Aliases for NEU3 Gene
External Ids for NEU3 Gene
Previous GeneCards Identifiers for NEU3 Gene
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
GeneCards Summary for NEU3 Gene
NEU3 (Neuraminidase 3 (Membrane Sialidase)) is a Protein Coding gene. Diseases associated with NEU3 include Galactosialidosis and Angiokeratoma. Among its related pathways are Sphingolipid metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU4.
UniProtKB/Swiss-Prot for NEU3 Gene
Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.