBL:
Gene Tree for JTB (if available)
TreeFam:
Gene Tree for JTB (if available)

Paralogs for JTB Gene

Pseudogenes.org Pseudogenes for JTB Gene

genes like me logo Genes that share paralogs with JTB: view

No data available for Paralogs for JTB Gene

Variants for JTB Gene

Sequence variations from dbSNP and Humsavar for JTB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1547766 -- 153,979,729(+) TATTA(A/C)ACATA upstream-variant-2KB
rs1547767 -- 153,979,744(+) AATTA(C/T)ATATA upstream-variant-2KB
rs3182946 -- 153,977,614(-) ACCGG(C/G)CCCCG utr-variant-5-prime
rs7527963 -- 153,975,745(+) CCCCA(A/G/T)ACCAG intron-variant
rs11264763 -- 153,976,229(+) GAGGC(C/T)GAGGC intron-variant

Relevant External Links for JTB Gene

HapMap Linkage Disequilibrium report
JTB

No data available for Structural Variations from Database of Genomic Variants (DGV) for JTB Gene

Disorders for JTB Gene

(1) University of Copenhagen DISEASES for JTB Gene

genes like me logo Genes that share disorders with JTB: view

No data available for UniProtKB/Swiss-Prot for JTB Gene

Publications for JTB Gene

  1. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PMID: 10321732) Hatakeyama S. … Ishikawa F. (Oncogene 1999) 2 3 4
  2. PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PMID: 10762645) Platica O. … Platica M. (Int. J. Oncol. 2000) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PMID: 21225229) Platica M. … Platica O. (Int. J. Oncol. 2011) 3 4
  5. The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. (PMID: 22079049) Rousseau F. … Lingel A. (J. Mol. Biol. 2012) 3 4

Products for JTB Gene

Sources for JTB Gene

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