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Aliases for AHCYL1 Gene

Aliases for AHCYL1 Gene

  • Adenosylhomocysteinase-Like 1 2 3
  • Inositol 1,4,5-Trisphosphate Receptor-Binding Protein 2 3
  • S-Adenosylhomocysteine Hydrolase-Like Protein 1 3 4
  • IP(3)Rs Binding Protein Released With IP(3) 3 4
  • S-Adenosyl-L-Homocysteine Hydrolase 2 3 4
  • DC-Expressed AHCY-Like Molecule 3 4
  • AdoHcyase 2 3 4
  • EC 3.3.1.1 4 63
  • XPVKONA 3 4
  • IRBIT 3 4
  • DCAL 3 4
  • Protein Phosphatase 1, Regulatory Subunit 78 3
  • Dendritic Cell Expressed AHCY-Like Protein 3
  • S-Adenosyl Homocysteine Hydrolase Homolog 3
  • S-Adenosylhomocysteine Hydrolase-Like 1 2
  • Putative Adenosylhomocysteinase 2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 78 2
  • PPP1R78 3
  • PRO0233 3

External Ids for AHCYL1 Gene

Summaries for AHCYL1 Gene

Entrez Gene Summary for AHCYL1 Gene

  • The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AHCYL1 Gene

AHCYL1 (Adenosylhomocysteinase-Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and One carbon pool by folate. GO annotations related to this gene include adenosylhomocysteinase activity. An important paralog of this gene is AHCYL2.

UniProtKB/Swiss-Prot for AHCYL1 Gene

  • Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression.

Gene Wiki entry for AHCYL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHCYL1 Gene

Genomics for AHCYL1 Gene

Genomic Location for AHCYL1 Gene

Start:
109,984,686 bp from pter
End:
110,023,742 bp from pter
Size:
39,057 bases
Orientation:
Plus strand

Genomic View for AHCYL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHCYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHCYL1 Gene

Regulatory Elements for AHCYL1 Gene

Proteins for AHCYL1 Gene

  • Protein details for AHCYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43865-SAHH2_HUMAN
    Recommended name:
    Putative adenosylhomocysteinase 2
    Protein Accession:
    O43865
    Secondary Accessions:
    • B4E168
    • Q2TAJ6
    • Q502W8
    • Q5VSM0
    • Q6P171
    • Q96PK4
    • Q9UG84

    Protein attributes for AHCYL1 Gene

    Size:
    530 amino acids
    Molecular mass:
    58951 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540; Note=Binds 1 NAD(+) per subunit.;
    Quaternary structure:
    • Interacts with ITPR1. Competes with IP3 for interaction with ITPR1 and attenuates IP3-induced Ca(2+) release through the ITPR1 from the non-mitochondrial intracellular stores (By similarity). Interacts with RRM1, in a phosphorylation- and (dATP)-dependent manner.
    Miscellaneous:
    • Ablation of expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.
    SequenceCaution:
    • Sequence=AAC01960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BI460083; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAB43223.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AHCYL1 Gene

    Alternative splice isoforms for AHCYL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHCYL1 Gene

Proteomics data for AHCYL1 Gene at MOPED

Post-translational modifications for AHCYL1 Gene

  • Phosphorylated at Ser/Thr residues between Ser-68 and Thr-72 in the PEST region: required for interaction with dATP-bound RRM1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys377

Other Protein References for AHCYL1 Gene

Domains for AHCYL1 Gene

Graphical View of Domain Structure for InterPro Entry

O43865

UniProtKB/Swiss-Prot:

SAHH2_HUMAN
Domain:
  • The PEST region is essential for the interaction with ITPR1, and, when phosphorylated, is also the RRM1-binding region. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity).:
    • O43865
Family:
  • Belongs to the adenosylhomocysteinase family.:
    • O43865
genes like me logo Genes that share domains with AHCYL1: view

No data available for Gene Families for AHCYL1 Gene

Function for AHCYL1 Gene

Molecular function for AHCYL1 Gene

GENATLAS Biochemistry: S-adenosylhomocysteine hydrolase-like 1
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine
UniProtKB/Swiss-Prot Function: Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression.

Enzyme Numbers (IUBMB) for AHCYL1 Gene

Gene Ontology (GO) - Molecular Function for AHCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004013 NOT adenosylhomocysteinase activity IBA --
GO:0004455 ketol-acid reductoisomerase activity --
GO:0005515 protein binding IPI 16769890
GO:0051287 NAD binding --
genes like me logo Genes that share ontologies with AHCYL1: view
genes like me logo Genes that share phenotypes with AHCYL1: view

miRNA for AHCYL1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AHCYL1 Gene

Localization for AHCYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHCYL1 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHCYL1 Gene COMPARTMENTS Subcellular localization image for AHCYL1 gene
Compartment Confidence
cytosol 3
chloroplast 2
endoplasmic reticulum 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AHCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IBA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with AHCYL1: view

Pathways for AHCYL1 Gene

genes like me logo Genes that share pathways with AHCYL1: view

Pathways by source for AHCYL1 Gene

1 GeneGo (Thomson Reuters) pathway for AHCYL1 Gene
1 BioSystems pathway for AHCYL1 Gene
2 KEGG pathways for AHCYL1 Gene

UniProtKB/Swiss-Prot O43865-SAHH2_HUMAN

  • Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1

Gene Ontology (GO) - Biological Process for AHCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IEA --
GO:0006611 protein export from nucleus IEA --
GO:0006730 one-carbon metabolic process IEA --
GO:0008150 biological_process ND --
GO:0008652 cellular amino acid biosynthetic process --
genes like me logo Genes that share ontologies with AHCYL1: view

Compounds for AHCYL1 Gene

(8) HMDB Compounds for AHCYL1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
58-61-7
Homocysteine
  • (+-)-homocysteine
454-29-5
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(2) Novoseek inferred chemical compound relationships for AHCYL1 Gene

Compound -log(P) Hits PubMed IDs
s-adenosylhomocysteine 92.1 17
deoxyadenosine 64.9 2
genes like me logo Genes that share compounds with AHCYL1: view

Transcripts for AHCYL1 Gene

Unigene Clusters for AHCYL1 Gene

Adenosylhomocysteinase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
SP1: - - - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:

ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - -
SP12:
SP13:
SP14:

Relevant External Links for AHCYL1 Gene

GeneLoc Exon Structure for
AHCYL1
ECgene alternative splicing isoforms for
AHCYL1

Expression for AHCYL1 Gene

mRNA expression in normal human tissues for AHCYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AHCYL1 Gene

SOURCE GeneReport for Unigene cluster for AHCYL1 Gene Hs.743973

mRNA Expression by UniProt/SwissProt for AHCYL1 Gene

O43865-SAHH2_HUMAN
Tissue specificity: Expressed in dendritic cells.
genes like me logo Genes that share expressions with AHCYL1: view

No data available for mRNA differential expression in normal tissues for AHCYL1 Gene

Orthologs for AHCYL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHCYL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHCYL1 35
  • 99.81 (n)
  • 100 (a)
AHCYL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AHCYL1 35
  • 96.16 (n)
  • 100 (a)
AHCYL1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AHCYL1 35
  • 96.12 (n)
  • 100 (a)
AHCYL1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ahcyl1 35
  • 93.65 (n)
  • 100 (a)
Ahcyl1 16
Ahcyl1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHCYL1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHCYL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ahcyl1 35
  • 94.57 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves AHCYL1 35
  • 84.05 (n)
  • 96.32 (a)
AHCYL1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AHCYL1 36
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ahcyl1 35
  • 79.02 (n)
  • 92.43 (a)
ahcyl1 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000792 35
  • 68.44 (n)
  • 76.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ahcy89E 36
  • 67 (a)
ManyToMany
CG9977 35
  • 70.35 (n)
  • 78.81 (a)
CG9977 36
  • 72 (a)
ManyToMany
CG9977 37
  • 78 (a)
Ahcy89E 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea ahcy-1 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAH1 36
  • 48 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13830 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10842 36
  • 67 (a)
OneToMany
Species with no ortholog for AHCYL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AHCYL1 Gene

ENSEMBL:
Gene Tree for AHCYL1 (if available)
TreeFam:
Gene Tree for AHCYL1 (if available)

Paralogs for AHCYL1 Gene

Paralogs for AHCYL1 Gene

Selected SIMAP similar genes for AHCYL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AHCYL1: view

Variants for AHCYL1 Gene

Sequence variations from dbSNP and Humsavar for AHCYL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12987 -- 110,023,066(-) ACTTA(A/T)AGCTC utr-variant-3-prime
rs167985 -- 110,021,192(-) ATGAT(C/T)CCAGC intron-variant
rs179644 -- 109,992,251(+) aaaac(A/C)caaaa intron-variant
rs186724 -- 110,018,293(-) TAGGA(A/G)ACCAG intron-variant
rs193084 -- 110,007,089(+) CTGAA(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHCYL1 Gene

Variant ID Type Subtype PubMed ID
esv269322 CNV Insertion 20981092

Relevant External Links for AHCYL1 Gene

HapMap Linkage Disequilibrium report
AHCYL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHCYL1 Gene

Disorders for AHCYL1 Gene

Relevant External Links for AHCYL1

Genetic Association Database (GAD)
AHCYL1
genes like me logo Genes that share disorders with AHCYL1: view

No data available for UniProtKB/Swiss-Prot for AHCYL1 Gene

Publications for AHCYL1 Gene

  1. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. (PMID: 16754674) Cooper B.J. … Kato M. (J. Biol. Chem. 2006) 2 3 4 23
  2. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. (PMID: 11904675) Dekker J.W. … Kato M. (Immunogenetics 2002) 2 3 4
  3. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. (PMID: 12525476) Ando H. … Mikoshiba K. (J. Biol. Chem. 2003) 2 3
  4. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PMID: 12878157) Imabayashi H. … Umezawa A. (Exp. Cell Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AHCYL1 Gene

  • antibodies-online proteins for AHCYL1
  • antibodies-online antibodies for AHCYL1
  • antibodies-online kits for AHCYL1

Sources for AHCYL1 Gene

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