Aliases for CPLX1 Gene
External Ids for CPLX1 Gene
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPLX1 Gene
CPLX1 (Complexin 1) is a Protein Coding gene. Diseases associated with CPLX1 include wernicke encephalopathy. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include syntaxin-1 binding and neurotransmitter transporter activity. An important paralog of this gene is CPLX2.
UniProtKB/Swiss-Prot for CPLX1 Gene
Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).