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Aliases for FAM114A2 Gene

Aliases for FAM114A2 Gene

  • Family With Sequence Similarity 114 Member A2 2 3 5
  • C5orf3 3 4
  • Family With Sequence Similarity 114, Member A2 2
  • Testis Tissue Sperm-Binding Protein Li 81P 3
  • Chromosome 5 Open Reading Frame 3 2
  • 133K02 3

External Ids for FAM114A2 Gene

Previous HGNC Symbols for FAM114A2 Gene

  • C5orf3

Previous GeneCards Identifiers for FAM114A2 Gene

  • GC05M153352
  • GC05M148512

Summaries for FAM114A2 Gene

GeneCards Summary for FAM114A2 Gene

FAM114A2 (Family With Sequence Similarity 114 Member A2) is a Protein Coding gene. GO annotations related to this gene include purine nucleotide binding. An important paralog of this gene is FAM114A1.

Gene Wiki entry for FAM114A2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM114A2 Gene

Genomics for FAM114A2 Gene

Regulatory Elements for FAM114A2 Gene

Enhancers for FAM114A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM114A2 on UCSC Golden Path with GeneCards custom track

Promoters for FAM114A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM114A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM114A2 Gene

153,990,128 bp from pter
154,038,937 bp from pter
48,810 bases
Minus strand

Genomic View for FAM114A2 Gene

Genes around FAM114A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM114A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM114A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM114A2 Gene

Proteins for FAM114A2 Gene

  • Protein details for FAM114A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM114A2
    Protein Accession:
    Secondary Accessions:
    • B2R8D8
    • Q9H7E0

    Protein attributes for FAM114A2 Gene

    505 amino acids
    Molecular mass:
    55468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM114A2 Gene

Proteomics data for FAM114A2 Gene at MOPED

Post-translational modifications for FAM114A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM114A2 Gene

Domains & Families for FAM114A2 Gene

Protein Domains for FAM114A2 Gene


Suggested Antigen Peptide Sequences for FAM114A2 Gene

Graphical View of Domain Structure for InterPro Entry



F1142_HUMAN :
  • Belongs to the FAM114 family.
  • Belongs to the FAM114 family.
genes like me logo Genes that share domains with FAM114A2: view

No data available for Gene Families for FAM114A2 Gene

Function for FAM114A2 Gene

Phenotypes for FAM114A2 Gene

GenomeRNAi human phenotypes for FAM114A2:
genes like me logo Genes that share phenotypes with FAM114A2: view

Animal Model Products

miRNA for FAM114A2 Gene

miRTarBase miRNAs that target FAM114A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM114A2 Gene

Localization for FAM114A2 Gene

Subcellular locations from

Jensen Localization Image for FAM114A2 Gene COMPARTMENTS Subcellular localization image for FAM114A2 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM114A2 Gene

Pathways & Interactions for FAM114A2 Gene

SuperPathways for FAM114A2 Gene

No Data Available

Interacting Proteins for FAM114A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000341597 for FAM114A2 Gene via STRING

Gene Ontology (GO) - Biological Process for FAM114A2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM114A2 Gene

Drugs & Compounds for FAM114A2 Gene

No Compound Related Data Available

Transcripts for FAM114A2 Gene

Unigene Clusters for FAM114A2 Gene

Family with sequence similarity 114, member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM114A2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - - -
SP14: - - -

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP15: -

Relevant External Links for FAM114A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM114A2 Gene

mRNA expression in normal human tissues for FAM114A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM114A2 Gene

This gene is overexpressed in Bone (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM114A2 Gene

SOURCE GeneReport for Unigene cluster for FAM114A2 Gene Hs.166551

genes like me logo Genes that share expression patterns with FAM114A2: view

Protein tissue co-expression partners for FAM114A2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM114A2 Gene

Orthologs for FAM114A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM114A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM114A2 35
  • 89.43 (n)
  • 87.73 (a)
FAM114A2 36
  • 85 (a)
(Canis familiaris)
Mammalia FAM114A2 35
  • 89.25 (n)
  • 86.73 (a)
FAM114A2 36
  • 84 (a)
(Mus musculus)
Mammalia Fam114a2 35
  • 83.47 (n)
  • 81.76 (a)
Fam114a2 16
Fam114a2 36
  • 79 (a)
(Pan troglodytes)
Mammalia FAM114A2 35
  • 99.54 (n)
  • 99.21 (a)
FAM114A2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia FAM114A2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia FAM114A2 36
  • 68 (a)
(Gallus gallus)
Aves FAM114A2 35
  • 71 (n)
  • 71 (a)
FAM114A2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia FAM114A2 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam114a2 35
  • 63.14 (n)
  • 62.37 (a)
Str.15039 35
(Danio rerio)
Actinopterygii si:dkey-13f9.5 35
  • 60.65 (n)
  • 58.26 (a)
wufi43h01 35
FAM114A2 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004464 35
  • 44.7 (n)
  • 37.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9590 35
  • 45.13 (n)
  • 32.58 (a)
CG9590 36
  • 21 (a)
Species with no ortholog for FAM114A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM114A2 Gene

Gene Tree for FAM114A2 (if available)
Gene Tree for FAM114A2 (if available)

Paralogs for FAM114A2 Gene

Paralogs for FAM114A2 Gene

genes like me logo Genes that share paralogs with FAM114A2: view

Variants for FAM114A2 Gene

Sequence variations from dbSNP and Humsavar for FAM114A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs707178 -- 153,991,845(-) TTGTG(A/G)TTTTT utr-variant-3-prime
rs707179 -- 153,991,903(-) CTGTC(A/G)TCTTC utr-variant-3-prime
rs720985 -- 154,032,969(+) CTCCA(A/C/G)TTCAC intron-variant
rs720986 -- 154,033,139(+) AAATA(A/G)GCAGC intron-variant
rs720987 -- 154,033,285(+) CTCTC(A/G)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM114A2 Gene

Variant ID Type Subtype PubMed ID
nsv883056 CNV Gain 21882294
nsv508385 CNV Loss 20534489

Variation tolerance for FAM114A2 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 54.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM114A2 Gene

Disorders for FAM114A2 Gene

Relevant External Links for FAM114A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM114A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM114A2 Gene

Publications for FAM114A2 Gene

  1. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J. … Wainscoat J.S. (Genomics 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for FAM114A2 Gene

Sources for FAM114A2 Gene