Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STARD10 Gene

Aliases for STARD10 Gene

  • StAR-Related Lipid Transfer (START) Domain Containing 10 2 3
  • Serologically Defined Colon Cancer Antigen 28 2 3 4
  • StAR-Related Lipid Transfer Protein 10 3 4
  • START Domain-Containing Protein 10 3 4
  • START Domain Containing 10 2 3
  • Antigen NY-CO-28 3 4
  • SDCCAG28 3 4
  • PCTP-L 3 4
  • PCTP-Like Protein 3
  • NY-CO-28 3
  • StARD10 4
  • CGI-52 3
  • PCTP2 3

External Ids for STARD10 Gene

Previous HGNC Symbols for STARD10 Gene

  • SDCCAG28

Previous GeneCards Identifiers for STARD10 Gene

  • GC11M074005
  • GC11M072192
  • GC11M072143
  • GC11M072465
  • GC11M068761

Summaries for STARD10 Gene

GeneCards Summary for STARD10 Gene

STARD10 (StAR-Related Lipid Transfer (START) Domain Containing 10) is a Protein Coding gene. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for STARD10 Gene

  • May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Gene Wiki entry for STARD10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD10 Gene

Genomics for STARD10 Gene

Regulatory Elements for STARD10 Gene

Genomic Location for STARD10 Gene

Start:
72,754,729 bp from pter
End:
72,794,168 bp from pter
Size:
39,440 bases
Orientation:
Minus strand

Genomic View for STARD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD10 Gene

Proteins for STARD10 Gene

  • Protein details for STARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y365-PCTL_HUMAN
    Recommended name:
    PCTP-like protein
    Protein Accession:
    Q9Y365
    Secondary Accessions:
    • O60532

    Protein attributes for STARD10 Gene

    Size:
    291 amino acids
    Molecular mass:
    33049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC18045.1; Type=Miscellaneous discrepancy; Note=Various sequencing problems as well as a translation in a wrong frame.; Evidence={ECO:0000305}; Sequence=AAD34047.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for STARD10 Gene

Proteomics data for STARD10 Gene at MOPED

Post-translational modifications for STARD10 Gene

  • Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD10 Gene

Domains for STARD10 Gene

Gene Families for STARD10 Gene

HGNC:
  • StARD :StAR-related lipid transfer (START) domain containing

Protein Domains for STARD10 Gene

Suggested Antigen Peptide Sequences for STARD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y365

UniProtKB/Swiss-Prot:

PCTL_HUMAN :
  • Q9Y365
Domain:
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD10: view

Function for STARD10 Gene

Molecular function for STARD10 Gene

UniProtKB/Swiss-Prot Function: May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Gene Ontology (GO) - Molecular Function for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD10: view
genes like me logo Genes that share phenotypes with STARD10: view

Animal Models for STARD10 Gene

MGI Knock Outs for STARD10:

miRNA for STARD10 Gene

miRTarBase miRNAs that target STARD10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STARD10 Gene

Localization for STARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD10 Gene

Cell projection, cilium, flagellum. Cytoplasm. Membrane. Note=In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD10 Gene COMPARTMENTS Subcellular localization image for STARD10 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005902 microvillus IEA --
GO:0016020 membrane IEA --
GO:0046581 intercellular canaliculus IEA --
genes like me logo Genes that share ontologies with STARD10: view

Pathways for STARD10 Gene

SuperPathways for STARD10 Gene

No Data Available

Interacting Proteins for STARD10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335247%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: ENSP00000335247 Q9Y365-PCTL_HUMAN for STARD10 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032782 bile acid secretion IEA --
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with STARD10: view

No data available for Pathways by source for STARD10 Gene

Transcripts for STARD10 Gene

Unigene Clusters for STARD10 Gene

StAR-related lipid transfer (START) domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD10 Gene

No ASD Table

Relevant External Links for STARD10 Gene

GeneLoc Exon Structure for
STARD10
ECgene alternative splicing isoforms for
STARD10

Expression for STARD10 Gene

mRNA expression in normal human tissues for STARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STARD10 Gene

This gene is overexpressed in Liver (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STARD10 Gene

SOURCE GeneReport for Unigene cluster for STARD10 Gene Hs.188606

genes like me logo Genes that share expressions with STARD10: view

No data available for mRNA Expression by UniProt/SwissProt for STARD10 Gene

Orthologs for STARD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD10 35
  • 99.66 (n)
  • 99.31 (a)
STARD10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STARD10 35
  • 91.41 (n)
  • 94.5 (a)
STARD10 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD10 35
  • 92.9 (n)
  • 96.56 (a)
STARD10 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard10 35
  • 91.18 (n)
  • 97.25 (a)
Stard10 16
Stard10 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STARD10 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard10 35
  • 90.46 (n)
  • 97.59 (a)
chicken
(Gallus gallus)
Aves STARD10 35
  • 71.41 (n)
  • 69.57 (a)
STARD10 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD10 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8320 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stard10 35
  • 73.28 (n)
  • 75.28 (a)
Str.11784 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5576 35
zebrafish
(Danio rerio)
Actinopterygii STARD10 36
  • 43 (a)
OneToOne
zgc56270 35
zgc:77147 35
  • 72.28 (n)
  • 75.28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008308 35
  • 50.73 (n)
  • 39.47 (a)
worm
(Caenorhabditis elegans)
Secernentea T28D6.7 35
  • 47.16 (n)
  • 39.53 (a)
T28D6.7 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9553 36
  • 40 (a)
OneToOne
Species with no ortholog for STARD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD10 Gene

ENSEMBL:
Gene Tree for STARD10 (if available)
TreeFam:
Gene Tree for STARD10 (if available)

Paralogs for STARD10 Gene

genes like me logo Genes that share paralogs with STARD10: view

No data available for Paralogs for STARD10 Gene

Variants for STARD10 Gene

Sequence variations from dbSNP and Humsavar for STARD10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs479490 -- 72,786,276(+) GAGCC(C/T)GGGAG intron-variant
rs481206 -- 72,786,417(+) TGGCT(C/T)GGCCT intron-variant
rs485099 -- 72,789,015(+) cacgc(C/T)cagct intron-variant
rs510285 -- 72,788,546(-) aatac(A/T)ttttt intron-variant
rs519201 -- 72,765,197(+) agagg(C/T)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD10 Gene

Variant ID Type Subtype PubMed ID
nsv832207 CNV Loss 17160897
nsv825992 CNV Gain 20364138
esv2744771 CNV Deletion 23290073

Relevant External Links for STARD10 Gene

HapMap Linkage Disequilibrium report
STARD10
Human Gene Mutation Database (HGMD)
STARD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD10 Gene

Disorders for STARD10 Gene

Relevant External Links for STARD10

Genetic Association Database (GAD)
STARD10
Human Genome Epidemiology (HuGE) Navigator
STARD10
genes like me logo Genes that share disorders with STARD10: view

No data available for UniProtKB/Swiss-Prot for STARD10 Gene

Publications for STARD10 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. (PMID: 17561512) Olayioye M.A. … Pomorski T. (J. Biol. Chem. 2007) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for STARD10 Gene

Sources for STARD10 Gene

Back to Top

Content