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Aliases for ADCY2 Gene

Aliases for ADCY2 Gene

  • Adenylate Cyclase 2 (Brain) 2 3
  • Adenylate Cyclase Type II 3 4
  • ATP Pyrophosphate-Lyase 2 3 4
  • Adenylyl Cyclase 2 3 4
  • EC 4 63
  • 3,5-Cyclic AMP Synthetase 3
  • Type II Adenylate Cyclase 3
  • Adenylate Cyclase Type 2 3
  • Adenylate Cyclase II 3
  • KIAA1060 4
  • HBAC2 3
  • AC2 3

External Ids for ADCY2 Gene

Previous GeneCards Identifiers for ADCY2 Gene

  • GC05P007810
  • GC05P007429

Summaries for ADCY2 Gene

Entrez Gene Summary for ADCY2 Gene

  • This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY2 Gene

ADCY2 (Adenylate Cyclase 2 (Brain)) is a Protein Coding gene. Diseases associated with ADCY2 include adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY2 Gene

  • This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

Tocris Summary for ADCY2 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY2 Gene

Genomics for ADCY2 Gene

Regulatory Elements for ADCY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCY2 Gene

7,396,208 bp from pter
7,830,081 bp from pter
433,874 bases
Plus strand

Genomic View for ADCY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY2 Gene

Proteins for ADCY2 Gene

  • Protein details for ADCY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylate cyclase type 2
    Protein Accession:
    Secondary Accessions:
    • B7Z2C1
    • Q2NKL8
    • Q9UDB2
    • Q9UPU2

    Protein attributes for ADCY2 Gene

    1091 amino acids
    Molecular mass:
    123603 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Interacts with RAF1.

    Alternative splice isoforms for ADCY2 Gene


neXtProt entry for ADCY2 Gene

Proteomics data for ADCY2 Gene at MOPED

Post-translational modifications for ADCY2 Gene

Other Protein References for ADCY2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ADCY2 Gene

Gene Families for ADCY2 Gene

Protein Domains for ADCY2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY2: view

Function for ADCY2 Gene

Molecular function for ADCY2 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type II,calmodulin insensitive,brain,lung
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation.
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

Enzyme Numbers (IUBMB) for ADCY2 Gene

Gene Ontology (GO) - Molecular Function for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity NAS 1427768
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008179 adenylate cyclase binding ISS --
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity IEA --
genes like me logo Genes that share ontologies with ADCY2: view

Phenotypes for ADCY2 Gene

GenomeRNAi human phenotypes for ADCY2:
genes like me logo Genes that share phenotypes with ADCY2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADCY2 Gene

Localization for ADCY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCY2 Gene COMPARTMENTS Subcellular localization image for ADCY2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular ISS --
GO:0005737 cytoplasm IDA 11549699
GO:0005886 plasma membrane TAS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCY2: view

Pathways for ADCY2 Gene

SuperPathways for ADCY2 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process ISS --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY2: view

Drugs for ADCY2 Gene

(2) Drugbank Compounds for ADCY2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
444894 Target experimental
64657-11-0 47936 Target experimental

(5) Tocris Compounds for ADCY2 Gene

Compound Action Cas Number
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
PACAP 1-38 Potent stimulator of adenylyl cyclase [137061-48-4]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Ca
Cyclic AMP
  • 3'5'-Cyclic AMP
Cyclic GMP
  • 3',5'-Cyclic GMP
Guanosine triphosphate
  • 5'-GTP

(8) Novoseek inferred chemical compound relationships for ADCY2 Gene

Compound -log(P) Hits PubMed IDs
adenylate 61.6 12
forskolin 49.2 3
phorbol 46.7 1
cyclic amp 41.1 1
isoproterenol 34.3 1

(1) PharmGKB related drug/compound annotations for ADCY2 Gene

Drug/compound Annotation
capecitabine Clinical Annotation
genes like me logo Genes that share compounds with ADCY2: view

Transcripts for ADCY2 Gene

Unigene Clusters for ADCY2 Gene

Adenylate cyclase 2 (brain):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY2 Gene

No ASD Table

Relevant External Links for ADCY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCY2 Gene

mRNA expression in normal human tissues for ADCY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY2 Gene

This gene is overexpressed in Muscle - Skeletal (5.3), Brain - Anterior cingulate cortex (BA24) (5.0), Brain - Frontal Cortex (BA9) (4.8), Brain - Cortex (4.4), and Brain - Amygdala (4.1).

Protein differential expression in normal tissues for ADCY2 Gene

This gene is overexpressed in Monocytes (32.6) and Frontal cortex (27.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY2 Gene

SOURCE GeneReport for Unigene cluster for ADCY2 Gene Hs.481545

mRNA Expression by UniProt/SwissProt for ADCY2 Gene

Tissue specificity: Expressed in brain
genes like me logo Genes that share expressions with ADCY2: view

Expression partners for ADCY2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for ADCY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCY2 35
  • 89.13 (n)
  • 96.03 (a)
ADCY2 36
  • 96 (a)
(Canis familiaris)
Mammalia ADCY2 35
  • 90.21 (n)
  • 96.15 (a)
ADCY2 36
  • 97 (a)
(Mus musculus)
Mammalia Adcy2 35
  • 88.42 (n)
  • 95.6 (a)
Adcy2 16
Adcy2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Adcy2 35
  • 88.23 (n)
  • 95.81 (a)
(Monodelphis domestica)
Mammalia ADCY2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia ADCY2 36
  • 92 (a)
(Gallus gallus)
Aves ADCY2 35
  • 80.51 (n)
  • 89.08 (a)
ADCY2 36
  • 88 (a)
(Anolis carolinensis)
Reptilia ADCY2 36
  • 84 (a)
(Danio rerio)
Actinopterygii adcy2a 35
  • 73.74 (n)
  • 83.01 (a)
adcy2a 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 37
  • 39 (a)
  • 27 (a)
  • 27 (a)
  • 27 (a)
  • 28 (a)
rut 37
  • 44 (a)
Ac76E 35
  • 53.83 (n)
  • 45.27 (a)
Ac76E 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010436 35
  • 50.76 (n)
  • 44.55 (a)
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 39 (a)
acy-4 37
  • 43 (a)
acy-2 36
  • 31 (a)
Species with no ortholog for ADCY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADCY2 Gene

Gene Tree for ADCY2 (if available)
Gene Tree for ADCY2 (if available)

Paralogs for ADCY2 Gene

(9) SIMAP similar genes for ADCY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY2: view

Variants for ADCY2 Gene

Sequence variations from dbSNP and Humsavar for ADCY2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26738 -- 7,464,943(-) cctcc(A/C)tagcc intron-variant
rs26739 -- 7,466,063(+) CACTA(A/G)GAATC intron-variant
rs27378 -- 7,468,447(+) CAGTT(C/T)GAGAG intron-variant
rs27692 -- 7,463,962(-) TGTTA(C/T)ATAAG intron-variant
rs34843 -- 7,460,123(-) TATTC(A/C)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY2 Gene

Variant ID Type Subtype PubMed ID
nsv880826 CNV Gain 21882294
nsv881207 CNV Gain 21882294
nsv830198 CNV Gain 17160897
esv23386 CNV Loss 19812545
nsv517197 CNV Gain 19592680
nsv461926 CNV Gain 19166990
esv272820 CNV Insertion 20981092
esv267668 CNV Insertion 20981092
esv2729708 CNV Deletion 23290073
esv2676111 CNV Deletion 23128226
esv22556 CNV Loss 19812545
esv8296 CNV Gain 19470904
nsv4704 CNV Insertion 18451855
nsv327244 CNV Loss 16902084
esv2638984 CNV Insertion 19546169

Relevant External Links for ADCY2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY2 Gene

Disorders for ADCY2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADCY2 Gene in MalaCards »

(1) Disease for ADCY2 Gene

Relevant External Links for ADCY2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCY2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ADCY2 Gene

Publications for ADCY2 Gene

  1. Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. (PMID: 1427768) Stengel D. … Hanoune J. (Hum. Genet. 1992) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 48
  5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 48

Products for ADCY2 Gene

Sources for ADCY2 Gene

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