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Aliases for CGA Gene

Aliases for CGA Gene

  • Glycoprotein Hormones, Alpha Polypeptide 2 3 5
  • Thyroid-Stimulating Hormone Alpha Chain 2 3 4
  • Luteinizing Hormone Alpha Chain 2 3 4
  • Lutropin Alpha Chain 2 3 4
  • Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha 3 4
  • Follicle-Stimulating Hormone Alpha Subunit 2 3
  • Chorionic Gonadotropin, Alpha Polypeptide 2 3
  • Follicle-Stimulating Hormone Alpha Chain 3 4
  • Chorionic Gonadotrophin Subunit Alpha 3 4
  • Glycoprotein Hormones Alpha Chain 2 3
  • Choriogonadotropin Alpha Chain 3 4
  • Follitropin Alpha Chain 3 4
  • Thyrotropin Alpha Chain 3 4
  • FSH-Alpha 3 4
  • LSH-Alpha 3 4
  • TSH-Alpha 3 4
  • CG-ALPHA 3 4
  • GPHA1 3
  • FSHA 3
  • GPHa 3
  • TSHA 3
  • HCG 3
  • LHA 3

External Ids for CGA Gene

Previous GeneCards Identifiers for CGA Gene

  • GC06M087741
  • GC06M087790
  • GC06M087851
  • GC06M087795
  • GC06M085012

Summaries for CGA Gene

Entrez Gene Summary for CGA Gene

  • The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CGA Gene

CGA (Glycoprotein Hormones, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with CGA include Ectopic Pregnancy and Triploidy. Among its related pathways are Peptide hormone metabolism and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include hormone activity.

Gene Wiki entry for CGA Gene

Additional gene information for CGA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGA Gene

Genomics for CGA Gene

GeneHancer (GH) Regulatory Elements for CGA Gene

Promoters and enhancers for CGA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I087095 Promoter 1.1 EPDnew 550.8 +0.3 281 0.1 ATF1 KLF17 ZNF76 FEZF1 BRCA1 ZEB1 ZNF366 SCRT2 ZNF391 ATF7 CGA LINC01590 RN7SKP209
GH06I087088 Promoter 0.9 EPDnew 550.4 +7.2 7184 0.1 JUNB BATF ATF2 IRF4 BCL11A NFATC1 RUNX3 BCLAF1 CGA SLC35A1 RN7SKP209
GH06I087093 Enhancer 0.6 ENCODE 550.8 +1.3 1346 1.4 SMAD1 JUN GFI1B INSM2 FEZF1 ZNF843 BCL11B OSR2 ZNF610 GLI2 CGA SLC35A1 RN7SKP209
GH06I087151 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 -59.0 -58994 6.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF292 ENSG00000272008 RARS2 SLC35A1 LINC01590 ORC3 SMIM8 CGA C6orf163
GH06I087213 Enhancer 1 Ensembl ENCODE 10.6 -118.6 -118637 2 HDAC1 CLOCK FOXA2 ZFP64 SIN3A TCF12 FOS ATF7 NCOA1 ELF1 SMIM8 LINC01590 CGA SLC35A1 ORC3 GC06P087226 LOC100418923 ZNF292
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CGA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CGA gene promoter:

Genomic Locations for CGA Gene

Genomic Locations for CGA Gene
chr6:87,085,498-87,095,406
(GRCh38/hg38)
Size:
9,909 bases
Orientation:
Minus strand
chr6:87,795,216-87,804,824
(GRCh37/hg19)

Genomic View for CGA Gene

Genes around CGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGA Gene

Proteins for CGA Gene

  • Protein details for CGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01215-GLHA_HUMAN
    Recommended name:
    Glycoprotein hormones alpha chain
    Protein Accession:
    P01215

    Protein attributes for CGA Gene

    Size:
    116 amino acids
    Molecular mass:
    13075 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for CGA Gene

neXtProt entry for CGA Gene

Post-translational modifications for CGA Gene

  • Glycosylation at Asn76 and Asn102

Other Protein References for CGA Gene

Antibody Products

  • R&D Systems Antibodies for CGA (Chorionic Gonadotropin alpha Chain (HCG alpha))

Protein Products

No data available for DME Specific Peptides for CGA Gene

Domains & Families for CGA Gene

Gene Families for CGA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P01215

UniProtKB/Swiss-Prot:

GLHA_HUMAN :
  • Belongs to the glycoprotein hormones subunit alpha family.
Family:
  • Belongs to the glycoprotein hormones subunit alpha family.
genes like me logo Genes that share domains with CGA: view

Function for CGA Gene

Molecular function for CGA Gene

GENATLAS Biochemistry:
glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH

Phenotypes From GWAS Catalog for CGA Gene

Gene Ontology (GO) - Molecular Function for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 11207219
GO:0005515 protein binding IPI 11222739
genes like me logo Genes that share ontologies with CGA: view
genes like me logo Genes that share phenotypes with CGA: view

Animal Models for CGA Gene

MGI Knock Outs for CGA:

Animal Model Products

miRNA for CGA Gene

miRTarBase miRNAs that target CGA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CGA Gene

Localization for CGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGA gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with CGA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CGA Gene

Pathways & Interactions for CGA Gene

genes like me logo Genes that share pathways with CGA: view

SIGNOR curated interactions for CGA Gene

Activates:

Gene Ontology (GO) - Biological Process for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0006590 thyroid hormone generation IEA --
GO:0007165 signal transduction TAS 481597
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 481597
genes like me logo Genes that share ontologies with CGA: view

Drugs & Compounds for CGA Gene

(98) Drugs for CGA Gene - From: ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
leucovorin Approved Nutra 3402,1193
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 784
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1970
Levoleucovorin Approved, Investigational Pharma 777
Folic Acid Approved, Vet_approved Nutra 4610

(51) Additional Compounds for CGA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGA Gene

genes like me logo Genes that share compounds with CGA: view

Drug Products

Transcripts for CGA Gene

Unigene Clusters for CGA Gene

Glycoprotein hormones, alpha polypeptide:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for CGA Gene

GeneLoc Exon Structure for
CGA
ECgene alternative splicing isoforms for
CGA

Expression for CGA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGA Gene

mRNA differential expression in normal tissues according to GTEx for CGA Gene

This gene is overexpressed in Pituitary (x52.6).

Protein differential expression in normal tissues from HIPED for CGA Gene

This gene is overexpressed in Placenta (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CGA Gene



Protein tissue co-expression partners for CGA Gene

NURSA nuclear receptor signaling pathways regulating expression of CGA Gene:

CGA

SOURCE GeneReport for Unigene cluster for CGA Gene:

Hs.119689

Evidence on tissue expression from TISSUES for CGA Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CGA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGA Gene

Orthologs for CGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGA 33 34
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia CGA 33 34
  • 83.89 (n)
cow
(Bos Taurus)
Mammalia CGA 33 34
  • 80 (n)
mouse
(Mus musculus)
Mammalia Cga 33 16 34
  • 76.39 (n)
rat
(Rattus norvegicus)
Mammalia Cga 33
  • 76.11 (n)
oppossum
(Monodelphis domestica)
Mammalia CGA 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGA 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CGA 33 34
  • 69.17 (n)
lizard
(Anolis carolinensis)
Reptilia CGA 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cga 33
  • 66.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia tsha-A 33
zebrafish
(Danio rerio)
Actinopterygii cga 33 34
  • 65.2 (n)
Dr.13896 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11927 33
Species where no ortholog for CGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGA Gene

ENSEMBL:
Gene Tree for CGA (if available)
TreeFam:
Gene Tree for CGA (if available)

Paralogs for CGA Gene

No data available for Paralogs for CGA Gene

Variants for CGA Gene

Sequence variations from dbSNP and Humsavar for CGA Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000087058 -- 87,088,358(-) T/C intron_variant
rs1000517628 -- 87,091,572(-) G/C intron_variant
rs1000547065 -- 87,091,199(-) G/A intron_variant
rs1001045094 -- 87,085,315(-) A/G downstream_transcript_variant
rs1001057817 -- 87,085,029(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CGA Gene

Variant ID Type Subtype PubMed ID
esv1002835 CNV deletion 20482838
esv2763585 CNV gain 21179565
nsv5385 CNV deletion 18451855
nsv604106 CNV gain 21841781

Variation tolerance for CGA Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGA Gene

Human Gene Mutation Database (HGMD)
CGA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGA Gene

Disorders for CGA Gene

MalaCards: The human disease database

(44) MalaCards diseases for CGA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
triploidy
  • chromosome triploidy syndrome
ovarian remnant syndrome
  • residual ovary syndrome
scalp dermatosis
  • dermatosis of scalp
ovarian hyperstimulation syndrome
  • ohss
- elite association - COSMIC cancer census association via MalaCards
Search CGA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CGA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGA Gene

Publications for CGA Gene

  1. The gene encoding the common alpha subunit of the four human glycoprotein hormones. (PMID: 6286817) Fiddes JC … Goodman HM (Journal of molecular and applied genetics 1981) 2 3 4 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  5. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F … Feigelson HS (Human molecular genetics 2010) 3 44 58

Products for CGA Gene

Sources for CGA Gene

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