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Aliases for FGL2 Gene

Aliases for FGL2 Gene

  • Fibrinogen-Like 2 2 3
  • Fibrinogen-Like Protein 2 3 4
  • PT49 3 4
  • Fibroleukin 3
  • T49 3

External Ids for FGL2 Gene

Summaries for FGL2 Gene

Entrez Gene Summary for FGL2 Gene

  • The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL2 Gene

FGL2 (Fibrinogen-Like 2) is a Protein Coding gene. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for FGL2 Gene

  • May play a role in physiologic lymphocyte functions at mucosal sites

Gene Wiki entry for FGL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL2 Gene

Genomics for FGL2 Gene

Genomic Location for FGL2 Gene

Start:
77,193,371 bp from pter
End:
77,199,833 bp from pter
Size:
6,463 bases
Orientation:
Minus strand

Genomic View for FGL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGL2 Gene

Regulatory Elements for FGL2 Gene

Proteins for FGL2 Gene

  • Protein details for FGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14314-FGL2_HUMAN
    Recommended name:
    Fibroleukin
    Protein Accession:
    Q14314
    Secondary Accessions:

    Protein attributes for FGL2 Gene

    Size:
    439 amino acids
    Molecular mass:
    50229 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked

neXtProt entry for FGL2 Gene

Proteomics data for FGL2 Gene at MOPED

Post-translational modifications for FGL2 Gene

  • Glycosylation at Asn25, Asn179, Asn235, Asn263, and Asn336

Other Protein References for FGL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGL2 Gene

Domains for FGL2 Gene

Gene Families for FGL2 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

UniProtKB/Swiss-Prot:

FGL2_HUMAN
Domain:
  • Contains 1 fibrinogen C-terminal domain.:
    • Q14314
genes like me logo Genes that share domains with FGL2: view

Function for FGL2 Gene

Molecular function for FGL2 Gene

GENATLAS Biochemistry: fibrinogen-like 2,expressed in T lymphocytes
UniProtKB/Swiss-Prot Function: May play a role in physiologic lymphocyte functions at mucosal sites

Phenotypes for FGL2 Gene

genes like me logo Genes that share phenotypes with FGL2: view

Animal Models for FGL2 Gene

MGI Knock Outs for FGL2:

miRNA for FGL2 Gene

miRTarBase miRNAs that target FGL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for FGL2 Gene

Localization for FGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGL2 Gene COMPARTMENTS Subcellular localization image for FGL2 gene
Compartment Confidence
extracellular 5
cytosol 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005577 fibrinogen complex TAS 7642106
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FGL2: view

Pathways for FGL2 Gene

SuperPathways for FGL2 Gene

No Data Available

Interacting Proteins for FGL2 Gene

Gene Ontology (GO) - Biological Process for FGL2 Gene

None

No data available for Pathways by source for FGL2 Gene

Compounds for FGL2 Gene

(3) Novoseek inferred chemical compound relationships for FGL2 Gene

Compound -log(P) Hits PubMed IDs
hirudin 59.3 2
serine 17.7 3
fibrinogen 17.1 2
genes like me logo Genes that share compounds with FGL2: view

Transcripts for FGL2 Gene

mRNA/cDNA for FGL2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGL2 Gene

Fibrinogen-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGL2 Gene

No ASD Table

Relevant External Links for FGL2 Gene

GeneLoc Exon Structure for
FGL2
ECgene alternative splicing isoforms for
FGL2

Expression for FGL2 Gene

mRNA expression in normal human tissues for FGL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGL2 Gene

This gene is overexpressed in Artery - Aorta (8.3), Esophagus - Gastroesophageal Junction (6.6), Esophagus - Muscularis (5.4), and Whole Blood (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGL2 Gene

SOURCE GeneReport for Unigene cluster for FGL2 Gene Hs.520989

mRNA Expression by UniProt/SwissProt for FGL2 Gene

Q14314-FGL2_HUMAN
Tissue specificity: Constitutively expressed in cytotoxic T-cells
genes like me logo Genes that share expressions with FGL2: view

Orthologs for FGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGL2 36
  • 99.54 (n)
  • 99.77 (a)
FGL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGL2 36
  • 89.83 (n)
  • 90.66 (a)
FGL2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGL2 36
  • 83.94 (n)
  • 83.56 (a)
FGL2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgl2 36
  • 80.51 (n)
  • 79.12 (a)
Fgl2 16
Fgl2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGL2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgl2 36
  • 80.89 (n)
  • 79.02 (a)
chicken
(Gallus gallus)
Aves FGL2 36
  • 69.55 (n)
  • 66.82 (a)
FGL2 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGL2 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23684 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fgl2 36
  • 66.1 (n)
  • 64.41 (a)
Str.15307 36
zebrafish
(Danio rerio)
Actinopterygii fgl2 36
  • 61.69 (n)
  • 59.95 (a)
fgl2 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1889 38
  • 37 (a)
CG1791 38
  • 33 (a)
CG8642 38
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CS-FIBRINOGEN-LIKE 37
  • 26 (a)
OneToOne
Species with no ortholog for FGL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL2 Gene

ENSEMBL:
Gene Tree for FGL2 (if available)
TreeFam:
Gene Tree for FGL2 (if available)

Paralogs for FGL2 Gene

Selected SIMAP similar genes for FGL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGL2: view

Variants for FGL2 Gene

Sequence variations from dbSNP and Humsavar for FGL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_013066 -

Structural Variations from Database of Genomic Variants (DGV) for FGL2 Gene

Variant ID Type Subtype PubMed ID
essv14753 CNV CNV 17122850
dgv2104e1 CNV Complex 17122850
nsv428174 CNV Gain 18775914
nsv526097 CNV Gain 19592680
dgv2109e1 CNV Complex 17122850
esv34102 CNV Loss 18971310
nsv888508 CNV Gain 21882294

Relevant External Links for FGL2 Gene

HapMap Linkage Disequilibrium report
FGL2

Disorders for FGL2 Gene

(1) University of Copenhagen DISEASES for FGL2 Gene

(13) Novoseek inferred disease relationships for FGL2 Gene

Disease -log(P) Hits PubMed IDs
hepatitis fulminant 74.1 1
hepatic necrosis 67 1
viral hepatitis 66.7 8
hepatic failure fulminant 58.5 4
hepatitis b chronic 58.1 3

Relevant External Links for FGL2

Genetic Association Database (GAD)
FGL2
Human Genome Epidemiology (HuGE) Navigator
FGL2
genes like me logo Genes that share disorders with FGL2: view

No data available for UniProtKB/Swiss-Prot for FGL2 Gene

Publications for FGL2 Gene

  1. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PMID: 9647217) Marazzi S. … Ruegg C. (J. Immunol. 1998) 3 4 23
  2. Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PMID: 7642106) Ruegg C. … Pytela R. (Gene 1995) 2 3 4
  3. The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PMID: 20438701) Liu Y. … Ning Q. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Candidate genes associated with susceptibility for SARS-coronavirus. (PMID: 19590927) Hsieh Y.H. … Ho M.S. (Bull. Math. Biol. 2010) 3 49
  5. Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant. (PMID: 11170750) Yuwaraj S. … Levy G.A. (Genomics 2001) 3 23

Products for FGL2 Gene

Sources for FGL2 Gene

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