Aliases for FTCD Gene
External Ids for FTCD Gene
Previous GeneCards Identifiers for FTCD Gene
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
GeneCards Summary for FTCD Gene
FTCD (Formimidoyltransferase Cyclodeaminase) is a Protein Coding gene. Diseases associated with FTCD include glutamate formiminotransferase deficiency and autoimmune hepatitis. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity and glutamate formimidoyltransferase activity. An important paralog of this gene is FTCDNL1.
UniProtKB/Swiss-Prot for FTCD Gene
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool
Binds and promotes bundling of vimentin filaments originating from the Golgi.