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Aliases for MMP24 Gene

Aliases for MMP24 Gene

  • Matrix Metallopeptidase 24 (Membrane-Inserted) 2 3
  • Matrix Metalloproteinase 24 (Membrane-Inserted) 2 3
  • Membrane-Type 5 Matrix Metalloproteinase 2 3
  • Membrane-Type Matrix Metalloproteinase 5 3 4
  • Membrane-Type-5 Matrix Metalloproteinase 3 4
  • MT-MMP 5 3 4
  • MT5-MMP 3 4
  • MMP-24 3 4
  • MT5MMP 3 4
  • MTMMP5 3 4
  • MMP25 3 6
  • Matrix Metalloproteinase-24 3
  • EC 3.4.24.80 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • MT-MMP5 3

External Ids for MMP24 Gene

Previous GeneCards Identifiers for MMP24 Gene

  • GC20P033573
  • GC20P034483
  • GC20P034530
  • GC20P033278
  • GC20P033814
  • GC20P030592

Summaries for MMP24 Gene

Entrez Gene Summary for MMP24 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP24 Gene

MMP24 (Matrix Metallopeptidase 24 (Membrane-Inserted)) is a Protein Coding gene. Diseases associated with MMP24 include arthritis. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and enzyme activator activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP24 Gene

  • Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

Tocris Summary for MMP24 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP24 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP24 Gene

Genomics for MMP24 Gene

Regulatory Elements for MMP24 Gene

Genomic Location for MMP24 Gene

Start:
35,226,654 bp from pter
End:
35,277,001 bp from pter
Size:
50,348 bases
Orientation:
Plus strand

Genomic View for MMP24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP24 Gene

Proteins for MMP24 Gene

  • Protein details for MMP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5R2-MMP24_HUMAN
    Recommended name:
    Matrix metalloproteinase-24
    Protein Accession:
    Q9Y5R2
    Secondary Accessions:
    • B7ZBG8
    • Q9H440

    Protein attributes for MMP24 Gene

    Size:
    645 amino acids
    Molecular mass:
    73231 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with APBA3 (via PDZ domain). Interacts with GRIP1 and GRIP2 (By similarity).

neXtProt entry for MMP24 Gene

Proteomics data for MMP24 Gene at MOPED

Post-translational modifications for MMP24 Gene

  • Cleaved by a furin endopeptidase in the trans-Golgi network.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP24 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MMP24 Gene

Suggested Antigen Peptide Sequences for MMP24 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5R2

UniProtKB/Swiss-Prot:

MMP24_HUMAN :
  • Q9Y5R2
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • The PDZ-binding motif (also named EWV motif) is required for interaction with PDZ domains of APBA3 and recycling through the trans-Golgi network.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP24: view

Function for MMP24 Gene

Molecular function for MMP24 Gene

GENATLAS Biochemistry: matrix metalloproteinase 24,membrane type (MT),expressed in brain,kidney,pancreas and lung activator of progelalinase,overexpressed in brain tumor,involved in neurogenesis
UniProtKB/Swiss-Prot Function: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

Enzyme Numbers (IUBMB) for MMP24 Gene

Gene Ontology (GO) - Molecular Function for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0008047 enzyme activator activity TAS 10363975
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP24: view
genes like me logo Genes that share phenotypes with MMP24: view

Animal Models for MMP24 Gene

MGI Knock Outs for MMP24:

Animal Model Products

CRISPR Products

miRNA for MMP24 Gene

miRTarBase miRNAs that target MMP24

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP24

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MMP24 Gene

Localization for MMP24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP24 Gene

Matrix metalloproteinase-24: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.
Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP24 Gene COMPARTMENTS Subcellular localization image for MMP24 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005887 integral component of plasma membrane ISS --
GO:0031012 extracellular matrix --
GO:0032588 trans-Golgi network membrane ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MMP24: view

Pathways for MMP24 Gene

genes like me logo Genes that share pathways with MMP24: view

Pathways by source for MMP24 Gene

Gene Ontology (GO) - Biological Process for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
GO:0010001 glial cell differentiation ISS --
GO:0043085 positive regulation of catalytic activity TAS 10363975
GO:0044331 cell-cell adhesion mediated by cadherin ISS --
GO:0050965 detection of temperature stimulus involved in sensory perception of pain ISS --
genes like me logo Genes that share ontologies with MMP24: view

Compounds for MMP24 Gene

(5) Tocris Compounds for MMP24 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(2) HMDB Compounds for MMP24 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Dermatan
  • Chondroitin sulfate B
24967-94-0

(1) Drugbank Compounds for MMP24 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Marimastat
154039-60-8 target inhibitor
genes like me logo Genes that share compounds with MMP24: view

Transcripts for MMP24 Gene

mRNA/cDNA for MMP24 Gene

(180) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP24 Gene

Matrix metallopeptidase 24 (membrane-inserted):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP24

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MMP24
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP24 Gene

No ASD Table

Relevant External Links for MMP24 Gene

GeneLoc Exon Structure for
MMP24
ECgene alternative splicing isoforms for
MMP24

Expression for MMP24 Gene

mRNA expression in normal human tissues for MMP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP24 Gene

This gene is overexpressed in Brain - Cerebellum (8.4) and Brain - Cerebellar Hemisphere (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP24 Gene

SOURCE GeneReport for Unigene cluster for MMP24 Gene Hs.715494

mRNA Expression by UniProt/SwissProt for MMP24 Gene

Q9Y5R2-MMP24_HUMAN
Tissue specificity: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
genes like me logo Genes that share expressions with MMP24: view

In Situ Assay Products

Orthologs for MMP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP24 35
  • 99.74 (n)
  • 100 (a)
MMP24 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP24 35
  • 93.91 (n)
  • 98.4 (a)
MMP24 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP24 35
  • 93.5 (n)
  • 99.29 (a)
MMP24 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp24 35
  • 91.36 (n)
  • 97.72 (a)
Mmp24 16
Mmp24 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP24 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp24 35
  • 90.48 (n)
  • 98.07 (a)
chicken
(Gallus gallus)
Aves MMP24 35
  • 78.74 (n)
  • 89.93 (a)
MMP24 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP24 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp24 35
  • 74.85 (n)
  • 87.72 (a)
zebrafish
(Danio rerio)
Actinopterygii mmp24 35
  • 75.96 (n)
  • 82.98 (a)
mmp24 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 36
  • 25 (a)
OneToMany
Mmp1 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea H19M22.3a 37
  • 33 (a)
C31B8.8 37
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7631 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
Species with no ortholog for MMP24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP24 Gene

ENSEMBL:
Gene Tree for MMP24 (if available)
TreeFam:
Gene Tree for MMP24 (if available)

Paralogs for MMP24 Gene

Selected SIMAP similar genes for MMP24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MMP24: view

Variants for MMP24 Gene

Sequence variations from dbSNP and Humsavar for MMP24 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs639763 -- 35,274,101(+) GGGTG(C/T)CCCCC intron-variant
rs665212 -- 35,225,191(+) ATCCT(A/T)ATTTC upstream-variant-2KB
rs671988 -- 35,249,611(+) tgaga(C/T)ggagt intron-variant
rs751887 - 35,274,362(-) AGTCA(C/T)GCAGG missense, reference
rs1205411 -- 35,269,439(+) GATGT(C/T)AGTGA intron-variant

Relevant External Links for MMP24 Gene

HapMap Linkage Disequilibrium report
MMP24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MMP24 Gene

Disorders for MMP24 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MMP24 Gene including...

Search for MMP24 Gene in MalaCards »

(1) Novoseek inferred disease relationships for MMP24 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for MMP24

Genetic Association Database (GAD)
MMP24
Human Genome Epidemiology (HuGE) Navigator
MMP24
genes like me logo Genes that share disorders with MMP24: view

No data available for UniProtKB/Swiss-Prot for MMP24 Gene

Publications for MMP24 Gene

  1. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase a overexpressed in brain tumors. (PMID: 10363975) Llano E. … Lopez-Otin C. (Cancer Res. 1999) 2 3 4 23
  2. Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->q12, respectively, by radiation hybrid and in situ hybridization. (PMID: 10640822) Kinoh H. … Seiki M. (Cytogenet. Cell Genet. 1999) 3 23
  3. Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients. (PMID: 11457723) Romanic A.M. … Ohlstein E.H. (Am. J. Physiol. Renal Physiol. 2001) 3 23
  4. Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. (PMID: 17952761) Gaetje R. … Kaufmann M. (Gynecol. Endocrinol. 2007) 3 23
  5. Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells. (PMID: 18062926) Ross H.H. … Fillmore H.L. (FEBS Lett. 2007) 3 23

Products for MMP24 Gene

Sources for MMP24 Gene

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