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Aliases for CPLX1 Gene

Aliases for CPLX1 Gene

  • Complexin 1 2 3
  • Complexin I 3 4
  • Synaphin-2 3 4
  • CPX I 3 4
  • CPX1 3 6
  • Complexin-1 3
  • Synaphin 2 3
  • CPX-I 3

External Ids for CPLX1 Gene

Previous GeneCards Identifiers for CPLX1 Gene

  • GC04M000804
  • GC04M000769
  • GC04M000770
  • GC04M000771
  • GC04M000749

Summaries for CPLX1 Gene

Entrez Gene Summary for CPLX1 Gene

  • Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPLX1 Gene

CPLX1 (Complexin 1) is a Protein Coding gene. Diseases associated with CPLX1 include wernicke encephalopathy. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include syntaxin-1 binding and neurotransmitter transporter activity. An important paralog of this gene is CPLX2.

UniProtKB/Swiss-Prot for CPLX1 Gene

  • Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).

Gene Wiki entry for CPLX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPLX1 Gene

Genomics for CPLX1 Gene

Regulatory Elements for CPLX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPLX1 Gene

Start:
784,957 bp from pter
End:
826,198 bp from pter
Size:
41,242 bases
Orientation:
Minus strand

Genomic View for CPLX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPLX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPLX1 Gene

Proteins for CPLX1 Gene

  • Protein details for CPLX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14810-CPLX1_HUMAN
    Recommended name:
    Complexin-1
    Protein Accession:
    O14810
    Secondary Accessions:
    • A6NI80
    • B2R4R5
    • D3DVN3
    • F1T0G1

    Protein attributes for CPLX1 Gene

    Size:
    134 amino acids
    Molecular mass:
    15030 Da
    Quaternary structure:
    • Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

    Three dimensional structures from OCA and Proteopedia for CPLX1 Gene

neXtProt entry for CPLX1 Gene

Proteomics data for CPLX1 Gene at MOPED

Post-translational modifications for CPLX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPLX1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CPLX1 (CPLX1)

No data available for DME Specific Peptides for CPLX1 Gene

Domains for CPLX1 Gene

Protein Domains for CPLX1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPLX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14810

UniProtKB/Swiss-Prot:

CPLX1_HUMAN :
  • O14810
Family:
  • Belongs to the complexin/synaphin family.
genes like me logo Genes that share domains with CPLX1: view

No data available for Gene Families for CPLX1 Gene

Function for CPLX1 Gene

Molecular function for CPLX1 Gene

UniProtKB/Swiss-Prot Function: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).

Gene Ontology (GO) - Molecular Function for CPLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding --
GO:0005326 neurotransmitter transporter activity IEA --
GO:0017075 syntaxin-1 binding IEA --
GO:0019905 syntaxin binding --
genes like me logo Genes that share ontologies with CPLX1: view
genes like me logo Genes that share phenotypes with CPLX1: view

Animal Models for CPLX1 Gene

MGI Knock Outs for CPLX1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPLX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CPLX1 Gene

Localization for CPLX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPLX1 Gene

Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPLX1 Gene COMPARTMENTS Subcellular localization image for CPLX1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CPLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030425 dendrite IEA --
GO:0031201 SNARE complex --
GO:0043025 neuronal cell body IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with CPLX1: view

Pathways for CPLX1 Gene

genes like me logo Genes that share pathways with CPLX1: view

Gene Ontology (GO) - Biological Process for CPLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport --
GO:0006887 exocytosis TAS 7553862
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0014047 glutamate secretion TAS --
genes like me logo Genes that share ontologies with CPLX1: view

Transcripts for CPLX1 Gene

Unigene Clusters for CPLX1 Gene

Complexin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPLX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPLX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for CPLX1 Gene

GeneLoc Exon Structure for
CPLX1
ECgene alternative splicing isoforms for
CPLX1

Expression for CPLX1 Gene

mRNA expression in normal human tissues for CPLX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPLX1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (6.0), Brain - Cortex (5.4), Brain - Frontal Cortex (BA9) (5.3), Brain - Caudate (basal ganglia) (4.3), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPLX1 Gene

SOURCE GeneReport for Unigene cluster for CPLX1 Gene Hs.478930

mRNA Expression by UniProt/SwissProt for CPLX1 Gene

O14810-CPLX1_HUMAN
Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
genes like me logo Genes that share expressions with CPLX1: view

In Situ Assay Products

Orthologs for CPLX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPLX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPLX1 35
  • 94.03 (n)
  • 95.52 (a)
dog
(Canis familiaris)
Mammalia CPLX1 35
  • 93.53 (n)
  • 97.01 (a)
CPLX1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cplx1 35
  • 87.06 (n)
  • 97.01 (a)
Cplx1 16
Cplx1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPLX1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPLX1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cplx1 35
  • 88.31 (n)
  • 97.01 (a)
chicken
(Gallus gallus)
Aves CPLX1 36
  • 89 (a)
OneToOne
CPLX2 35
  • 79.85 (n)
  • 91.79 (a)
lizard
(Anolis carolinensis)
Reptilia CPLX1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cplx1 35
  • 72.68 (n)
  • 90.23 (a)
zebrafish
(Danio rerio)
Actinopterygii CPLX1 (2 of 2) 36
  • 84 (a)
OneToMany
cplx2l 36
  • 74 (a)
OneToMany
LOC563082 35
  • 82.46 (n)
  • 84.96 (a)
wufc97e10 35
Species with no ortholog for CPLX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPLX1 Gene

ENSEMBL:
Gene Tree for CPLX1 (if available)
TreeFam:
Gene Tree for CPLX1 (if available)

Paralogs for CPLX1 Gene

Paralogs for CPLX1 Gene

Selected SIMAP similar genes for CPLX1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPLX1: view

Variants for CPLX1 Gene

Sequence variations from dbSNP and Humsavar for CPLX1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs936551 -- 827,702(+) GCTCC(A/G)TCTGC upstream-variant-2KB
rs1052595 -- 785,425(-) CCACA(G/T)CAAAA utr-variant-3-prime
rs2086211 -- 824,859(-) TGAGC(A/G)ATGCC intron-variant
rs2242236 -- 785,822(-) TTCCC(A/G)AGTCC utr-variant-3-prime
rs2242237 -- 785,606(-) GCAGC(C/T)GGCGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPLX1 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
dgv5389n71 CNV Loss 21882294
dgv5390n71 CNV Loss 21882294
nsv818207 CNV Gain 17921354
dgv5391n71 CNV Loss 21882294
nsv520136 CNV Gain 19592680
nsv515844 CNV Loss 19592680
nsv526780 CNV Loss 19592680
nsv521402 CNV Loss 19592680
nsv878262 CNV Loss 21882294
nsv10419 CNV Loss 18304495
esv2726709 CNV Deletion 23290073
esv2354094 CNV Deletion 18987734
esv990610 CNV Deletion 20482838
esv996415 CNV Deletion 20482838
esv2661833 CNV Deletion 23128226
esv2726710 CNV Deletion 23290073
esv998617 CNV Gain 20482838
nsv878267 CNV Loss 21882294
dgv5392n71 CNV Loss 21882294
nsv461147 CNV Loss 19166990
nsv878271 CNV Loss 21882294
nsv469998 CNV Loss 18288195
nsv822427 CNV Gain 20364138
esv32803 CNV Gain 17666407
dgv5393n71 CNV Loss 21882294
esv2726711 CNV Deletion 23290073
esv2726712 CNV Deletion 23290073
esv2726713 CNV Deletion 23290073

Relevant External Links for CPLX1 Gene

HapMap Linkage Disequilibrium report
CPLX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPLX1 Gene

Disorders for CPLX1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CPLX1 Gene including...

Search for CPLX1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CPLX1 Gene

Relevant External Links for CPLX1

Genetic Association Database (GAD)
CPLX1
Human Genome Epidemiology (HuGE) Navigator
CPLX1
genes like me logo Genes that share disorders with CPLX1: view

No data available for UniProtKB/Swiss-Prot for CPLX1 Gene

Publications for CPLX1 Gene

  1. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. (PMID: 16442780) Kishi T. … Iwata N. (Schizophr. Res. 2006) 3 23 48
  2. Complexins: cytosolic proteins that regulate SNAP receptor function. (PMID: 7553862) McMahon H.T. … Suedhof T.C. (Cell 1995) 2 3 4
  3. Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex. (PMID: 18240322) Salimi K. … Jarskog L.F. (Synapse 2008) 3 23
  4. Cerebellar synaptic protein expression in schizophrenia. (PMID: 11483314) Eastwood S.L. … Harrison P.J. (Neuroscience 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPLX1 Gene

Sources for CPLX1 Gene

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