Aliases for ADAM28 Gene
- ADAM Metallopeptidase Domain 28 2 3 5
- Epididymal Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 3 4
- ADAM 28 3 4
- EMDC II 3 4
- MDC-L 3 4
- MDCL 3 4
- Epididymial Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 3
- Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein-L 3
External Ids for ADAM28 Gene
Previous GeneCards Identifiers for ADAM28 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for ADAM28 Gene
ADAM28 (ADAM Metallopeptidase Domain 28) is a Protein Coding gene. Diseases associated with ADAM28 include Hyperostosis Cranialis Interna. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM8.
UniProtKB/Swiss-Prot for ADAM28 Gene
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.