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Aliases for C1QL1 Gene

Aliases for C1QL1 Gene

  • Complement Component 1, Q Subcomponent-Like 1 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 14 3 4
  • C1q/TNF-Related Protein 14 3 4
  • C1QRF 3 4
  • CRF 3 4
  • Complement Component 1 Q Subcomponent-Like 1 4
  • C1QTNF14 3
  • CTRP14 4

External Ids for C1QL1 Gene

Previous GeneCards Identifiers for C1QL1 Gene

  • GC17M043513
  • GC17M040392
  • GC17M043037
  • GC17M038803

Summaries for C1QL1 Gene

GeneCards Summary for C1QL1 Gene

C1QL1 (Complement Component 1, Q Subcomponent-Like 1) is a Protein Coding gene. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for C1QL1 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Gene Wiki entry for C1QL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL1 Gene

Genomics for C1QL1 Gene

Regulatory Elements for C1QL1 Gene

Enhancers for C1QL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1QL1 on UCSC Golden Path with GeneCards custom track

Promoters for C1QL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1QL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1QL1 Gene

Chromosome:
17
Start:
44,959,693 bp from pter
End:
44,968,276 bp from pter
Size:
8,584 bases
Orientation:
Minus strand

Genomic View for C1QL1 Gene

Genes around C1QL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL1 Gene

Proteins for C1QL1 Gene

  • Protein details for C1QL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75973-C1QRF_HUMAN
    Recommended name:
    C1q-related factor
    Protein Accession:
    O75973

    Protein attributes for C1QL1 Gene

    Size:
    258 amino acids
    Molecular mass:
    26453 Da
    Quaternary structure:
    • Interacts with ADGRB3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

neXtProt entry for C1QL1 Gene

Proteomics data for C1QL1 Gene at MOPED

Post-translational modifications for C1QL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for C1QL1

No data available for DME Specific Peptides for C1QL1 Gene

Domains & Families for C1QL1 Gene

Protein Domains for C1QL1 Gene

Suggested Antigen Peptide Sequences for C1QL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75973

UniProtKB/Swiss-Prot:

C1QRF_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QL1: view

No data available for Gene Families for C1QL1 Gene

Function for C1QL1 Gene

Molecular function for C1QL1 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
genes like me logo Genes that share phenotypes with C1QL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL1 Gene

Localization for C1QL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QL1 Gene COMPARTMENTS Subcellular localization image for C1QL1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for C1QL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C1QL1: view

Pathways & Interactions for C1QL1 Gene

SuperPathways for C1QL1 Gene

No Data Available

Interacting Proteins for C1QL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253407%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000253407 O75973-C1QRF_HUMAN for C1QL1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for C1QL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QL1 Gene

Drugs & Compounds for C1QL1 Gene

No Compound Related Data Available

Transcripts for C1QL1 Gene

mRNA/cDNA for C1QL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL1 Gene

Complement component 1, q subcomponent-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL1 Gene

No ASD Table

Relevant External Links for C1QL1 Gene

GeneLoc Exon Structure for
C1QL1
ECgene alternative splicing isoforms for
C1QL1

Expression for C1QL1 Gene

mRNA expression in normal human tissues for C1QL1 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL1 Gene

This gene is overexpressed in Brain - Amygdala (x4.3).

Protein differential expression in normal tissues from HIPED for C1QL1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C1QL1 Gene



SOURCE GeneReport for Unigene cluster for C1QL1 Gene Hs.134012

mRNA Expression by UniProt/SwissProt for C1QL1 Gene

O75973-C1QRF_HUMAN
Tissue specificity: Expressed in brainstem.
genes like me logo Genes that share expression patterns with C1QL1: view

Protein tissue co-expression partners for C1QL1 Gene

Primer Products

Orthologs for C1QL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1QL1 35
  • 93.28 (n)
  • 98.45 (a)
C1QL1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL1 35
  • 94.57 (n)
  • 98.44 (a)
C1QL1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C1ql1 35
  • 93.41 (n)
  • 98.45 (a)
C1ql1 16
C1ql1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1QL1 35
  • 99.73 (n)
  • 99.59 (a)
C1QL1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C1ql1 35
  • 92.77 (n)
  • 98.72 (a)
oppossum
(Monodelphis domestica)
Mammalia C1QL1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 8 (a)
ManyToMany
chicken
(Gallus gallus)
Aves C1QL4 35
  • 82.47 (n)
  • 87.07 (a)
C1QL1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql1 35
  • 73.22 (n)
  • 84.02 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16893 35
LOC556064 35
  • 71.91 (n)
  • 76.6 (a)
C1QL1 (2 of 2) 36
  • 64 (a)
OneToMany
c1ql3b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 5 (a)
OneToMany
Species with no ortholog for C1QL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL1 Gene

ENSEMBL:
Gene Tree for C1QL1 (if available)
TreeFam:
Gene Tree for C1QL1 (if available)

Paralogs for C1QL1 Gene

(8) SIMAP similar genes for C1QL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QL1: view

Variants for C1QL1 Gene

Sequence variations from dbSNP and Humsavar for C1QL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1007190 -- 44,960,841(+) GGGCA(C/T)ACCTT intron-variant
rs1055641 -- 44,959,841(-) GCGCT(C/T)TGAGA utr-variant-3-prime
rs1055646 -- 44,959,823(-) CCCTC(C/G)GCTCC utr-variant-3-prime
rs2981585 -- 44,964,824(-) AAAAC(A/G)AAAAG intron-variant
rs2981586 -- 44,964,586(-) CCCCA(A/G)CGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL1 Gene

Variant ID Type Subtype PubMed ID
nsv833457 CNV Loss 17160897
nsv527788 CNV Loss 19592680
nsv908289 CNV Loss 21882294
dgv3177n71 CNV Loss 21882294
nsv908294 CNV Loss 21882294

Variation tolerance for C1QL1 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C1QL1 Gene

Disorders for C1QL1 Gene

Relevant External Links for C1QL1

Genetic Association Database (GAD)
C1QL1
Human Genome Epidemiology (HuGE) Navigator
C1QL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QL1

No disorders were found for C1QL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL1 Gene

Publications for C1QL1 Gene

  1. Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function. (PMID: 9878755) Berube N.G. … Pereira-Smith O.M. (Brain Res. Mol. Brain Res. 1999) 2 3 4 23 67
  2. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. (PMID: 19666007) Peterson J.M. … Wong G.W. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3
  5. GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association. (PMID: 23725790) RenterA-a M.E. … Medland S.E. (Twin Res Hum Genet 2013) 3

Products for C1QL1 Gene

Sources for C1QL1 Gene

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