Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR5I1 Gene

Aliases for OR5I1 Gene

  • Olfactory Receptor, Family 5, Subfamily I, Member 1 2 3
  • Olfactory Receptor-Like Protein OLF1 3 4
  • Olfactory Receptor OR11-159 3 4
  • OLF1 3 4
  • HSOlf1 3

External Ids for OR5I1 Gene

Previous GeneCards Identifiers for OR5I1 Gene

  • GC11M058096
  • GC11M057215
  • GC11M055953
  • GC11M055456
  • GC11M055478
  • GC11M055459
  • GC11M055703

Summaries for OR5I1 Gene

Entrez Gene Summary for OR5I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5I1 Gene

OR5I1 (Olfactory Receptor, Family 5, Subfamily I, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot for OR5I1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5I1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5I1 Gene

Genomics for OR5I1 Gene

Regulatory Elements for OR5I1 Gene

Genomic Location for OR5I1 Gene

55,935,456 bp from pter
55,936,400 bp from pter
945 bases
Minus strand

Genomic View for OR5I1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5I1 Gene

Proteins for OR5I1 Gene

  • Protein details for OR5I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5I1
    Protein Accession:
    Secondary Accessions:
    • Q6IEU4

    Protein attributes for OR5I1 Gene

    314 amino acids
    Molecular mass:
    36049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5I1 Gene

Proteomics data for OR5I1 Gene at MOPED

Post-translational modifications for OR5I1 Gene

  • Glycosylation at Asn 7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5I1 Gene

Domains & Families for OR5I1 Gene

Gene Families for OR5I1 Gene

Protein Domains for OR5I1 Gene

Suggested Antigen Peptide Sequences for OR5I1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5I1: view

Function for OR5I1 Gene

Molecular function for OR5I1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 5,subfamily I,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5I1: view
genes like me logo Genes that share phenotypes with OR5I1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5I1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5I1 Gene

Localization for OR5I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5I1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR5I1 Gene COMPARTMENTS Subcellular localization image for OR5I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5I1: view

Pathways & Interactions for OR5I1 Gene

genes like me logo Genes that share pathways with OR5I1: view

Pathways by source for OR5I1 Gene

1 KEGG pathway for OR5I1 Gene

Interacting Proteins for OR5I1 Gene

Gene Ontology (GO) - Biological Process for OR5I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9787077
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5I1: view

No data available for SIGNOR curated interactions for OR5I1 Gene

Drugs & Compounds for OR5I1 Gene

No Compound Related Data Available

Transcripts for OR5I1 Gene

mRNA/cDNA for OR5I1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5I1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5I1 Gene

No ASD Table

Relevant External Links for OR5I1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5I1 Gene

mRNA expression in normal human tissues for OR5I1 Gene

SOURCE GeneReport for Unigene cluster for OR5I1 Gene Hs.533706

genes like me logo Genes that share expression patterns with OR5I1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5I1 Gene

Orthologs for OR5I1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5I1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR5I1 35
  • 87.69 (n)
  • 89.81 (a)
-- 36
  • 80 (a)
-- 36
  • 90 (a)
-- 36
  • 84 (a)
-- 36
  • 85 (a)
(Canis familiaris)
Mammalia LOC100686849 35
  • 87.79 (n)
  • 90.45 (a)
-- 36
  • 90 (a)
  • 89 (a)
(Mus musculus)
Mammalia Olfr152 35
  • 82.85 (n)
  • 90.42 (a)
Olfr152 16
Olfr152 36
  • 90 (a)
(Pan troglodytes)
Mammalia LOC747283 35
  • 98.83 (n)
  • 97.13 (a)
OR5I1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Olr588 35
  • 81.85 (n)
  • 89.17 (a)
(Monodelphis domestica)
Mammalia OR5I1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
(Gallus gallus)
Aves LOC428827 35
  • 60.33 (n)
  • 56.07 (a)
OR5I1 36
  • 55 (a)
Species with no ortholog for OR5I1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5I1 Gene

Gene Tree for OR5I1 (if available)
Gene Tree for OR5I1 (if available)

Paralogs for OR5I1 Gene

Paralogs for OR5I1 Gene

(450) SIMAP similar genes for OR5I1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5I1: view

Variants for OR5I1 Gene

Sequence variations from dbSNP and Humsavar for OR5I1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4367963 - 55,936,252(+) TGATC(A/G)ACAGC missense, reference
rs4465383 -- 55,935,771(+) CAAAT(A/G)ATTTC reference, synonymous-codon
rs7952311 -- 55,938,255(+) TCTTA(C/T)AGATG upstream-variant-2KB
rs9665861 - 55,935,485(+) TAGAA(C/T)TTTCT missense, reference
rs9665863 -- 55,935,534(+) ATCAA(A/C/T)GGATT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for OR5I1 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv821668 CNV Loss 15273396
nsv437718 CNV Loss 16327808
nsv468568 CNV Loss 19166990
nsv469959 CNV Loss 18288195
nsv517590 CNV Loss 19592680
dgv52e55 CNV Loss 17911159
dgv151n27 CNV Loss 19166990
dgv384e1 CNV Complex 17122850
nsv468571 CNV Loss 19166990

Variation tolerance for OR5I1 Gene

Residual Variation Intolerance Score: 77.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.30; 81.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5I1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5I1 Gene

Disorders for OR5I1 Gene

Relevant External Links for OR5I1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OR5I1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5I1 Gene

Publications for OR5I1 Gene

  1. Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (PMID: 15037199) Cayla C. … Paris H. (Biochem. Pharmacol. 2004) 23 67
  2. Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a regulatory role for NFI transcription factors in olfactory neuron gene expression. (PMID: 10521600) Baumeister H. … Margolis F.L. (Brain Res. Mol. Brain Res. 1999) 23 67
  3. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner J.A. … Evans G.A. (Genomics 1998) 2 67
  4. The evolution of mammalian olfactory receptor genes. (PMID: 9017400) Issel-Tarver L. … Rine J. (Genetics 1997) 2 67
  5. Evidence for different chemosensory signal transduction pathways in olfactory and vomeronasal neurons. (PMID: 8607864) Wu Y. … Ryba N.J. (Biochem. Biophys. Res. Commun. 1996) 23 67

Products for OR5I1 Gene

Sources for OR5I1 Gene

Back to Top