Aliases for FAM114A2 Gene
Aliases for FAM114A2 Gene
External Ids for FAM114A2 Gene
- HGNC: 1333
- Entrez Gene: 10827
- Ensembl: ENSG00000055147
- UniProtKB: Q9NRY5
Previous HGNC Symbols for FAM114A2 Gene
- C5orf3
Previous GeneCards Identifiers for FAM114A2 Gene
- GC05M153352
- GC05M148512
Summaries for FAM114A2 Gene
GeneCards Summary for FAM114A2 Gene
FAM114A2 (Family With Sequence Similarity 114 Member A2) is a Protein Coding gene. GO annotations related to this gene include purine nucleotide binding. An important paralog of this gene is FAM114A1.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM114A2 Gene
Genomics for FAM114A2 Gene
Regulatory Elements for FAM114A2 Gene
Enhancers for FAM114A2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FAM114A2 on UCSC Golden Path with GeneCards custom track
Promoters for FAM114A2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around FAM114A2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM114A2 gene promoter:
Regulatory Element Products
Genomic Location for FAM114A2 Gene
- Chromosome:
- 5
- Start:
- 153,990,128 bp from pter
- End:
- 154,038,937 bp from pter
- Size:
- 48,810 bases
- Orientation:
- Minus strand
Genomic View for FAM114A2 Gene
Genes around FAM114A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.2 by Ensembl
- 5q33.2 by Entrez Gene
- 5q33.2 by HGNC
FAM114A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM114A2 Gene
Proteins for FAM114A2 Gene
-
Protein details for FAM114A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRY5-F1142_HUMAN
- Recommended name:
- Protein FAM114A2
- Protein Accession:
- Q9NRY5
- B2R8D8
- Q9H7E0
Protein attributes for FAM114A2 Gene
- Size:
- 505 amino acids
- Molecular mass:
- 55468 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM114A2 Gene
Post-translational modifications for FAM114A2 Gene
Other Protein References for FAM114A2 Gene
Antibody Products
- Novus Biologicals Antibodies for FAM114A2
- Search GeneTex for Antibodies for FAM114A2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FAM114A2
Protein Products
-
OriGene Purified Proteins for FAM114A2
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM114A2
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- Search GeneTex for Proteins for FAM114A2
Assay Products
No data available for DME Specific Peptides for FAM114A2 Gene
Domains & Families for FAM114A2 Gene
Suggested Antigen Peptide Sequences for FAM114A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NRY5- Family:
-
- Belongs to the FAM114 family.
No data available for Gene Families for FAM114A2 Gene
Function for FAM114A2 Gene
Phenotypes for FAM114A2 Gene
- GenomeRNAi human phenotypes for FAM114A2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM114A2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM114A2 gene
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CRISPR Products
-
OriGene CRISPR knockouts for FAM114A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM114A2
miRNA for FAM114A2 Gene
- miRTarBase miRNAs that target FAM114A2
miRNA Products
- Search ViGene Biosciences for FAM114A2
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for FAM114A2
- Browse OriGene Inhibitory RNA Products For FAM114A2
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM114A2 gene
Clone Products
- OriGene clones in human for FAM114A2
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM114A2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM114A2 gene
-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM114A2 Gene
Localization for FAM114A2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM114A2 Gene
Pathways & Interactions for FAM114A2 Gene
More details on SuperPathways for FAM114A2
No Data Available
Interacting Proteins for FAM114A2 Gene
No data available for Pathways by source and SIGNOR curated interactions for FAM114A2 Gene
Transcripts for FAM114A2 Gene
mRNA/cDNA for FAM114A2 Gene
- (12) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM114A2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM114A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM114A2
miRNA Products
- Search ViGene Biosciences for FAM114A2
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for FAM114A2
- Browse OriGene Inhibitory RNA Products For FAM114A2
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM114A2 gene
Clone Products
- OriGene clones in human for FAM114A2
- OriGene ORF clones in human,mouse for FAM114A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | · | 18d | · | 18e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | - | - | |||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | |||||||||||||||||
| SP14: | |||||||||||||||||
| SP15: | - |
Expression for FAM114A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
This gene is overexpressed in Bone (27.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM114A2 Gene
SOURCE GeneReport for Unigene cluster for FAM114A2 Gene Hs.166551
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for FAM114A2
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM114A2 Gene
Orthologs for FAM114A2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | FAM114A2 35 |
|
||
| FAM114A2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | FAM114A2 35 |
|
||
| FAM114A2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Fam114a2 35 |
|
||
| Fam114a2 16 |
|
||||
| Fam114a2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | FAM114A2 35 |
|
||
| FAM114A2 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | FAM114A2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM114A2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM114A2 35 |
|
||
| FAM114A2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FAM114A2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam114a2 35 |
|
||
| Str.15039 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-13f9.5 35 |
|
||
| wufi43h01 35 |
|
||||
| FAM114A2 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004464 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9590 35 |
|
||
| CG9590 36 |
|
OneToMany |
- Species with no ortholog for FAM114A2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM114A2 Gene
(2) SIMAP similar genes for FAM114A2 Gene using alignment to 10 proteins:
Variants for FAM114A2 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs707178 | -- | 153,991,845(-) | TTGTG(A/G)TTTTT | utr-variant-3-prime | |
| rs707179 | -- | 153,991,903(-) | CTGTC(A/G)TCTTC | utr-variant-3-prime | |
| rs720985 | -- | 154,032,969(+) | CTCCA(A/C/G)TTCAC | intron-variant | |
| rs720986 | -- | 154,033,139(+) | AAATA(A/G)GCAGC | intron-variant | |
| rs720987 | -- | 154,033,285(+) | CTCTC(A/G)ATTTC | intron-variant |
Residual Variation Intolerance Score:
18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.37;
54.00% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM114A2 Gene
Disorders for FAM114A2 Gene
Relevant External Links for FAM114A2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM114A2
No disorders were found for FAM114A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM114A2 Gene
Publications for FAM114A2 Gene
- Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J. … Wainscoat J.S. (Genomics 2000) 2 3 4 67
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
Products for FAM114A2 Gene
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- OriGene Purified Proteins for FAM114A2
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- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for FAM114A2
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- OriGene qPCR primer pairs for FAM114A2
- OriGene CRISPR knockouts for FAM114A2
- OriGene clones in human for FAM114A2
- OriGene ORF clones in human,mouse for FAM114A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals Antibodies for FAM114A2
- Novus Biologicals proteins and lysates for FAM114A2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for FAM114A2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM114A2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM114A2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM114A2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM114A2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM114A2 gene
- Search ViGene Biosciences for FAM114A2
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- Santa Cruz Biotechnology (SCBT) Antibodies for FAM114A2
- Search Santa Cruz Biotechnology (SCBT) for FAM114A2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FAM114A2
Sources for FAM114A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon