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Aliases for ADAM28 Gene

Aliases for ADAM28 Gene

  • ADAM Metallopeptidase Domain 28 2 3 5
  • Epididymal Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 3 4
  • ADAM 28 3 4
  • EMDC II 3 4
  • MDC-L 3 4
  • MDCL 3 4
  • Epididymial Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 3
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein-L 3
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein L 4
  • A Disintegrin And Metalloproteinase Domain 28 2
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • EMDCII 3
  • ADAM23 4

External Ids for ADAM28 Gene

Previous GeneCards Identifiers for ADAM28 Gene

  • GC08P023884
  • GC08P024505
  • GC08P024173
  • GC08P024207
  • GC08P022696
  • GC08P024151

Summaries for ADAM28 Gene

Entrez Gene Summary for ADAM28 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for ADAM28 Gene

ADAM28 (ADAM Metallopeptidase Domain 28) is a Protein Coding gene. Diseases associated with ADAM28 include hyperostosis cranialis interna. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM28 Gene

  • May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Gene Wiki entry for ADAM28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM28 Gene

Genomics for ADAM28 Gene

Regulatory Elements for ADAM28 Gene

Enhancers for ADAM28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAM28 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM28 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM28 Gene

Chromosome:
8
Start:
24,294,040 bp from pter
End:
24,359,018 bp from pter
Size:
64,979 bases
Orientation:
Plus strand

Genomic View for ADAM28 Gene

Genes around ADAM28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM28 Gene

Proteins for ADAM28 Gene

  • Protein details for ADAM28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKQ2-ADA28_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 28
    Protein Accession:
    Q9UKQ2
    Secondary Accessions:
    • B2RMV5
    • Q9Y339
    • Q9Y3S0

    Protein attributes for ADAM28 Gene

    Size:
    775 amino acids
    Molecular mass:
    87148 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM28 Gene

Proteomics data for ADAM28 Gene at MOPED

Selected DME Specific Peptides for ADAM28 Gene

Post-translational modifications for ADAM28 Gene

  • Pro-domain removal and maturation may be, at least in part, autocatalytic.
  • Glycosylation at Asn 268, Asn 275, Asn 557, Asn 602, and Asn 628
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM28 Gene

Domains & Families for ADAM28 Gene

Gene Families for ADAM28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKQ2

UniProtKB/Swiss-Prot:

ADA28_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM28: view

Function for ADAM28 Gene

Molecular function for ADAM28 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Enzyme Numbers (IUBMB) for ADAM28 Gene

Gene Ontology (GO) - Molecular Function for ADAM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM28: view
genes like me logo Genes that share phenotypes with ADAM28: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAM28 Gene

Localization for ADAM28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM28 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM28 Gene COMPARTMENTS Subcellular localization image for ADAM28 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADAM28: view

Pathways & Interactions for ADAM28 Gene

SuperPathways for ADAM28 Gene

No Data Available

Interacting Proteins for ADAM28 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265769%0d%0a9606.ENSP00000303351%0d%0a9606.ENSP00000380227%0d%0a9606.ENSP00000293813%0d%0a
Selected Interacting proteins: Q9UKQ2-ADA28_HUMAN ENSP00000265769 for ADAM28 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ADAM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAM28: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM28 Gene

Drugs & Compounds for ADAM28 Gene

(7) Drugs for ADAM28 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE Experimental Pharma Target 0
2-(Thiomethylene)-4-Methylpentanoic Acid Experimental Pharma Target 0
Batimastat Experimental Pharma Target 0
Furoyl-Leucine Experimental Pharma Target 0
GM6001 Experimental Pharma Target 0
genes like me logo Genes that share compounds with ADAM28: view

Transcripts for ADAM28 Gene

Unigene Clusters for ADAM28 Gene

ADAM metallopeptidase domain 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM28 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: -
SP8: - -
SP9:

ExUns: 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ADAM28 Gene

GeneLoc Exon Structure for
ADAM28
ECgene alternative splicing isoforms for
ADAM28

Expression for ADAM28 Gene

mRNA expression in normal human tissues for ADAM28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM28 Gene

This gene is overexpressed in Stomach (x8.5) and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for ADAM28 Gene

This gene is overexpressed in Liver, secretome (51.5) and Heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM28 Gene



SOURCE GeneReport for Unigene cluster for ADAM28 Gene Hs.174030

mRNA Expression by UniProt/SwissProt for ADAM28 Gene

Q9UKQ2-ADA28_HUMAN
Tissue specificity: Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
genes like me logo Genes that share expression patterns with ADAM28: view

Protein tissue co-expression partners for ADAM28 Gene

Primer Products

In Situ Assay Products

Orthologs for ADAM28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM28 35
  • 81.66 (n)
  • 75.1 (a)
ADAM28 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM28 35
  • 86.35 (n)
  • 84.03 (a)
ADAM28 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam28 35
  • 77.88 (n)
  • 70.86 (a)
Adam28 16
Adam28 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam28 35
  • 78.45 (n)
  • 73.15 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAM28 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM28 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM28 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM28 35
  • 58.46 (n)
  • 48.26 (a)
-- 36
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adam7 35
  • 54.36 (n)
  • 46.03 (a)
zebrafish
(Danio rerio)
Actinopterygii adam28 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for ADAM28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM28 Gene

ENSEMBL:
Gene Tree for ADAM28 (if available)
TreeFam:
Gene Tree for ADAM28 (if available)

Paralogs for ADAM28 Gene

genes like me logo Genes that share paralogs with ADAM28: view

Variants for ADAM28 Gene

Sequence variations from dbSNP and Humsavar for ADAM28 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_024596 -
VAR_057067 -
VAR_057068 -
VAR_057069 -
VAR_057070 -

Structural Variations from Database of Genomic Variants (DGV) for ADAM28 Gene

Variant ID Type Subtype PubMed ID
nsv831271 CNV Gain 17160897
nsv6120 CNV Loss 18451855
nsv890682 CNV Gain 21882294
esv2673011 CNV Deletion 23128226

Variation tolerance for ADAM28 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM28 Gene

HapMap Linkage Disequilibrium report
ADAM28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM28 Gene

Disorders for ADAM28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM28 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hyperostosis cranialis interna
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAM28

Genetic Association Database (GAD)
ADAM28
Human Genome Epidemiology (HuGE) Navigator
ADAM28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM28
genes like me logo Genes that share disorders with ADAM28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM28 Gene

Publications for ADAM28 Gene

  1. MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes. (PMID: 10506182) Roberts C.M. … Bowditch R.D. (J. Biol. Chem. 1999) 3 4 23 67
  2. The regulatory role of a disintegrin and metalloproteinase 28 on the biologic property of human periodontal ligament stem cells. (PMID: 20450360) Zhao Z. … Liu H. (J. Periodontol. 2010) 3 23
  3. ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. (PMID: 17047053) Mitsui Y. … Okada Y. (Cancer Res. 2006) 3 23
  4. ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. (PMID: 15013428) Mochizuki S. … Okada Y. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. Integrin alpha4beta1-dependent adhesion to ADAM 28 (MDC-L) requires an extended surface of the disintegrin domain. (PMID: 12667064) Bridges L.C. … Bowditch R.D. (Biochemistry 2003) 3 23

Products for ADAM28 Gene

Sources for ADAM28 Gene

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