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FGL2 Gene(Protein Coding)

Fibrinogen Like 2

GCID:
GC07M077193
GIFtS:
58
Genes Participants
UDN Logo

Aliases for FGL2 Gene

Aliases for FGL2 Gene

  • Fibrinogen Like 2 2 3
  • Fibrinogen-Like 2 2 3 5
  • Fibrinogen-Like Protein 2 3 4
  • PT49 3 4
  • T49 3

External Ids for FGL2 Gene

Previous GeneCards Identifiers for FGL2 Gene

  • GC07M075361
  • GC07M076423
  • GC07M076437
  • GC07M076470
  • GC07M076662
  • GC07M076822
  • GC07M071425

Summaries for FGL2 Gene

Entrez Gene Summary for FGL2 Gene

  • The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL2 Gene

FGL2 (Fibrinogen Like 2) is a Protein Coding gene. Diseases associated with FGL2 include viral hepatitis and hepatitis b. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for FGL2 Gene

  • May play a role in physiologic lymphocyte functions at mucosal sites.

Gene Wiki entry for FGL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL2 Gene

Genomics for FGL2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FGL2 Gene

Enhancers for FGL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGL2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FGL2 gene promoter:

Genomic Location for FGL2 Gene

Chromosome:
7
Start:
77,193,371 bp from pter
End:
77,199,833 bp from pter
Size:
6,463 bases
Orientation:
Minus strand

Genomic View for FGL2 Gene

Genes around FGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGL2 Gene

Proteins for FGL2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14314-FGL2_HUMAN
    Recommended name:
    Fibroleukin
    Protein Accession:
    Q14314

    Protein attributes for FGL2 Gene

    Size:
    439 amino acids
    Molecular mass:
    50229 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked.

neXtProt entry for FGL2 Gene

Proteomics data for FGL2 Gene at MOPED

Protein Expression for FGL2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FGL2 Gene

  • Glycosylation at Asn 25, Asn 179, Asn 235, Asn 263, and Asn 336
  • Modification sites at PhosphoSitePlus

Other Protein References for FGL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGL2 Gene

Domains & Families for FGL2 Gene

Gene Families for FGL2 Gene

HGNC:

Protein Domains for FGL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FGL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14314

UniProtKB/Swiss-Prot:

FGL2_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGL2: view

Function for FGL2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FGL2 Gene

GENATLAS Biochemistry:
fibrinogen-like 2,expressed in T lymphocytes
UniProtKB/Swiss-Prot Function:
May play a role in physiologic lymphocyte functions at mucosal sites.

Phenotypes for FGL2 Gene

MGI mutant phenotypes for FGL2:
inferred from 2 alleles
GenomeRNAi human phenotypes for FGL2:
genes like me logo Genes that share phenotypes with FGL2: view

Animal Models for FGL2 Gene

MGI Knock Outs for FGL2:

Animal Model Products

miRNA for FGL2 Gene

miRTarBase miRNAs that target FGL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGL2 Gene

Localization for FGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGL2 Gene COMPARTMENTS Subcellular localization image for FGL2 gene
Compartment Confidence
extracellular 5
cytosol 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FGL2: view

Pathways & Interactions for FGL2 Gene

SuperPathways for FGL2 Gene

PathCards logoMore details on SuperPathways for FGL2
No Data Available

Interacting Proteins for FGL2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000248598%0d%0a9606.ENSP00000306099%0d%0a9606.ENSP00000306361%0d%0a9606.ENSP00000321853%0d%0a9606.ENSP00000336829%0d%0a9606.ENSP00000346839%0d%0a
Selected Interacting proteins: ENSP00000248598 Q14314-FGL2_HUMAN for FGL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FGL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FGL2 Gene

Drugs & Compounds for FGL2 Gene

Products:

  1. Drug

(3) Drugs for FGL2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antiviral Agents Pharma 9483
Liver Extracts Pharma 3644

(2) Additional Compounds for FGL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGL2: view

Transcripts for FGL2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FGL2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGL2 Gene

Fibrinogen-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGL2 Gene

No ASD Table

Relevant External Links for FGL2 Gene

GeneLoc Exon Structure for
FGL2
ECgene alternative splicing isoforms for
FGL2

Expression for FGL2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for FGL2 Gene

mRNA expression in normal human tissues for FGL2 Gene
mRNA expression by BioGPS for FGL2 GenemRNA expression by GTEx for FGL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGL2 Gene

This gene is overexpressed in Artery - Aorta (x8.3), Esophagus - Gastroesophageal Junction (x6.6), Esophagus - Muscularis (x5.4), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for FGL2 Gene

This gene is overexpressed in Plasma (21.8), Serum (12.4), and Spleen (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGL2 Gene



SOURCE GeneReport for Unigene cluster for FGL2 Gene Hs.520989

mRNA Expression by UniProt/SwissProt for FGL2 Gene

Q14314-FGL2_HUMAN
Tissue specificity: Constitutively expressed in cytotoxic T-cells.
genes like me logo Genes that share expression patterns with FGL2: view

Primer Products

No data available for Protein tissue co-expression partners for FGL2 Gene

Orthologs for FGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia FGL2 35
  • 89.83 (n)
  • 90.66 (a)
FGL2 36
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FGL2 35
  • 83.94 (n)
  • 83.56 (a)
FGL2 36
  • 83 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fgl2 35
  • 80.51 (n)
  • 79.12 (a)
Fgl2 16
Fgl2 36
  • 79 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia FGL2 35
  • 99.54 (n)
  • 99.77 (a)
FGL2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Fgl2 35
  • 80.89 (n)
  • 79.02 (a)
oppossum
(Monodelphis domestica)
 Mammalia FGL2 36
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FGL2 35
  • 69.55 (n)
  • 66.82 (a)
FGL2 36
  • 60 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FGL2 36
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fgl2 35
  • 66.1 (n)
  • 64.41 (a)
Str.15307 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.23684 35
zebrafish
(Danio rerio)
 Actinopterygii fgl2 35
  • 61.69 (n)
  • 59.95 (a)
fgl2 36
  • 53 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG1791 37
  • 33 (a)
CG1889 37
  • 37 (a)
CG8642 37
  • 40 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CS-FIBRINOGEN-LIKE 36
  • 26 (a)
 OneToOne
Species with no ortholog for FGL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL2 Gene

ENSEMBL:
Gene Tree for FGL2 (if available)
TreeFam:
Gene Tree for FGL2 (if available)

Paralogs for FGL2 Gene

Paralogs for FGL2 Gene

(6) SIMAP similar genes for FGL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGL2: view

Variants for FGL2 Gene

Sequence variations from dbSNP and Humsavar for FGL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_013066 -

Structural Variations from Database of Genomic Variants (DGV) for FGL2 Gene

Variant ID Type Subtype PubMed ID
essv14753 CNV CNV 17122850
dgv2104e1 CNV Complex 17122850
nsv428174 CNV Gain 18775914
nsv526097 CNV Gain 19592680
dgv2109e1 CNV Complex 17122850
esv34102 CNV Loss 18971310
nsv888508 CNV Gain 21882294

Variation tolerance for FGL2 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGL2 Gene

HapMap Linkage Disequilibrium report
FGL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL2 Gene

Disorders for FGL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
viral hepatitis
  • animal viral hepatitis
hepatitis b
  • chronic hepatitis b
- elite association - COSMIC cancer census association via MalaCards
Search FGL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGL2

Genetic Association Database (GAD)
FGL2
Human Genome Epidemiology (HuGE) Navigator
FGL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGL2
genes like me logo Genes that share disorders with FGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGL2 Gene

Publications for FGL2 Gene

  1. Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PMID: 7642106) Ruegg C. … Pytela R. (Gene 1995) 2 3 4 67
  2. The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PMID: 20438701) Liu Y. … Ning Q. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway. (PMID: 18801734) Han M. … Ning Q. (J. Biol. Chem. 2008) 3 23
  4. Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. (PMID: 18932275) Su K. … Ning Q. (World J. Gastroenterol. 2008) 3 23
  5. Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection. (PMID: 15905589) Ning Q. … Luo X. (J. Immunol. 2005) 3 23

Products for FGL2 Gene

Sources for FGL2 Gene

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